| 326152 |
Q9VQ56 |
ERM_DROME |
Fez family zinc finger protein erm (Earmuff) |
DISRUPTION PHENOTYPE |
Results in abnormal expansion of type II neuroblasts and in ectopic expression of pnt and grh (PubMed:28245922, PubMed:20152183). Simultaneous RNAi-mediated knockdown of N partially restores normal neuroblast numbers and prevents loss of pnt expression (PubMed:27151950). Simultaneous RNAi-mediated knockdown of erm with either HDAC3 or members of the Brm-associated protein (BAP) chromatin-remodeling complex brm and Snr1 further increases the number of type II neuroblasts compared with the single knockdown (PubMed:24618901). Simultaneous RNAi-mediated knockdown of both erm and the ETS protein pnt restores normal neuroblast numbers (PubMed:28899667). RNAi-mediated knockdown in lamina neurons and their precursor cells, results in defective targeting of R8 neurons, with 45% of them terminating in medulla layers other than the correct M3 layer (PubMed:29513217). RNAi-mediated knockdown in L3 neurons, reduces expression of NetB in L3 neurons, L3 somas and the developing M3 layer (PubMed:29513217). {ECO:0000269|PubMed:20152183, ECO:0000269|PubMed:24618901, ECO:0000269|PubMed:27151950, ECO:0000269|PubMed:28245922, ECO:0000269|PubMed:28899667, ECO:0000269|PubMed:29513217}. |