| 32780 |
P08510 |
KCNAS_DROME |
Potassium voltage-gated channel protein Shaker (Protein minisleep) |
DISRUPTION PHENOTYPE |
Reduced sleep (PubMed:15858564). Flies sleep for one-third of the wild-type amount (PubMed:15858564). They perform normally in a number of tasks, have preserved sleep homeostasis, but are not impaired by sleep deprivation (PubMed:15858564). They also have a reduced lifespan (PubMed:15858564). Males are able to discriminate between males and females during courtship but their courtship of females is reduced, suggesting that their perception and/or response to wild-type female pheromones is decreased (PubMed:22292044). RNAi-mediated knockdown in all neurons or specifically in the mushroom bodies of adult males, impairs their ability to discriminate between males and females (PubMed:22292044). However, knockdown in various chemosensory peripheral neurons has no effect on male sex discrimination (PubMed:22292044). {ECO:0000269|PubMed:15858564, ECO:0000269|PubMed:22292044}. |