Mine Disruption Phenotype

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 33374
  • Symbol: Npc2a
  • Description: Niemann-Pick type C-2a
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Gene ID Entry Entry Name Protein Name Type Information
33374 Q9VQ62 NPC2_DROME NPC intracellular cholesterol transporter 2 homolog a (Niemann Pick type C2 protein homolog) DISRUPTION PHENOTYPE Abnormal sterol distribution in many cells, also lower than normal ecdysteroid levels. Npc2a and Npc2b double mutants undergo apoptotic neurodegeneration. {ECO:0000269|PubMed:17804599}.