Mine Disruption Phenotype

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 33627
  • Symbol: ft
  • Description: fat
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Gene ID Entry Entry Name Protein Name Type Information
33627 P33450 FAT_DROME Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito] DISRUPTION PHENOTYPE Severe overgrown imaginal disk derivatives and pupal death (PubMed:16996265). Overall larval growth is reduced (PubMed:25215488). Cells are round, swollen and have abnormal mitochondrial cristae due to defects in assembly of the mitochondrial electron chain complexes I and V (CI and CV) (PubMed:25215488). Loss of CI activity results in a switch to aerobic glycosis which increases lactate levels (PubMed:25215488). RNAi-mediated knockdown results in dorsal-ventral inversions in ommatidia planar cell polarity (PubMed:25215488). {ECO:0000269|PubMed:16996265, ECO:0000269|PubMed:25215488}.