Mine Disruption Phenotype

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 33999
  • Symbol: MICU1
  • Description: Mitochondrial calcium uptake 1
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Gene ID Entry Entry Name Protein Name Type Information
33999 A2VEI2 MICU1_DROME Calcium uptake protein 1 homolog, mitochondrial (Mitochondrial calcium uptake 1) DISRUPTION PHENOTYPE RNAi-mediated knockdown results in lethality (PubMed:27568554). RNAi-mediated knockdown in neurons shortens lifespan and severely impairs climbing ability (PubMed:28198506). RNAi-mediated knockdown in the developing eye decreases ommatidia number and disrupts ommatidial array (PubMed:28198506). RNAi-mediated knockdown in neurons and, more specifically, in alpha/beta or gamma mushroom body neurons, impairs mitochondrial calcium entry and decreases intermediate-term memory after conditioning (PubMed:27568554). Does not affect olfactory learning (PubMed:27568554). {ECO:0000269|PubMed:27568554, ECO:0000269|PubMed:28198506}.