| 34792 |
Q27607 |
DPOG1_DROME |
DNA polymerase subunit gamma-1, mitochondrial (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase gamma subunit 1) (Mitochondrial DNA polymerase catalytic subunit) (Protein tamas) |
DISRUPTION PHENOTYPE |
Larval lethal due to severe defects in mitochondrial DNA (mtDNA) replication and synthesis (PubMed:26554610). Larvae display a severe decrease in body weight and a 70% decrease in mtDNA levels but are able to survive on maternal contribution until the third larval stage (PubMed:26554610). RNAi-mediated knockdown in male germline cells, results in defective clearance of paternal mitochondrial nucleoids (containing mitochondrial DNA) during spermatogenesis (PubMed:28318978). Eggs fertilized by mutant males do not display an increase in male mtDNA levels, suggesting that it does not affect regulatory pathways in the embryo that prevent the paternal transmission of mtDNA (PubMed:28318978). {ECO:0000269|PubMed:26554610, ECO:0000269|PubMed:28318978}. |