| 35532 |
A1Z6J5 |
TBCE_DROME |
Tubulin-specific chaperone E (Tubulin-folding cofactor E) |
DISRUPTION PHENOTYPE |
Embryonic lethal, with a few escapers that develop to first-instar larvae. In larval muscles the microtubule (MT) network is greatly reduced with a decrease in the number and length of MT fibers. RNAi-mediated knockdown in larval neurons and muscles results in a significant increase in roll-over time. RNAi-mediated knockdown in pre- and post-synaptic neurons results in increased branching number, increased bouton number and decreased bouton size at the neuromuscular junction (NMJ) synaptic terminals. Presynaptic knockdown also results in increased excitatory junction potentials (EJPs) and miniature excitatory junction potentials (mEJPs) of NMJ synapses, whereas knockdown in postsynaptic neurons has no effect on neurotransmission parameters. {ECO:0000269|PubMed:19297412}. |