| 35847 |
Q7JXV9 |
VPS25_DROME |
Vacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25) (Vacuolar protein sorting 25) |
DISRUPTION PHENOTYPE |
Vps25 mutant cells exhibit multivesicular body sorting defects, with large amounts of ubiquitinated proteins detected on endosomes. This leads to activation of signals (through Notch and Dpp receptors) that drive cell proliferation, non-autonomous overgrowth, loss of epithelial organization, and render cells sensitive to apoptosis. Vps25 mutant cells display accumulation of autophagosomes. Bicoid mRNA is mislocalized in developing eggs. {ECO:0000269|PubMed:16256743, ECO:0000269|PubMed:16256745, ECO:0000269|PubMed:16611691, ECO:0000269|PubMed:17088062, ECO:0000269|PubMed:17268469, ECO:0000269|PubMed:17935992, ECO:0000269|PubMed:19132102}. |