| 36405 |
Q9V6G5 |
TAZ_DROME |
Tafazzin (TAZ) (dTAZ) (EC 2.3.1.-) |
DISRUPTION PHENOTYPE |
Cardiolipin (CL) deficiency, faster turnover, abnormal CL fatty acyl composition and abnormal muscle mitochondria (PubMed:17082194, PubMed:16855048, PubMed:19700766, PubMed:19114128, PubMed:31110016). Poor motor performance of flight muscles (PubMed:16855048, PubMed:19114128, PubMed:29405656). Significantly reduced climbing speed and endurance which does not improve with endurance training in contrast to wild-type flies (PubMed:16855048, PubMed:29405656). Normal response to cardiac pacing (PubMed:29405656). Male sterility (PubMed:19164547). Male-sterile phenotype can be suppressed by genetic inactivation of iPLA2-VIA, which prevents CL depletion and monolyso-CL accumulation without correcting the abnormal CL acyl composition, suggesting that the abnormal levels of CL and/or monolyso-CL are important pathogenetic factors (PubMed:19164547). {ECO:0000269|PubMed:16855048, ECO:0000269|PubMed:17082194, ECO:0000269|PubMed:19114128, ECO:0000269|PubMed:19164547, ECO:0000269|PubMed:19700766, ECO:0000269|PubMed:29405656, ECO:0000269|PubMed:31110016}. |