Mine Disruption Phenotype

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 36543
  • Symbol: DJ-1alpha
  • Description: DJ-1alpha
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Gene ID Entry Entry Name Protein Name Type Information
36543 A1Z9J4 DJ1A_DROME Protein DJ-1alpha DISRUPTION PHENOTYPE Double knockouts for dj-1beta and dj-1alpha is viable but with reduced male fertility (PubMed:16139213, PubMed:20457924). Double knockouts for dj-1beta and dj-1alpha is more sensitive to chemical agents that induce oxidative stress (PubMed:16139213). Double knockouts for dj-1beta and dj-1alpha shows reduced lifespan and decreased spontaneous movement over time (PubMed:20457924). Double knockouts for dj-1beta and dj-1alpha spermatozoa are morphologically normal but immotile with abnormal vacuoles in the Nebenkern, abnormal mitochondria and aberrant separation of investment cones during sperm individualization (PubMed:20457924). {ECO:0000269|PubMed:16139213, ECO:0000269|PubMed:20457924}.