| 36849 |
Q7K4Y6 |
DAT_DROME |
Sodium-dependent dopamine transporter (Protein fumin) |
DISRUPTION PHENOTYPE |
No effect on fertility or longevity but mutants display longer periods of daily activity than controls, reduced rest, enhanced sensitivity to mechanical stimuli when inactive and decreased rest rebound in response to rest deprivation (PubMed:16093388). Impaired aversive olfactory memory due to excessive dopaminergic signaling (PubMed:25232310). RNAi-mediated knockdown in neurons causes significant reduction in the sleep-like rest state with total daily resting periods decreased to about half of that of control flies (PubMed:25232310). {ECO:0000269|PubMed:16093388, ECO:0000269|PubMed:25232310}. |