| 37456 |
D5SHR0 |
TIWAZ_DROME |
BTB/POZ domain-containing protein Tiwaz (Potassium channel tetramerization domain-containing protein Tiwaz) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown in adult octopaminergic neurons, disrupts TfAP-2 expression resulting in behavioral abnormalities such as increased male aggression, reduced walking pace and overeating (PubMed:24142897, PubMed:25187989). Males display an increase in low-intensity fighting, with males performing more wing flicks and shoves during a 20 min fighting bout (PubMed:24142897). Males also display increased courtship behaviors, such as singing, circling and abdomen bends, towards males and virgin females (PubMed:24142897). Adults also eat significantly more over a 24 hr period and some overeat after starvation (PubMed:25187989). Inhibits expression of TfAP-2 in adults fed a normal diet, and inhibits the up-regulation of TfAP-2 in adults fed a low calorie diet or undergoing starvation (PubMed:25187989). Adults display decreased expression of the octopamine synthesis genes Tbh and Vmat, and the octopmaine signaling gene Dsk (PubMed:24142897). RNAi-mediated knockdown in class I, II, III, and IV md neurons, results in hypersensitive nociception behaviors, with larvae displaying reduced nocifensive escape locomotion (NEL) response latency to a 42 degrees Celsius heat probe (PubMed:30231996). {ECO:0000269|PubMed:24142897, ECO:0000269|PubMed:25187989, ECO:0000269|PubMed:30231996}. |