| 37724 |
P12428 |
BROWN_DROME |
Protein brown (EC 7.6.2.-) (EC 7.6.2.6) (ATP-binding cassette transporter sub-family G member brown) (Broad substrate specificity ATP-binding cassette transporter brown) |
DISRUPTION PHENOTYPE |
Eyes are brown due to a defect in red pigment production (PubMed:10407069). In Malpighian tubules, guanine uptake is impaired (PubMed:117796). Reduces the levels of several metabolites, including kynurenine, kynurenic acid, 3-hydroxykynurenine, guanosine, xanthine, urate, riboflavin, and tetrahydrofolate, and increases the levels of guanine (PubMed:33820991). In the head, levels of neurotransmitters histamine, dopamine and serotonin are reduced; specifically, histamine is reduced in the retina (PubMed:18931318). Severe loss of white protein in the retina lamina and photoreceptors (PubMed:18931318). In addition, in lamina photoreceptor terminals R1-R6, number of synaptic vesicles is reduced (PubMed:18931318). Inhibits aging-induced intestinal stem cell proliferation (PubMed:33820991). {ECO:0000269|PubMed:10407069, ECO:0000269|PubMed:117796, ECO:0000269|PubMed:18931318, ECO:0000269|PubMed:33820991}. |