| 37841 |
P45594 |
CADF_DROME |
Cofilin/actin-depolymerizing factor homolog (Protein D61) (Protein twinstar) |
DISRUPTION PHENOTYPE |
Late larval or pupal lethality with mutants showing defects in cytokinesis in both mitotic and meiotic cells, abnormal accumulation of F-actin in mature primary spermatocytes, and defective aster migration where the asters remain in close proximity to each other rather than separating from each other and migrating around the periphery of the nuclear envelope as in the wild type (PubMed:8522587). Failure of terminal filament formation in the ovary at the third larval instar at 25 degrees Celsius but formation occurs at 18 degrees Celsius (PubMed:11175754). Significantly thinner retina than controls, significantly increased F-actin levels in pupal eye disks and defective rhabdomere morphogenesis (PubMed:18423434). Defective mushroom body neuroblast proliferation with newly hatched larvae containing significantly fewer neurons than controls and severe axon growth defects with mutants failing to extend axons beyond the peduncle (PubMed:15572110). RNAi-mediated knockdown in the wing results in increased F-actin levels, altered subcellular location of the transcriptional coactivator yki, strong expression of the yki target genes wg and ex, cell extrusion from the basement membrane, reduced levels of the junction proteins dlg1, arm and shg, up-regulation of Rho1, apoptosis and JNK signaling (PubMed:27041568). {ECO:0000269|PubMed:11175754, ECO:0000269|PubMed:15572110, ECO:0000269|PubMed:18423434, ECO:0000269|PubMed:27041568, ECO:0000269|PubMed:8522587}. |