Mine Disruption Phenotype

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 37916
  • Symbol: Brca2
  • Description: BRCA2, DNA repair associated
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Gene ID Entry Entry Name Protein Name Type Information
37916 Q9W157 BRCA2_DROME Breast cancer type 2 susceptibility protein homolog (dmbrca2) DISRUPTION PHENOTYPE Induced sensitivity to DNA damage induced by irradiation or treatment with hydroxyurea/ Repair by homologous recombination is dramatically decreased. Instead, large flanking deletions are formed, and repair by the non-conservative single-strand annealing pathway predominates. {ECO:0000269|PubMed:17822964, ECO:0000269|PubMed:18266476}.