| 38076 |
Q9W0P5 |
GALE_DROME |
UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase) |
DISRUPTION PHENOTYPE |
Required from embryogenesis through pupation, even in the absence of galactose. Loss of Gale during pupation leads to defects in fecundity, both in male and female. Gale activity toward UDP-Gal is both necessary and sufficient for male fecundity, but Gale activities toward both UDP-Gal and UDP-GalNAc are required for female fecundity. Eggs may require a more substantial pool of specific UDP-sugar substrates than sperm. Individual loss of one activity or the other later in development results in differential sensitivity to galactose. Both male and female deficient in Gale activity toward UDP-Gal exhibit a reduced lifespan when exposed to galactose; this effect is not seen in flies uniquely deficient in Gale activity toward UDP-GalNAc. {ECO:0000269|PubMed:22654673}. |