| 38176 |
Q9W0E3 |
IML1_DROME |
GATOR complex protein Iml1 (Increased minichromosome loss 1) |
DISRUPTION PHENOTYPE |
Pupal lethal (PubMed:27672113). Under nutrient-replete conditions, larvae display a significant increase in TORC1 activity, indicated by increased phosphorylation of S6K/p70S6K (PubMed:27672113). RNAi-mediated knockdown in the female germline results in a large percentage of ovarian cysts delaying mitotic exit (PubMed:25512509, PubMed:27672113). Instead, cysts undergo a fifth mitotic division before meiotic commitment to produce 32-cell cysts with a single oocyte (PubMed:25512509, PubMed:27672113). Double RNAi-mediated knockdown with GATOR1 complex member Nprl2 in the female germline increases the penetrance of ovarian cysts displaying delayed mitotic exit and producing 32-cell cysts (PubMed:27672113, PubMed:25512509). The number of ovarian cysts that delay meiotic commitment and undergo a fifth mitotic division are decreased when females are fed the mTORC1 complex inhibitor rapamycin (PubMed:25512509). {ECO:0000269|PubMed:25512509, ECO:0000269|PubMed:27672113}. |