| 38347 |
M9NEY8 |
TET_DROME |
Methylcytosine dioxygenase TET (EC 1.14.11.80) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase) (EC 1.14.11.51) |
DISRUPTION PHENOTYPE |
Lethality at the pupa stage. A small population of mutant animals are however able to pass through the pupa stage but die within 3 days post-eclosion. Strong developmental defects and significantly increases the abundance of N(6)-methyladenosine (m6A) modification in DNA. RNAi-mediated knockdown results in mushroom bodies abnormalities, including beta-lobes which erroneously cross the midline, missing or misdirected alpha- and beta-lobes, as well as truncated or overbranched lobes (PubMed:30078725). RNAi-mediated knockdown in neurons results in mushroom body abnormalities in adult flies (PubMed:30078725). Simultaneous RNAi-mediated knockdown of Tet and wds results in enhanced mushroom body alpha lobe development defects compared to the single Tet knockdown (PubMed:30078725). {ECO:0000269|PubMed:25936838, ECO:0000269|PubMed:30078725}. |