| 39550 |
Q9VUB4 |
NPRL3_DROME |
GATOR complex protein NPRL3 (Nitrogen permease regulator 3-like protein) |
DISRUPTION PHENOTYPE |
A high percentage of mutants die as pupae or pharate adults (PubMed:27166823, PubMed:27672113). Under nutrient-replete conditions, larvae display a significant increase in TORC1 activity (PubMed:27672113, PubMed:27166823). Adult escapers display a small but significant increase in body weight and a reduction in climbing (PubMed:27672113). Newly hatched males have a decreased tolerance to both complete starvation and amino acid starvation, likely due to decreased triacylglyceride (TAG) storage and the inability to down-regulate TORC1 activity and activate catabolic metabolism and autophagy (PubMed:27672113). Conditional RNAi-mediated knockdown in the female germline results in a small decrease in the rate of egg production when females are provided with a protein source of wet yeast (PubMed:24786828). Females starved of amino acids for a brief period have increased numbers of degenerating young eggs and show permanent loss of fertility (PubMed:24786828). Mid-stage egg chambers are unaffected (PubMed:24786828). {ECO:0000269|PubMed:24786828, ECO:0000269|PubMed:27166823, ECO:0000269|PubMed:27672113}. |