| 39813 |
Q9VV43 |
TPPP_DROME |
Tubulin polymerization-promoting protein homolog (TPPP) (Protein ringmaker) |
DISRUPTION PHENOTYPE |
Embryonic nervous system defects characterized by cell misplacement and errors in axonal extension and targeting (PubMed:27422099). Neurons display defective axonal extension (PubMed:27422099). Defects are probably caused by impaired microtubule organization and integrity (PubMed:27422099). During larval neuromuscular junction (NMJ) synaptic development, larvae show reduced synaptic growth and transmission (PubMed:31156389). Flies lacking both Ringer and Futsch display a significant reduction in microtubule loops at the neuromuscular junctions (NMJ) and reduced acetylated-tubulin levels (PubMed:31156389). {ECO:0000269|PubMed:27422099, ECO:0000269|PubMed:31156389}. |