| 39836 |
P45843 |
SCRT_DROME |
Protein scarlet (EC 7.6.2.-) (ATP-binding cassette transporter sub-family G member scarlet) (Broad substrate specificity ATP-binding cassette transporter scarlet) |
DISRUPTION PHENOTYPE |
Eyes are scarlet due to a defect in brown pigment production (PubMed:10407069). In larval Malpighian tubules and pupal eyes, kynurenine uptake is impaired resulting in a severe decrease in 3-hydroxykynurenine production (PubMed:812484). In the head, levels of neurotransmitters histamine, dopamine and serotonin are reduced (PubMed:18931318). In addition, in lamina photoreceptor terminals R1-R6, numbers of synaptic vesicles and capitate projections, which are sites of endocytosis of vesicle membrane, are reduced (PubMed:18931318). Reduces the levels of several metabolites, including tryptophan, kynurenine, 3-hydroxykynurenine, guanosine, and, to a lesser extent, xanthine and riboflavin, and increases the levels of guanine and tetrahydrofolate (PubMed:33820991). 3-fold reduction in Malpighian tubule zinc stores (PubMed:29367274). {ECO:0000269|PubMed:10407069, ECO:0000269|PubMed:18931318, ECO:0000269|PubMed:29367274, ECO:0000269|PubMed:33820991, ECO:0000269|PubMed:812484}. |