| 40438 |
Q9VNX1 |
POLH_DROME |
DNA polymerase eta (EC 2.7.7.7) |
DISRUPTION PHENOTYPE |
Viable and fertile (PubMed:24553286). Results in spindle defects (PubMed:24553286). Results in severe sensitivity of third-instar larvae to ultraviolet radiation (UV) (PubMed:22532806, PubMed:24553286). Exhibits a significant reduction in survival after hydroxyurea (HU)-induced DNA damage (PubMed:24553286). Decreases homologous recombination (HR) (PubMed:22532806). Simultaneous knockout of PolH/DNApol-eta and PolZ1/DNApol-zeta does not show any difference in the frequency of full HR repair compared to the single knockouts suggesting they have overlapping roles (PubMed:22532806). {ECO:0000269|PubMed:22532806, ECO:0000269|PubMed:24553286}. |