| 40582 |
Q9VN45 |
SPART_DROME |
Protein spartin |
DISRUPTION PHENOTYPE |
Mutant larvae show an overgrowth of the third-instar NMJ, with an overall bouton number and satellite bouton number increase of 40% and 90%, respectively, compared with wild type. Mutant larvae also show a decrease in the amplitude of evoked excitatory junction currents (EJCs), but normal spontaneous miniature EJCs (mEJCs) and axonal transport. Adult mutants display reduced locomotor activity and progressive vacuolization in the brain, which is associated with neurodegeneration. {ECO:0000269|PubMed:23439121}. |