Mine Disruption Phenotype

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 40754
  • Symbol: NPFR
  • Description: Neuropeptide F receptor
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Gene ID Entry Entry Name Protein Name Type Information
40754 Q9VNM1 NPFR_DROME Neuropeptide F receptor (DmNPFR1) DISRUPTION PHENOTYPE Increased NPF or NPFR activity dominantly suppresses PAIN-mediated food aversion in postfeeding larvae. Deficiency in NPF/NPFR signaling causes decreased alcohol sensitivity and overexpression causes a hypersensitive response to alcohol sedation. Controlled functional disruption of NPF or NPFR neurons rapidly triggers acute resistance to ethanol sedation. {ECO:0000269|PubMed:11897397, ECO:0000269|PubMed:15677721, ECO:0000269|PubMed:20164335, ECO:0000269|PubMed:22422983}.