| 41230 |
Q9VH36 |
CRBN_DROME |
Protein cereblon (Protein ohgata) |
DISRUPTION PHENOTYPE |
Viable and fertile however, adults and larvae display an increase in body size and tissue growth as a result of increased cell number (PubMed:27702999). Overgrowth is due to an up-regulation in insulin-like signaling both systematically and in the fat body, which in turn results in the down-regulation of insulin-like peptide (ILP) inhibitors, conv and ImpL2, and thus allows increased activity of the ILPs (PubMed:27702999). RNAi-mediated knockdown in the fat body results in an increase in pupal length, adult body weight and posterior wing area (PubMed:27702999). {ECO:0000269|PubMed:27702999}. |