| 41861 |
Q9VF87 |
CYFIP_DROME |
Cytoplasmic FMR1-interacting protein (Specifically Rac1-associated protein 1) (DSra-1) |
DISRUPTION PHENOTYPE |
Flies display pupal lethality with defects in axon growth, branching and pathfinding, synaptic length and organization of the neuromuscular junction. They also display defects in cell morphology with cells exhibiting a starfish-like shape with multiple slender cell extensions and loss of actin filaments at the cell periphery (PubMed:12818175, PubMed:14588242, PubMed:15269173). RNAi-mediated knockdown in gamma-aminobutyric acid (GABA)ergic neurons, or specifically in the anterior paired lateral (APL) neurons or in the antennal lobe local interneurons (LNs), results in feeding-dependent socialization defects (PubMed:32200800). {ECO:0000269|PubMed:12818175, ECO:0000269|PubMed:14588242, ECO:0000269|PubMed:15269173, ECO:0000269|PubMed:32200800}. |