| 42109 |
Q9VEJ0 |
PRDX3_DROME |
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Peroxiredoxin 3) (Thioredoxinperoxidase 3) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown leads to decreased lifespan, increased susceptibility to oxidative stress and an increase in apoptotic cells in the central brain (PubMed:33889951, PubMed:20869434, PubMed:23124252). Exposure of young (10-15 days old) flies to paraquat or hydrogen peroxide leads to decreased resistance to oxidants (PubMed:20869434). Reduced survival rate under oxidative stress conditions; further decrease in responsiveness to oxidative stress with age (PubMed:23124252). Affects coordinated motor behavior, such as shorter distance covered in a given time interval (15% reduction) and reduced velocity (16% reduction) compared to wild-type animals (PubMed:33889951). RNAi-mediated knockdown in neurons and glia, but not in muscles, significantly affects motor behavior (PubMed:33889951). Pan-neuronal RNAi-mediated knockdown reduces distance covered over time by 14%, with velocity during periods of moving being reduced by 13% compared to control animals (PubMed:33889951). Pan-glial RNAi-mediated knockdown reduces the distance covered by 7% and velocity during periods of moving by 8% (PubMed:33889951). RNAi-mediated knockdown in a Prx5 null mutant background leads to mean life span reduction from 55-70 days to 12.8 days and, after appearing relatively normal for the first 9-11 days after eclosion, animals undergo a very rapid increase in mortality rate (PubMed:20869434). Accelerated pro-oxidizing shift in the redox state (PubMed:20869434). Increase in the number of cells undergoing apoptosis in the thoracic muscles, digestive tract and oenocytes (PubMed:20869434). Reduction in night activity offset and age-dependent increase in temperature sensitive paralysis (PubMed:33585478). RNAi-mediated knockdown in motor neurons in a Prx5 null mutant background shortens life span and decreases negative geotaxis and phototaxis (PubMed:33585478). {ECO:0000269|PubMed:20869434, ECO:0000269|PubMed:23124252, ECO:0000269|PubMed:33585478, ECO:0000269|PubMed:33889951}. |