Mine Disruption Phenotype

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 42208
  • Symbol: WRNexo
  • Description: WRN exonuclease
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Gene ID Entry Entry Name Protein Name Type Information
42208 Q9VE86 WRNXO_DROME 3'-5' exonuclease (EC 3.1.11.-) (Werner Syndrome-like exonuclease) (DmWRNexo) DISRUPTION PHENOTYPE Females are sterile. Hypersensitive to the topoisomerase I inhibitor camptothecin. Highly elevated rates of mitotic DNA recombination resulting from excessive reciprocal exchange. {ECO:0000269|PubMed:18346216, ECO:0000269|PubMed:18956248}.