Mine Disruption Phenotype

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 42327
  • Symbol: Dys
  • Description: Dystrophin
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Gene ID Entry Entry Name Protein Name Type Information
42327 Q9VDW3 DMDB_DROME Dystrophin, isoform B (Protein detached) DISRUPTION PHENOTYPE Flies that have reduced expression of all isoforms (transgenic RNA interference targeting the common C-terminal region) exhibit severe muscle degeneration in larvae and adult flies. Muscles were either ruptured, absent or the fibers were detached from their attachment sites at tendon cells. These are necrotic, not apoptotic processes. {ECO:0000269|PubMed:17543506}.
42327 Q0KI50 DMDD_DROME Dystrophin, isoform D (Protein detached) DISRUPTION PHENOTYPE Flies that have reduced expression of all isoforms (due to transgenic RNA interference targeting the common C-terminal region) exhibit severe muscle degeneration in larvae and adult flies. Muscles were either ruptured, absent, or the fibers were detached from their attachment sites at tendon cells. These are necrotic, not apoptotic processes. {ECO:0000269|PubMed:17543506}.
42327 Q7YU29 DMDE_DROME Dystrophin, isoform E (Protein detached) DISRUPTION PHENOTYPE Flies exhibit muscle degeneration and lethality. Flies that have reduced expression of all isoforms (due to transgenic RNA interference targeting the common C-terminal region) exhibit severe muscle degeneration in larvae and adult flies. Muscles were either ruptured, absent or the fibers were detached from their attachment sites at tendon cells. These are necrotic, not apoptotic processes. {ECO:0000269|PubMed:17543506}.
42327 Q9VDW6 DMDA_DROME Dystrophin, isoforms A/C/F/G/H (DmDYS) (Protein detached) DISRUPTION PHENOTYPE Wings exhibit a 'crossveinless' phenotype. Adult flies are viable and the crossvein defect is the sole overt morphological defect observed. Flies that have reduced expression of all isoforms (due to transgenic RNA interference targeting the common C-terminal region) exhibit severe muscle degeneration in larvae and adult flies. Muscles were either ruptured, absent or the fibers were detached from their attachment sites at tendon cells. These are necrotic, not apoptotic processes. {ECO:0000269|PubMed:17543506, ECO:0000269|PubMed:18093579}.