Mine Disruption Phenotype

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 42679
  • Symbol: wfs1
  • Description: wolfram syndrome 1
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Gene ID Entry Entry Name Protein Name Type Information
42679 Q8IMZ9 WFS1_DROME Wolframin DISRUPTION PHENOTYPE RNAi-mediated knockdown in neurons results in age-dependent behavioral deficits and neurodegeneration, which is further enhanced when the knockdown is in both neurons and glial cells; the defects include age-dependent locomotor deficits, increased susceptibility to oxidative stress and glutamate excitotoxicity, increased age-dependent appearance of vacuoles in the central neuropil and optic lobes of the fly brain, and shortened lifespan. {ECO:0000269|PubMed:29357349}.