| 42816 |
Q9VCH5 |
NUP98_DROME |
Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (Nucleoporin Nup96) (Nup96)] |
DISRUPTION PHENOTYPE |
Defective germline population maintenance and differentiation when both Nup98 and Nup96 are disrupted (PubMed:21949861). RNAi-mediated knockdown in the larval salivary glands results in reduced transcription of developmental genes Eip74EF and Eip75B and compromised transcriptional recovery after heat shock (PubMed:20144761). RNAi-mediated knockdown in the larva results in reduced expression of Hox genes such as Ubx and Antp (PubMed:25310983). RNA-mediated knockdown in the adult fly increases viral replication of Sindbis virus (SINV), vesicular stomatitis virus (VSV) and Drosophila C virus (DCV) (PubMed:25197089). {ECO:0000269|PubMed:20144761, ECO:0000269|PubMed:21949861, ECO:0000269|PubMed:25197089, ECO:0000269|PubMed:25310983}. |