| 42845 |
Q8IMX7 |
MIRO_DROME |
Mitochondrial Rho GTPase (Miro) (dMiro) (EC 3.6.5.-) |
DISRUPTION PHENOTYPE |
Flies die at early pupal stage and exhibit abnormal locomotion (PubMed:16055062). Mitochondria in muscles and neurons are abnormally distributed (PubMed:16055062). Instead of being transported into axons and dendrites, mitochondria accumulate in parallel rows in neuronal somata (PubMed:16055062). Mutant NMJs lack presynaptic mitochondria, but neurotransmitter release and acute Ca(2+) buffering is only impaired during prolonged stimulation (PubMed:16055062). RNAi-mediated knockdown perturbs mitochondrial distribution and dynamics (PubMed:27716788). RNAi-mediated knockdown in the dopaminergic (DA) neurons decreases mitochondrial length and mitochondrial flux, and mitochondria accumulate in the most distal boutons of the DA motor neuron nerve terminals (PubMed:22396657). {ECO:0000269|PubMed:16055062, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:27716788}. |