Mine Disruption Phenotype

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 43437
  • Symbol: Pdhb
  • Description: Pyruvate dehydrogenase E1 beta subunit
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Gene ID Entry Entry Name Protein Name Type Information
43437 Q7K5K3 ODPB_DROME Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (EC 1.2.4.1) DISRUPTION PHENOTYPE RNAi-mediated knockdown in neurons reduces life span of adult flies and results in locomotor defects at both larval and adult stages accompanied by abnormal morphology of motor neuron terminals at neuromuscular junctions and mitochondrial fragmentation in brains (PubMed:29501567). RNAi-mediated knockdown in eye disks induces morphologically aberrant rough eye phenotype in adults and aberrant photoreceptor axon targeting (PubMed:29501567). {ECO:0000269|PubMed:29501567}.