| 43652 |
Q9VA37 |
DJ1B_DROME |
Protein dj-1beta |
DISRUPTION PHENOTYPE |
Viable and fertile (PubMed:16203113). Larvae develop normally but show increased oxidative stress-induced cell death (PubMed:23593018, PubMed:30540251). Larvae show structurally normal neuromuscular junctions, however they fail to show structural synaptic plasticity in response to oxygen species (ROS) levels (PubMed:30540251). Adult flies show severe defects in locomotor ability without loss of dopaminergic neurons and increased sensitivity to oxidative stress (PubMed:16139214, PubMed:16203113, PubMed:23593018). Results in altered subcellular localization of Daxx (PubMed:23593018). Does not show more elevated levels of methylglyoxal adducts than controls (PubMed:27903648). Double knockouts for dj-1beta and dj-1alpha is viable but with reduced male fertility (PubMed:16139213, PubMed:20457924). Double knockouts for dj-1beta and dj-1alpha is more sensitive to chemical agents that induce oxidative stress (PubMed:16139213). Double knockouts for dj-1beta and dj-1alpha shows reduced lifespan and decreased spontaneous movement over time (PubMed:20457924). Double knockouts for dj-1beta and dj-1alpha spermatozoa are morphologically normal but immotile with abnormal vacuoles in the Nebenkern, abnormal mitochondria and aberrant separation of investment cones during sperm individualization (PubMed:20457924). Double knockouts for DJ-1beta and Daxx restore normal number of dopaminergic neurons, locomotor activity and sensitivity to oxidative stress and UV-induced damage (PubMed:23593018). {ECO:0000269|PubMed:16139213, ECO:0000269|PubMed:16139214, ECO:0000269|PubMed:16203113, ECO:0000269|PubMed:20457924, ECO:0000269|PubMed:23593018, ECO:0000269|PubMed:27903648, ECO:0000269|PubMed:30540251}. |