Mine Disruption Phenotype

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 43772
  • Symbol: Abcd1
  • Description: ATP binding cassette subfamily D member 1
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Gene ID Entry Entry Name Protein Name Type Information
43772 Q7JUN3 ABCD1_DROME ATP-binding cassette sub-family D member 1 (EC 7.6.2.4) DISRUPTION PHENOTYPE RNAi-mediated knockdown survives to adulthood, but suffer from neurodegeneration including age-dependent retinal disorganization with retinal holes and pigment cell loss (PubMed:29739804). RNAi-mediated knockdown in the neurons results in a similar phenotype (PubMed:29739804). Effects are probably due to elevated levels of very long chain fatty acids (VLCFAs) (PubMed:29739804). In contrast, glial-specific RNAi-mediated knockdown results in no defect (PubMed:29739804). {ECO:0000269|PubMed:29739804}.