| 44207 |
Q9VF27 |
NDUS8_DROME |
NADH dehydrogenase (ubiquinone) 23 kDa subunit (EC 7.1.1.2) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown is lethal (PubMed:29285794). RNAi-mediated knockdown in the muscles impairs biogenesis of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:28683319). RNAi-mediated knockdown in neurons impairs neuronal ATP production, reduces locomotor activity and shortens lifespan (PubMed:29285794). In addition, results in large vacuoles in the retina, ommatidia disorganization and selective axonal alterations in mushroom bodies (PubMed:29285794). RNAi-mediated knockdown in glia results in large vacuoles and lipid droplets in both cortical region of the brain and optic lobes suggesting altered lipid metabolism; does not alter lifespan or behavior (PubMed:29285794). {ECO:0000269|PubMed:28683319, ECO:0000269|PubMed:29285794}. |