| 44544 |
P49866 |
HNF4_DROME |
Transcription factor HNF-4 homolog (dHNF4) (Nuclear receptor subfamily 2 group A member 4) |
DISRUPTION PHENOTYPE |
Under normal culture conditions, the flies progress through development until they die during or shortly after adult eclosion. Under low density culture conditions, many flies survive and develop into morphologically normal adults. The mutant flies are, however, very sensitive to starvation, displaying inability to efficiently mobilize stored lipid in the midgut and fat body, increased levels of long-chain fatty acids and triglycerides, and premature death. {ECO:0000269|PubMed:19254568}. |