| 45380 |
Q9GQQ0 |
SPIN_DROME |
Protein spinster (Protein benchwarmer) (Protein diphthong) |
DISRUPTION PHENOTYPE |
In most cases, death at the late pupal stage, probably due to lipid accumulation in endosomes/lysosomes. Some flies survive until adulthood and display a strong rejection behavior of female flies in response to male courtship accompanied by decreases in the viability, adult life span, and oviposition rate of the flies. Some oocytes and adult neural cells undergo degeneration, which is preceded by reductions in programmed cell death of nurse cells in ovaries and of neurons in the pupal nervous system, respectively. The central nervous system (CNS) of flies accumulates lipopigments. Flies also display a strong synaptic overgrowth: synapses reveal a strong increase in bouton number and a deficit in presynaptic release caused by enhanced/misregulated TGF-beta signaling. A widespread accumulation of enlarged lysosomal and late endosomal inclusions is also present in yolk spheres during oogenesis. {ECO:0000269|PubMed:11340170, ECO:0000269|PubMed:12408844, ECO:0000269|PubMed:15998804}. |