| 49804 |
Q9VFC2 |
SP88E_DROME |
Serine protease inhibitor 88Ea (Serpin 88Ea) |
DISRUPTION PHENOTYPE |
Larval lethal (PubMed:19581577). Larvae develop melanotic spots and display an increase in the activity of the activated form of prophenoloxidase 1 (PPO1), phenoloxidase (PO) (PubMed:19581577). Larvae display enhanced activation of the Toll signaling pathway, with increased Tl, spz and Drs expression (PubMed:19581577). RNAi-mediated knockdown of maternal and zygotic expression results in adults that have a reduced lifespan (PubMed:19581577). Wing development appears to be unaffected, however after emergence from the pupal case adult wings fail to unfold and instead remain folded and hypotrophic until death (PubMed:18956323). Other aspects of development in embryos, larvae, pupae and adults appears to be unaffected. {ECO:0000269|PubMed:18956323, ECO:0000269|PubMed:19581577}. |