| 406207 |
A0A0R4IVV0 |
MTP_DANRE |
Microsomal triglyceride transfer protein large subunit |
DISRUPTION PHENOTYPE |
Larvae do not absorb dietary neutral lipids, consume very little yolk, are small and die by 6 days post-fertilization (dpf) with pronounced edema. No defects in intestinal absorption of short chain fatty acids. Loss of visualization of neutral lipids in the vasculature, heart and head structures by oil red o staining. Levels of apolipoprotein B, vitellogenin and lipovitellin unchanged. No cardiovascular defects or global intestinal function impairment. Increased expression of Foza2 and Pgc1 proteins (PubMed:17176039). Leads to excess angiogenesis and yolk absorption defects. Decreased mRNA levels of flt1 at 24 hours post-fertilization (hpf) with no change in the mRNA levels of kdrl or flt4 or in other vascular genes (PubMed:22581286). {ECO:0000269|PubMed:17176039, ECO:0000269|PubMed:22581286}. |