Mine Disruption Phenotype

Gene Info

  • Species: Zebrafish (Danio rerio)
  • GeneID: 436831
  • Symbol: slc25a46
  • Description: solute carrier family 25 member 46
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Gene ID Entry Entry Name Protein Name Type Information
436831 Q6DGU5 S2546_DANRE Mitochondrial outer membrane protein SLC25A46 (Solute carrier family 25 member 46) DISRUPTION PHENOTYPE Morpholino knockdown of the protein produces embryos with a curly tail morphology and impaired swimming, suggesting dysfunction of neural circuits (PubMed:26168012). Spinal motor neurons have shortened axon tracts due to degeneration of neuronal processes (PubMed:27543974). Mitochondria in knockdown embryos show incomplete fission, abnormal aggregation and abnormal cell localization (PubMed:26168012, PubMed:27543974). {ECO:0000269|PubMed:26168012, ECO:0000269|PubMed:27543974}.