Mine Disruption Phenotype

Gene Info

  • Species: Zebrafish (Danio rerio)
  • GeneID: 550447
  • Symbol: osgep
  • Description: O-sialoglycoprotein endopeptidase
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Gene ID Entry Entry Name Protein Name Type Information
550447 Q5RHZ6 OSGEP_DANRE tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (O-sialoglycoprotein endopeptidase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep) (tRNA threonylcarbamoyladenosine biosynthesis protein osgep) DISRUPTION PHENOTYPE Embryos display primary microcephaly, leading to early lethality (PubMed:29346415, PubMed:28805828). Marked apoptosis is observed in the brain (telencephalon) (PubMed:28805828). Fishes do not show a renal phenotype, possibly as a result of early lethality (PubMed:28805828). {ECO:0000269|PubMed:28805828, ECO:0000269|PubMed:29346415}.