| 553051 |
F1Q8X5 |
FERM2_DANRE |
Fermitin family homolog 2 (Kindlin-2) |
DISRUPTION PHENOTYPE |
Morpholino knockdown results in severe defects in embryonic development. Nearly all embryos display pericardial edema. Most embryos display abnormal body shape and size, defects in heart morphogenesis, impaired mobility, and die at about 7 dpf. The embryonic cardiac muscle and skeletal muscle show defects in the association of the actin-myosin myofibers with the myocyte membrane (PubMed:18174465). Likewise, morpholino knockdown results in defective angiogenesis, with abnormally short and thin vessels and very little blood flow (PubMed:21378273). {ECO:0000269|PubMed:18174465, ECO:0000269|PubMed:21378273}. |