| 556228 |
E7F4V8 |
PEX2_DANRE |
Peroxisome biogenesis factor 2 (EC 2.3.2.27) (EC 2.3.2.36) (Peroxin-2) |
DISRUPTION PHENOTYPE |
Mutant fishes show a loss of peroxisomal structure, associated with high-mortality (PubMed:34016526). Defects are similar to human Zellweger syndrome (ZS), characterized by developmental abnormalities in many organs, organ-specific accumulation and reduction of distinct fatty acid species, such as an accumulation of ultra-very-long-chain polyunsaturated fatty acids (ultra-VLC-PUFAs) (PubMed:34016526). {ECO:0000269|PubMed:34016526}. |