Mine Disruption Phenotype

Gene Info

  • Species: Zebrafish (Danio rerio)
  • GeneID: 568554
  • Symbol: kcnma1a
  • Description: potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
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Gene ID Entry Entry Name Protein Name Type Information
568554 B7ZC96 KCMA1_DANRE Calcium-activated potassium channel subunit alpha-1a (BK channel) (Potassium large conductance calcium-activated channel, subfamily M, alpha member 1a) (Slo1a) (Slowpoke homolog) DISRUPTION PHENOTYPE Morpholino knockdown causes circling phenotype characteristic of hearing and balance deficits (PubMed:24803460). Causes a dose-dependent increase in auditory threshold in hair cells; simultaneous knockdown of kcnma1b does not significantly increase auditory threshold (PubMed:24803460). {ECO:0000269|PubMed:24803460}.