Mine Disruption Phenotype

Gene Info

  • Species: Zebrafish (Danio rerio)
  • GeneID: 571549
  • Symbol: kank2
  • Description: KN motif and ankyrin repeat domains 2
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Gene ID Entry Entry Name Protein Name Type Information
571549 X1WE18 KANK2_DANRE KN motif and ankyrin repeat domain-containing protein 2 DISRUPTION PHENOTYPE Morpholino knockdown of the protein results in an edematous phenotype and proteinuria (PubMed:25961457). Podocyte foot process effacement and disorganization, rarefaction of slit membranes, and disorganization of the glomerular basement membrane in glomeruli which are characteritic of nephrosis are observed (PubMed:25961457). {ECO:0000269|PubMed:25961457}.