Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 84444
• Symbol: DOT1L
• Description: DOT1 like histone lysine methyltransferase

DataSource: http://genomecrispr.dkfz.de/#!/results/DOT1L

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
2210655	2210678	19	-	26472758	Jiyoye	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-0.18650433631639174	[82]	[54]	-1	hSpCas9	negative selection	46066
2210818	2210841	19	+	26472758	Jiyoye	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-0.8058183418283249	[101]	[43]	-5	hSpCas9	negative selection	46067
2222452	2222475	19	+	26472758	Jiyoye	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	-0.37043219715767883	[179]	[104]	-3	hSpCas9	negative selection	46068
2164202	2164225	19	+	26472758	Jiyoye	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.5611157587667885	[44]	[22]	-4	hSpCas9	negative selection	46069
2164251	2164274	19	-	26472758	Jiyoye	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	1.4071753815058734	[26]	[53]	8	hSpCas9	negative selection	46070
2189728	2189751	19	+	26472758	Jiyoye	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-0.9189283893526821	[172]	[68]	-6	hSpCas9	negative selection	46071
2191055	2191078	19	-	26472758	Jiyoye	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	0.43248647003506085	[112]	[114]	3	hSpCas9	negative selection	46072
2193762	2193785	19	+	26472758	Jiyoye	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	0.2816444994220144	[23]	[21]	2	hSpCas9	negative selection	46073
2210694	2210717	19	+	26472758	Jiyoye	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	1.3680047842251954	[55]	[108]	7	hSpCas9	negative selection	46074
2210717	2210740	19	+	26472758	Jiyoye	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	-0.48777859433494664	[330]	[177]	-3	hSpCas9	negative selection	46075
2210655	2210678	19	-	26472758	KBM7	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-1.1462616326005515	[458,243]	[68,75]	-7	hSpCas9	negative selection	237184
2210818	2210841	19	+	26472758	KBM7	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-0.5444041011191831	[257,245]	[91,71]	-5	hSpCas9	negative selection	237185
2222452	2222475	19	+	26472758	KBM7	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	0.22021109001863712	[419,392]	[213,230]	2	hSpCas9	negative selection	237186
2164202	2164225	19	+	26472758	KBM7	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-2.76039950553212	[320,143]	[13,16]	-9	hSpCas9	negative selection	237187
2164251	2164274	19	-	26472758	KBM7	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.22017926706325097	[293,317]	[131,117]	-2	hSpCas9	negative selection	237188
2189728	2189751	19	+	26472758	KBM7	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-1.2519998862922468	[765,619]	[135,135]	-7	hSpCas9	negative selection	237189
2191055	2191078	19	-	26472758	KBM7	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-1.6781250911237955	[613,530]	[47,115]	-8	hSpCas9	negative selection	237190
2193762	2193785	19	+	26472758	KBM7	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-2.5176162993248288	[168,143]	[6,17]	-9	hSpCas9	negative selection	237191
2210694	2210717	19	+	26472758	KBM7	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	-0.0002328657790733324	[605,453]	[185,300]	0	hSpCas9	negative selection	237192
2210717	2210740	19	+	26472758	KBM7	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	0.7963455908075707	[851,879]	[923,521]	8	hSpCas9	negative selection	237193
2210655	2210678	19	-	26472758	Raji	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-1.1150088859628484	[223]	[23]	-7	hSpCas9	negative selection	428302
2210818	2210841	19	+	26472758	Raji	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-0.49252930681352836	[96]	[15]	-4	hSpCas9	negative selection	428303
2222452	2222475	19	+	26472758	Raji	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	0.3000286133159953	[202]	[57]	3	hSpCas9	negative selection	428304
2164202	2164225	19	+	26472758	Raji	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.5974884290827535	[162]	[24]	-5	hSpCas9	negative selection	428305
2164251	2164274	19	-	26472758	Raji	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.10738353537359924	[103]	[25]	1	hSpCas9	negative selection	428306
2189728	2189751	19	+	26472758	Raji	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-0.07053425682224346	[180]	[39]	0	hSpCas9	negative selection	428307
2191055	2191078	19	-	26472758	Raji	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-1.6962863398761487	[390]	[27]	-8	hSpCas9	negative selection	428308
2193762	2193785	19	+	26472758	Raji	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-2.405686046865771	[136]	[5]	-9	hSpCas9	negative selection	428309
2210694	2210717	19	+	26472758	Raji	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	-0.23906687864783188	[355]	[69]	-2	hSpCas9	negative selection	428310
2210717	2210740	19	+	26472758	Raji	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	-0.10721051540244109	[491]	[105]	-1	hSpCas9	negative selection	428311
2210655	2210678	19	-	26472758	K562	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-1.0823103534847367	[300]	[119]	-5	hSpCas9	negative selection	619420
2210818	2210841	19	+	26472758	K562	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-0.3613023332215066	[174]	[114]	-2	hSpCas9	negative selection	619421
2222452	2222475	19	+	26472758	K562	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	0.316689014156609	[291]	[306]	2	hSpCas9	negative selection	619422
2164202	2164225	19	+	26472758	K562	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.796608540593608	[213]	[51]	-7	hSpCas9	negative selection	619423
2164251	2164274	19	-	26472758	K562	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.9721657918032743	[156]	[259]	7	hSpCas9	negative selection	619424
2189728	2189751	19	+	26472758	K562	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-1.0948512639944323	[543]	[214]	-6	hSpCas9	negative selection	619425
2191055	2191078	19	-	26472758	K562	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-1.3294885845457134	[389]	[130]	-6	hSpCas9	negative selection	619426
2193762	2193785	19	+	26472758	K562	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-2.725207623290035	[140]	[17]	-8	hSpCas9	negative selection	619427
2210694	2210717	19	+	26472758	K562	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	-0.6233088123706391	[426]	[233]	-4	hSpCas9	negative selection	619428
2210717	2210740	19	+	26472758	K562	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	1.1197631080257957	[748]	[1373]	8	hSpCas9	negative selection	619429
2164245	2164268	19	-	26627737	DLD1	viability	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	-1.9085837624122237	[1157]	[85,73,123]	-8	hSpCas9	negative selection	803701
2180750	2180773	19	-	26627737	DLD1	viability	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-4.810273532916799	[1228]	[28,12,0]	-9	hSpCas9	negative selection	803702
2189774	2189797	19	+	26627737	DLD1	viability	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-2.187633387441804	[814]	[90,0,70]	-9	hSpCas9	negative selection	803703
2190997	2191020	19	+	26627737	DLD1	viability	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	-0.38430875034572826	[610]	[36,79,295]	-4	hSpCas9	negative selection	803704
2193762	2193785	19	+	26627737	DLD1	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-3.0279408299398964	[466]	[26,0,23]	-9	hSpCas9	negative selection	803705
2194519	2194542	19	+	26627737	DLD1	viability	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-2.4679533563244345	[759]	[35,60,33]	-9	hSpCas9	negative selection	803706
2164245	2164268	19	-	26627737	GBM cells	viability after 5 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.6842247767708469	[357]	[317,298]	8	hSpCas9	negative selection	886016
2180750	2180773	19	-	26627737	GBM cells	viability after 5 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.2852651102368686	[266]	[95,138]	-4	hSpCas9	negative selection	886017
2189774	2189797	19	+	26627737	GBM cells	viability after 5 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	0.19392067045775935	[237]	[168,122]	3	hSpCas9	negative selection	886018
2190997	2191020	19	+	26627737	GBM cells	viability after 5 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	0.01257065668125279	[365]	[196,198]	0	hSpCas9	negative selection	886019
2193762	2193785	19	+	26627737	GBM cells	viability after 5 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-0.351064378122662	[131]	[57,52]	-5	hSpCas9	negative selection	886020
2194519	2194542	19	+	26627737	GBM cells	viability after 5 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-0.336781822357598	[689]	[308,276]	-5	hSpCas9	negative selection	886021
2164245	2164268	19	-	26627737	GBM cells	viability after 13 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.8468288223524012	[357]	[366,334]	8	hSpCas9	negative selection	968331
2180750	2180773	19	-	26627737	GBM cells	viability after 13 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-1.0136858814334186	[266]	[127,25]	-8	hSpCas9	negative selection	968332
2189774	2189797	19	+	26627737	GBM cells	viability after 13 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-0.22654112447178476	[237]	[159,69]	-3	hSpCas9	negative selection	968333
2190997	2191020	19	+	26627737	GBM cells	viability after 13 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	-0.1638950507425358	[365]	[211,148]	-2	hSpCas9	negative selection	968334
2193762	2193785	19	+	26627737	GBM cells	viability after 13 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-1.9071235383519376	[131]	[1,32]	-9	hSpCas9	negative selection	968335
2194519	2194542	19	+	26627737	GBM cells	viability after 13 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-1.1681430423828383	[689]	[186,149]	-8	hSpCas9	negative selection	968336
2164245	2164268	19	-	26627737	GBM cells	viability after 21 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.019526767814667	[357]	[410,378]	8	hSpCas9	negative selection	1050646
2180750	2180773	19	-	26627737	GBM cells	viability after 21 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-3.1576016742630837	[266]	[21,10]	-9	hSpCas9	negative selection	1050647
2189774	2189797	19	+	26627737	GBM cells	viability after 21 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-0.24360863076025463	[237]	[115,102]	-2	hSpCas9	negative selection	1050648
2190997	2191020	19	+	26627737	GBM cells	viability after 21 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	-0.4147926345582356	[365]	[168,130]	-4	hSpCas9	negative selection	1050649
2193762	2193785	19	+	26627737	GBM cells	viability after 21 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-2.842232724855432	[131]	[9,9]	-9	hSpCas9	negative selection	1050650
2194519	2194542	19	+	26627737	GBM cells	viability after 21 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-1.800089198685219	[689]	[115,99]	-8	hSpCas9	negative selection	1050651
2164245	2164268	19	-	26627737	RPE1	viability after 9 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.054577342326328	[847]	[364,791]	6	hSpCas9	negative selection	1132961
2180750	2180773	19	-	26627737	RPE1	viability after 9 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.46080297455439	[1515]	[391,283]	-3	hSpCas9	negative selection	1132962
2189774	2189797	19	+	26627737	RPE1	viability after 9 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-1.1235024358493688	[1221]	[96,276]	-7	hSpCas9	negative selection	1132963
2190997	2191020	19	+	26627737	RPE1	viability after 9 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	0.12176843520291691	[1018]	[309,394]	0	hSpCas9	negative selection	1132964
2193762	2193785	19	+	26627737	RPE1	viability after 9 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-2.928996053802052	[1339]	[96,0]	-9	hSpCas9	negative selection	1132965
2194519	2194542	19	+	26627737	RPE1	viability after 9 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-1.7058226752895558	[3470]	[326,340]	-8	hSpCas9	negative selection	1132966
2164245	2164268	19	-	26627737	RPE1	viability after 12 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.0027071540967427	[847]	[388,527]	6	hSpCas9	negative selection	1215276
2180750	2180773	19	-	26627737	RPE1	viability after 12 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.5292223900644761	[1515]	[357,201]	-4	hSpCas9	negative selection	1215277
2189774	2189797	19	+	26627737	RPE1	viability after 12 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-0.8797143185952386	[1221]	[158,198]	-6	hSpCas9	negative selection	1215278
2190997	2191020	19	+	26627737	RPE1	viability after 12 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	-0.26737599429470527	[1018]	[259,192]	-2	hSpCas9	negative selection	1215279
2193762	2193785	19	+	26627737	RPE1	viability after 12 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-3.475256744796448	[1339]	[61,0]	-9	hSpCas9	negative selection	1215280
2194519	2194542	19	+	26627737	RPE1	viability after 12 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-1.853796982732254	[3470]	[223,293]	-8	hSpCas9	negative selection	1215281
2164245	2164268	19	-	26627737	RPE1	viability after 15 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.7559046803156024	[847]	[315,490]	4	hSpCas9	negative selection	1297591
2180750	2180773	19	-	26627737	RPE1	viability after 15 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.9376498438268969	[1515]	[229,217]	-5	hSpCas9	negative selection	1297592
2189774	2189797	19	+	26627737	RPE1	viability after 15 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-1.3753002209542053	[1221]	[62,200]	-7	hSpCas9	negative selection	1297593
2190997	2191020	19	+	26627737	RPE1	viability after 15 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	-0.09011276556517095	[1018]	[253,286]	0	hSpCas9	negative selection	1297594
2193762	2193785	19	+	26627737	RPE1	viability after 15 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-7.579383911263498	[1339]	[2,0]	-9	hSpCas9	negative selection	1297595
2194519	2194542	19	+	26627737	RPE1	viability after 15 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-1.6486694110382476	[3470]	[388,239]	-7	hSpCas9	negative selection	1297596
2164245	2164268	19	-	26627737	RPE1	viability after 18 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.44927419534942414	[847]	[150,484]	3	hSpCas9	negative selection	1379906
2180750	2180773	19	-	26627737	RPE1	viability after 18 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.40083494760164085	[1515]	[349,266]	-3	hSpCas9	negative selection	1379907
2189774	2189797	19	+	26627737	RPE1	viability after 18 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-1.7147509073451626	[1221]	[84,116]	-8	hSpCas9	negative selection	1379908
2190997	2191020	19	+	26627737	RPE1	viability after 18 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	-0.2854528623081438	[1018]	[243,205]	-2	hSpCas9	negative selection	1379909
2193762	2193785	19	+	26627737	RPE1	viability after 18 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-3.1670499818799946	[1339]	[76,0]	-9	hSpCas9	negative selection	1379910
2194519	2194542	19	+	26627737	RPE1	viability after 18 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-1.9035514065365253	[3470]	[231,269]	-8	hSpCas9	negative selection	1379911
2164245	2164268	19	-	26627737	HeLa	viability after 8 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.0315292909899647	[412]	[321,341,423]	7	hSpCas9	negative selection	1462221
2180750	2180773	19	-	26627737	HeLa	viability after 8 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.0667865718112447	[708]	[362,185,345]	0	hSpCas9	negative selection	1462222
2189774	2189797	19	+	26627737	HeLa	viability after 8 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	0.016848355601682408	[295]	[137,114,138]	0	hSpCas9	negative selection	1462223
2190997	2191020	19	+	26627737	HeLa	viability after 8 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	0.8665117068199952	[289]	[177,214,281]	7	hSpCas9	negative selection	1462224
2193762	2193785	19	+	26627737	HeLa	viability after 8 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	7.151215630104813	[0]	[154,17,34]	9	hSpCas9	negative selection	1462225
2194519	2194542	19	+	26627737	HeLa	viability after 8 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	0.05057015504675855	[1071]	[395,711,332]	0	hSpCas9	negative selection	1462226
2164245	2164268	19	-	26627737	HeLa	viability after 12 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.004376628102509	[412]	[453,185,406]	7	hSpCas9	negative selection	1544536
2180750	2180773	19	-	26627737	HeLa	viability after 12 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-1.130748515891259	[708]	[250,18,146]	-8	hSpCas9	negative selection	1544537
2189774	2189797	19	+	26627737	HeLa	viability after 12 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	0.6506675555557299	[295]	[169,205,197]	5	hSpCas9	negative selection	1544538
2190997	2191020	19	+	26627737	HeLa	viability after 12 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	1.0220654732930534	[289]	[74,311,330]	7	hSpCas9	negative selection	1544539
2193762	2193785	19	+	26627737	HeLa	viability after 12 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	7.138515359824883	[0]	[41,97,29]	9	hSpCas9	negative selection	1544540
2194519	2194542	19	+	26627737	HeLa	viability after 12 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-0.962680206618922	[1071]	[253,252,172]	-7	hSpCas9	negative selection	1544541
2164245	2164268	19	-	26627737	HeLa	viability after 15 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.0452415548151175	[412]	[293,226,534]	7	hSpCas9	negative selection	1626851
2180750	2180773	19	-	26627737	HeLa	viability after 15 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.7916732418913333	[708]	[42,325,129]	-6	hSpCas9	negative selection	1626852
2189774	2189797	19	+	26627737	HeLa	viability after 15 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-0.1420041293160429	[295]	[150,91,81]	-1	hSpCas9	negative selection	1626853
2190997	2191020	19	+	26627737	HeLa	viability after 15 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	1.5124077809030916	[289]	[229,345,443]	8	hSpCas9	negative selection	1626854
2193762	2193785	19	+	26627737	HeLa	viability after 15 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	7.032258248039669	[0]	[3,72,85]	9	hSpCas9	negative selection	1626855
2194519	2194542	19	+	26627737	HeLa	viability after 15 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-0.6298212578293831	[1071]	[172,289,392]	-5	hSpCas9	negative selection	1626856
2164245	2164268	19	-	26627737	HeLa	viability after 18 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.0400294673197354	[412]	[193,188,534]	7	hSpCas9	negative selection	1709166
2180750	2180773	19	-	26627737	HeLa	viability after 18 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.8350240207022072	[708]	[27,258,129]	-6	hSpCas9	negative selection	1709167
2189774	2189797	19	+	26627737	HeLa	viability after 18 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-0.1505788527964118	[295]	[96,79,81]	-1	hSpCas9	negative selection	1709168
2190997	2191020	19	+	26627737	HeLa	viability after 18 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	1.5125838661792312	[289]	[153,286,443]	8	hSpCas9	negative selection	1709169
2193762	2193785	19	+	26627737	HeLa	viability after 18 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	7.000730818432886	[0]	[3,55,85]	9	hSpCas9	negative selection	1709170
2194519	2194542	19	+	26627737	HeLa	viability after 18 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-0.6360919383575173	[1071]	[120,230,392]	-5	hSpCas9	negative selection	1709171
2164245	2164268	19	-	26627737	HCT116	viability after 6 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.4005833841121669	[761]	[352,295]	7	hSpCas9	negative selection	1791481
2180750	2180773	19	-	26627737	HCT116	viability after 6 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	0.32113334832033397	[689]	[237,78]	1	hSpCas9	negative selection	1791482
2189774	2189797	19	+	26627737	HCT116	viability after 6 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-0.1044564523389151	[978]	[273,70]	0	hSpCas9	negative selection	1791483
2190997	2191020	19	+	26627737	HCT116	viability after 6 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	0.512581444868299	[808]	[96,227]	3	hSpCas9	negative selection	1791484
2193762	2193785	19	+	26627737	HCT116	viability after 6 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	2.8424456157238867	[306]	[204,423]	9	hSpCas9	negative selection	1791485
2194519	2194542	19	+	26627737	HCT116	viability after 6 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	0.7134374787662996	[1539]	[298,450]	4	hSpCas9	negative selection	1791486
2164245	2164268	19	-	26627737	HCT116	viability after 8 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.7070568812422167	[388]	[252,442,351]	6	hSpCas9	negative selection	1873796
2180750	2180773	19	-	26627737	HCT116	viability after 8 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.6929398352496063	[515]	[112,193,218]	-7	hSpCas9	negative selection	1873797
2189774	2189797	19	+	26627737	HCT116	viability after 8 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	0.23506337735569305	[309]	[137,96,364]	2	hSpCas9	negative selection	1873798
2190997	2191020	19	+	26627737	HCT116	viability after 8 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	0.47047455202183813	[313]	[317,195,206]	5	hSpCas9	negative selection	1873799
2193762	2193785	19	+	26627737	HCT116	viability after 8 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-1.5360248605036209	[219]	[27,41,54]	-9	hSpCas9	negative selection	1873800
2194519	2194542	19	+	26627737	HCT116	viability after 8 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	0.0003894560488910681	[780]	[432,390,466]	0	hSpCas9	negative selection	1873801
2164245	2164268	19	-	26627737	HCT116	viability after 9 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.0374885836756433	[761]	[296,512]	7	hSpCas9	negative selection	1956111
2180750	2180773	19	-	26627737	HCT116	viability after 9 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	0.5181434516423766	[689]	[331,209]	4	hSpCas9	negative selection	1956112
2189774	2189797	19	+	26627737	HCT116	viability after 9 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	0.36650667590004704	[978]	[374,306]	2	hSpCas9	negative selection	1956113
2190997	2191020	19	+	26627737	HCT116	viability after 9 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	0.47545798945767326	[808]	[525,121]	3	hSpCas9	negative selection	1956114
2193762	2193785	19	+	26627737	HCT116	viability after 9 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-1.7421299642291148	[306]	[33,16]	-8	hSpCas9	negative selection	1956115
2194519	2194542	19	+	26627737	HCT116	viability after 9 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-0.2906726249058411	[1539]	[262,393]	-2	hSpCas9	negative selection	1956116
2164245	2164268	19	-	26627737	HCT116	viability after 12 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.05785526561894905	[388]	[200,277,161]	0	hSpCas9	negative selection	2038426
2180750	2180773	19	-	26627737	HCT116	viability after 12 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.4106637591762862	[515]	[266,143,193]	-4	hSpCas9	negative selection	2038427
2189774	2189797	19	+	26627737	HCT116	viability after 12 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-0.3889379429908869	[309]	[125,119,126]	-4	hSpCas9	negative selection	2038428
2190997	2191020	19	+	26627737	HCT116	viability after 12 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	0.027411234043658583	[313]	[129,254,124]	0	hSpCas9	negative selection	2038429
2193762	2193785	19	+	26627737	HCT116	viability after 12 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-1.0688538728133552	[219]	[53,36,73]	-8	hSpCas9	negative selection	2038430
2194519	2194542	19	+	26627737	HCT116	viability after 12 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	0.012830490652114168	[780]	[366,436,442]	0	hSpCas9	negative selection	2038431
2164245	2164268	19	-	26627737	HCT116	viability after 15 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.6245577793826909	[388]	[381,323,331]	6	hSpCas9	negative selection	2120741
2180750	2180773	19	-	26627737	HCT116	viability after 15 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.7798626384331351	[515]	[194,193,131]	-7	hSpCas9	negative selection	2120742
2189774	2189797	19	+	26627737	HCT116	viability after 15 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-0.33035747423072725	[309]	[98,211,108]	-3	hSpCas9	negative selection	2120743
2190997	2191020	19	+	26627737	HCT116	viability after 15 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	0.2461546744029579	[313]	[302,261,88]	2	hSpCas9	negative selection	2120744
2193762	2193785	19	+	26627737	HCT116	viability after 15 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-1.5500152490808652	[219]	[41,18,67]	-8	hSpCas9	negative selection	2120745
2194519	2194542	19	+	26627737	HCT116	viability after 15 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-0.5556154737620564	[780]	[169,337,389]	-5	hSpCas9	negative selection	2120746
2164245	2164268	19	-	26627737	HCT116	viability after 18 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.6860760603621583	[388]	[263,375,260]	5	hSpCas9	negative selection	2203056
2180750	2180773	19	-	26627737	HCT116	viability after 18 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	0.0037106892964541283	[515]	[332,252,159]	0	hSpCas9	negative selection	2203057
2189774	2189797	19	+	26627737	HCT116	viability after 18 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-0.6140692195600508	[309]	[133,80,78]	-5	hSpCas9	negative selection	2203058
2190997	2191020	19	+	26627737	HCT116	viability after 18 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	0.2123398760293292	[313]	[115,299,99]	1	hSpCas9	negative selection	2203059
2193762	2193785	19	+	26627737	HCT116	viability after 18 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-2.3655396747694533	[219]	[24,0,37]	-9	hSpCas9	negative selection	2203060
2194519	2194542	19	+	26627737	HCT116	viability after 18 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-0.215338088775622	[780]	[338,350,281]	-2	hSpCas9	negative selection	2203061
2164202	2164225	19	+	24336569	HL60	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	0.8432477720668664	[176]	[671]	7	hSpCas9	negative selection	2261219
2164228	2164251	19	+	24336569	HL60	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.2582630621993819	[434]	[1100]	2	hSpCas9	negative selection	2261220
2164233	2164256	19	-	24336569	HL60	viability	AGCGGCCACGGGTAGACGGCGGG	DOT1L	ENSG00000104885	0.05414238794844095	[760]	[1671]	0	hSpCas9	negative selection	2261221
2164238	2164261	19	+	24336569	HL60	viability	CGTCTACCCGTGGCCGCTGCCGG	DOT1L	ENSG00000104885	0.2656856397482716	[532]	[1355]	2	hSpCas9	negative selection	2261222
2164244	2164267	19	-	24336569	HL60	viability	CGTAGACCGGCAGCGGCCACGGG	DOT1L	ENSG00000104885	-0.2668664386901538	[368]	[648]	-2	hSpCas9	negative selection	2261223
2164251	2164274	19	-	24336569	HL60	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.5886734376112261	[1674]	[2356]	-5	hSpCas9	negative selection	2261224
2164257	2164280	19	-	24336569	HL60	viability	AGGGCGGCACTCACGTAGACCGG	DOT1L	ENSG00000104885	0.16464438968135908	[542]	[1287]	1	hSpCas9	negative selection	2261225
2180735	2180758	19	+	24336569	HL60	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.04243236976901124	[551]	[1202]	0	hSpCas9	negative selection	2261226
2185855	2185878	19	+	24336569	HL60	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.23668749684158874	[298]	[536]	-2	hSpCas9	negative selection	2261227
2185873	2185896	19	+	24336569	HL60	viability	CCCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	0.2915093390834036	[260]	[675]	2	hSpCas9	negative selection	2261228
2164202	2164225	19	+	24336569	KBM7	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-8.661898317349648	[296]	[1]	-9	hSpCas9	negative selection	2328396
2164228	2164251	19	+	24336569	KBM7	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-1.7344121750229753	[598]	[490]	-8	hSpCas9	negative selection	2328397
2164233	2164256	19	-	24336569	KBM7	viability	AGCGGCCACGGGTAGACGGCGGG	DOT1L	ENSG00000104885	-0.9281420912723097	[532]	[763]	-6	hSpCas9	negative selection	2328398
2164238	2164261	19	+	24336569	KBM7	viability	CGTCTACCCGTGGCCGCTGCCGG	DOT1L	ENSG00000104885	0.5190559846526974	[338]	[1324]	5	hSpCas9	negative selection	2328399
2164244	2164267	19	-	24336569	KBM7	viability	CGTAGACCGGCAGCGGCCACGGG	DOT1L	ENSG00000104885	-0.8733867800835813	[492]	[733]	-6	hSpCas9	negative selection	2328400
2164251	2164274	19	-	24336569	KBM7	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-1.0437689526932927	[1160]	[1535]	-6	hSpCas9	negative selection	2328401
2164257	2164280	19	-	24336569	KBM7	viability	AGGGCGGCACTCACGTAGACCGG	DOT1L	ENSG00000104885	0.015431424273432151	[365]	[1008]	0	hSpCas9	negative selection	2328402
2180735	2180758	19	+	24336569	KBM7	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.38122270198465585	[495]	[1761]	3	hSpCas9	negative selection	2328403
2185855	2185878	19	+	24336569	KBM7	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.5266134157286414	[271]	[514]	-4	hSpCas9	negative selection	2328404
2185873	2185896	19	+	24336569	KBM7	viability	CCCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	-0.06418431907624814	[362]	[946]	0	hSpCas9	negative selection	2328405
2196526	2196549	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTTCACCATGTTGGTCAGGCGGG	DOT1L	ENSG00000104885	-0.9950505910624323	[34,30]	[4,1]	-6	dCas9-VP64	positive selection	2385305
2175829	2175852	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	ACACCACTGCACTCCAGCCTCGG	DOT1L	ENSG00000104885	-0.9885038950311584	[179,367]	[28,30]	-6	dCas9-VP64	positive selection	2395986
2178765	2178788	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	AGAGACCATCCTGGCTAACAAGG	DOT1L	ENSG00000104885	-1.1174807317499718	[30,74]	[4,4]	-6	dCas9-VP64	positive selection	2405384
2169963	2169986	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGGGTTTCGTCATGTTGGCCAAG	DOT1L	ENSG00000104885	-0.08437565892322141	[6,12]	[1,0]	0	dCas9-VP64	positive selection	2405604
2169617	2169640	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	CACCTGTAATCCCAGCTACTCGG	DOT1L	ENSG00000104885	-0.8190110364213175	[438,580]	[39,87]	-4	dCas9-VP64	positive selection	2406416
2172217	2172240	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCTCGCTCTGTGGCCCAGGCTGG	DOT1L	ENSG00000104885	-0.09023650690316742	[168,102]	[18,36]	0	dCas9-VP64	positive selection	2411321
2181770	2181793	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCTGGGGCTGGGGCTGGGGCTGG	DOT1L	ENSG00000104885	4.687211381256624	[18,3]	[129,1]	9	dCas9-VP64	positive selection	2427216
2219147	2219170	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCATGAGCCACCGCACCCGG	DOT1L	ENSG00000104885	-0.89146844564302	[3,30]	[1,1]	-5	dCas9-VP64	positive selection	2429485
2185651	2185674	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCCAGCTACTTGGGAGGCTGAGG	DOT1L	ENSG00000104885	1.7381005027272516	[41,48]	[11,55]	6	dCas9-VP64	positive selection	2458181
2166618	2166641	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTAGGAGTTCGAGACCAGCCTAG	DOT1L	ENSG00000104885	-0.8844378867613548	[237,84]	[20,15]	-5	dCas9-VP64	positive selection	2461524
2219079	2219102	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	TCAGGAGTTTGAGACCAGCTCGG	DOT1L	ENSG00000104885	0.362963240197711	[121,64]	[24,26]	1	dCas9-VP64	positive selection	2472620
2227904	2227927	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGCGGAGGCGGAGGCGGAGGGGG	DOT1L	ENSG00000104885	4.624516986046515	[0,2]	[2,23]	9	dCas9-VP64	positive selection	2475025
2196526	2196549	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTTCACCATGTTGGTCAGGCGGG	DOT1L	ENSG00000104885	-0.9351084987288634	[176,47]	[27,9]	-8	dCas9-VP64	positive selection	2480560
2175829	2175852	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	ACACCACTGCACTCCAGCCTCGG	DOT1L	ENSG00000104885	0.0430865282742412	[329,462]	[142,122]	0	dCas9-VP64	positive selection	2491241
2178765	2178788	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	AGAGACCATCCTGGCTAACAAGG	DOT1L	ENSG00000104885	-0.3866569806865121	[139,148]	[35,34]	-4	dCas9-VP64	positive selection	2500639
2169963	2169986	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGGGTTTCGTCATGTTGGCCAAG	DOT1L	ENSG00000104885	-0.9208015753873722	[12,58]	[1,8]	-8	dCas9-VP64	positive selection	2500859
2169617	2169640	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	CACCTGTAATCCCAGCTACTCGG	DOT1L	ENSG00000104885	0.2665454673496357	[718,321]	[136,269]	2	dCas9-VP64	positive selection	2501671
2172217	2172240	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCTCGCTCTGTGGCCCAGGCTGG	DOT1L	ENSG00000104885	-0.18719047674947265	[8,181]	[7,43]	-2	dCas9-VP64	positive selection	2506576
2181770	2181793	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCTGGGGCTGGGGCTGGGGCTGG	DOT1L	ENSG00000104885	0.7843109750104308	[123,86]	[55,62]	5	dCas9-VP64	positive selection	2522471
2219147	2219170	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCATGAGCCACCGCACCCGG	DOT1L	ENSG00000104885	0.12972035773098467	[57,36]	[16,15]	1	dCas9-VP64	positive selection	2524740
2185651	2185674	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCCAGCTACTTGGGAGGCTGAGG	DOT1L	ENSG00000104885	0.27268558780642654	[105,40]	[39,17]	2	dCas9-VP64	positive selection	2553436
2166618	2166641	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTAGGAGTTCGAGACCAGCCTAG	DOT1L	ENSG00000104885	2.6650986342381273	[238,153]	[58,738]	9	dCas9-VP64	positive selection	2556779
2219079	2219102	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	TCAGGAGTTTGAGACCAGCTCGG	DOT1L	ENSG00000104885	-1.016658803330618	[35,140]	[14,11]	-8	dCas9-VP64	positive selection	2567875
2227904	2227927	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGCGGAGGCGGAGGCGGAGGGGG	DOT1L	ENSG00000104885	0.19922026917770452	[38,4]	[7,7]	1	dCas9-VP64	positive selection	2570280
2191129	2191152	19	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CTACGAGCCCTTCTCCCCCGAGG	DOT1L	ENSG00000104885	-1.211377628253643	[4,4]	[2,0]	-9	hSpCas9	positive selection	2984242
2191081	2191104	19	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCAGCAGGTCTACAACCACTCGG	DOT1L	ENSG00000104885	-1.2490127939440656	[3,3]	[0,1]	-9	hSpCas9	positive selection	2984243
2210433	2210456	19	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCGCGAGAGCAAGAGCAACGCGG	DOT1L	ENSG00000104885	-0.3857395877970283	[3,3]	[3,0]	-5	hSpCas9	positive selection	2984244
2210755	2210778	19	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGAACACTGCGAACCCCGAGCGG	DOT1L	ENSG00000104885	-1.0595567746353336	[3,3]	[0,0]	-9	hSpCas9	positive selection	2984245
2191129	2191152	19	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CTACGAGCCCTTCTCCCCCGAGG	DOT1L	ENSG00000104885	-0.43599933667219554	[4,4]	[2,1]	-6	hSpCas9	positive selection	3052100
2191081	2191104	19	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCAGCAGGTCTACAACCACTCGG	DOT1L	ENSG00000104885	-1.1098797693083484	[3,3]	[1,0]	-9	hSpCas9	positive selection	3052101
2210433	2210456	19	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCGCGAGAGCAAGAGCAACGCGG	DOT1L	ENSG00000104885	-0.7879696927176841	[3,3]	[2,0]	-9	hSpCas9	positive selection	3052102
2210755	2210778	19	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGAACACTGCGAACCCCGAGCGG	DOT1L	ENSG00000104885	0.2181965721494477	[3,3]	[2,3]	4	hSpCas9	positive selection	3052103
2180735	2180758		+	24336571	A375	resistance to PLX after 7 days	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	-0.08145967526521908	[10,11]	[10,10]	-2	hSpCas9	positive selection	3110481
2164228	2164251		+	24336571	A375	resistance to PLX after 7 days	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.24995638730819325	[5,6]	[8,6]	7	hSpCas9	positive selection	3110482
2164251	2164274		-	24336571	A375	resistance to PLX after 7 days	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.11153240956232502	[7,7]	[7,8]	4	hSpCas9	positive selection	3110483
2180735	2180758		+	24336571	A375	resistance to PLX after 14 days	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	-0.9239347555318096	[12,14]	[2,2]	-9	hSpCas9	positive selection	3168274
2164228	2164251		+	24336571	A375	resistance to PLX after 14 days	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	1.2315848740868724	[2,4]	[3,3]	8	hSpCas9	positive selection	3168275
2164251	2164274		-	24336571	A375	resistance to PLX after 14 days	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.4117637989248022	[6,7]	[3,4]	4	hSpCas9	positive selection	3168276
2180735	2180758		+	24336571	A375	viability after 7 days	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	-0.05607668931399194	[12]	[10,11]	-1	hSpCas9	negative selection	3226067
2164228	2164251		+	24336571	A375	viability after 7 days	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.9565622275855353	[13]	[5,6]	-8	hSpCas9	negative selection	3226068
2164251	2164274		-	24336571	A375	viability after 7 days	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.8017957005719769	[14]	[7,7]	-8	hSpCas9	negative selection	3226069
2180735	2180758		+	24336571	A375	viability after 14 days	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.23357606626674288	[12]	[12,14]	3	hSpCas9	negative selection	3283860
2164228	2164251		+	24336571	A375	viability after 14 days	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-1.6513796903710634	[13]	[2,4]	-9	hSpCas9	negative selection	3283861
2164251	2164274		-	24336571	A375	viability after 14 days	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.9014323912919286	[14]	[6,7]	-8	hSpCas9	negative selection	3283862
2164228	2164251	19	+	27383988	293T	resistance to West Nile virus (flavivirus)	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	2.640116861736853	[30,17]	[0,0]	8	hSpCas9	positive selection	3346807
2164202	2164225	19	+	27383988	293T	resistance to West Nile virus (flavivirus)	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	1.4897475702647076	[50,57]	[0,0]	6	hSpCas9	positive selection	3346808
2180735	2180758	19	+	27383988	293T	resistance to West Nile virus (flavivirus)	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.5505537150381504	[97,110]	[0,0]	2	hSpCas9	positive selection	3346809
2185874	2185897	19	-	27383988	293T	resistance to West Nile virus (flavivirus)	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.19123702098806272	[133,133]	[0,0]	1	hSpCas9	positive selection	3366002
2185855	2185878	19	+	27383988	293T	resistance to West Nile virus (flavivirus)	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	1.1912370209880627	[66,66]	[0,0]	5	hSpCas9	positive selection	3366003
2164251	2164274	19	-	27383988	293T	resistance to West Nile virus (flavivirus)	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.3504356158373165	[119,119]	[0,0]	1	hSpCas9	positive selection	3366004
2191128	2191151	19	+	26780180	HT29	viability (Avana library 4 designs)	CTACGAGCCCTTCTCCCCCGAGG	DOT1L	ENSG00000104885	3.04735141983451	[]	[]	8	hSpCas9	negative selection	3421022
2191080	2191103	19	+	26780180	HT29	viability (Avana library 4 designs)	GCAGCAGGTCTACAACCACTCGG	DOT1L	ENSG00000104885	2.24979758890647	[]	[]	7	hSpCas9	negative selection	3421023
2210432	2210455	19	+	26780180	HT29	viability (Avana library 4 designs)	GCGCGAGAGCAAGAGCAACGCGG	DOT1L	ENSG00000104885	0.146473774114894	[]	[]	0	hSpCas9	negative selection	3421024
2210754	2210777	19	+	26780180	HT29	viability (Avana library 4 designs)	TGAACACTGCGAACCCCGAGCGG	DOT1L	ENSG00000104885	3.20031516152491	[]	[]	8	hSpCas9	negative selection	3421025
2191080	2191103	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGCAGGTCTACAACCACTCGG	DOT1L	ENSG00000104885	2.07015147717807	[]	[]	3	hSpCas9	negative selection	3500981
2191128	2191151	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	CTACGAGCCCTTCTCCCCCGAGG	DOT1L	ENSG00000104885	0.709609508671626	[]	[]	1	hSpCas9	negative selection	3500982
2210754	2210777	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	TGAACACTGCGAACCCCGAGCGG	DOT1L	ENSG00000104885	1.62234914214677	[]	[]	2	hSpCas9	negative selection	3500983
2210432	2210455	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCGCGAGAGCAAGAGCAACGCGG	DOT1L	ENSG00000104885	2.66128473366086	[]	[]	4	hSpCas9	negative selection	3500984
2191095	2191118	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	TCTCGGGGTCGGTCACCGAGTGG	DOT1L	ENSG00000104885	-1.49396790778	[]	[]	-2	hSpCas9	negative selection	3500985
2199898	2199921	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	TTTCCTCTCAGAAGAGTGGAGGG	DOT1L	ENSG00000104885	1.27594086610657	[]	[]	1	hSpCas9	negative selection	3500986
2191080	2191103	19	+	26780180	A375	viability (Avana lentiGuide)	GCAGCAGGTCTACAACCACTCGG	DOT1L	ENSG00000104885	12.6944389087505	[]	[]	7	hSpCas9	negative selection	3609640
2191128	2191151	19	+	26780180	A375	viability (Avana lentiGuide)	CTACGAGCCCTTCTCCCCCGAGG	DOT1L	ENSG00000104885	20.8080830377737	[]	[]	8	hSpCas9	negative selection	3609641
2210754	2210777	19	+	26780180	A375	viability (Avana lentiGuide)	TGAACACTGCGAACCCCGAGCGG	DOT1L	ENSG00000104885	4.87932925907476	[]	[]	4	hSpCas9	negative selection	3609642
2210432	2210455	19	+	26780180	A375	viability (Avana lentiGuide)	GCGCGAGAGCAAGAGCAACGCGG	DOT1L	ENSG00000104885	7.57770723889606	[]	[]	6	hSpCas9	negative selection	3609643
2191095	2191118	19	-	26780180	A375	viability (Avana lentiGuide)	TCTCGGGGTCGGTCACCGAGTGG	DOT1L	ENSG00000104885	5.04214345528618	[]	[]	4	hSpCas9	negative selection	3609644
2199898	2199921	19	+	26780180	A375	viability (Avana lentiGuide)	TTTCCTCTCAGAAGAGTGGAGGG	DOT1L	ENSG00000104885	18.2223165627784	[]	[]	8	hSpCas9	negative selection	3609645
2191080	2191103	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGCAGGTCTACAACCACTCGG	DOT1L	ENSG00000104885	0.32329361309434357	[4]	[5,5]	8	hSpCas9	positive selection	3718299
2191128	2191151	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTACGAGCCCTTCTCCCCCGAGG	DOT1L	ENSG00000104885	0.06666806480013364	[4]	[5,3]	1	hSpCas9	positive selection	3718300
2210754	2210777	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGAACACTGCGAACCCCGAGCGG	DOT1L	ENSG00000104885	0.14878071645546617	[4]	[5,4]	4	hSpCas9	positive selection	3718301
2210432	2210455	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCGCGAGAGCAAGAGCAACGCGG	DOT1L	ENSG00000104885	0.1514169681809198	[4]	[5,5]	4	hSpCas9	positive selection	3718302
2191095	2191118	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCTCGGGGTCGGTCACCGAGTGG	DOT1L	ENSG00000104885	-0.05489769746458606	[0]	[0,0]	-1	hSpCas9	positive selection	3718303
2199898	2199921	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTTCCTCTCAGAAGAGTGGAGGG	DOT1L	ENSG00000104885	0.15522611057629374	[5]	[6,6]	4	hSpCas9	positive selection	3718304
2191080	2191103	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGCAGGTCTACAACCACTCGG	DOT1L	ENSG00000104885	-0.48090256285239324	[5]	[2,3]	-6	hSpCas9	positive selection	3826906
2191128	2191151	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTACGAGCCCTTCTCCCCCGAGG	DOT1L	ENSG00000104885	-0.14490843632151001	[6]	[4,4]	-2	hSpCas9	positive selection	3826907
2210754	2210777	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGAACACTGCGAACCCCGAGCGG	DOT1L	ENSG00000104885	0.002892551120152312	[5]	[4,3]	0	hSpCas9	positive selection	3826908
2210432	2210455	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCGCGAGAGCAAGAGCAACGCGG	DOT1L	ENSG00000104885	-0.08876510968985019	[5]	[4,3]	-1	hSpCas9	positive selection	3826909
2191095	2191118	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCTCGGGGTCGGTCACCGAGTGG	DOT1L	ENSG00000104885	-0.5881362222363911	[0]	[0,0]	-6	hSpCas9	positive selection	3826910
2199898	2199921	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTTCCTCTCAGAAGAGTGGAGGG	DOT1L	ENSG00000104885	0.13321169124233	[4]	[4,3]	3	hSpCas9	positive selection	3826911
2180735	2180758	19	+	26780180	A375	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.779357191335293	[]	[]	3	hSpCas9	negative selection	3934321
2185855	2185878	19	+	26780180	A375	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	1.36434749976202	[]	[]	7	hSpCas9	negative selection	3934322
2164228	2164251	19	+	26780180	A375	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.735642608526342	[]	[]	2	hSpCas9	negative selection	3934323
2164251	2164274	19	-	26780180	A375	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.71052609179217	[]	[]	2	hSpCas9	negative selection	3934324
2164202	2164225	19	+	26780180	A375	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	1.49845303190383	[]	[]	8	hSpCas9	negative selection	3934325
2185874	2185897	19	-	26780180	A375	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	1.51376329254125	[]	[]	8	hSpCas9	negative selection	3934326
2180735	2180758	19	+	26780180	HT29	viability (GeCKOv2 library)	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.00152710979758543	[]	[]	0	hSpCas9	negative selection	4042287
2185855	2185878	19	+	26780180	HT29	viability (GeCKOv2 library)	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	1.62921317101913	[]	[]	8	hSpCas9	negative selection	4042288
2164228	2164251	19	+	26780180	HT29	viability (GeCKOv2 library)	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.798094131968259	[]	[]	3	hSpCas9	negative selection	4042289
2164251	2164274	19	-	26780180	HT29	viability (GeCKOv2 library)	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	1.6547602550206	[]	[]	8	hSpCas9	negative selection	4042290
2164202	2164225	19	+	26780180	HT29	viability (GeCKOv2 library)	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	1.51554120575997	[]	[]	7	hSpCas9	negative selection	4042291
2185874	2185897	19	-	26780180	HT29	viability (GeCKOv2 library)	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	1.08782061116884	[]	[]	5	hSpCas9	negative selection	4042292
2180735	2180758	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	-0.3615661410234039	[3]	[1,1]	-7	hSpCas9	positive selection	4133024
2164228	2164251	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.2597714739041713	[4]	[1,1]	-6	hSpCas9	positive selection	4133025
2164251	2164274	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.21293141734440735	[2]	[2,1]	5	hSpCas9	positive selection	4133026
2180735	2180758	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.5176394433287146	[4]	[0,0,2,3]	3	hSpCas9	positive selection	4197046
2164228	2164251	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.6527077926289658	[3]	[0,0,0,0]	-8	hSpCas9	positive selection	4197047
2164251	2164274	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.10519263396612782	[3]	[1,2,1,0]	-1	hSpCas9	positive selection	4197048
2164228	2164251	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.06756235534153565	[1]	[0,1]	1	hSpCas9	positive selection	4267495
2164202	2164225	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.32467669231396845	[1]	[1,0]	-6	hSpCas9	positive selection	4267496
2180735	2180758	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.5509310643578803	[3]	[3,3]	9	hSpCas9	positive selection	4267497
2185874	2185897	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.30431287061577883	[2]	[2,0]	-6	hSpCas9	positive selection	4331762
2185855	2185878	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.3037843123232693	[2]	[2,0]	-6	hSpCas9	positive selection	4331763
2164251	2164274	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.11949204484918605	[2]	[2,0]	-2	hSpCas9	positive selection	4331764
2216542	2216564	19	-	27760321	OCIAML3	viability	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	-0.08329913507756082	[776,742]	[494,648]	-1	hSpCas9	negative selection	4395639
2216607	2216629	19	+	27760321	OCIAML3	viability	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	-0.6358523395310631	[1163,1048]	[436,711]	-6	hSpCas9	negative selection	4395640
2185874	2185896	19	+	27760321	OCIAML3	viability	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	-0.4739325801287043	[530,459]	[187,395]	-5	hSpCas9	negative selection	4395641
2191040	2191062	19	+	27760321	OCIAML3	viability	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	-0.8373601917362739	[615,476]	[220,258]	-7	hSpCas9	negative selection	4395642
2199919	2199941	19	+	27760321	OCIAML3	viability	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	-1.923052659134895	[575,501]	[73,158]	-9	hSpCas9	negative selection	4395643
2216542	2216564	19	-	27760321	OCIAML2	viability	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	-0.3671639422839347	[776,742]	[466,490]	-4	hSpCas9	negative selection	4479102
2216607	2216629	19	+	27760321	OCIAML2	viability	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	-0.5245925468971454	[1163,1048]	[549,715]	-5	hSpCas9	negative selection	4479103
2185874	2185896	19	+	27760321	OCIAML2	viability	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	-1.2707665634844623	[530,459]	[147,188]	-8	hSpCas9	negative selection	4479104
2191040	2191062	19	+	27760321	OCIAML2	viability	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	-1.123449955106893	[615,476]	[153,263]	-8	hSpCas9	negative selection	4479105
2199919	2199941	19	+	27760321	OCIAML2	viability	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	-1.634539613672667	[575,501]	[124,159]	-8	hSpCas9	negative selection	4479106
2216542	2216564	19	-	27760321	MV411	viability	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	0.43048259884886664	[776,742]	[767,539]	3	hSpCas9	negative selection	4562565
2216607	2216629	19	+	27760321	MV411	viability	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	0.02709282588442452	[1163,1048]	[853,576]	0	hSpCas9	negative selection	4562566
2185874	2185896	19	+	27760321	MV411	viability	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	-0.10699795613584137	[530,459]	[325,267]	-1	hSpCas9	negative selection	4562567
2191040	2191062	19	+	27760321	MV411	viability	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	0.6037622323153331	[615,476]	[697,312]	4	hSpCas9	negative selection	4562568
2199919	2199941	19	+	27760321	MV411	viability	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	-2.905423628725894	[575,501]	[0,116]	-9	hSpCas9	negative selection	4562569
2216542	2216564	19	-	27760321	HL60	viability	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	-0.007538885355900082	[776,742]	[617,618]	0	hSpCas9	negative selection	4646028
2216607	2216629	19	+	27760321	HL60	viability	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	-0.505916704881899	[1163,1048]	[764,498]	-5	hSpCas9	negative selection	4646029
2185874	2185896	19	+	27760321	HL60	viability	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	0.09029556324335292	[530,459]	[488,366]	1	hSpCas9	negative selection	4646030
2191040	2191062	19	+	27760321	HL60	viability	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	-0.36915842409742017	[615,476]	[331,354]	-4	hSpCas9	negative selection	4646031
2199919	2199941	19	+	27760321	HL60	viability	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	-0.3887594898508929	[575,501]	[318,352]	-4	hSpCas9	negative selection	4646032
2216542	2216564	19	-	27760321	HT1080	viability	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	1.9869791499530978	[742,579]	[1489,556]	9	hSpCas9	negative selection	4729491
2216607	2216629	19	+	27760321	HT1080	viability	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	2.2055012251700727	[1048,818]	[1793,1630]	9	hSpCas9	negative selection	4729492
2185874	2185896	19	+	27760321	HT1080	viability	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	0.1702436568509169	[459,358]	[205,158]	0	hSpCas9	negative selection	4729493
2191040	2191062	19	+	27760321	HT1080	viability	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	1.9403849016240147	[476,371]	[522,786]	8	hSpCas9	negative selection	4729494
2199919	2199941	19	+	27760321	HT1080	viability	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	2.6247634552265495	[501,391]	[1442,720]	9	hSpCas9	negative selection	4729495
2216542	2216564	19	-	27760321	HT29	viability after 7 days	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	-0.45437229596660655	[742,579]	[882,468,548]	-6	hSpCas9	negative selection	4812954
2216607	2216629	19	+	27760321	HT29	viability after 7 days	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	-0.07816852755942438	[1048,818]	[1305,1022,1106]	-1	hSpCas9	negative selection	4812955
2185874	2185896	19	+	27760321	HT29	viability after 7 days	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	0.25328621479631214	[459,358]	[653,492,734]	4	hSpCas9	negative selection	4812956
2191040	2191062	19	+	27760321	HT29	viability after 7 days	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	0.15053601930286706	[476,371]	[1140,438,321]	2	hSpCas9	negative selection	4812957
2199919	2199941	19	+	27760321	HT29	viability after 7 days	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	0.3368418238816125	[501,391]	[692,787,691]	5	hSpCas9	negative selection	4812958
2216542	2216564	19	-	27760321	HT29	viability after 25 days	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	-0.11032230417854527	[742,579]	[497,497,1164]	-1	hSpCas9	negative selection	4896417
2216607	2216629	19	+	27760321	HT29	viability after 25 days	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	-0.002063046850839134	[1048,818]	[927,1001,1298]	0	hSpCas9	negative selection	4896418
2185874	2185896	19	+	27760321	HT29	viability after 25 days	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	-0.3236244153313801	[459,358]	[278,398,457]	-3	hSpCas9	negative selection	4896419
2191040	2191062	19	+	27760321	HT29	viability after 25 days	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	-1.3088191433762466	[476,371]	[148,202,242]	-7	hSpCas9	negative selection	4896420
2199919	2199941	19	+	27760321	HT29	viability after 25 days	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	-1.355420206157802	[501,391]	[172,221,205]	-7	hSpCas9	negative selection	4896421
2216542	2216564	19	-	27760321	HT29	viability after 22 days	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	0.03334508383387225	[742,579]	[682,624,1044]	0	hSpCas9	negative selection	4979880
2216607	2216629	19	+	27760321	HT29	viability after 22 days	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	0.05696461441275025	[1048,818]	[1098,1084,1186]	0	hSpCas9	negative selection	4979881
2185874	2185896	19	+	27760321	HT29	viability after 22 days	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	-0.6271135733622738	[459,358]	[274,273,371]	-5	hSpCas9	negative selection	4979882
2191040	2191062	19	+	27760321	HT29	viability after 22 days	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	-0.7121165978437292	[476,371]	[295,378,222]	-6	hSpCas9	negative selection	4979883
2199919	2199941	19	+	27760321	HT29	viability after 22 days	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	-1.5401572109066988	[501,391]	[81,134,319]	-7	hSpCas9	negative selection	4979884
2216542	2216564	19	-	27760321	HT29	viability after 19 days	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	0.2817283050401945	[742,579]	[984,878,901]	2	hSpCas9	negative selection	5063343
2216607	2216629	19	+	27760321	HT29	viability after 19 days	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	0.27594406145516936	[1048,818]	[1073,1587,1197]	2	hSpCas9	negative selection	5063344
2185874	2185896	19	+	27760321	HT29	viability after 19 days	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	0.12634803090544988	[459,358]	[312,245,936]	1	hSpCas9	negative selection	5063345
2191040	2191062	19	+	27760321	HT29	viability after 19 days	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	-0.5708860487310885	[476,371]	[446,223,321]	-5	hSpCas9	negative selection	5063346
2199919	2199941	19	+	27760321	HT29	viability after 19 days	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	-0.826698798194021	[501,391]	[170,358,320]	-6	hSpCas9	negative selection	5063347
2216542	2216564	19	-	27760321	HT29	viability after 16 days	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	-0.08204392390731474	[742,579]	[746,620,735]	-1	hSpCas9	negative selection	5146806
2216607	2216629	19	+	27760321	HT29	viability after 16 days	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	0.07079502055163123	[1048,818]	[1221,875,1211]	0	hSpCas9	negative selection	5146807
2185874	2185896	19	+	27760321	HT29	viability after 16 days	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	-0.017409899873832207	[459,358]	[443,531,378]	0	hSpCas9	negative selection	5146808
2191040	2191062	19	+	27760321	HT29	viability after 16 days	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	-0.37707842451535456	[476,371]	[525,446,136]	-4	hSpCas9	negative selection	5146809
2199919	2199941	19	+	27760321	HT29	viability after 16 days	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	-0.484375667593766	[501,391]	[407,287,382]	-5	hSpCas9	negative selection	5146810
2216542	2216564	19	-	27760321	HT29	viability after 13 days	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	-0.17832427990269983	[742,579]	[684,680,668]	-2	hSpCas9	negative selection	5230269
2216607	2216629	19	+	27760321	HT29	viability after 13 days	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	0.1717292370503689	[1048,818]	[1101,1293,1262]	2	hSpCas9	negative selection	5230270
2185874	2185896	19	+	27760321	HT29	viability after 13 days	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	0.10264846606047262	[459,358]	[573,308,638]	1	hSpCas9	negative selection	5230271
2191040	2191062	19	+	27760321	HT29	viability after 13 days	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	-0.0037634235368441404	[476,371]	[758,311,406]	0	hSpCas9	negative selection	5230272
2199919	2199941	19	+	27760321	HT29	viability after 13 days	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	-0.24717592409888517	[501,391]	[352,266,675]	-3	hSpCas9	negative selection	5230273
2216542	2216564	19	-	27760321	HT29	viability after 10 days	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	-0.4642900832208596	[742,579]	[630,686,482]	-5	hSpCas9	negative selection	5313732
2216607	2216629	19	+	27760321	HT29	viability after 10 days	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	-0.07807441869818899	[1048,818]	[1353,871,1081]	-1	hSpCas9	negative selection	5313733
2185874	2185896	19	+	27760321	HT29	viability after 10 days	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	0.4601161679954825	[459,358]	[491,598,1008]	6	hSpCas9	negative selection	5313734
2191040	2191062	19	+	27760321	HT29	viability after 10 days	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	0.32272444544050816	[476,371]	[751,533,697]	4	hSpCas9	negative selection	5313735
2199919	2199941	19	+	27760321	HT29	viability after 10 days	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	0.31171820006575585	[501,391]	[547,855,678]	4	hSpCas9	negative selection	5313736
2216542	2216564	19	-	27760321	MOLM13	viability	GCGTGTTCTGCTTCGACGAAGG	DOT1L	ENSG00000104885	0.3446594949031555	[776,742]	[527,559]	2	hSpCas9	negative selection	5397195
2216607	2216629	19	+	27760321	MOLM13	viability	TACCCCTAGCCACGTCGGCCGG	DOT1L	ENSG00000104885	-1.8438745995205683	[1163,1048]	[183,164]	-7	hSpCas9	negative selection	5397196
2185874	2185896	19	+	27760321	MOLM13	viability	CCGGATCTCAAGCTCGCTATGG	DOT1L	ENSG00000104885	-1.0237215353047602	[530,459]	[262,29]	-6	hSpCas9	negative selection	5397197
2191040	2191062	19	+	27760321	MOLM13	viability	TGAACACGCGGCCGTCCACTGG	DOT1L	ENSG00000104885	-2.392180825245532	[615,476]	[6,101]	-8	hSpCas9	negative selection	5397198
2199919	2199941	19	+	27760321	MOLM13	viability	GGAGCGAATCGCCAACACGAGG	DOT1L	ENSG00000104885	-1.1450342791378492	[575,501]	[53,207]	-6	hSpCas9	negative selection	5397199
2164167	2164190	19	+	27661255	K562	viability	GCGGCCGCGCGCGCGGACATGGG	DOT1L	ENSG00000104885	-0.2608051173924037	[676,689]	[515,403]	-6	dCas9-KRAB	negative selection	5475782
2164348	2164371	19	+	27661255	K562	viability	GCGCTCACCGGTCCCCCCTGCGG	DOT1L	ENSG00000104885	0.009407534779881987	[366,473]	[308,359]	0	dCas9-KRAB	negative selection	5475783
2164314	2164337	19	-	27661255	K562	viability	GTTTGGGGTGTCCCCAGGGGCGG	DOT1L	ENSG00000104885	-0.11884373693742106	[787,946]	[756,532]	-4	dCas9-KRAB	negative selection	5475784
2164228	2164251	19	+	27260156	BXPC3	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.48546723779388534	[70]	[95,99,118,100]	8	hSpCas9	negative selection	5539955
2164202	2164225	19	+	27260156	BXPC3	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	0.582700096578033	[185]	[288,261,376,230]	9	hSpCas9	negative selection	5539956
2180735	2180758	19	+	27260156	BXPC3	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.3695544866444716	[471]	[573,517,705,780]	7	hSpCas9	negative selection	5539957
2185874	2185897	19	-	27260156	BXPC3	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.2737349681481828	[388]	[414,558,459,538]	6	hSpCas9	negative selection	5604222
2185855	2185878	19	+	27260156	BXPC3	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	0.14235435789658113	[205]	[303,115,293,235]	3	hSpCas9	negative selection	5604223
2164251	2164274	19	-	27260156	BXPC3	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.026497921426222037	[370]	[326,407,363,431]	0	hSpCas9	negative selection	5604224
2164228	2164251	19	+	27260156	A673	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.6699691051546592	[70]	[77,28,51,58]	-9	hSpCas9	negative selection	5661206
2164202	2164225	19	+	27260156	A673	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.9101221366804357	[185]	[152,111,87,126]	-9	hSpCas9	negative selection	5661207
2180735	2180758	19	+	27260156	A673	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.12313578752950208	[471]	[735,543,580,622]	3	hSpCas9	negative selection	5661208
2185874	2185897	19	-	27260156	A673	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.11869457945570228	[388]	[477,479,350,414]	-3	hSpCas9	negative selection	5725473
2185855	2185878	19	+	27260156	A673	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.2882114129944664	[205]	[203,247,201,151]	-6	hSpCas9	negative selection	5725474
2164251	2164274	19	-	27260156	A673	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.39306821356326366	[370]	[376,331,283,369]	-7	hSpCas9	negative selection	5725475
2164228	2164251	19	+	27260156	A375	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.8264382510967261	[70]	[30,44,58,50]	-8	hSpCas9	negative selection	5782457
2164202	2164225	19	+	27260156	A375	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.276034957554594	[185]	[108,89,146,20]	-9	hSpCas9	negative selection	5782458
2180735	2180758	19	+	27260156	A375	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.25029757525713575	[471]	[775,727,708,443]	3	hSpCas9	negative selection	5782459
2185874	2185897	19	-	27260156	A375	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.31933353261254227	[388]	[502,787,421,580]	5	hSpCas9	negative selection	5846724
2185855	2185878	19	+	27260156	A375	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.9013929554157016	[205]	[131,166,109,112]	-8	hSpCas9	negative selection	5846725
2164251	2164274	19	-	27260156	A375	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.41187756739047426	[370]	[364,296,366,274]	-5	hSpCas9	negative selection	5846726
2164228	2164251	19	+	27260156	COLO741	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.3908412631228346	[70]	[73,161,116]	7	hSpCas9	negative selection	5903708
2164202	2164225	19	+	27260156	COLO741	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.21291407449421484	[185]	[151,290,169]	-4	hSpCas9	negative selection	5903709
2180735	2180758	19	+	27260156	COLO741	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.46986271744121877	[471]	[928,877,713]	8	hSpCas9	negative selection	5903710
2185874	2185897	19	-	27260156	COLO741	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.15591599372487877	[388]	[463,542,638]	3	hSpCas9	negative selection	5967975
2185855	2185878	19	+	27260156	COLO741	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.1105294348488357	[205]	[334,209,196]	-2	hSpCas9	negative selection	5967976
2164251	2164274	19	-	27260156	COLO741	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.2631569130121186	[370]	[402,445,339]	-5	hSpCas9	negative selection	5967977
2164228	2164251	19	+	27260156	CAL120	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.5208806694373891	[70]	[138,31,25]	-6	hSpCas9	negative selection	6024959
2164202	2164225	19	+	27260156	CAL120	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	0.3368523057191182	[185]	[237,187,439]	5	hSpCas9	negative selection	6024960
2180735	2180758	19	+	27260156	CAL120	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.6506319815964918	[471]	[990,1021,765]	8	hSpCas9	negative selection	6024961
2185874	2185897	19	-	27260156	CAL120	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.3491746464428655	[388]	[646,524,680]	5	hSpCas9	negative selection	6089226
2185855	2185878	19	+	27260156	CAL120	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.7784165574560755	[205]	[99,143,195]	-8	hSpCas9	negative selection	6089227
2164251	2164274	19	-	27260156	CAL120	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.13340720983981835	[370]	[244,679,312]	-2	hSpCas9	negative selection	6089228
2164228	2164251	19	+	27260156	CADOES1	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.14154701933618874	[70]	[89,46,25,76]	-2	hSpCas9	negative selection	6146210
2164202	2164225	19	+	27260156	CADOES1	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.940051903823925	[185]	[72,107,82,96]	-9	hSpCas9	negative selection	6146211
2180735	2180758	19	+	27260156	CADOES1	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.31077613199743914	[471]	[498,483,675,517]	5	hSpCas9	negative selection	6146212
2185874	2185897	19	-	27260156	CADOES1	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.2523324662245571	[388]	[240,288,382,301]	-4	hSpCas9	negative selection	6210477
2185855	2185878	19	+	27260156	CADOES1	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.8205934705159632	[205]	[128,137,107,56]	-8	hSpCas9	negative selection	6210478
2164251	2164274	19	-	27260156	CADOES1	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.4290137140658135	[370]	[258,267,144,356]	-6	hSpCas9	negative selection	6210479
2164228	2164251	19	+	27260156	EWS502	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.4619330123798169	[70]	[69,18,74,53]	-7	hSpCas9	negative selection	6267461
2164202	2164225	19	+	27260156	EWS502	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.3380006511801461	[185]	[95,167,135,234]	-5	hSpCas9	negative selection	6267462
2180735	2180758	19	+	27260156	EWS502	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.5610952170069056	[471]	[517,755,941,761]	8	hSpCas9	negative selection	6267463
2185874	2185897	19	-	27260156	EWS502	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.17334147648366488	[388]	[337,245,543,340]	-3	hSpCas9	negative selection	6331728
2185855	2185878	19	+	27260156	EWS502	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.062454916424883766	[205]	[166,117,106,468]	-1	hSpCas9	negative selection	6331729
2164251	2164274	19	-	27260156	EWS502	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.038186080523119836	[370]	[349,468,362,435]	0	hSpCas9	negative selection	6331730
2164228	2164251	19	+	27260156	EW8	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.7166916269607841	[70]	[54,29,41,13]	-8	hSpCas9	negative selection	6388712
2164202	2164225	19	+	27260156	EW8	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.47833217074690393	[185]	[141,64,89,141]	-7	hSpCas9	negative selection	6388713
2180735	2180758	19	+	27260156	EW8	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.19151763385687168	[471]	[606,455,336,381]	3	hSpCas9	negative selection	6388714
2185874	2185897	19	-	27260156	EW8	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.2686719396226323	[388]	[581,187,387,379]	5	hSpCas9	negative selection	6452979
2185855	2185878	19	+	27260156	EW8	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.26454517669664557	[205]	[118,172,111,153]	-5	hSpCas9	negative selection	6452980
2164251	2164274	19	-	27260156	EW8	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.4339141446581573	[370]	[236,350,145,170]	-7	hSpCas9	negative selection	6452981
2164228	2164251	19	+	27260156	CORL105	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.05348226102854792	[70]	[101,67,33,109]	-1	hSpCas9	negative selection	6509963
2164202	2164225	19	+	27260156	CORL105	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.1635728487254937	[185]	[119,77,134,62]	-9	hSpCas9	negative selection	6509964
2180735	2180758	19	+	27260156	CORL105	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.544649968064576	[471]	[956,573,973,754]	8	hSpCas9	negative selection	6509965
2185874	2185897	19	-	27260156	CORL105	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.04278565611548532	[388]	[457,481,508,432]	0	hSpCas9	negative selection	6574230
2185855	2185878	19	+	27260156	CORL105	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.2394822593449264	[205]	[222,184,278,142]	-4	hSpCas9	negative selection	6574231
2164251	2164274	19	-	27260156	CORL105	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.3427913734105548	[370]	[435,331,332,270]	-6	hSpCas9	negative selection	6574232
2164228	2164251	19	+	27260156	HS294T	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.7577427695779209	[70]	[7,10,19,28]	-8	hSpCas9	negative selection	6631214
2164202	2164225	19	+	27260156	HS294T	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.2540834494171751	[185]	[45,89,46,57]	-4	hSpCas9	negative selection	6631215
2180735	2180758	19	+	27260156	HS294T	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.3899504283803477	[471]	[245,201,300,200]	5	hSpCas9	negative selection	6631216
2185874	2185897	19	-	27260156	HS294T	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.2807465187767508	[388]	[243,167,123,189]	4	hSpCas9	negative selection	6695481
2185855	2185878	19	+	27260156	HS294T	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.7469746281102361	[205]	[32,42,58,57]	-8	hSpCas9	negative selection	6695482
2164251	2164274	19	-	27260156	HS294T	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.17438365258854654	[370]	[78,108,129,208]	-2	hSpCas9	negative selection	6695483
2164228	2164251	19	+	27260156	HCC44	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.3413476370107955	[70]	[178,98,112,26]	5	hSpCas9	negative selection	6752465
2164202	2164225	19	+	27260156	HCC44	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	0.1438269272952759	[185]	[232,171,205,317]	2	hSpCas9	negative selection	6752466
2180735	2180758	19	+	27260156	HCC44	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.4908133409513454	[471]	[583,1214,682,429]	7	hSpCas9	negative selection	6752467
2185874	2185897	19	-	27260156	HCC44	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.11875381325776424	[388]	[511,235,528,395]	-2	hSpCas9	negative selection	6816732
2185855	2185878	19	+	27260156	HCC44	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.1806620940778898	[205]	[199,242,295,94]	-3	hSpCas9	negative selection	6816733
2164251	2164274	19	-	27260156	HCC44	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.11764173902503991	[370]	[584,558,459,218]	1	hSpCas9	negative selection	6816734
2164228	2164251	19	+	27260156	G402	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.4721946377868189	[70]	[38,197,16,2]	-5	hSpCas9	negative selection	6873716
2164202	2164225	19	+	27260156	G402	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.2660091168164551	[185]	[152,67,109,54]	-8	hSpCas9	negative selection	6873717
2180735	2180758	19	+	27260156	G402	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.32652722630297865	[471]	[506,937,773,651]	4	hSpCas9	negative selection	6873718
2185874	2185897	19	-	27260156	G402	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.29548475281645714	[388]	[574,469,388,154]	-4	hSpCas9	negative selection	6937983
2185855	2185878	19	+	27260156	G402	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.5839480986677299	[205]	[139,122,242,157]	-6	hSpCas9	negative selection	6937984
2164251	2164274	19	-	27260156	G402	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.12984887724329924	[370]	[651,324,368,638]	1	hSpCas9	negative selection	6937985
2164228	2164251	19	+	27260156	L33	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	1.0105322419039224	[70]	[175,55,85,121]	9	hSpCas9	negative selection	6994967
2164202	2164225	19	+	27260156	L33	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	0.41136149933155763	[185]	[188,96,196,251]	8	hSpCas9	negative selection	6994968
2180735	2180758	19	+	27260156	L33	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.40372934564056423	[471]	[671,226,406,622]	8	hSpCas9	negative selection	6994969
2185874	2185897	19	-	27260156	L33	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.44058484453244406	[388]	[498,250,340,458]	8	hSpCas9	negative selection	7059234
2185855	2185878	19	+	27260156	L33	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	0.05798569814297405	[205]	[185,75,202,164]	1	hSpCas9	negative selection	7059235
2164251	2164274	19	-	27260156	L33	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.2551248766906839	[370]	[444,166,259,503]	5	hSpCas9	negative selection	7059236
2164228	2164251	19	+	27260156	K562	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.11159108095508952	[70]	[9,4,171,75]	1	hSpCas9	negative selection	7116218
2164202	2164225	19	+	27260156	K562	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.5642708457560976	[185]	[45,64,86,27]	-9	hSpCas9	negative selection	7116219
2180735	2180758	19	+	27260156	K562	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.49714371573787647	[471]	[971,597,262,563]	6	hSpCas9	negative selection	7116220
2185874	2185897	19	-	27260156	K562	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.7959678897975493	[388]	[866,531,666,373]	8	hSpCas9	negative selection	7180485
2185855	2185878	19	+	27260156	K562	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.3412024739402022	[205]	[134,254,125,73]	-4	hSpCas9	negative selection	7180486
2164251	2164274	19	-	27260156	K562	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.8960198779197266	[370]	[175,230,156,148]	-7	hSpCas9	negative selection	7180487
2164228	2164251	19	+	27260156	HT29	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.6240849648838371	[70]	[97,76,18,36]	-8	hSpCas9	negative selection	7237469
2164202	2164225	19	+	27260156	HT29	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.8629597912470883	[185]	[126,173,94,106]	-8	hSpCas9	negative selection	7237470
2180735	2180758	19	+	27260156	HT29	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.5838650211388737	[471]	[944,985,847,692]	9	hSpCas9	negative selection	7237471
2185874	2185897	19	-	27260156	HT29	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.24521001160953138	[388]	[513,511,307,290]	-5	hSpCas9	negative selection	7301736
2185855	2185878	19	+	27260156	HT29	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.8138386894870395	[205]	[160,153,129,127]	-8	hSpCas9	negative selection	7301737
2164251	2164274	19	-	27260156	HT29	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.5417756840336727	[370]	[474,373,166,246]	-7	hSpCas9	negative selection	7301738
2164228	2164251	19	+	27260156	MHHES1	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.603087983672955	[70]	[109,203,111,74]	9	hSpCas9	negative selection	7358720
2164202	2164225	19	+	27260156	MHHES1	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	0.0610758453267044	[185]	[258,303,176,156]	1	hSpCas9	negative selection	7358721
2180735	2180758	19	+	27260156	MHHES1	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.25283230977737825	[471]	[1001,604,507,480]	4	hSpCas9	negative selection	7358722
2185874	2185897	19	-	27260156	MHHES1	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.12953786150075838	[388]	[661,487,375,416]	2	hSpCas9	negative selection	7422987
2185855	2185878	19	+	27260156	MHHES1	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.24118898468349048	[205]	[202,126,345,117]	-4	hSpCas9	negative selection	7422988
2164251	2164274	19	-	27260156	MHHES1	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.03765039714491025	[370]	[607,455,359,258]	0	hSpCas9	negative selection	7422989
2164228	2164251	19	+	27260156	MEWO	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.27079652828162804	[70]	[13,96,45]	-5	hSpCas9	negative selection	7479971
2164202	2164225	19	+	27260156	MEWO	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.8340570598852364	[185]	[163,31,109]	-9	hSpCas9	negative selection	7479972
2180735	2180758	19	+	27260156	MEWO	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.5488046549895849	[471]	[979,546,475]	9	hSpCas9	negative selection	7479973
2185874	2185897	19	-	27260156	MEWO	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.12278954293705113	[388]	[376,319,313]	-3	hSpCas9	negative selection	7544238
2185855	2185878	19	+	27260156	MEWO	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.8818370826372912	[205]	[99,73,138]	-9	hSpCas9	negative selection	7544239
2164251	2164274	19	-	27260156	MEWO	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.15687429983521012	[370]	[291,347,289]	-3	hSpCas9	negative selection	7544240
2164228	2164251	19	+	27260156	LNCAPCLONEFGC	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.9251919345265907	[70]	[62,18,27,24]	-8	hSpCas9	negative selection	7601222
2164202	2164225	19	+	27260156	LNCAPCLONEFGC	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.368048974984613	[185]	[81,59,57,59]	-9	hSpCas9	negative selection	7601223
2180735	2180758	19	+	27260156	LNCAPCLONEFGC	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.2879530192673828	[471]	[458,509,597,533]	4	hSpCas9	negative selection	7601224
2185874	2185897	19	-	27260156	LNCAPCLONEFGC	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.14238665591465904	[388]	[316,300,311,346]	-2	hSpCas9	negative selection	7665489
2185855	2185878	19	+	27260156	LNCAPCLONEFGC	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.5649628432479095	[205]	[164,77,146,119]	-7	hSpCas9	negative selection	7665490
2164251	2164274	19	-	27260156	LNCAPCLONEFGC	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.7572796692195358	[370]	[236,102,341,139]	-8	hSpCas9	negative selection	7665491
2164228	2164251	19	+	27260156	PANC0327	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.4469466276134475	[70]	[22,108,10,31]	-6	hSpCas9	negative selection	7722473
2164202	2164225	19	+	27260156	PANC0327	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.0726685530419986	[185]	[354,129,65,96]	-1	hSpCas9	negative selection	7722474
2180735	2180758	19	+	27260156	PANC0327	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.43597199641047746	[471]	[638,493,563,586]	6	hSpCas9	negative selection	7722475
2185874	2185897	19	-	27260156	PANC0327	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.1505232779399503	[388]	[610,232,295,431]	2	hSpCas9	negative selection	7786740
2185855	2185878	19	+	27260156	PANC0327	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.17760240312665343	[205]	[365,90,123,91]	-3	hSpCas9	negative selection	7786741
2164251	2164274	19	-	27260156	PANC0327	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.3186154801111753	[370]	[305,206,373,180]	-5	hSpCas9	negative selection	7786742
2164228	2164251	19	+	27260156	NCIH2009	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.019272273050478628	[70]	[63,221,5]	0	hSpCas9	negative selection	7843724
2164202	2164225	19	+	27260156	NCIH2009	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.7249016465140063	[185]	[251,110,127]	-7	hSpCas9	negative selection	7843725
2180735	2180758	19	+	27260156	NCIH2009	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	-0.05580962198537643	[471]	[751,659,512]	0	hSpCas9	negative selection	7843726
2185874	2185897	19	-	27260156	NCIH2009	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.43090163327770026	[388]	[747,290,239]	-5	hSpCas9	negative selection	7907991
2185855	2185878	19	+	27260156	NCIH2009	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-1.0169855326641817	[205]	[166,104,159]	-8	hSpCas9	negative selection	7907992
2164251	2164274	19	-	27260156	NCIH2009	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.04780299314952352	[370]	[819,416,330]	0	hSpCas9	negative selection	7907993
2164228	2164251	19	+	27260156	NCIH1373	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-3.0402414185307474	[70]	[9,2,7,4]	-9	hSpCas9	negative selection	7964975
2164202	2164225	19	+	27260156	NCIH1373	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-2.6552813061714136	[185]	[45,18,39,7]	-9	hSpCas9	negative selection	7964976
2180735	2180758	19	+	27260156	NCIH1373	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.301180386573996	[471]	[518,704,564,209]	3	hSpCas9	negative selection	7964977
2185874	2185897	19	-	27260156	NCIH1373	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.6273388223886859	[388]	[365,124,417,63]	-6	hSpCas9	negative selection	8029242
2185855	2185878	19	+	27260156	NCIH1373	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.9208886059216264	[205]	[240,145,80,7]	-7	hSpCas9	negative selection	8029243
2164251	2164274	19	-	27260156	NCIH1373	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.7425218475921644	[370]	[136,242,377,55]	-6	hSpCas9	negative selection	8029244
2164228	2164251	19	+	27260156	PATU8902	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.23503954309835295	[70]	[274,9,21,35]	-2	hSpCas9	negative selection	8086226
2164202	2164225	19	+	27260156	PATU8902	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	0.12270980119054276	[185]	[167,479,294,167]	1	hSpCas9	negative selection	8086227
2180735	2180758	19	+	27260156	PATU8902	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	-0.12766225625488575	[471]	[613,933,372,532]	-1	hSpCas9	negative selection	8086228
2185874	2185897	19	-	27260156	PATU8902	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.03081795465428072	[388]	[657,271,335,1057]	0	hSpCas9	negative selection	8150493
2185855	2185878	19	+	27260156	PATU8902	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	0.6279232651941973	[205]	[331,598,439,395]	6	hSpCas9	negative selection	8150494
2164251	2164274	19	-	27260156	PATU8902	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.5772932728821789	[370]	[189,359,317,547]	-5	hSpCas9	negative selection	8150495
2164228	2164251	19	+	27260156	PANC1	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.40660957440764234	[70]	[40,22,36,72]	-6	hSpCas9	negative selection	8207477
2164202	2164225	19	+	27260156	PANC1	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.3458623811818895	[185]	[148,104,103,135]	-5	hSpCas9	negative selection	8207478
2180735	2180758	19	+	27260156	PANC1	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.598662538310262	[471]	[552,685,790,458]	8	hSpCas9	negative selection	8207479
2185874	2185897	19	-	27260156	PANC1	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.28023683717502257	[388]	[392,429,535,283]	4	hSpCas9	negative selection	8271744
2185855	2185878	19	+	27260156	PANC1	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.07974752477397806	[205]	[219,105,185,144]	-1	hSpCas9	negative selection	8271745
2164251	2164274	19	-	27260156	PANC1	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.09739656274962549	[370]	[298,339,292,267]	-1	hSpCas9	negative selection	8271746
2164228	2164251	19	+	27260156	PANC0813	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.6756457435895009	[70]	[80,46,76,8]	-7	hSpCas9	negative selection	8328728
2164202	2164225	19	+	27260156	PANC0813	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.1949139444788504	[185]	[117,115,28,118]	-9	hSpCas9	negative selection	8328729
2180735	2180758	19	+	27260156	PANC0813	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	-0.04655955966429125	[471]	[605,698,453,400]	0	hSpCas9	negative selection	8328730
2185874	2185897	19	-	27260156	PANC0813	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.05045558321700172	[388]	[560,488,360,367]	-1	hSpCas9	negative selection	8392995
2185855	2185878	19	+	27260156	PANC0813	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.800929253328257	[205]	[272,131,88,76]	-8	hSpCas9	negative selection	8392996
2164251	2164274	19	-	27260156	PANC0813	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.6428426458147161	[370]	[317,172,384,245]	-7	hSpCas9	negative selection	8392997
2164228	2164251	19	+	27260156	RDES	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.19345518266801598	[70]	[73,107,108,80]	3	hSpCas9	negative selection	8449979
2164202	2164225	19	+	27260156	RDES	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.36259467624562136	[185]	[138,128,199,209]	-6	hSpCas9	negative selection	8449980
2180735	2180758	19	+	27260156	RDES	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.5854771833109527	[471]	[775,664,1044,769]	8	hSpCas9	negative selection	8449981
2185874	2185897	19	-	27260156	RDES	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.23122448317118816	[388]	[380,638,509,582]	4	hSpCas9	negative selection	8514246
2185855	2185878	19	+	27260156	RDES	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.22315274620519077	[205]	[215,150,181,266]	-4	hSpCas9	negative selection	8514247
2164251	2164274	19	-	27260156	RDES	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.036032797763041524	[370]	[377,425,500,448]	0	hSpCas9	negative selection	8514248
2164228	2164251	19	+	27260156	PC3	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-1.058863188015796	[70]	[18,44,55,26]	-9	hSpCas9	negative selection	8571230
2164202	2164225	19	+	27260156	PC3	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.30507545751650267	[185]	[42,211,322,123]	-6	hSpCas9	negative selection	8571231
2180735	2180758	19	+	27260156	PC3	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.1341247117382426	[471]	[340,399,950,576]	3	hSpCas9	negative selection	8571232
2185874	2185897	19	-	27260156	PC3	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.21984659348140034	[388]	[219,510,762,497]	5	hSpCas9	negative selection	8635497
2185855	2185878	19	+	27260156	PC3	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.3841226266768203	[205]	[66,167,291,183]	-7	hSpCas9	negative selection	8635498
2164251	2164274	19	-	27260156	PC3	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.35434376365285886	[370]	[221,311,408,252]	-7	hSpCas9	negative selection	8635499
2164228	2164251	19	+	27260156	PATU8988T	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-1.0055410773998221	[70]	[40,26,33,33]	-8	hSpCas9	negative selection	8692481
2164202	2164225	19	+	27260156	PATU8988T	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.1520353441800939	[185]	[133,123,218,165]	-3	hSpCas9	negative selection	8692482
2180735	2180758	19	+	27260156	PATU8988T	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.2969503911580449	[471]	[427,457,513,855]	5	hSpCas9	negative selection	8692483
2185874	2185897	19	-	27260156	PATU8988T	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.3072851775995731	[388]	[554,261,509,517]	5	hSpCas9	negative selection	8756748
2185855	2185878	19	+	27260156	PATU8988T	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-1.047505798125385	[205]	[123,142,51,68]	-9	hSpCas9	negative selection	8756749
2164251	2164274	19	-	27260156	PATU8988T	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.2464021087720542	[370]	[402,342,180,285]	-4	hSpCas9	negative selection	8756750
2164228	2164251	19	+	27260156	T47D	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.05390599994256284	[70]	[114,64,88,75]	1	hSpCas9	negative selection	8813732
2164202	2164225	19	+	27260156	T47D	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.5547177581469833	[185]	[186,138,125,138]	-8	hSpCas9	negative selection	8813733
2180735	2180758	19	+	27260156	T47D	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.47423781932678133	[471]	[734,741,778,801]	8	hSpCas9	negative selection	8813734
2185874	2185897	19	-	27260156	T47D	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.11942490034563746	[388]	[520,410,454,592]	2	hSpCas9	negative selection	8877999
2185855	2185878	19	+	27260156	T47D	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.5222872501221758	[205]	[181,133,206,146]	-8	hSpCas9	negative selection	8878000
2164251	2164274	19	-	27260156	T47D	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.4165392617781675	[370]	[316,339,310,325]	-7	hSpCas9	negative selection	8878001
2164228	2164251	19	+	27260156	SU8686	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.1436923718982439	[70]	[54,63,113,15]	-3	hSpCas9	negative selection	8934983
2164202	2164225	19	+	27260156	SU8686	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.7145968956172148	[185]	[94,92,99,174]	-8	hSpCas9	negative selection	8934984
2180735	2180758	19	+	27260156	SU8686	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.19271146076865933	[471]	[511,481,643,504]	3	hSpCas9	negative selection	8934985
2185874	2185897	19	-	27260156	SU8686	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.018414553858565164	[388]	[450,272,387,420]	0	hSpCas9	negative selection	8999250
2185855	2185878	19	+	27260156	SU8686	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.2688316915314024	[205]	[83,182,250,168]	-4	hSpCas9	negative selection	8999251
2164251	2164274	19	-	27260156	SU8686	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.09649866457256412	[370]	[307,275,360,460]	-2	hSpCas9	negative selection	8999252
2164228	2164251	19	+	27260156	SKES1	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.37995517210553675	[70]	[73,73,54,22]	-7	hSpCas9	negative selection	9056234
2164202	2164225	19	+	27260156	SKES1	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.1897651704738421	[185]	[67,122,34,99]	-9	hSpCas9	negative selection	9056235
2180735	2180758	19	+	27260156	SKES1	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.15867831074598293	[471]	[550,576,688,312]	3	hSpCas9	negative selection	9056236
2185874	2185897	19	-	27260156	SKES1	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.16663239387944317	[388]	[432,276,324,347]	-4	hSpCas9	negative selection	9120501
2185855	2185878	19	+	27260156	SKES1	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.05069667264006039	[205]	[207,282,123,189]	-1	hSpCas9	negative selection	9120502
2164251	2164274	19	-	27260156	SKES1	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.5625925661551161	[370]	[183,322,259,233]	-8	hSpCas9	negative selection	9120503
2164228	2164251	19	+	27260156	TOV112D	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-1.0046071626363555	[70]	[34,24,39,38]	-9	hSpCas9	negative selection	9177485
2164202	2164225	19	+	27260156	TOV112D	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.5540885690819766	[185]	[81,225,95,123]	-8	hSpCas9	negative selection	9177486
2180735	2180758	19	+	27260156	TOV112D	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.34365341961459367	[471]	[631,643,532,602]	6	hSpCas9	negative selection	9177487
2185874	2185897	19	-	27260156	TOV112D	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	-0.1472567118121414	[388]	[375,349,467,217]	-3	hSpCas9	negative selection	9241752
2185855	2185878	19	+	27260156	TOV112D	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.4258108300855725	[205]	[190,172,175,83]	-7	hSpCas9	negative selection	9241753
2164251	2164274	19	-	27260156	TOV112D	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.47022782553329995	[370]	[332,189,243,290]	-7	hSpCas9	negative selection	9241754
2164228	2164251	19	+	27260156	TC71	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	-0.011301598622282416	[70]	[97,59,85,55]	0	hSpCas9	negative selection	9298736
2164202	2164225	19	+	27260156	TC71	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.13411407523116736	[185]	[189,195,171,167]	-4	hSpCas9	negative selection	9298737
2180735	2180758	19	+	27260156	TC71	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.4030022559930783	[471]	[773,598,590,714]	8	hSpCas9	negative selection	9298738
2185874	2185897	19	-	27260156	TC71	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.07314830639623357	[388]	[312,531,485,423]	1	hSpCas9	negative selection	9363003
2185855	2185878	19	+	27260156	TC71	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.22491864697510877	[205]	[172,197,154,233]	-6	hSpCas9	negative selection	9363004
2164251	2164274	19	-	27260156	TC71	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.058409719235195	[370]	[334,459,328,407]	-1	hSpCas9	negative selection	9363005
2164228	2164251	19	+	27260156	TC32	viability	CTGAGCCCGCCGTCTACCCGTGG	DOT1L	ENSG00000104885	0.13844216131847764	[70]	[66,79,107,35]	2	hSpCas9	negative selection	9419987
2164202	2164225	19	+	27260156	TC32	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.004595647659042	[185]	[117,5,155,103]	-9	hSpCas9	negative selection	9419988
2180735	2180758	19	+	27260156	TC32	viability	ATGAAATCATCGAGACCATCCGG	DOT1L	ENSG00000104885	0.18815281653911942	[471]	[391,548,514,532]	3	hSpCas9	negative selection	9419989
2185874	2185897	19	-	27260156	TC32	viability	TCCATAGCGAGCTTGAGATCCGG	DOT1L	ENSG00000104885	0.18010703416235008	[388]	[380,306,514,495]	3	hSpCas9	negative selection	9484254
2185855	2185878	19	+	27260156	TC32	viability	ATGGGTCTGTGAAGAAATCCCGG	DOT1L	ENSG00000104885	-0.24240010115302435	[205]	[144,157,158,186]	-4	hSpCas9	negative selection	9484255
2164251	2164274	19	-	27260156	TC32	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.40845009963755435	[370]	[268,142,429,267]	-6	hSpCas9	negative selection	9484256
2164245	2164268	19	-	27869803	HPAFII	viability after 27 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.7870958125020096	[435]	[580,240,NaN]	6	hSpCas9	negative selection	9566737
2180750	2180773	19	-	27869803	HPAFII	viability after 27 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.5187555066499103	[328]	[135,107,NaN]	-4	hSpCas9	negative selection	9566738
2189774	2189797	19	+	27869803	HPAFII	viability after 27 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	0.23586493960014004	[310]	[173,207,NaN]	2	hSpCas9	negative selection	9566739
2190997	2191020	19	+	27869803	HPAFII	viability after 27 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	-1.0413110583737413	[341]	[142,40,NaN]	-6	hSpCas9	negative selection	9566740
2193762	2193785	19	+	27869803	HPAFII	viability after 27 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-1.3802380410962232	[184]	[68,10,NaN]	-7	hSpCas9	negative selection	9566741
2194519	2194542	19	+	27869803	HPAFII	viability after 27 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-0.01850344149541816	[794]	[380,438,NaN]	0	hSpCas9	negative selection	9566742
2164245	2164268	19	-	27869803	HPAFII	viability after 15 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.17188305873462262	[435]	[747,390,NaN]	2	hSpCas9	negative selection	9649186
2180750	2180773	19	-	27869803	HPAFII	viability after 15 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.38711189181581673	[328]	[159,338,NaN]	-4	hSpCas9	negative selection	9649187
2189774	2189797	19	+	27869803	HPAFII	viability after 15 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	-0.22998955151800068	[310]	[329,256,NaN]	-3	hSpCas9	negative selection	9649188
2190997	2191020	19	+	27869803	HPAFII	viability after 15 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	0.006195810369146515	[341]	[608,219,NaN]	0	hSpCas9	negative selection	9649189
2193762	2193785	19	+	27869803	HPAFII	viability after 15 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-1.5274224651027508	[184]	[121,35,NaN]	-8	hSpCas9	negative selection	9649190
2194519	2194542	19	+	27869803	HPAFII	viability after 15 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-0.6955937683872052	[794]	[632,461,NaN]	-6	hSpCas9	negative selection	9649191
2164245	2164268	19	-	27869803	ASPC1	viability after 36 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.0501645778824296	[1075]	[923,734,700]	8	hSpCas9	negative selection	9731635
2180750	2180773	19	-	27869803	ASPC1	viability after 36 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	0.9918426745539111	[945]	[772,782,467]	8	hSpCas9	negative selection	9731636
2189774	2189797	19	+	27869803	ASPC1	viability after 36 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	0.6795618572736326	[629]	[663,288,179]	6	hSpCas9	negative selection	9731637
2190997	2191020	19	+	27869803	ASPC1	viability after 36 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	1.237444328159329	[799]	[1001,488,544]	9	hSpCas9	negative selection	9731638
2193762	2193785	19	+	27869803	ASPC1	viability after 36 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	0.6129969546310953	[212]	[34,28,234]	6	hSpCas9	negative selection	9731639
2194519	2194542	19	+	27869803	ASPC1	viability after 36 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	-0.4361348202201645	[1789]	[412,674,321]	-4	hSpCas9	negative selection	9731640
2164245	2164268	19	-	27869803	PATU8988S	viability after 35 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.4297023790206054	[787]	[836,872,NaN]	9	hSpCas9	negative selection	9814084
2180750	2180773	19	-	27869803	PATU8988S	viability after 35 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	0.3522522464076082	[745]	[401,364,NaN]	4	hSpCas9	negative selection	9814085
2189774	2189797	19	+	27869803	PATU8988S	viability after 35 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	1.6403280668256142	[495]	[726,517,NaN]	9	hSpCas9	negative selection	9814086
2190997	2191020	19	+	27869803	PATU8988S	viability after 35 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	-0.43767749423527386	[759]	[222,228,NaN]	-4	hSpCas9	negative selection	9814087
2193762	2193785	19	+	27869803	PATU8988S	viability after 35 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	0.756138235329811	[292]	[114,283,NaN]	7	hSpCas9	negative selection	9814088
2194519	2194542	19	+	27869803	PATU8988S	viability after 35 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	1.0930252926675532	[1496]	[1569,1000,NaN]	9	hSpCas9	negative selection	9814089
2164245	2164268	19	-	27869803	PATU8988S	viability after 31 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	1.4600485948358362	[787]	[702,1069,NaN]	9	hSpCas9	negative selection	9896533
2180750	2180773	19	-	27869803	PATU8988S	viability after 31 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	0.4783360891497094	[745]	[442,377,NaN]	6	hSpCas9	negative selection	9896534
2189774	2189797	19	+	27869803	PATU8988S	viability after 31 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	1.080725287293861	[495]	[405,433,NaN]	9	hSpCas9	negative selection	9896535
2190997	2191020	19	+	27869803	PATU8988S	viability after 31 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	0.03493987264666054	[759]	[280,347,NaN]	0	hSpCas9	negative selection	9896536
2193762	2193785	19	+	27869803	PATU8988S	viability after 31 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	0.7226580039607421	[292]	[183,203,NaN]	8	hSpCas9	negative selection	9896537
2194519	2194542	19	+	27869803	PATU8988S	viability after 31 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	0.9188936000071117	[1496]	[1194,1043,NaN]	8	hSpCas9	negative selection	9896538
2164245	2164268	19	-	27869803	HPAFII	viability after 35 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.13104630826187336	[435]	[252,228,NaN]	0	hSpCas9	negative selection	9978982
2180750	2180773	19	-	27869803	HPAFII	viability after 35 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.9717394913911959	[328]	[51,121,NaN]	-5	hSpCas9	negative selection	9978983
2189774	2189797	19	+	27869803	HPAFII	viability after 35 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	0.4911542328262873	[310]	[106,349,NaN]	3	hSpCas9	negative selection	9978984
2190997	2191020	19	+	27869803	HPAFII	viability after 35 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	-1.1468568641919896	[341]	[104,47,NaN]	-6	hSpCas9	negative selection	9978985
2193762	2193785	19	+	27869803	HPAFII	viability after 35 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-1.9779374601505082	[184]	[43,0,NaN]	-7	hSpCas9	negative selection	9978986
2194519	2194542	19	+	27869803	HPAFII	viability after 35 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	0.5213150025090014	[794]	[571,583,NaN]	3	hSpCas9	negative selection	9978987
2164245	2164268	19	-	27869803	HPAFII	viability after 31 days	ACGTAGACCGGCAGCGGCCACGG	DOT1L	ENSG00000104885	0.20988153057308456	[435]	[338,221,NaN]	1	hSpCas9	negative selection	10061431
2180750	2180773	19	-	27869803	HPAFII	viability after 31 days	CAGGCCGTGCACTCACCGGATGG	DOT1L	ENSG00000104885	-0.6794132492989415	[328]	[65,168,NaN]	-4	hSpCas9	negative selection	10061432
2189774	2189797	19	+	27869803	HPAFII	viability after 31 days	CATCGACAGCATCCACCAGCTGG	DOT1L	ENSG00000104885	0.5033437720824085	[310]	[155,346,NaN]	3	hSpCas9	negative selection	10061433
2190997	2191020	19	+	27869803	HPAFII	viability after 31 days	ACCCTCCGTCCGCAGTGGAAGGG	DOT1L	ENSG00000104885	-1.2231641191360136	[341]	[86,76,NaN]	-6	hSpCas9	negative selection	10061434
2193762	2193785	19	+	27869803	HPAFII	viability after 31 days	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-1.2929903953313904	[184]	[72,8,NaN]	-7	hSpCas9	negative selection	10061435
2194519	2194542	19	+	27869803	HPAFII	viability after 31 days	TGGACCGCGAGTTCAGGAAGTGG	DOT1L	ENSG00000104885	0.34827098346537166	[794]	[522,616,NaN]	2	hSpCas9	negative selection	10061436
2210655	2210678	19	-	28162770	P31FUJ	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-0.7633169211131585	[181]	[125]	-5	hSpCas9	negative selection	10146009
2210818	2210841	19	+	28162770	P31FUJ	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-1.4958366102481726	[143]	[59]	-7	hSpCas9	negative selection	10146010
2222452	2222475	19	+	28162770	P31FUJ	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	-0.3265166392365724	[158]	[148]	-3	hSpCas9	negative selection	10146011
2164202	2164225	19	+	28162770	P31FUJ	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-2.6550352050974264	[133]	[24]	-9	hSpCas9	negative selection	10146012
2164251	2164274	19	-	28162770	P31FUJ	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-3.2916958934679474	[74]	[8]	-9	hSpCas9	negative selection	10146013
2189728	2189751	19	+	28162770	P31FUJ	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-1.5421302625221074	[227]	[91]	-7	hSpCas9	negative selection	10146014
2191055	2191078	19	-	28162770	P31FUJ	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-2.2577485615446093	[349]	[85]	-8	hSpCas9	negative selection	10146015
2193762	2193785	19	+	28162770	P31FUJ	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-3.463099823836173	[121]	[12]	-9	hSpCas9	negative selection	10146016
2210694	2210717	19	+	28162770	P31FUJ	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	-0.5936839336463171	[243]	[189]	-5	hSpCas9	negative selection	10146017
2210717	2210740	19	+	28162770	P31FUJ	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	0.6756904957906411	[479]	[900]	7	hSpCas9	negative selection	10146018
2210655	2210678	19	-	28162770	TF1	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	NaN	[NaN]	[59]	1	hSpCas9	negative selection	10315375
2210818	2210841	19	+	28162770	TF1	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	NaN	[NaN]	[73]	1	hSpCas9	negative selection	10315376
2222452	2222475	19	+	28162770	TF1	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	NaN	[NaN]	[144]	1	hSpCas9	negative selection	10315377
2164202	2164225	19	+	28162770	TF1	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	NaN	[NaN]	[22]	1	hSpCas9	negative selection	10315378
2164251	2164274	19	-	28162770	TF1	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	NaN	[NaN]	[32]	1	hSpCas9	negative selection	10315379
2189728	2189751	19	+	28162770	TF1	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	NaN	[NaN]	[101]	1	hSpCas9	negative selection	10315380
2191055	2191078	19	-	28162770	TF1	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	NaN	[NaN]	[71]	1	hSpCas9	negative selection	10315381
2193762	2193785	19	+	28162770	TF1	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10315382
2210694	2210717	19	+	28162770	TF1	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	NaN	[NaN]	[123]	1	hSpCas9	negative selection	10315383
2210717	2210740	19	+	28162770	TF1	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	NaN	[NaN]	[910]	1	hSpCas9	negative selection	10315384
2210655	2210678	19	-	28162770	SKM1	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-0.34334809944718997	[60]	[84]	-3	hSpCas9	negative selection	10484741
2210818	2210841	19	+	28162770	SKM1	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-0.760601153357862	[22]	[23]	-5	hSpCas9	negative selection	10484742
2222452	2222475	19	+	28162770	SKM1	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	0.8184559152908544	[33]	[105]	7	hSpCas9	negative selection	10484743
2164202	2164225	19	+	28162770	SKM1	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.1963972128035034	[34]	[26]	-7	hSpCas9	negative selection	10484744
2164251	2164274	19	-	28162770	SKM1	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.4219238848640836	[18]	[44]	4	hSpCas9	negative selection	10484745
2189728	2189751	19	+	28162770	SKM1	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-0.8399236060192679	[80]	[79]	-6	hSpCas9	negative selection	10484746
2191055	2191078	19	-	28162770	SKM1	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	0.42145233884227223	[67]	[160]	4	hSpCas9	negative selection	10484747
2193762	2193785	19	+	28162770	SKM1	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-0.6520766965796931	[15]	[17]	-5	hSpCas9	negative selection	10484748
2210694	2210717	19	+	28162770	SKM1	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	0.44808746534573884	[50]	[122]	4	hSpCas9	negative selection	10484749
2210717	2210740	19	+	28162770	SKM1	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	0.5511517202205299	[82]	[214]	5	hSpCas9	negative selection	10484750
2210655	2210678	19	-	28162770	SKM1	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-0.34334809944718997	[60]	[84]	-3	hSpCas9	negative selection	10654107
2210818	2210841	19	+	28162770	SKM1	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-0.760601153357862	[22]	[23]	-5	hSpCas9	negative selection	10654108
2222452	2222475	19	+	28162770	SKM1	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	0.8184559152908544	[33]	[105]	7	hSpCas9	negative selection	10654109
2164202	2164225	19	+	28162770	SKM1	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.1963972128035034	[34]	[26]	-7	hSpCas9	negative selection	10654110
2164251	2164274	19	-	28162770	SKM1	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.4219238848640836	[18]	[44]	4	hSpCas9	negative selection	10654111
2189728	2189751	19	+	28162770	SKM1	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-0.8399236060192679	[80]	[79]	-6	hSpCas9	negative selection	10654112
2191055	2191078	19	-	28162770	SKM1	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	0.42145233884227223	[67]	[160]	4	hSpCas9	negative selection	10654113
2193762	2193785	19	+	28162770	SKM1	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-0.6520766965796931	[15]	[17]	-5	hSpCas9	negative selection	10654114
2210694	2210717	19	+	28162770	SKM1	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	0.44808746534573884	[50]	[122]	4	hSpCas9	negative selection	10654115
2210717	2210740	19	+	28162770	SKM1	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	0.5511517202205299	[82]	[214]	5	hSpCas9	negative selection	10654116
2210655	2210678	19	-	28162770	PL21	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-3.099984110079694	[196]	[9]	-9	hSpCas9	negative selection	10823473
2210818	2210841	19	+	28162770	PL21	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-0.1422525829577579	[70]	[27]	-1	hSpCas9	negative selection	10823474
2222452	2222475	19	+	28162770	PL21	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	0.4164575214160837	[135]	[78]	3	hSpCas9	negative selection	10823475
2164202	2164225	19	+	28162770	PL21	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.7113237109090225	[157]	[20]	-8	hSpCas9	negative selection	10823476
2164251	2164274	19	-	28162770	PL21	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	0.2716928755143544	[58]	[30]	2	hSpCas9	negative selection	10823477
2189728	2189751	19	+	28162770	PL21	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-1.516734561737417	[308]	[46]	-7	hSpCas9	negative selection	10823478
2191055	2191078	19	-	28162770	PL21	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-0.15775397768591476	[263]	[102]	-1	hSpCas9	negative selection	10823479
2193762	2193785	19	+	28162770	PL21	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-4.226125140212778	[85]	[1]	-9	hSpCas9	negative selection	10823480
2210694	2210717	19	+	28162770	PL21	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	0.3909619568248982	[197]	[112]	3	hSpCas9	negative selection	10823481
2210717	2210740	19	+	28162770	PL21	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	1.019931639785147	[263]	[232]	8	hSpCas9	negative selection	10823482
2210655	2210678	19	-	28162770	P31FUJ	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-0.7633169211131585	[181]	[125]	-5	hSpCas9	negative selection	10992839
2210818	2210841	19	+	28162770	P31FUJ	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-1.4958366102481726	[143]	[59]	-7	hSpCas9	negative selection	10992840
2222452	2222475	19	+	28162770	P31FUJ	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	-0.3265166392365724	[158]	[148]	-3	hSpCas9	negative selection	10992841
2164202	2164225	19	+	28162770	P31FUJ	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-2.6550352050974264	[133]	[24]	-9	hSpCas9	negative selection	10992842
2164251	2164274	19	-	28162770	P31FUJ	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-3.2916958934679474	[74]	[8]	-9	hSpCas9	negative selection	10992843
2189728	2189751	19	+	28162770	P31FUJ	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-1.5421302625221074	[227]	[91]	-7	hSpCas9	negative selection	10992844
2191055	2191078	19	-	28162770	P31FUJ	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-2.2577485615446093	[349]	[85]	-8	hSpCas9	negative selection	10992845
2193762	2193785	19	+	28162770	P31FUJ	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-3.463099823836173	[121]	[12]	-9	hSpCas9	negative selection	10992846
2210694	2210717	19	+	28162770	P31FUJ	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	-0.5936839336463171	[243]	[189]	-5	hSpCas9	negative selection	10992847
2210717	2210740	19	+	28162770	P31FUJ	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	0.6756904957906411	[479]	[900]	7	hSpCas9	negative selection	10992848
2210655	2210678	19	-	28162770	OCIAML5	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-1.8691400842229384	[84]	[41]	-7	hSpCas9	negative selection	11162205
2210818	2210841	19	+	28162770	OCIAML5	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-0.6316765024386968	[102]	[119]	-4	hSpCas9	negative selection	11162206
2222452	2222475	19	+	28162770	OCIAML5	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	-1.3840801916361942	[106]	[73]	-7	hSpCas9	negative selection	11162207
2164202	2164225	19	+	28162770	OCIAML5	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	0.024358744017470402	[66]	[122]	0	hSpCas9	negative selection	11162208
2164251	2164274	19	-	28162770	OCIAML5	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.08956588459065329	[55]	[94]	0	hSpCas9	negative selection	11162209
2189728	2189751	19	+	28162770	OCIAML5	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-0.360886216463458	[142]	[200]	-3	hSpCas9	negative selection	11162210
2191055	2191078	19	-	28162770	OCIAML5	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	0.5039090048510427	[133]	[342]	4	hSpCas9	negative selection	11162211
2193762	2193785	19	+	28162770	OCIAML5	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-0.5852800301690956	[63]	[76]	-4	hSpCas9	negative selection	11162212
2210694	2210717	19	+	28162770	OCIAML5	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	-0.19618228421222333	[171]	[270]	-1	hSpCas9	negative selection	11162213
2210717	2210740	19	+	28162770	OCIAML5	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	0.8000101257156962	[230]	[725]	7	hSpCas9	negative selection	11162214
2210655	2210678	19	-	28162770	EOL1	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-2.8967913799227705	[310]	[21]	-9	hSpCas9	negative selection	11331571
2210818	2210841	19	+	28162770	EOL1	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-1.6071727078736422	[132]	[22]	-7	hSpCas9	negative selection	11331572
2222452	2222475	19	+	28162770	EOL1	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	-0.23772365732834252	[328]	[146]	-2	hSpCas9	negative selection	11331573
2164202	2164225	19	+	28162770	EOL1	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-5.048144882433729	[313]	[4]	-9	hSpCas9	negative selection	11331574
2164251	2164274	19	-	28162770	EOL1	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.8724652062656104	[138]	[39]	-6	hSpCas9	negative selection	11331575
2189728	2189751	19	+	28162770	EOL1	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-1.1057549885929912	[432]	[105]	-6	hSpCas9	negative selection	11331576
2191055	2191078	19	-	28162770	EOL1	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-1.8192069882583106	[354]	[52]	-8	hSpCas9	negative selection	11331577
2193762	2193785	19	+	28162770	EOL1	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	0.014745580542112613	[61]	[32]	0	hSpCas9	negative selection	11331578
2210694	2210717	19	+	28162770	EOL1	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	-0.02695371073827535	[233]	[120]	0	hSpCas9	negative selection	11331579
2210717	2210740	19	+	28162770	EOL1	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	-0.4217301847325767	[477]	[187]	-3	hSpCas9	negative selection	11331580
2210655	2210678	19	-	28162770	MOLM13	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-3.762408237877215	[243]	[12]	-9	hSpCas9	negative selection	11500937
2210818	2210841	19	+	28162770	MOLM13	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-1.6919819552338107	[142]	[31]	-7	hSpCas9	negative selection	11500938
2222452	2222475	19	+	28162770	MOLM13	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	0.1408483632635638	[211]	[168]	1	hSpCas9	negative selection	11500939
2164202	2164225	19	+	28162770	MOLM13	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-1.0060418067878336	[199]	[71]	-5	hSpCas9	negative selection	11500940
2164251	2164274	19	-	28162770	MOLM13	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-3.215375192788381	[166]	[12]	-8	hSpCas9	negative selection	11500941
2189728	2189751	19	+	28162770	MOLM13	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	0.9269596488860887	[362]	[498]	7	hSpCas9	negative selection	11500942
2191055	2191078	19	-	28162770	MOLM13	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-3.1311483043883	[411]	[33]	-8	hSpCas9	negative selection	11500943
2193762	2193785	19	+	28162770	MOLM13	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-6.339465540513025	[111]	[0]	-9	hSpCas9	negative selection	11500944
2210694	2210717	19	+	28162770	MOLM13	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	-1.0575721074279159	[284]	[98]	-5	hSpCas9	negative selection	11500945
2210717	2210740	19	+	28162770	MOLM13	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	0.5259103345143039	[462]	[481]	4	hSpCas9	negative selection	11500946
2210655	2210678	19	-	28162770	HEL	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-0.5545626083732603	[265]	[115]	-4	hSpCas9	negative selection	11670303
2210818	2210841	19	+	28162770	HEL	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-3.8703307502390136	[136]	[5]	-9	hSpCas9	negative selection	11670304
2222452	2222475	19	+	28162770	HEL	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	-0.19679649580639694	[203]	[113]	-1	hSpCas9	negative selection	11670305
2164202	2164225	19	+	28162770	HEL	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-0.7752519846678343	[162]	[60]	-5	hSpCas9	negative selection	11670306
2164251	2164274	19	-	28162770	HEL	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.6018835367195565	[108]	[45]	-4	hSpCas9	negative selection	11670307
2189728	2189751	19	+	28162770	HEL	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-0.26851695616956345	[330]	[175]	-2	hSpCas9	negative selection	11670308
2191055	2191078	19	-	28162770	HEL	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-0.6957404391508532	[262]	[103]	-4	hSpCas9	negative selection	11670309
2193762	2193785	19	+	28162770	HEL	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-3.208117728693834	[100]	[6]	-9	hSpCas9	negative selection	11670310
2210694	2210717	19	+	28162770	HEL	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	-0.16308862031065335	[235]	[134]	-1	hSpCas9	negative selection	11670311
2210717	2210740	19	+	28162770	HEL	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	0.6349193275410576	[369]	[367]	5	hSpCas9	negative selection	11670312
2210655	2210678	19	-	28162770	MV411	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-2.3375249499383806	[203]	[33]	-8	hSpCas9	negative selection	11839669
2210818	2210841	19	+	28162770	MV411	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-0.5017543457166902	[78]	[46]	-4	hSpCas9	negative selection	11839670
2222452	2222475	19	+	28162770	MV411	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	0.4079022229760214	[152]	[170]	3	hSpCas9	negative selection	11839671
2164202	2164225	19	+	28162770	MV411	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-2.4477078676888038	[135]	[20]	-8	hSpCas9	negative selection	11839672
2164251	2164274	19	-	28162770	MV411	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-1.422413847524894	[69]	[21]	-7	hSpCas9	negative selection	11839673
2189728	2189751	19	+	28162770	MV411	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-0.6661476973997513	[242]	[128]	-5	hSpCas9	negative selection	11839674
2191055	2191078	19	-	28162770	MV411	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-0.10814609828582608	[205]	[160]	-1	hSpCas9	negative selection	11839675
2193762	2193785	19	+	28162770	MV411	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-2.185521856493331	[53]	[9]	-8	hSpCas9	negative selection	11839676
2210694	2210717	19	+	28162770	MV411	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	0.07140718669127585	[147]	[130]	0	hSpCas9	negative selection	11839677
2210717	2210740	19	+	28162770	MV411	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	0.5280066159090802	[367]	[446]	5	hSpCas9	negative selection	11839678
2210655	2210678	19	-	28162770	MONOMAC1	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-0.7534301955839391	[124]	[84]	-6	hSpCas9	negative selection	12009035
2210818	2210841	19	+	28162770	MONOMAC1	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-0.5271854487518848	[43]	[34]	-4	hSpCas9	negative selection	12009036
2222452	2222475	19	+	28162770	MONOMAC1	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	-0.8898553375413778	[117]	[72]	-6	hSpCas9	negative selection	12009037
2164202	2164225	19	+	28162770	MONOMAC1	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-2.410030570393752	[101]	[21]	-9	hSpCas9	negative selection	12009038
2164251	2164274	19	-	28162770	MONOMAC1	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-1.9783965605842133	[54]	[15]	-8	hSpCas9	negative selection	12009039
2189728	2189751	19	+	28162770	MONOMAC1	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-1.7089358855909864	[153]	[53]	-8	hSpCas9	negative selection	12009040
2191055	2191078	19	-	28162770	MONOMAC1	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-2.034765418160677	[167]	[46]	-8	hSpCas9	negative selection	12009041
2193762	2193785	19	+	28162770	MONOMAC1	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-3.9696263509564815	[40]	[2]	-9	hSpCas9	negative selection	12009042
2210694	2210717	19	+	28162770	MONOMAC1	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	-0.3237939893454923	[106]	[97]	-3	hSpCas9	negative selection	12009043
2210717	2210740	19	+	28162770	MONOMAC1	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	0.1828112237569901	[248]	[323]	1	hSpCas9	negative selection	12009044
2210655	2210678	19	-	28162770	OCIAML2	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-2.129592907407094	[29]	[37]	-8	hSpCas9	negative selection	12178401
2210818	2210841	19	+	28162770	OCIAML2	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	-1.3662931654274257	[19]	[42]	-7	hSpCas9	negative selection	12178402
2222452	2222475	19	+	28162770	OCIAML2	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	-0.42482613562903637	[30]	[127]	-3	hSpCas9	negative selection	12178403
2164202	2164225	19	+	28162770	OCIAML2	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-3.3450989431583027	[10]	[5]	-9	hSpCas9	negative selection	12178404
2164251	2164274	19	-	28162770	OCIAML2	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.1905219060494261	[13]	[67]	-1	hSpCas9	negative selection	12178405
2189728	2189751	19	+	28162770	OCIAML2	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-1.9731301657713443	[50]	[71]	-8	hSpCas9	negative selection	12178406
2191055	2191078	19	-	28162770	OCIAML2	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	-2.7634115744700067	[48]	[39]	-9	hSpCas9	negative selection	12178407
2193762	2193785	19	+	28162770	OCIAML2	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-3.4706298252421615	[11]	[5]	-9	hSpCas9	negative selection	12178408
2210694	2210717	19	+	28162770	OCIAML2	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	0.05293213081485165	[27]	[160]	0	hSpCas9	negative selection	12178409
2210717	2210740	19	+	28162770	OCIAML2	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	1.0709400799656144	[44]	[523]	8	hSpCas9	negative selection	12178410
2210655	2210678	19	-	28162770	OCIAML3	viability	GGGAGACGGCTTCTTCACGGTGG	DOT1L	ENSG00000104885	-2.9565777197088714	[71]	[27]	-9	hSpCas9	negative selection	12347767
2210818	2210841	19	+	28162770	OCIAML3	viability	TCAGACCGTGTCTCAGACGGCGG	DOT1L	ENSG00000104885	0.6337982771986492	[18]	[88]	6	hSpCas9	negative selection	12347768
2222452	2222475	19	+	28162770	OCIAML3	viability	GGGACGCCCAGCTTGAGCGCAGG	DOT1L	ENSG00000104885	0.6334028557789092	[40]	[191]	6	hSpCas9	negative selection	12347769
2164202	2164225	19	+	28162770	OCIAML3	viability	GCTGAGACTGAAGTCGCCCGTGG	DOT1L	ENSG00000104885	-4.963241449989883	[30]	[2]	-9	hSpCas9	negative selection	12347770
2164251	2164274	19	-	28162770	OCIAML3	viability	GCACTCACGTAGACCGGCAGCGG	DOT1L	ENSG00000104885	-0.6554081849883067	[23]	[45]	-5	hSpCas9	negative selection	12347771
2189728	2189751	19	+	28162770	OCIAML3	viability	TCAGCTTCGAGAGCATGCAGAGG	DOT1L	ENSG00000104885	-2.278505814596234	[89]	[55]	-8	hSpCas9	negative selection	12347772
2191055	2191078	19	-	28162770	OCIAML3	viability	GATATGGCGCAGGAGTCCAGTGG	DOT1L	ENSG00000104885	0.561787032283261	[56]	[253]	5	hSpCas9	negative selection	12347773
2193762	2193785	19	+	28162770	OCIAML3	viability	CATCCCGGCCAAGTATGCGGAGG	DOT1L	ENSG00000104885	-2.155886527932278	[30]	[20]	-8	hSpCas9	negative selection	12347774
2210694	2210717	19	+	28162770	OCIAML3	viability	AGAAGCTAAACAAGAAGGGGAGG	DOT1L	ENSG00000104885	-1.0715866056717198	[54]	[78]	-6	hSpCas9	negative selection	12347775
2210717	2210740	19	+	28162770	OCIAML3	viability	AAGATGGCTGGCCGCAAGCGCGG	DOT1L	ENSG00000104885	0.3500359537018213	[91]	[353]	3	hSpCas9	negative selection	12347776