Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 3670
• Symbol: ISL1
• Description: ISL LIM homeobox 1

DataSource: http://genomecrispr.dkfz.de/#!/results/ISL1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
51387616	51387639	5	-	26472758	Jiyoye	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.27122788347667615	[277]	[252]	2	hSpCas9	negative selection	79412
51387667	51387690	5	-	26472758	Jiyoye	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	-0.4819226899932674	[412]	[222]	-3	hSpCas9	negative selection	79413
51387680	51387703	5	+	26472758	Jiyoye	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	0.6828098241193007	[75]	[91]	5	hSpCas9	negative selection	79414
51387734	51387757	5	-	26472758	Jiyoye	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.841071908036033	[170]	[230]	6	hSpCas9	negative selection	79415
51389709	51389732	5	-	26472758	Jiyoye	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	1.5864990809504356	[33]	[76]	8	hSpCas9	negative selection	79416
51389760	51389783	5	+	26472758	Jiyoye	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.8975010080889543	[83]	[117]	6	hSpCas9	negative selection	79417
51391282	51391305	5	+	26472758	Jiyoye	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	0.3076397079549593	[29]	[27]	2	hSpCas9	negative selection	79418
51391310	51391333	5	+	26472758	Jiyoye	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	2.594802384681645	[8]	[40]	9	hSpCas9	negative selection	79419
51387555	51387578	5	-	26472758	Jiyoye	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.4932889449432122	[139]	[74]	-4	hSpCas9	negative selection	79420
51387600	51387623	5	+	26472758	Jiyoye	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	1.0195143211583346	[173]	[265]	6	hSpCas9	negative selection	79421
51387616	51387639	5	-	26472758	KBM7	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	1.0204833658580341	[1239,719]	[735,1072]	9	hSpCas9	negative selection	270530
51387667	51387690	5	-	26472758	KBM7	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.8422647063528612	[1574,1487]	[1622,998]	8	hSpCas9	negative selection	270531
51387680	51387703	5	+	26472758	KBM7	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	-0.23254711834341002	[247,239]	[60,130]	-2	hSpCas9	negative selection	270532
51387734	51387757	5	-	26472758	KBM7	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.7263215991310557	[669,683]	[543,516]	7	hSpCas9	negative selection	270533
51389709	51389732	5	-	26472758	KBM7	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	-0.2719117757146763	[168,135]	[86,33]	-3	hSpCas9	negative selection	270534
51389760	51389783	5	+	26472758	KBM7	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.5672106468271721	[363,328]	[206,271]	6	hSpCas9	negative selection	270535
51391282	51391305	5	+	26472758	KBM7	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-0.5421362118757169	[362,263]	[88,109]	-5	hSpCas9	negative selection	270536
51391310	51391333	5	+	26472758	KBM7	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	0.4815586542259429	[155,156]	[31,166]	5	hSpCas9	negative selection	270537
51387555	51387578	5	-	26472758	KBM7	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.188559755246899	[632,514]	[308,302]	2	hSpCas9	negative selection	270538
51387600	51387623	5	+	26472758	KBM7	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	0.4987286080102487	[812,519]	[453,417]	5	hSpCas9	negative selection	270539
51387616	51387639	5	-	26472758	Raji	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.3244127719429546	[615]	[178]	3	hSpCas9	negative selection	461648
51387667	51387690	5	-	26472758	Raji	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	-0.4455386991888779	[756]	[128]	-4	hSpCas9	negative selection	461649
51387680	51387703	5	+	26472758	Raji	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	-0.3706637614310446	[116]	[20]	-3	hSpCas9	negative selection	461650
51387734	51387757	5	-	26472758	Raji	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.6219567082033578	[391]	[139]	6	hSpCas9	negative selection	461651
51389709	51389732	5	-	26472758	Raji	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	-0.25518654401110896	[143]	[27]	-2	hSpCas9	negative selection	461652
51389760	51389783	5	+	26472758	Raji	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.4069438172325074	[155]	[47]	4	hSpCas9	negative selection	461653
51391282	51391305	5	+	26472758	Raji	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-0.7417915623786318	[244]	[33]	-5	hSpCas9	negative selection	461654
51391310	51391333	5	+	26472758	Raji	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	0.785455440486237	[44]	[17]	7	hSpCas9	negative selection	461655
51387555	51387578	5	-	26472758	Raji	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.8705901582964015	[259]	[32]	-6	hSpCas9	negative selection	461656
51387600	51387623	5	+	26472758	Raji	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	-0.14725642971796182	[376]	[78]	-1	hSpCas9	negative selection	461657
51387616	51387639	5	-	26472758	K562	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.5985030157134277	[700]	[895]	5	hSpCas9	negative selection	652766
51387667	51387690	5	-	26472758	K562	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.11014922239895375	[1113]	[1014]	0	hSpCas9	negative selection	652767
51387680	51387703	5	+	26472758	K562	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	-0.020037753236544886	[202]	[168]	0	hSpCas9	negative selection	652768
51387734	51387757	5	-	26472758	K562	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.2560534281498502	[740]	[746]	2	hSpCas9	negative selection	652769
51389709	51389732	5	-	26472758	K562	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	0.5772234118044148	[184]	[232]	5	hSpCas9	negative selection	652770
51389760	51389783	5	+	26472758	K562	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.6007379522078102	[256]	[328]	5	hSpCas9	negative selection	652771
51391282	51391305	5	+	26472758	K562	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-3.49254686649976	[239]	[17]	-8	hSpCas9	negative selection	652772
51391310	51391333	5	+	26472758	K562	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	1.450002861316341	[110]	[255]	9	hSpCas9	negative selection	652773
51387555	51387578	5	-	26472758	K562	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.9163242464288069	[380]	[606]	7	hSpCas9	negative selection	652774
51387600	51387623	5	+	26472758	K562	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	0.05088116900218398	[461]	[403]	0	hSpCas9	negative selection	652775
51387555	51387578	5	-	26627737	DLD1	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.3212498936365376	[358]	[188,121,112]	3	hSpCas9	negative selection	828942
51387725	51387748	5	-	26627737	DLD1	viability	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	0.5567953672407334	[220]	[194,93,26]	5	hSpCas9	negative selection	828943
51389777	51389800	5	-	26627737	DLD1	viability	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.07879431760321087	[1686]	[435,674,563]	0	hSpCas9	negative selection	828944
51391333	51391356	5	+	26627737	DLD1	viability	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.599729094127107	[728]	[314,426,303]	6	hSpCas9	negative selection	828945
51393512	51393535	5	+	26627737	DLD1	viability	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	0.15150827019497548	[206]	[32,80,97]	1	hSpCas9	negative selection	828946
51393528	51393551	5	-	26627737	DLD1	viability	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.7243677861635844	[473]	[242,208,275]	7	hSpCas9	negative selection	828947
51387555	51387578	5	-	26627737	GBM cells	viability after 5 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.915530471958238	[203]	[57,57]	-8	hSpCas9	negative selection	911257
51387725	51387748	5	-	26627737	GBM cells	viability after 5 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	1.0713810708904514	[62]	[82,58]	9	hSpCas9	negative selection	911258
51389777	51389800	5	-	26627737	GBM cells	viability after 5 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.20694752811466688	[625]	[343,430]	3	hSpCas9	negative selection	911259
51391333	51391356	5	+	26627737	GBM cells	viability after 5 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.1730888383246797	[472]	[314,256]	2	hSpCas9	negative selection	911260
51393512	51393535	5	+	26627737	GBM cells	viability after 5 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	0.2329148020736227	[118]	[75,73]	3	hSpCas9	negative selection	911261
51393528	51393551	5	-	26627737	GBM cells	viability after 5 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.9935507490237607	[176]	[193,183]	9	hSpCas9	negative selection	911262
51387555	51387578	5	-	26627737	GBM cells	viability after 13 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.22124846780478546	[203]	[132,63]	-3	hSpCas9	negative selection	993572
51387725	51387748	5	-	26627737	GBM cells	viability after 13 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	0.7000034081900328	[62]	[81,33]	8	hSpCas9	negative selection	993573
51389777	51389800	5	-	26627737	GBM cells	viability after 13 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.46235832627094164	[625]	[478,458]	6	hSpCas9	negative selection	993574
51391333	51391356	5	+	26627737	GBM cells	viability after 13 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.3210506006941515	[472]	[431,229]	4	hSpCas9	negative selection	993575
51393512	51393535	5	+	26627737	GBM cells	viability after 13 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	0.6172847493698299	[118]	[119,81]	7	hSpCas9	negative selection	993576
51393528	51393551	5	-	26627737	GBM cells	viability after 13 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	1.0840079584105582	[176]	[207,199]	9	hSpCas9	negative selection	993577
51387555	51387578	5	-	26627737	GBM cells	viability after 21 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.7480408213969625	[203]	[77,54]	-6	hSpCas9	negative selection	1075887
51387725	51387748	5	-	26627737	GBM cells	viability after 21 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	0.7048592894539316	[62]	[48,61]	7	hSpCas9	negative selection	1075888
51389777	51389800	5	-	26627737	GBM cells	viability after 21 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.49810657213663156	[625]	[495,465]	5	hSpCas9	negative selection	1075889
51391333	51391356	5	+	26627737	GBM cells	viability after 21 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.658806418595174	[472]	[447,366]	6	hSpCas9	negative selection	1075890
51393512	51393535	5	+	26627737	GBM cells	viability after 21 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	0.2621603221724147	[118]	[64,88]	2	hSpCas9	negative selection	1075891
51393528	51393551	5	-	26627737	GBM cells	viability after 21 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	1.9580213004216973	[176]	[417,332]	9	hSpCas9	negative selection	1075892
51387555	51387578	5	-	26627737	RPE1	viability after 9 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.4075843671941256	[514]	[114,129]	-3	hSpCas9	negative selection	1158202
51387725	51387748	5	-	26627737	RPE1	viability after 9 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	0.9983811580769903	[334]	[188,235]	6	hSpCas9	negative selection	1158203
51389777	51389800	5	-	26627737	RPE1	viability after 9 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	1.1896786337663137	[2001]	[1261,1645]	7	hSpCas9	negative selection	1158204
51391333	51391356	5	+	26627737	RPE1	viability after 9 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	-0.4564438053311427	[1640]	[328,432]	-3	hSpCas9	negative selection	1158205
51393512	51393535	5	+	26627737	RPE1	viability after 9 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	-0.2052552008919285	[488]	[120,147]	-1	hSpCas9	negative selection	1158206
51393528	51393551	5	-	26627737	RPE1	viability after 9 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.6906124902413581	[816]	[290,569]	4	hSpCas9	negative selection	1158207
51387555	51387578	5	-	26627737	RPE1	viability after 12 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.02576391737995476	[514]	[166,102]	0	hSpCas9	negative selection	1240517
51387725	51387748	5	-	26627737	RPE1	viability after 12 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	1.147822430480051	[334]	[196,201]	7	hSpCas9	negative selection	1240518
51389777	51389800	5	-	26627737	RPE1	viability after 12 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	1.092103519138736	[2001]	[1066,1230]	6	hSpCas9	negative selection	1240519
51391333	51391356	5	+	26627737	RPE1	viability after 12 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	-0.017104112615940803	[1640]	[373,500]	0	hSpCas9	negative selection	1240520
51393512	51393535	5	+	26627737	RPE1	viability after 12 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	0.3009979804838156	[488]	[122,202]	2	hSpCas9	negative selection	1240521
51393528	51393551	5	-	26627737	RPE1	viability after 12 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.674307485160632	[816]	[376,321]	4	hSpCas9	negative selection	1240522
51387555	51387578	5	-	26627737	RPE1	viability after 15 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.059426511226093215	[514]	[178,101]	0	hSpCas9	negative selection	1322832
51387725	51387748	5	-	26627737	RPE1	viability after 15 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	1.2605676256553662	[334]	[336,120]	7	hSpCas9	negative selection	1322833
51389777	51389800	5	-	26627737	RPE1	viability after 15 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	1.1718508121259983	[2001]	[1476,1081]	6	hSpCas9	negative selection	1322834
51391333	51391356	5	+	26627737	RPE1	viability after 15 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	-0.24780291320012626	[1640]	[337,441]	-1	hSpCas9	negative selection	1322835
51393512	51393535	5	+	26627737	RPE1	viability after 15 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	-0.19210775832103977	[488]	[3,233]	-1	hSpCas9	negative selection	1322836
51393528	51393551	5	-	26627737	RPE1	viability after 15 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.430110462279429	[816]	[345,277]	2	hSpCas9	negative selection	1322837
51387555	51387578	5	-	26627737	RPE1	viability after 18 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.0665613411862136	[514]	[175,112]	0	hSpCas9	negative selection	1405147
51387725	51387748	5	-	26627737	RPE1	viability after 18 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	0.9269613556362057	[334]	[153,190]	5	hSpCas9	negative selection	1405148
51389777	51389800	5	-	26627737	RPE1	viability after 18 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	1.1688843112158296	[2001]	[1119,1315]	6	hSpCas9	negative selection	1405149
51391333	51391356	5	+	26627737	RPE1	viability after 18 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.1457233957081867	[1640]	[443,538]	0	hSpCas9	negative selection	1405150
51393512	51393535	5	+	26627737	RPE1	viability after 18 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	-0.779368572806844	[488]	[58,95]	-5	hSpCas9	negative selection	1405151
51393528	51393551	5	-	26627737	RPE1	viability after 18 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.6986804739411295	[816]	[265,455]	4	hSpCas9	negative selection	1405152
51387555	51387578	5	-	26627737	HeLa	viability after 8 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.8542470231092992	[281]	[150,18,52]	-7	hSpCas9	negative selection	1487462
51387725	51387748	5	-	26627737	HeLa	viability after 8 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	1.2807406396076981	[88]	[146,53,92]	8	hSpCas9	negative selection	1487463
51389777	51389800	5	-	26627737	HeLa	viability after 8 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.8694024698756255	[635]	[548,392,578]	7	hSpCas9	negative selection	1487464
51391333	51391356	5	+	26627737	HeLa	viability after 8 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	-0.11195420935117517	[779]	[481,254,246]	-1	hSpCas9	negative selection	1487465
51393512	51393535	5	+	26627737	HeLa	viability after 8 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	-0.194982499604207	[236]	[129,72,76]	-2	hSpCas9	negative selection	1487466
51393528	51393551	5	-	26627737	HeLa	viability after 8 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.3150555979429951	[411]	[316,167,205]	3	hSpCas9	negative selection	1487467
51387555	51387578	5	-	26627737	HeLa	viability after 12 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.22616773274841362	[281]	[212,156,38]	2	hSpCas9	negative selection	1569777
51387725	51387748	5	-	26627737	HeLa	viability after 12 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	1.7074200587431307	[88]	[149,74,140]	9	hSpCas9	negative selection	1569778
51389777	51389800	5	-	26627737	HeLa	viability after 12 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.8177221684784142	[635]	[390,592,389]	6	hSpCas9	negative selection	1569779
51391333	51391356	5	+	26627737	HeLa	viability after 12 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	-0.0716566949683961	[779]	[284,377,248]	0	hSpCas9	negative selection	1569780
51393512	51393535	5	+	26627737	HeLa	viability after 12 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	0.3085495915950709	[236]	[191,101,73]	2	hSpCas9	negative selection	1569781
51393528	51393551	5	-	26627737	HeLa	viability after 12 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.37949216536485897	[411]	[209,288,157]	3	hSpCas9	negative selection	1569782
51387555	51387578	5	-	26627737	HeLa	viability after 15 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.5865916307161038	[281]	[112,49,64]	-5	hSpCas9	negative selection	1652092
51387725	51387748	5	-	26627737	HeLa	viability after 15 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	1.3756999188213461	[88]	[73,93,115]	8	hSpCas9	negative selection	1652093
51389777	51389800	5	-	26627737	HeLa	viability after 15 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	1.0934775209175287	[635]	[339,673,653]	7	hSpCas9	negative selection	1652094
51391333	51391356	5	+	26627737	HeLa	viability after 15 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.1811206347315092	[779]	[504,323,239]	1	hSpCas9	negative selection	1652095
51393512	51393535	5	+	26627737	HeLa	viability after 15 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	0.6190726026014559	[236]	[342,35,55]	5	hSpCas9	negative selection	1652096
51393528	51393551	5	-	26627737	HeLa	viability after 15 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.4297799965870618	[411]	[61,245,383]	3	hSpCas9	negative selection	1652097
51387555	51387578	5	-	26627737	HeLa	viability after 18 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.6413696904083873	[281]	[72,37,64]	-5	hSpCas9	negative selection	1734407
51387725	51387748	5	-	26627737	HeLa	viability after 18 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	1.3508821564131392	[88]	[51,70,115]	8	hSpCas9	negative selection	1734408
51389777	51389800	5	-	26627737	HeLa	viability after 18 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	1.119551478927193	[635]	[238,568,653]	7	hSpCas9	negative selection	1734409
51391333	51391356	5	+	26627737	HeLa	viability after 18 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.1635795582520282	[779]	[332,264,239]	1	hSpCas9	negative selection	1734410
51393512	51393535	5	+	26627737	HeLa	viability after 18 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	0.5430861548825773	[236]	[215,28,55]	4	hSpCas9	negative selection	1734411
51393528	51393551	5	-	26627737	HeLa	viability after 18 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.41938408851450315	[411]	[34,207,383]	3	hSpCas9	negative selection	1734412
51387555	51387578	5	-	26627737	HCT116	viability after 6 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.8963457613109869	[255]	[81,70]	5	hSpCas9	negative selection	1816722
51387725	51387748	5	-	26627737	HCT116	viability after 6 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	0.6273492590501754	[216]	[4,78]	3	hSpCas9	negative selection	1816723
51389777	51389800	5	-	26627737	HCT116	viability after 6 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.18040621072898588	[1384]	[510,100]	1	hSpCas9	negative selection	1816724
51391333	51391356	5	+	26627737	HCT116	viability after 6 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.31920357638357966	[1619]	[387,278]	1	hSpCas9	negative selection	1816725
51393512	51393535	5	+	26627737	HCT116	viability after 6 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	-3.6776859068707846	[254]	[6,0]	-9	hSpCas9	negative selection	1816726
51393528	51393551	5	-	26627737	HCT116	viability after 6 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.708336771195507	[705]	[239,148]	4	hSpCas9	negative selection	1816727
51387555	51387578	5	-	26627737	HCT116	viability after 8 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.7295792962271143	[209]	[51,83,72]	-7	hSpCas9	negative selection	1899037
51387725	51387748	5	-	26627737	HCT116	viability after 8 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	1.1514289527503165	[60]	[68,88,65]	8	hSpCas9	negative selection	1899038
51389777	51389800	5	-	26627737	HCT116	viability after 8 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	-0.21947894079257546	[903]	[381,499,400]	-3	hSpCas9	negative selection	1899039
51391333	51391356	5	+	26627737	HCT116	viability after 8 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.06958335278032735	[642]	[449,224,440]	0	hSpCas9	negative selection	1899040
51393512	51393535	5	+	26627737	HCT116	viability after 8 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	-0.014006970136928532	[149]	[63,78,101]	0	hSpCas9	negative selection	1899041
51393528	51393551	5	-	26627737	HCT116	viability after 8 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	-0.17322652261443877	[433]	[254,249,132]	-2	hSpCas9	negative selection	1899042
51387555	51387578	5	-	26627737	HCT116	viability after 9 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.6798362179194538	[255]	[56,150]	5	hSpCas9	negative selection	1981352
51387725	51387748	5	-	26627737	HCT116	viability after 9 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	-0.2386720824858446	[216]	[90,15]	-2	hSpCas9	negative selection	1981353
51389777	51389800	5	-	26627737	HCT116	viability after 9 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.40338226687090883	[1384]	[568,425]	3	hSpCas9	negative selection	1981354
51391333	51391356	5	+	26627737	HCT116	viability after 9 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	-1.3626153070612763	[1619]	[189,150]	-7	hSpCas9	negative selection	1981355
51393512	51393535	5	+	26627737	HCT116	viability after 9 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	0.7437543926172964	[254]	[89,132]	5	hSpCas9	negative selection	1981356
51393528	51393551	5	-	26627737	HCT116	viability after 9 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.14390334912022365	[705]	[195,217]	1	hSpCas9	negative selection	1981357
51387555	51387578	5	-	26627737	HCT116	viability after 12 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.13647217789541233	[209]	[103,143,117]	1	hSpCas9	negative selection	2063667
51387725	51387748	5	-	26627737	HCT116	viability after 12 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	1.169047952828853	[60]	[28,152,39]	8	hSpCas9	negative selection	2063668
51389777	51389800	5	-	26627737	HCT116	viability after 12 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.16171856276662133	[903]	[497,480,616]	1	hSpCas9	negative selection	2063669
51391333	51391356	5	+	26627737	HCT116	viability after 12 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	-0.18450671288693288	[642]	[319,253,314]	-2	hSpCas9	negative selection	2063670
51393512	51393535	5	+	26627737	HCT116	viability after 12 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	-1.2053730214011549	[149]	[50,30,18]	-8	hSpCas9	negative selection	2063671
51393528	51393551	5	-	26627737	HCT116	viability after 12 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.16871195912716064	[433]	[428,216,106]	1	hSpCas9	negative selection	2063672
51387555	51387578	5	-	26627737	HCT116	viability after 15 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.15950092135083127	[209]	[156,155,17]	-2	hSpCas9	negative selection	2145982
51387725	51387748	5	-	26627737	HCT116	viability after 15 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	1.1447601205017404	[60]	[66,77,85]	8	hSpCas9	negative selection	2145983
51389777	51389800	5	-	26627737	HCT116	viability after 15 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	-0.051832455930686416	[903]	[518,506,478]	0	hSpCas9	negative selection	2145984
51391333	51391356	5	+	26627737	HCT116	viability after 15 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.03107943331244689	[642]	[478,344,320]	0	hSpCas9	negative selection	2145985
51393512	51393535	5	+	26627737	HCT116	viability after 15 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	-0.36156343399703705	[149]	[129,27,50]	-4	hSpCas9	negative selection	2145986
51393528	51393551	5	-	26627737	HCT116	viability after 15 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	-0.7999260573353719	[433]	[237,140,62]	-7	hSpCas9	negative selection	2145987
51387555	51387578	5	-	26627737	HCT116	viability after 18 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.7268712435455856	[209]	[91,48,42]	-6	hSpCas9	negative selection	2228297
51387725	51387748	5	-	26627737	HCT116	viability after 18 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	1.031380853976724	[60]	[83,31,66]	7	hSpCas9	negative selection	2228298
51389777	51389800	5	-	26627737	HCT116	viability after 18 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.3149065501643056	[903]	[573,564,487]	2	hSpCas9	negative selection	2228299
51391333	51391356	5	+	26627737	HCT116	viability after 18 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.01628908443559851	[642]	[278,278,390]	0	hSpCas9	negative selection	2228300
51393512	51393535	5	+	26627737	HCT116	viability after 18 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	-0.6696041087558693	[149]	[81,2,54]	-6	hSpCas9	negative selection	2228301
51393528	51393551	5	-	26627737	HCT116	viability after 18 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.17682199569803947	[433]	[408,213,82]	1	hSpCas9	negative selection	2228302
51383662	51383685	5	+	24336569	HL60	viability	TCTTACAGATATGGGAGACATGG	ISL1	ENSG00000016082	-0.04643208447413416	[772]	[1583]	0	hSpCas9	negative selection	2272281
51384546	51384569	5	+	24336569	HL60	viability	CGTCTGATTTCCCTATGTGTTGG	ISL1	ENSG00000016082	-0.8960903532908502	[546]	[621]	-7	hSpCas9	negative selection	2272282
51384552	51384575	5	+	24336569	HL60	viability	ATTTCCCTATGTGTTGGTTGCGG	ISL1	ENSG00000016082	1.1450444291797834	[274]	[1286]	8	hSpCas9	negative selection	2272283
51384557	51384580	5	-	24336569	HL60	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.11210548554179783	[584]	[1337]	1	hSpCas9	negative selection	2272284
51384583	51384606	5	+	24336569	HL60	viability	TTCACGATCAGTATATTCTGAGG	ISL1	ENSG00000016082	0.5491702584775423	[569]	[1764]	5	hSpCas9	negative selection	2272285
51384593	51384616	5	+	24336569	HL60	viability	GTATATTCTGAGGGTTTCTCCGG	ISL1	ENSG00000016082	-0.17538196401653483	[118]	[222]	-1	hSpCas9	negative selection	2272286
51384599	51384622	5	+	24336569	HL60	viability	TCTGAGGGTTTCTCCGGATTTGG	ISL1	ENSG00000016082	-1.0279776647069212	[555]	[576]	-7	hSpCas9	negative selection	2272287
51384604	51384627	5	+	24336569	HL60	viability	GGGTTTCTCCGGATTTGGAATGG	ISL1	ENSG00000016082	-0.2662039804859462	[103]	[182]	-2	hSpCas9	negative selection	2272288
51384611	51384634	5	+	24336569	HL60	viability	TCCGGATTTGGAATGGCATGCGG	ISL1	ENSG00000016082	-1.1024237192645425	[207]	[204]	-7	hSpCas9	negative selection	2272289
51384629	51384652	5	+	24336569	HL60	viability	TGCGGCATGTTTGAAATGTGCGG	ISL1	ENSG00000016082	1.7731965362070645	[149]	[1084]	9	hSpCas9	negative selection	2272290
51383662	51383685	5	+	24336569	KBM7	viability	TCTTACAGATATGGGAGACATGG	ISL1	ENSG00000016082	0.8712091908079128	[275]	[1376]	7	hSpCas9	negative selection	2339458
51384546	51384569	5	+	24336569	KBM7	viability	CGTCTGATTTCCCTATGTGTTGG	ISL1	ENSG00000016082	0.06330185643880387	[312]	[891]	0	hSpCas9	negative selection	2339459
51384552	51384575	5	+	24336569	KBM7	viability	ATTTCCCTATGTGTTGGTTGCGG	ISL1	ENSG00000016082	0.010578519099781414	[411]	[1131]	0	hSpCas9	negative selection	2339460
51384557	51384580	5	-	24336569	KBM7	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.6025442828769539	[395]	[1639]	5	hSpCas9	negative selection	2339461
51384583	51384606	5	+	24336569	KBM7	viability	TTCACGATCAGTATATTCTGAGG	ISL1	ENSG00000016082	0.07256383607745864	[697]	[2001]	0	hSpCas9	negative selection	2339462
51384593	51384616	5	+	24336569	KBM7	viability	GTATATTCTGAGGGTTTCTCCGG	ISL1	ENSG00000016082	1.0783389498748848	[132]	[765]	8	hSpCas9	negative selection	2339463
51384599	51384622	5	+	24336569	KBM7	viability	TCTGAGGGTTTCTCCGGATTTGG	ISL1	ENSG00000016082	0.39979866041884393	[258]	[931]	3	hSpCas9	negative selection	2339464
51384604	51384627	5	+	24336569	KBM7	viability	GGGTTTCTCCGGATTTGGAATGG	ISL1	ENSG00000016082	0.22841838032589656	[86]	[277]	2	hSpCas9	negative selection	2339465
51384611	51384634	5	+	24336569	KBM7	viability	TCCGGATTTGGAATGGCATGCGG	ISL1	ENSG00000016082	3.2651388513706463	[17]	[471]	9	hSpCas9	negative selection	2339466
51384629	51384652	5	+	24336569	KBM7	viability	TGCGGCATGTTTGAAATGTGCGG	ISL1	ENSG00000016082	1.049435604896571	[216]	[1224]	8	hSpCas9	negative selection	2339467
51384552	51384575	5	+	27260157	DLD1	viability	ATTTCCCTATGTGTTGGTTGCGG	ISL1	ENSG00000016082	-1.2343571362285	[]	[]	-7	hSpCas9	negative selection	2574427
51387544	51387567	5	+	27260157	DLD1	viability	CGTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.112452839403003	[]	[]	3	hSpCas9	negative selection	2580802
51384593	51384616	5	+	27260157	DLD1	viability	GTATATTCTGAGGGTTTCTCCGG	ISL1	ENSG00000016082	-0.563811428037688	[]	[]	-4	hSpCas9	negative selection	2581910
51384611	51384634	5	+	27260157	DLD1	viability	TCCGGATTTGGAATGGCATGCGG	ISL1	ENSG00000016082	-0.772151198935631	[]	[]	-6	hSpCas9	negative selection	2587339
51387510	51387533	5	-	27260157	DLD1	viability	GCTGAAGCCGATGCTGCACTTGG	ISL1	ENSG00000016082	-0.591612533207954	[]	[]	-5	hSpCas9	negative selection	2587544
51384546	51384569	5	+	27260157	DLD1	viability	CGTCTGATTTCCCTATGTGTTGG	ISL1	ENSG00000016082	2.25628499006403	[]	[]	9	hSpCas9	negative selection	2605136
51387555	51387578	5	-	27260157	DLD1	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.429442123012258	[]	[]	7	hSpCas9	negative selection	2606618
51384604	51384627	5	+	27260157	DLD1	viability	GGGTTTCTCCGGATTTGGAATGG	ISL1	ENSG00000016082	-0.316823165078208	[]	[]	-3	hSpCas9	negative selection	2607077
51387658	51387681	5	-	27260157	DLD1	viability	CCACCACATCGTGGTCTGCTCGG	ISL1	ENSG00000016082	0.550780370401632	[]	[]	8	hSpCas9	negative selection	2608907
51384556	51384579	5	-	27260157	DLD1	viability	ATTGCCGCAACCAACACATAGGG	ISL1	ENSG00000016082	0.887900190985468	[]	[]	9	hSpCas9	negative selection	2611947
51387574	51387597	5	+	27260157	DLD1	viability	CATCGAGTGTTTCCGCTGTGTGG	ISL1	ENSG00000016082	-0.12579190608978	[]	[]	-1	hSpCas9	negative selection	2613867
51384599	51384622	5	+	27260157	DLD1	viability	TCTGAGGGTTTCTCCGGATTTGG	ISL1	ENSG00000016082	0.375653541754029	[]	[]	4	hSpCas9	negative selection	2615034
51389709	51389732	5	-	27260157	DLD1	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	0.397674161830395	[]	[]	4	hSpCas9	negative selection	2620388
51384629	51384652	5	+	27260157	DLD1	viability	TGCGGCATGTTTGAAATGTGCGG	ISL1	ENSG00000016082	-1.1105555751311	[]	[]	-7	hSpCas9	negative selection	2621137
51387655	51387678	5	+	27260157	DLD1	viability	CTGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	-0.196523964971767	[]	[]	-1	hSpCas9	negative selection	2621548
51387622	51387645	5	+	27260157	DLD1	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.767258734890073	[]	[]	-5	hSpCas9	negative selection	2621952
51384583	51384606	5	+	27260157	DLD1	viability	TTCACGATCAGTATATTCTGAGG	ISL1	ENSG00000016082	0.193813100035924	[]	[]	3	hSpCas9	negative selection	2623665
51387687	51387710	5	-	27260157	DLD1	viability	CGGGTCGCCAGCGCCTAGACTGG	ISL1	ENSG00000016082	0.422805839601685	[]	[]	7	hSpCas9	negative selection	2642354
51384557	51384580	5	-	27260157	DLD1	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.567165911753805	[]	[]	8	hSpCas9	negative selection	2645020
51383662	51383685	5	+	27260157	DLD1	viability	TCTTACAGATATGGGAGACATGG	ISL1	ENSG00000016082	0.449016177315289	[]	[]	7	hSpCas9	negative selection	2648538
51384552	51384575	5	+	27260157	HT1080	viability	ATTTCCCTATGTGTTGGTTGCGG	ISL1	ENSG00000016082	-1.01664194950024	[]	[]	-8	hSpCas9	negative selection	2650557
51387544	51387567	5	+	27260157	HT1080	viability	CGTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.0795392278969427	[]	[]	0	hSpCas9	negative selection	2656932
51384593	51384616	5	+	27260157	HT1080	viability	GTATATTCTGAGGGTTTCTCCGG	ISL1	ENSG00000016082	-0.750462269646734	[]	[]	-8	hSpCas9	negative selection	2658040
51384611	51384634	5	+	27260157	HT1080	viability	TCCGGATTTGGAATGGCATGCGG	ISL1	ENSG00000016082	-0.998661362930822	[]	[]	-8	hSpCas9	negative selection	2663469
51387510	51387533	5	-	27260157	HT1080	viability	GCTGAAGCCGATGCTGCACTTGG	ISL1	ENSG00000016082	-0.324078303390559	[]	[]	-7	hSpCas9	negative selection	2663674
51384546	51384569	5	+	27260157	HT1080	viability	CGTCTGATTTCCCTATGTGTTGG	ISL1	ENSG00000016082	-0.825146410560987	[]	[]	-8	hSpCas9	negative selection	2681266
51387555	51387578	5	-	27260157	HT1080	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-1.68768583090914	[]	[]	-9	hSpCas9	negative selection	2682748
51384604	51384627	5	+	27260157	HT1080	viability	GGGTTTCTCCGGATTTGGAATGG	ISL1	ENSG00000016082	-0.39351926743078	[]	[]	-7	hSpCas9	negative selection	2683207
51387658	51387681	5	-	27260157	HT1080	viability	CCACCACATCGTGGTCTGCTCGG	ISL1	ENSG00000016082	0.457350415013087	[]	[]	4	hSpCas9	negative selection	2685037
51384556	51384579	5	-	27260157	HT1080	viability	ATTGCCGCAACCAACACATAGGG	ISL1	ENSG00000016082	0.518921792029316	[]	[]	4	hSpCas9	negative selection	2688077
51387574	51387597	5	+	27260157	HT1080	viability	CATCGAGTGTTTCCGCTGTGTGG	ISL1	ENSG00000016082	-0.724644365529948	[]	[]	-8	hSpCas9	negative selection	2689997
51384599	51384622	5	+	27260157	HT1080	viability	TCTGAGGGTTTCTCCGGATTTGG	ISL1	ENSG00000016082	0.154860551157274	[]	[]	1	hSpCas9	negative selection	2691164
51389709	51389732	5	-	27260157	HT1080	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	0.534485538831613	[]	[]	5	hSpCas9	negative selection	2696518
51384629	51384652	5	+	27260157	HT1080	viability	TGCGGCATGTTTGAAATGTGCGG	ISL1	ENSG00000016082	-1.570613112023	[]	[]	-9	hSpCas9	negative selection	2697267
51387655	51387678	5	+	27260157	HT1080	viability	CTGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	-0.0265842159246219	[]	[]	0	hSpCas9	negative selection	2697678
51387622	51387645	5	+	27260157	HT1080	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.95410581231566	[]	[]	-8	hSpCas9	negative selection	2698082
51384583	51384606	5	+	27260157	HT1080	viability	TTCACGATCAGTATATTCTGAGG	ISL1	ENSG00000016082	0.0969987128549311	[]	[]	1	hSpCas9	negative selection	2699795
51387687	51387710	5	-	27260157	HT1080	viability	CGGGTCGCCAGCGCCTAGACTGG	ISL1	ENSG00000016082	0.547932534811922	[]	[]	5	hSpCas9	negative selection	2718484
51384557	51384580	5	-	27260157	HT1080	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.335220779135279	[]	[]	3	hSpCas9	negative selection	2721150
51383662	51383685	5	+	27260157	HT1080	viability	TCTTACAGATATGGGAGACATGG	ISL1	ENSG00000016082	-0.148387222811742	[]	[]	0	hSpCas9	negative selection	2724668
51384552	51384575	5	+	27260157	MKN45	viability	ATTTCCCTATGTGTTGGTTGCGG	ISL1	ENSG00000016082	-0.464172310890188	[]	[]	-6	hSpCas9	negative selection	2726687
51387544	51387567	5	+	27260157	MKN45	viability	CGTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.228235904149528	[]	[]	5	hSpCas9	negative selection	2733062
51384593	51384616	5	+	27260157	MKN45	viability	GTATATTCTGAGGGTTTCTCCGG	ISL1	ENSG00000016082	-0.674986865483206	[]	[]	-7	hSpCas9	negative selection	2734170
51384611	51384634	5	+	27260157	MKN45	viability	TCCGGATTTGGAATGGCATGCGG	ISL1	ENSG00000016082	-0.826593489259022	[]	[]	-7	hSpCas9	negative selection	2739599
51387510	51387533	5	-	27260157	MKN45	viability	GCTGAAGCCGATGCTGCACTTGG	ISL1	ENSG00000016082	-0.456835943222799	[]	[]	-6	hSpCas9	negative selection	2739804
51384546	51384569	5	+	27260157	MKN45	viability	CGTCTGATTTCCCTATGTGTTGG	ISL1	ENSG00000016082	-0.887584429367117	[]	[]	-7	hSpCas9	negative selection	2757396
51387555	51387578	5	-	27260157	MKN45	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.17057177540342	[]	[]	0	hSpCas9	negative selection	2758878
51384604	51384627	5	+	27260157	MKN45	viability	GGGTTTCTCCGGATTTGGAATGG	ISL1	ENSG00000016082	-0.793425649214831	[]	[]	-7	hSpCas9	negative selection	2759337
51387658	51387681	5	-	27260157	MKN45	viability	CCACCACATCGTGGTCTGCTCGG	ISL1	ENSG00000016082	0.290945917270674	[]	[]	5	hSpCas9	negative selection	2761167
51384556	51384579	5	-	27260157	MKN45	viability	ATTGCCGCAACCAACACATAGGG	ISL1	ENSG00000016082	-0.77501628441912	[]	[]	-7	hSpCas9	negative selection	2764207
51387574	51387597	5	+	27260157	MKN45	viability	CATCGAGTGTTTCCGCTGTGTGG	ISL1	ENSG00000016082	0.626433097999116	[]	[]	7	hSpCas9	negative selection	2766127
51384599	51384622	5	+	27260157	MKN45	viability	TCTGAGGGTTTCTCCGGATTTGG	ISL1	ENSG00000016082	0.505512538815986	[]	[]	6	hSpCas9	negative selection	2767294
51389709	51389732	5	-	27260157	MKN45	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	-0.361381433368133	[]	[]	-1	hSpCas9	negative selection	2772648
51384629	51384652	5	+	27260157	MKN45	viability	TGCGGCATGTTTGAAATGTGCGG	ISL1	ENSG00000016082	-1.93676423133806	[]	[]	-9	hSpCas9	negative selection	2773397
51387655	51387678	5	+	27260157	MKN45	viability	CTGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.202335253203704	[]	[]	5	hSpCas9	negative selection	2773808
51387622	51387645	5	+	27260157	MKN45	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.453694483980114	[]	[]	-6	hSpCas9	negative selection	2774212
51384583	51384606	5	+	27260157	MKN45	viability	TTCACGATCAGTATATTCTGAGG	ISL1	ENSG00000016082	-0.613105606492675	[]	[]	-6	hSpCas9	negative selection	2775925
51387687	51387710	5	-	27260157	MKN45	viability	CGGGTCGCCAGCGCCTAGACTGG	ISL1	ENSG00000016082	1.20494154192676	[]	[]	9	hSpCas9	negative selection	2794614
51384557	51384580	5	-	27260157	MKN45	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	-0.0528275169912196	[]	[]	0	hSpCas9	negative selection	2797280
51383662	51383685	5	+	27260157	MKN45	viability	TCTTACAGATATGGGAGACATGG	ISL1	ENSG00000016082	-0.10860984840084	[]	[]	0	hSpCas9	negative selection	2800798
51384552	51384575	5	+	27260157	RKO	viability	ATTTCCCTATGTGTTGGTTGCGG	ISL1	ENSG00000016082	-0.911662493228761	[]	[]	-8	hSpCas9	negative selection	2802817
51387544	51387567	5	+	27260157	RKO	viability	CGTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.915288899316162	[]	[]	8	hSpCas9	negative selection	2809192
51384593	51384616	5	+	27260157	RKO	viability	GTATATTCTGAGGGTTTCTCCGG	ISL1	ENSG00000016082	-1.47298686788631	[]	[]	-8	hSpCas9	negative selection	2810300
51384611	51384634	5	+	27260157	RKO	viability	TCCGGATTTGGAATGGCATGCGG	ISL1	ENSG00000016082	-1.00330236333044	[]	[]	-8	hSpCas9	negative selection	2815729
51387510	51387533	5	-	27260157	RKO	viability	GCTGAAGCCGATGCTGCACTTGG	ISL1	ENSG00000016082	1.05768777095266	[]	[]	9	hSpCas9	negative selection	2815934
51384546	51384569	5	+	27260157	RKO	viability	CGTCTGATTTCCCTATGTGTTGG	ISL1	ENSG00000016082	-1.76182780000386	[]	[]	-9	hSpCas9	negative selection	2833526
51387555	51387578	5	-	27260157	RKO	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.289857679178377	[]	[]	1	hSpCas9	negative selection	2835008
51384604	51384627	5	+	27260157	RKO	viability	GGGTTTCTCCGGATTTGGAATGG	ISL1	ENSG00000016082	-0.305088135639707	[]	[]	-6	hSpCas9	negative selection	2835467
51387658	51387681	5	-	27260157	RKO	viability	CCACCACATCGTGGTCTGCTCGG	ISL1	ENSG00000016082	0.131690818327133	[]	[]	0	hSpCas9	negative selection	2837297
51384556	51384579	5	-	27260157	RKO	viability	ATTGCCGCAACCAACACATAGGG	ISL1	ENSG00000016082	-0.487008203577492	[]	[]	-6	hSpCas9	negative selection	2840337
51387574	51387597	5	+	27260157	RKO	viability	CATCGAGTGTTTCCGCTGTGTGG	ISL1	ENSG00000016082	0.0870508236519844	[]	[]	0	hSpCas9	negative selection	2842257
51384599	51384622	5	+	27260157	RKO	viability	TCTGAGGGTTTCTCCGGATTTGG	ISL1	ENSG00000016082	0.455649207889585	[]	[]	2	hSpCas9	negative selection	2843424
51389709	51389732	5	-	27260157	RKO	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	0.263311441199272	[]	[]	1	hSpCas9	negative selection	2848778
51384629	51384652	5	+	27260157	RKO	viability	TGCGGCATGTTTGAAATGTGCGG	ISL1	ENSG00000016082	-1.80494005133527	[]	[]	-9	hSpCas9	negative selection	2849527
51387655	51387678	5	+	27260157	RKO	viability	CTGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.84764135592349	[]	[]	8	hSpCas9	negative selection	2849938
51387622	51387645	5	+	27260157	RKO	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.773319064397453	[]	[]	-7	hSpCas9	negative selection	2850342
51384583	51384606	5	+	27260157	RKO	viability	TTCACGATCAGTATATTCTGAGG	ISL1	ENSG00000016082	-0.379899053656502	[]	[]	-6	hSpCas9	negative selection	2852055
51387687	51387710	5	-	27260157	RKO	viability	CGGGTCGCCAGCGCCTAGACTGG	ISL1	ENSG00000016082	0.240636362782732	[]	[]	1	hSpCas9	negative selection	2870744
51384557	51384580	5	-	27260157	RKO	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.661868086839242	[]	[]	3	hSpCas9	negative selection	2873410
51383662	51383685	5	+	27260157	RKO	viability	TCTTACAGATATGGGAGACATGG	ISL1	ENSG00000016082	-0.119316988391238	[]	[]	0	hSpCas9	negative selection	2876928
51384552	51384575	5	+	27260157	SF268	viability	ATTTCCCTATGTGTTGGTTGCGG	ISL1	ENSG00000016082	-0.321755126221326	[]	[]	-3	hSpCas9	negative selection	2878947
51387544	51387567	5	+	27260157	SF268	viability	CGTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	-0.0574160812893784	[]	[]	0	hSpCas9	negative selection	2885322
51384593	51384616	5	+	27260157	SF268	viability	GTATATTCTGAGGGTTTCTCCGG	ISL1	ENSG00000016082	-0.614615291882505	[]	[]	-5	hSpCas9	negative selection	2886430
51384611	51384634	5	+	27260157	SF268	viability	TCCGGATTTGGAATGGCATGCGG	ISL1	ENSG00000016082	-0.886773720197397	[]	[]	-6	hSpCas9	negative selection	2891859
51387510	51387533	5	-	27260157	SF268	viability	GCTGAAGCCGATGCTGCACTTGG	ISL1	ENSG00000016082	-0.40371296698766	[]	[]	-3	hSpCas9	negative selection	2892064
51384546	51384569	5	+	27260157	SF268	viability	CGTCTGATTTCCCTATGTGTTGG	ISL1	ENSG00000016082	-1.28014871231212	[]	[]	-7	hSpCas9	negative selection	2909656
51387555	51387578	5	-	27260157	SF268	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.554701369046738	[]	[]	-4	hSpCas9	negative selection	2911138
51384604	51384627	5	+	27260157	SF268	viability	GGGTTTCTCCGGATTTGGAATGG	ISL1	ENSG00000016082	-0.181830492115322	[]	[]	-1	hSpCas9	negative selection	2911597
51387658	51387681	5	-	27260157	SF268	viability	CCACCACATCGTGGTCTGCTCGG	ISL1	ENSG00000016082	0.163899088573908	[]	[]	0	hSpCas9	negative selection	2913427
51384556	51384579	5	-	27260157	SF268	viability	ATTGCCGCAACCAACACATAGGG	ISL1	ENSG00000016082	-0.249808746659281	[]	[]	-2	hSpCas9	negative selection	2916467
51387574	51387597	5	+	27260157	SF268	viability	CATCGAGTGTTTCCGCTGTGTGG	ISL1	ENSG00000016082	0.188322676661302	[]	[]	0	hSpCas9	negative selection	2918387
51384599	51384622	5	+	27260157	SF268	viability	TCTGAGGGTTTCTCCGGATTTGG	ISL1	ENSG00000016082	0.138251261057916	[]	[]	0	hSpCas9	negative selection	2919554
51389709	51389732	5	-	27260157	SF268	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	-0.726091609702896	[]	[]	-5	hSpCas9	negative selection	2924908
51384629	51384652	5	+	27260157	SF268	viability	TGCGGCATGTTTGAAATGTGCGG	ISL1	ENSG00000016082	-1.27222155168299	[]	[]	-7	hSpCas9	negative selection	2925657
51387655	51387678	5	+	27260157	SF268	viability	CTGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.24514156314737	[]	[]	3	hSpCas9	negative selection	2926068
51387622	51387645	5	+	27260157	SF268	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-1.0559018901123	[]	[]	-7	hSpCas9	negative selection	2926472
51384583	51384606	5	+	27260157	SF268	viability	TTCACGATCAGTATATTCTGAGG	ISL1	ENSG00000016082	-0.737200357166245	[]	[]	-5	hSpCas9	negative selection	2928185
51387687	51387710	5	-	27260157	SF268	viability	CGGGTCGCCAGCGCCTAGACTGG	ISL1	ENSG00000016082	0.529248627949639	[]	[]	8	hSpCas9	negative selection	2946874
51384557	51384580	5	-	27260157	SF268	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.338212700584855	[]	[]	4	hSpCas9	negative selection	2949540
51383662	51383685	5	+	27260157	SF268	viability	TCTTACAGATATGGGAGACATGG	ISL1	ENSG00000016082	-1.2553200680452	[]	[]	-7	hSpCas9	negative selection	2953058
51387616	51387639	5	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.32111686673713874	[3,3]	[3,3]	6	hSpCas9	positive selection	2996043
51384557	51384580	5	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	-0.19214945683863358	[3,3]	[2,1]	-3	hSpCas9	positive selection	2996044
51387586	51387609	5	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGCGGCTGCAGGCCACACAGCGG	ISL1	ENSG00000016082	0.1618716519256274	[2,3]	[2,2]	3	hSpCas9	positive selection	2996045
51387712	51387735	5	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TCAGTCCCCTGCATCCAGCGCGG	ISL1	ENSG00000016082	0.45174596814103474	[3,3]	[4,3]	8	hSpCas9	positive selection	2996046
51387616	51387639	5	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.18735714993623273	[3,3]	[2,2]	3	hSpCas9	positive selection	3063901
51384557	51384580	5	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	-0.7792046693979211	[3,3]	[2,0]	-9	hSpCas9	positive selection	3063902
51387586	51387609	5	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGCGGCTGCAGGCCACACAGCGG	ISL1	ENSG00000016082	0.0921550529896853	[2,2]	[1,1]	1	hSpCas9	positive selection	3063903
51387712	51387735	5	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TCAGTCCCCTGCATCCAGCGCGG	ISL1	ENSG00000016082	-0.2523130262428324	[3,3]	[3,0]	-4	hSpCas9	positive selection	3063904
51387617	51387640		-	24336571	A375	resistance to PLX after 7 days	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.20345916500721684	[5,6]	[7,7]	6	hSpCas9	positive selection	3121658
51389823	51389846		+	24336571	A375	resistance to PLX after 7 days	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.3071892447931711	[17,19]	[12,16]	-8	hSpCas9	positive selection	3121659
51389788	51389811		+	24336571	A375	resistance to PLX after 7 days	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	0.0862346023854828	[8,9]	[9,9]	3	hSpCas9	positive selection	3121660
51387617	51387640		-	24336571	A375	resistance to PLX after 14 days	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.08461757056747143	[6,5]	[3,1]	0	hSpCas9	positive selection	3179451
51389823	51389846		+	24336571	A375	resistance to PLX after 14 days	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.08880236726146984	[13,19]	[5,7]	-1	hSpCas9	positive selection	3179452
51389788	51389811		+	24336571	A375	resistance to PLX after 14 days	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.07427207151238235	[4,10]	[2,2]	0	hSpCas9	positive selection	3179453
51387617	51387640		-	24336571	A375	viability after 7 days	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.0394180900599993	[6]	[5,6]	0	hSpCas9	negative selection	3237244
51389823	51389846		+	24336571	A375	viability after 7 days	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.33912760402541103	[14]	[17,19]	5	hSpCas9	negative selection	3237245
51389788	51389811		+	24336571	A375	viability after 7 days	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.07874389718963498	[10]	[8,9]	-1	hSpCas9	negative selection	3237246
51387617	51387640		-	24336571	A375	viability after 14 days	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	-0.029331407480449156	[6]	[6,5]	0	hSpCas9	negative selection	3295037
51389823	51389846		+	24336571	A375	viability after 14 days	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.21210863585511747	[14]	[13,19]	2	hSpCas9	negative selection	3295038
51389788	51389811		+	24336571	A375	viability after 14 days	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.2883735779541713	[10]	[4,10]	-3	hSpCas9	negative selection	3295039
51389823	51389846	5	+	27383988	293T	resistance to West Nile virus (flavivirus)	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.8564159546033534	[276,276]	[0,0]	-6	hSpCas9	positive selection	3374691
51384557	51384580	5	-	27383988	293T	resistance to West Nile virus (flavivirus)	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.8226979838091106	[172,172]	[1,1]	4	hSpCas9	positive selection	3374692
51384647	51384670	5	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-1.0958206140522475	[326,326]	[0,0]	-7	hSpCas9	positive selection	3374693
51387616	51387639	5	-	26780180	HT29	viability (Avana library 4 designs)	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	1.00488268906758	[]	[]	4	hSpCas9	negative selection	3433432
51384557	51384580	5	-	26780180	HT29	viability (Avana library 4 designs)	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.361363617967796	[]	[]	1	hSpCas9	negative selection	3433433
51387586	51387609	5	-	26780180	HT29	viability (Avana library 4 designs)	GGCGGCTGCAGGCCACACAGCGG	ISL1	ENSG00000016082	2.4345667504264	[]	[]	8	hSpCas9	negative selection	3433434
51387711	51387734	5	+	26780180	HT29	viability (Avana library 4 designs)	TCAGTCCCCTGCATCCAGCGCGG	ISL1	ENSG00000016082	0.505786305849487	[]	[]	2	hSpCas9	negative selection	3433435
51387711	51387734	5	+	26780180	A375	viability (Avana lentiCRISPRv2)	TCAGTCCCCTGCATCCAGCGCGG	ISL1	ENSG00000016082	4.53316400236774	[]	[]	7	hSpCas9	negative selection	3520042
51384557	51384580	5	-	26780180	A375	viability (Avana lentiCRISPRv2)	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	-4.72536592885883	[]	[]	-5	hSpCas9	negative selection	3520043
51387616	51387639	5	-	26780180	A375	viability (Avana lentiCRISPRv2)	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	-0.376942406291244	[]	[]	0	hSpCas9	negative selection	3520044
51387586	51387609	5	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGCGGCTGCAGGCCACACAGCGG	ISL1	ENSG00000016082	1.08597775503718	[]	[]	1	hSpCas9	negative selection	3520045
51389673	51389696	5	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTTGTGGACGTGGGGCCGCAGGG	ISL1	ENSG00000016082	2.81912263265192	[]	[]	4	hSpCas9	negative selection	3520046
51384593	51384616	5	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTATATTCTGAGGGTTTCTCCGG	ISL1	ENSG00000016082	-2.04603498833215	[]	[]	-2	hSpCas9	negative selection	3520047
51387711	51387734	5	+	26780180	A375	viability (Avana lentiGuide)	TCAGTCCCCTGCATCCAGCGCGG	ISL1	ENSG00000016082	5.47672091853985	[]	[]	5	hSpCas9	negative selection	3628701
51384557	51384580	5	-	26780180	A375	viability (Avana lentiGuide)	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	-2.13696656591566	[]	[]	-4	hSpCas9	negative selection	3628702
51387616	51387639	5	-	26780180	A375	viability (Avana lentiGuide)	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	5.16556798162868	[]	[]	4	hSpCas9	negative selection	3628703
51387586	51387609	5	-	26780180	A375	viability (Avana lentiGuide)	GGCGGCTGCAGGCCACACAGCGG	ISL1	ENSG00000016082	19.914423174854	[]	[]	8	hSpCas9	negative selection	3628704
51389673	51389696	5	-	26780180	A375	viability (Avana lentiGuide)	CTTGTGGACGTGGGGCCGCAGGG	ISL1	ENSG00000016082	5.88342117230304	[]	[]	5	hSpCas9	negative selection	3628705
51384593	51384616	5	+	26780180	A375	viability (Avana lentiGuide)	GTATATTCTGAGGGTTTCTCCGG	ISL1	ENSG00000016082	-0.235113820891568	[]	[]	0	hSpCas9	negative selection	3628706
51387711	51387734	5	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCAGTCCCCTGCATCCAGCGCGG	ISL1	ENSG00000016082	0.35435910321168107	[4]	[6,5]	9	hSpCas9	positive selection	3737360
51384557	51384580	5	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	-0.19763355513727288	[4]	[4,3]	-3	hSpCas9	positive selection	3737361
51387616	51387639	5	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.26900740332402084	[4]	[5,5]	7	hSpCas9	positive selection	3737362
51387586	51387609	5	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGCGGCTGCAGGCCACACAGCGG	ISL1	ENSG00000016082	0.4523439339655916	[3]	[4,5]	9	hSpCas9	positive selection	3737363
51389673	51389696	5	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTTGTGGACGTGGGGCCGCAGGG	ISL1	ENSG00000016082	0.4103143582684478	[4]	[6,6]	9	hSpCas9	positive selection	3737364
51384593	51384616	5	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTATATTCTGAGGGTTTCTCCGG	ISL1	ENSG00000016082	-0.04897885837879107	[7]	[6,6]	-1	hSpCas9	positive selection	3737365
51387711	51387734	5	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCAGTCCCCTGCATCCAGCGCGG	ISL1	ENSG00000016082	-0.0763469985267742	[5]	[3,4]	-1	hSpCas9	positive selection	3845967
51384557	51384580	5	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.08107396439363707	[5]	[4,4]	1	hSpCas9	positive selection	3845968
51387616	51387639	5	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.08533267200255454	[5]	[4,5]	1	hSpCas9	positive selection	3845969
51387586	51387609	5	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGCGGCTGCAGGCCACACAGCGG	ISL1	ENSG00000016082	-0.13863016677110776	[4]	[3,3]	-2	hSpCas9	positive selection	3845970
51389673	51389696	5	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTTGTGGACGTGGGGCCGCAGGG	ISL1	ENSG00000016082	0.2047680905769532	[5]	[4,5]	5	hSpCas9	positive selection	3845971
51384593	51384616	5	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTATATTCTGAGGGTTTCTCCGG	ISL1	ENSG00000016082	0.3106414408072342	[7]	[7,7]	8	hSpCas9	positive selection	3845972
51387617	51387640	5	-	26780180	A375	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.932225848480646	[]	[]	4	hSpCas9	negative selection	3951984
51384557	51384580	5	-	26780180	A375	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	1.24852441098029	[]	[]	6	hSpCas9	negative selection	3951985
51389823	51389846	5	+	26780180	A375	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	1.01886844856188	[]	[]	5	hSpCas9	negative selection	3951986
51387622	51387645	5	+	26780180	A375	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.838453152727043	[]	[]	3	hSpCas9	negative selection	3951987
51389788	51389811	5	+	26780180	A375	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	1.52703173519144	[]	[]	8	hSpCas9	negative selection	3951988
51384647	51384670	5	+	26780180	A375	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.904114205294654	[]	[]	4	hSpCas9	negative selection	3951989
51387617	51387640	5	-	26780180	HT29	viability (GeCKOv2 library)	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	1.33294576998108	[]	[]	6	hSpCas9	negative selection	4059950
51384557	51384580	5	-	26780180	HT29	viability (GeCKOv2 library)	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.876633504584762	[]	[]	3	hSpCas9	negative selection	4059951
51389823	51389846	5	+	26780180	HT29	viability (GeCKOv2 library)	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.507071383876565	[]	[]	1	hSpCas9	negative selection	4059952
51387622	51387645	5	+	26780180	HT29	viability (GeCKOv2 library)	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	1.28757171963492	[]	[]	6	hSpCas9	negative selection	4059953
51389788	51389811	5	+	26780180	HT29	viability (GeCKOv2 library)	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	1.66034395587663	[]	[]	8	hSpCas9	negative selection	4059954
51384647	51384670	5	+	26780180	HT29	viability (GeCKOv2 library)	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	1.28637952156418	[]	[]	6	hSpCas9	negative selection	4059955
51387617	51387640	5	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	-0.25032010046500885	[2]	[1,1]	-5	hSpCas9	positive selection	4145362
51389823	51389846	5	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.06191080007627829	[3]	[2,2]	1	hSpCas9	positive selection	4145363
51389788	51389811	5	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.32039071481767345	[3]	[1,1]	-7	hSpCas9	positive selection	4145364
51387617	51387640	5	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	2.0079846989417414	[0]	[0,0,0,3]	9	hSpCas9	positive selection	4209384
51389823	51389846	5	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.19304138218520986	[3]	[1,1,0,0]	-3	hSpCas9	positive selection	4209385
51389788	51389811	5	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	1.045664667861342	[0]	[0,0,0,0]	7	hSpCas9	positive selection	4209386
51387617	51387640	5	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.7408670951928487	[1]	[2,3]	9	hSpCas9	positive selection	4277343
51387622	51387645	5	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.3815582241998371	[1]	[1,0]	-7	hSpCas9	positive selection	4277344
51389788	51389811	5	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.2699867897637781	[2]	[2,0]	-5	hSpCas9	positive selection	4277345
51389823	51389846	5	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.1955943826502946	[3]	[3,3]	4	hSpCas9	positive selection	4341599
51384557	51384580	5	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.0913428390527529	[2]	[2,2]	1	hSpCas9	positive selection	4341600
51384647	51384670	5	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.30177509253983525	[3]	[3,3]	6	hSpCas9	positive selection	4341601
51387504	51387526	5	+	27760321	OCIAML3	viability	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	0.20988690981411234	[582,450]	[373,581]	2	hSpCas9	negative selection	4410396
51387545	51387567	5	+	27760321	OCIAML3	viability	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	-0.03613408509921334	[763,781]	[516,689]	0	hSpCas9	negative selection	4410397
51387623	51387645	5	+	27760321	OCIAML3	viability	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.16763206410182888	[622,523]	[412,377]	-2	hSpCas9	negative selection	4410398
51387656	51387678	5	+	27760321	OCIAML3	viability	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	-0.14394267710933872	[688,513]	[382,472]	-1	hSpCas9	negative selection	4410399
51389674	51389696	5	-	27760321	OCIAML3	viability	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	0.5435774240605638	[981,900]	[881,1321]	6	hSpCas9	negative selection	4410400
51387504	51387526	5	+	27760321	OCIAML2	viability	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	0.39931164281379056	[582,450]	[538,558]	5	hSpCas9	negative selection	4493859
51387545	51387567	5	+	27760321	OCIAML2	viability	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.4810946313066907	[763,781]	[860,896]	6	hSpCas9	negative selection	4493860
51387623	51387645	5	+	27760321	OCIAML2	viability	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.2986675190977701	[622,523]	[307,464]	-4	hSpCas9	negative selection	4493861
51387656	51387678	5	+	27760321	OCIAML2	viability	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	-0.3180491276474452	[688,513]	[332,457]	-4	hSpCas9	negative selection	4493862
51389674	51389696	5	-	27760321	OCIAML2	viability	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	0.7098526843567101	[981,900]	[1178,1332]	8	hSpCas9	negative selection	4493863
51387504	51387526	5	+	27760321	MV411	viability	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	-0.2804459374254194	[582,450]	[128,503]	-2	hSpCas9	negative selection	4577322
51387545	51387567	5	+	27760321	MV411	viability	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.8161171427154504	[763,781]	[813,1033]	6	hSpCas9	negative selection	4577323
51387623	51387645	5	+	27760321	MV411	viability	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.3909312771685138	[622,523]	[200,934]	3	hSpCas9	negative selection	4577324
51387656	51387678	5	+	27760321	MV411	viability	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	-0.08764052876144923	[688,513]	[251,547]	0	hSpCas9	negative selection	4577325
51389674	51389696	5	-	27760321	MV411	viability	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	0.7297114398943509	[981,900]	[1085,945]	5	hSpCas9	negative selection	4577326
51387504	51387526	5	+	27760321	HL60	viability	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	0.14409083845944665	[582,450]	[556,363]	1	hSpCas9	negative selection	4660785
51387545	51387567	5	+	27760321	HL60	viability	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.635562205375313	[763,781]	[939,1032]	7	hSpCas9	negative selection	4660786
51387623	51387645	5	+	27760321	HL60	viability	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.7886110092486782	[622,523]	[778,834]	8	hSpCas9	negative selection	4660787
51387656	51387678	5	+	27760321	HL60	viability	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.6856400292411566	[688,513]	[665,907]	7	hSpCas9	negative selection	4660788
51389674	51389696	5	-	27760321	HL60	viability	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	0.4436800020005749	[981,900]	[871,1229]	5	hSpCas9	negative selection	4660789
51387504	51387526	5	+	27760321	HT1080	viability	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	-0.43918230219886256	[450,351]	[32,210]	-2	hSpCas9	negative selection	4744248
51387545	51387567	5	+	27760321	HT1080	viability	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.9255302831785348	[781,609]	[507,546]	5	hSpCas9	negative selection	4744249
51387623	51387645	5	+	27760321	HT1080	viability	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.10210642710970558	[523,408]	[240,153]	0	hSpCas9	negative selection	4744250
51387656	51387678	5	+	27760321	HT1080	viability	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.2100364872996177	[513,400]	[248,168]	1	hSpCas9	negative selection	4744251
51389674	51389696	5	-	27760321	HT1080	viability	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	0.3294207890046712	[900,702]	[220,598]	1	hSpCas9	negative selection	4744252
51387504	51387526	5	+	27760321	HT29	viability after 7 days	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	-0.45067800313458917	[450,351]	[578,385,201]	-6	hSpCas9	negative selection	4827711
51387545	51387567	5	+	27760321	HT29	viability after 7 days	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	-0.2910354985615239	[781,609]	[1156,533,567]	-4	hSpCas9	negative selection	4827712
51387623	51387645	5	+	27760321	HT29	viability after 7 days	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.01431188970620384	[523,408]	[700,595,501]	0	hSpCas9	negative selection	4827713
51387656	51387678	5	+	27760321	HT29	viability after 7 days	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.3696948292978786	[513,400]	[833,712,742]	5	hSpCas9	negative selection	4827714
51389674	51389696	5	-	27760321	HT29	viability after 7 days	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	0.12712981649646382	[900,702]	[1128,1213,1036]	2	hSpCas9	negative selection	4827715
51387504	51387526	5	+	27760321	HT29	viability after 25 days	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	-0.182152483850775	[450,351]	[483,384,330]	-2	hSpCas9	negative selection	4911174
51387545	51387567	5	+	27760321	HT29	viability after 25 days	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.33977669253058806	[781,609]	[940,793,1319]	3	hSpCas9	negative selection	4911175
51387623	51387645	5	+	27760321	HT29	viability after 25 days	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.3015652148390731	[523,408]	[402,384,519]	-3	hSpCas9	negative selection	4911176
51387656	51387678	5	+	27760321	HT29	viability after 25 days	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.5672963992298017	[513,400]	[676,946,696]	6	hSpCas9	negative selection	4911177
51389674	51389696	5	-	27760321	HT29	viability after 25 days	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	-0.24758419810487609	[900,702]	[677,790,860]	-3	hSpCas9	negative selection	4911178
51387504	51387526	5	+	27760321	HT29	viability after 22 days	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	-0.7248298261682079	[450,351]	[303,350,185]	-6	hSpCas9	negative selection	4994637
51387545	51387567	5	+	27760321	HT29	viability after 22 days	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.3904220044827491	[781,609]	[921,1026,1219]	4	hSpCas9	negative selection	4994638
51387623	51387645	5	+	27760321	HT29	viability after 22 days	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.36398911267211526	[523,408]	[846,645,583]	4	hSpCas9	negative selection	4994639
51387656	51387678	5	+	27760321	HT29	viability after 22 days	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.38636230451648085	[513,400]	[757,523,790]	4	hSpCas9	negative selection	4994640
51389674	51389696	5	-	27760321	HT29	viability after 22 days	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	0.06011291968554833	[900,702]	[996,1027,872]	0	hSpCas9	negative selection	4994641
51387504	51387526	5	+	27760321	HT29	viability after 19 days	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	0.3497353744764037	[450,351]	[1047,370,391]	3	hSpCas9	negative selection	5078100
51387545	51387567	5	+	27760321	HT29	viability after 19 days	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.3608698048427115	[781,609]	[1068,958,1041]	3	hSpCas9	negative selection	5078101
51387623	51387645	5	+	27760321	HT29	viability after 19 days	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.005128606865432039	[523,408]	[223,743,591]	0	hSpCas9	negative selection	5078102
51387656	51387678	5	+	27760321	HT29	viability after 19 days	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.18347901080916923	[513,400]	[587,505,683]	1	hSpCas9	negative selection	5078103
51389674	51389696	5	-	27760321	HT29	viability after 19 days	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	0.39055289577610863	[900,702]	[656,1201,1671]	4	hSpCas9	negative selection	5078104
51387504	51387526	5	+	27760321	HT29	viability after 16 days	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	0.30560717923170844	[450,351]	[557,812,287]	3	hSpCas9	negative selection	5161563
51387545	51387567	5	+	27760321	HT29	viability after 16 days	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.01774144489343521	[781,609]	[1120,565,714]	0	hSpCas9	negative selection	5161564
51387623	51387645	5	+	27760321	HT29	viability after 16 days	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.05145376013787223	[523,408]	[588,390,650]	0	hSpCas9	negative selection	5161565
51387656	51387678	5	+	27760321	HT29	viability after 16 days	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.57364354886475	[513,400]	[883,673,740]	6	hSpCas9	negative selection	5161566
51389674	51389696	5	-	27760321	HT29	viability after 16 days	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	0.04481391364482312	[900,702]	[1010,1294,468]	0	hSpCas9	negative selection	5161567
51387504	51387526	5	+	27760321	HT29	viability after 13 days	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	-0.6732370891363632	[450,351]	[405,314,162]	-6	hSpCas9	negative selection	5245026
51387545	51387567	5	+	27760321	HT29	viability after 13 days	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.2577221323881156	[781,609]	[966,983,945]	3	hSpCas9	negative selection	5245027
51387623	51387645	5	+	27760321	HT29	viability after 13 days	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.09256425742603885	[523,408]	[701,548,284]	-1	hSpCas9	negative selection	5245028
51387656	51387678	5	+	27760321	HT29	viability after 13 days	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.5860553295333575	[513,400]	[984,649,756]	7	hSpCas9	negative selection	5245029
51389674	51389696	5	-	27760321	HT29	viability after 13 days	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	0.25672712750539417	[900,702]	[1277,1179,889]	3	hSpCas9	negative selection	5245030
51387504	51387526	5	+	27760321	HT29	viability after 10 days	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	-0.40780042216963813	[450,351]	[519,423,194]	-5	hSpCas9	negative selection	5328489
51387545	51387567	5	+	27760321	HT29	viability after 10 days	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	0.22887818179860808	[781,609]	[1316,685,1041]	3	hSpCas9	negative selection	5328490
51387623	51387645	5	+	27760321	HT29	viability after 10 days	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.008928897821860682	[523,408]	[457,600,696]	0	hSpCas9	negative selection	5328491
51387656	51387678	5	+	27760321	HT29	viability after 10 days	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.21507466076662413	[513,400]	[897,377,703]	3	hSpCas9	negative selection	5328492
51389674	51389696	5	-	27760321	HT29	viability after 10 days	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	0.0920864332924991	[900,702]	[1184,1058,959]	1	hSpCas9	negative selection	5328493
51387504	51387526	5	+	27760321	MOLM13	viability	AATGCGCCAAGTGCAGCATCGG	ISL1	ENSG00000016082	1.2347112085050833	[582,450]	[1205,234]	8	hSpCas9	negative selection	5411952
51387545	51387567	5	+	27760321	MOLM13	viability	GTGATGCGTGCCCGCTCCAAGG	ISL1	ENSG00000016082	1.0886474725921116	[763,781]	[884,970]	7	hSpCas9	negative selection	5411953
51387623	51387645	5	+	27760321	MOLM13	viability	GACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.35166665559608484	[622,523]	[507,328]	2	hSpCas9	negative selection	5411954
51387656	51387678	5	+	27760321	MOLM13	viability	TGCCGAGCAGACCACGATGTGG	ISL1	ENSG00000016082	0.3409964205858015	[688,513]	[336,501]	2	hSpCas9	negative selection	5411955
51389674	51389696	5	-	27760321	MOLM13	viability	CTTGTGGACGTGGGGCCGCAGG	ISL1	ENSG00000016082	-0.12594715990026484	[981,900]	[544,436]	-1	hSpCas9	negative selection	5411956
51387617	51387640	5	-	27260156	BXPC3	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.4572506027681348	[174]	[237,191,339,237]	8	hSpCas9	negative selection	5549803
51387622	51387645	5	+	27260156	BXPC3	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.01926915825671993	[168]	[162,155,244,151]	0	hSpCas9	negative selection	5549804
51389788	51389811	5	+	27260156	BXPC3	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.570682880531242	[327]	[246,162,211,311]	-8	hSpCas9	negative selection	5549805
51389823	51389846	5	+	27260156	BXPC3	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.003830089926264657	[886]	[947,939,978,831]	0	hSpCas9	negative selection	5614059
51384557	51384580	5	-	27260156	BXPC3	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.4420659796178148	[350]	[439,413,561,599]	8	hSpCas9	negative selection	5614060
51384647	51384670	5	+	27260156	BXPC3	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.08161851441584367	[946]	[926,977,1010,1317]	1	hSpCas9	negative selection	5614061
51387617	51387640	5	-	27260156	A673	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.10205360054536139	[174]	[268,220,236,176]	2	hSpCas9	negative selection	5671054
51387622	51387645	5	+	27260156	A673	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.2151792513197266	[168]	[236,218,297,184]	5	hSpCas9	negative selection	5671055
51389788	51389811	5	+	27260156	A673	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.3399757759811889	[327]	[293,308,311,327]	-7	hSpCas9	negative selection	5671056
51389823	51389846	5	+	27260156	A673	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.0944055162241697	[886]	[1018,1033,886,1053]	-2	hSpCas9	negative selection	5735310
51384557	51384580	5	-	27260156	A673	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.14690047802417316	[350]	[581,386,418,494]	3	hSpCas9	negative selection	5735311
51384647	51384670	5	+	27260156	A673	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.018524485913748667	[946]	[1205,1065,963,1272]	0	hSpCas9	negative selection	5735312
51387617	51387640	5	-	27260156	A375	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.22116285560776894	[174]	[222,223,319,188]	3	hSpCas9	negative selection	5792305
51387622	51387645	5	+	27260156	A375	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.37920778022353074	[168]	[138,179,145,145]	-5	hSpCas9	negative selection	5792306
51389788	51389811	5	+	27260156	A375	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.43996349775689725	[327]	[314,435,124,274]	-6	hSpCas9	negative selection	5792307
51389823	51389846	5	+	27260156	A375	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.026046024046475047	[886]	[1051,1358,900,824]	0	hSpCas9	negative selection	5856561
51384557	51384580	5	-	27260156	A375	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	-0.10506552471580327	[350]	[499,266,422,324]	-1	hSpCas9	negative selection	5856562
51384647	51384670	5	+	27260156	A375	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.0024621928439614305	[946]	[1029,1202,1072,1117]	0	hSpCas9	negative selection	5856563
51387617	51387640	5	-	27260156	COLO741	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.4744776786939169	[174]	[389,224,321]	8	hSpCas9	negative selection	5913556
51387622	51387645	5	+	27260156	COLO741	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.2398730246082137	[168]	[226,250,281]	5	hSpCas9	negative selection	5913557
51389788	51389811	5	+	27260156	COLO741	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.09506544787123594	[327]	[360,355,451]	-2	hSpCas9	negative selection	5913558
51389823	51389846	5	+	27260156	COLO741	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.1501006166466171	[886]	[1057,1155,862]	-3	hSpCas9	negative selection	5977812
51384557	51384580	5	-	27260156	COLO741	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.14431861337324042	[350]	[592,503,403]	3	hSpCas9	negative selection	5977813
51384647	51384670	5	+	27260156	COLO741	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.01081090342928892	[946]	[1116,1266,1258]	0	hSpCas9	negative selection	5977814
51387617	51387640	5	-	27260156	CAL120	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.1659521746820245	[174]	[286,248,203]	2	hSpCas9	negative selection	6034807
51387622	51387645	5	+	27260156	CAL120	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.17533581264619102	[168]	[208,107,243]	-3	hSpCas9	negative selection	6034808
51389788	51389811	5	+	27260156	CAL120	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	0.2532309430789493	[327]	[675,395,416]	4	hSpCas9	negative selection	6034809
51389823	51389846	5	+	27260156	CAL120	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.0019797440411046807	[886]	[1346,1135,872]	0	hSpCas9	negative selection	6099063
51384557	51384580	5	-	27260156	CAL120	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.7319881471416377	[350]	[525,834,783]	9	hSpCas9	negative selection	6099064
51384647	51384670	5	+	27260156	CAL120	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.1289758470519582	[946]	[1635,1012,1268]	2	hSpCas9	negative selection	6099065
51387617	51387640	5	-	27260156	CADOES1	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.16318992691487444	[174]	[138,161,170,259]	3	hSpCas9	negative selection	6156058
51387622	51387645	5	+	27260156	CADOES1	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.23618022190339283	[168]	[130,161,128,110]	-4	hSpCas9	negative selection	6156059
51389788	51389811	5	+	27260156	CADOES1	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.2855883723620526	[327]	[263,212,272,250]	-5	hSpCas9	negative selection	6156060
51389823	51389846	5	+	27260156	CADOES1	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.08154815896922651	[886]	[836,946,783,925]	1	hSpCas9	negative selection	6220314
51384557	51384580	5	-	27260156	CADOES1	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.11358862736543773	[350]	[336,384,410,276]	2	hSpCas9	negative selection	6220315
51384647	51384670	5	+	27260156	CADOES1	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.2083660316154632	[946]	[781,955,878,1470]	3	hSpCas9	negative selection	6220316
51387617	51387640	5	-	27260156	EWS502	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	-0.13178599673976787	[174]	[192,134,171,174]	-2	hSpCas9	negative selection	6277309
51387622	51387645	5	+	27260156	EWS502	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.020444264679096324	[168]	[123,219,193,193]	0	hSpCas9	negative selection	6277310
51389788	51389811	5	+	27260156	EWS502	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.5912877382222594	[327]	[131,234,316,251]	-7	hSpCas9	negative selection	6277311
51389823	51389846	5	+	27260156	EWS502	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.5262398842912563	[886]	[519,713,727,659]	-7	hSpCas9	negative selection	6341565
51384557	51384580	5	-	27260156	EWS502	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	-0.3641605935601126	[350]	[273,265,368,245]	-6	hSpCas9	negative selection	6341566
51384647	51384670	5	+	27260156	EWS502	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.09850582313004053	[946]	[870,1035,745,1103]	-2	hSpCas9	negative selection	6341567
51387617	51387640	5	-	27260156	EW8	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	-0.03254238335008153	[174]	[133,183,120,117]	0	hSpCas9	negative selection	6398560
51387622	51387645	5	+	27260156	EW8	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.048879422405170514	[168]	[229,94,89,131]	-1	hSpCas9	negative selection	6398561
51389788	51389811	5	+	27260156	EW8	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.5866333725281585	[327]	[266,176,96,189]	-8	hSpCas9	negative selection	6398562
51389823	51389846	5	+	27260156	EW8	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.03687923602275167	[886]	[879,666,476,833]	0	hSpCas9	negative selection	6462816
51384557	51384580	5	-	27260156	EW8	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.3088625662219167	[350]	[732,227,210,301]	5	hSpCas9	negative selection	6462817
51384647	51384670	5	+	27260156	EW8	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.06472023015117534	[946]	[1113,656,579,649]	-1	hSpCas9	negative selection	6462818
51387617	51387640	5	-	27260156	CORL105	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.38928801040313976	[174]	[274,152,347,311]	7	hSpCas9	negative selection	6519811
51387622	51387645	5	+	27260156	CORL105	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.41007403844808943	[168]	[234,187,396,252]	7	hSpCas9	negative selection	6519812
51389788	51389811	5	+	27260156	CORL105	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.05523532167137535	[327]	[319,306,580,302]	-1	hSpCas9	negative selection	6519813
51389823	51389846	5	+	27260156	CORL105	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.07177391289562818	[886]	[983,840,1226,939]	-1	hSpCas9	negative selection	6584067
51384557	51384580	5	-	27260156	CORL105	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.24987150370414396	[350]	[349,519,716,397]	4	hSpCas9	negative selection	6584068
51384647	51384670	5	+	27260156	CORL105	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.04698775261851473	[946]	[1287,915,1507,935]	0	hSpCas9	negative selection	6584069
51387617	51387640	5	-	27260156	HS294T	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	2.249663686861442	[174]	[280,773,94,84]	9	hSpCas9	negative selection	6641062
51387622	51387645	5	+	27260156	HS294T	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.130826691280723	[168]	[63,78,58,86]	1	hSpCas9	negative selection	6641063
51389788	51389811	5	+	27260156	HS294T	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	0.4861472841423207	[327]	[107,176,127,328]	6	hSpCas9	negative selection	6641064
51389823	51389846	5	+	27260156	HS294T	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.028704808124169312	[886]	[329,270,336,422]	0	hSpCas9	negative selection	6705318
51384557	51384580	5	-	27260156	HS294T	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.33487682693954285	[350]	[97,167,275,144]	4	hSpCas9	negative selection	6705319
51384647	51384670	5	+	27260156	HS294T	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.09539935204125083	[946]	[330,408,288,338]	-1	hSpCas9	negative selection	6705320
51387617	51387640	5	-	27260156	HCC44	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	-0.08995515658780162	[174]	[222,94,263,189]	-1	hSpCas9	negative selection	6762313
51387622	51387645	5	+	27260156	HCC44	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.3816267091931467	[168]	[163,144,146,131]	-5	hSpCas9	negative selection	6762314
51389788	51389811	5	+	27260156	HCC44	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.19956165849351204	[327]	[214,234,363,479]	-3	hSpCas9	negative selection	6762315
51389823	51389846	5	+	27260156	HCC44	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.08346919087386062	[886]	[1281,835,1274,942]	1	hSpCas9	negative selection	6826569
51384557	51384580	5	-	27260156	HCC44	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.3474805191136421	[350]	[563,451,549,471]	5	hSpCas9	negative selection	6826570
51384647	51384670	5	+	27260156	HCC44	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.285901221682586	[946]	[1327,1223,1756,1004]	4	hSpCas9	negative selection	6826571
51387617	51387640	5	-	27260156	G402	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	-0.02378153301091146	[174]	[310,83,164,282]	0	hSpCas9	negative selection	6883564
51387622	51387645	5	+	27260156	G402	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.5927865187575665	[168]	[118,111,144,164]	-6	hSpCas9	negative selection	6883565
51389788	51389811	5	+	27260156	G402	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.3069049657031804	[327]	[332,264,287,400]	-4	hSpCas9	negative selection	6883566
51389823	51389846	5	+	27260156	G402	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.021029806233204718	[886]	[1165,1176,804,1131]	0	hSpCas9	negative selection	6947820
51384557	51384580	5	-	27260156	G402	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.08092529807224857	[350]	[441,343,386,620]	1	hSpCas9	negative selection	6947821
51384647	51384670	5	+	27260156	G402	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.20520111316785328	[946]	[1777,1437,1206,987]	2	hSpCas9	negative selection	6947822
51387617	51387640	5	-	27260156	L33	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.20842207924408185	[174]	[143,91,130,232]	4	hSpCas9	negative selection	7004815
51387622	51387645	5	+	27260156	L33	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.8004825342458247	[168]	[230,77,266,332]	9	hSpCas9	negative selection	7004816
51389788	51389811	5	+	27260156	L33	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.044496901467276584	[327]	[292,101,202,406]	-1	hSpCas9	negative selection	7004817
51389823	51389846	5	+	27260156	L33	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.08223984326302769	[886]	[947,347,533,702]	-2	hSpCas9	negative selection	7069071
51384557	51384580	5	-	27260156	L33	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.2270042785087416	[350]	[412,226,199,357]	5	hSpCas9	negative selection	7069072
51384647	51384670	5	+	27260156	L33	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.22210734084068795	[946]	[672,404,594,644]	-5	hSpCas9	negative selection	7069073
51387617	51387640	5	-	27260156	K562	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	-0.07906141176383907	[174]	[141,66,284,94]	-1	hSpCas9	negative selection	7126066
51387622	51387645	5	+	27260156	K562	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.24237390938493553	[168]	[132,27,214,125]	-3	hSpCas9	negative selection	7126067
51389788	51389811	5	+	27260156	K562	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.024983938490972246	[327]	[317,316,175,330]	0	hSpCas9	negative selection	7126068
51389823	51389846	5	+	27260156	K562	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.3177647875818964	[886]	[1183,1579,597,645]	4	hSpCas9	negative selection	7190322
51384557	51384580	5	-	27260156	K562	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.501847209512999	[350]	[732,201,267,556]	6	hSpCas9	negative selection	7190323
51384647	51384670	5	+	27260156	K562	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.2812026180979259	[946]	[521,1561,1215,794]	3	hSpCas9	negative selection	7190324
51387617	51387640	5	-	27260156	HT29	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.3198352377576903	[174]	[392,150,338,186]	6	hSpCas9	negative selection	7247317
51387622	51387645	5	+	27260156	HT29	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.09564278476348442	[168]	[194,169,210,285]	1	hSpCas9	negative selection	7247318
51389788	51389811	5	+	27260156	HT29	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.3702745476161641	[327]	[176,297,341,392]	-6	hSpCas9	negative selection	7247319
51389823	51389846	5	+	27260156	HT29	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.012210901463567847	[886]	[1048,1385,1044,906]	0	hSpCas9	negative selection	7311573
51384557	51384580	5	-	27260156	HT29	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	-0.16163056993164954	[350]	[418,347,400,357]	-3	hSpCas9	negative selection	7311574
51384647	51384670	5	+	27260156	HT29	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.025663721720160737	[946]	[1234,1236,1078,1141]	0	hSpCas9	negative selection	7311575
51387617	51387640	5	-	27260156	MHHES1	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	-0.12237331610083246	[174]	[277,186,167,114]	-2	hSpCas9	negative selection	7368568
51387622	51387645	5	+	27260156	MHHES1	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.5223590412459173	[168]	[480,203,214,217]	8	hSpCas9	negative selection	7368569
51389788	51389811	5	+	27260156	MHHES1	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.1263144535163756	[327]	[465,371,289,255]	-2	hSpCas9	negative selection	7368570
51389823	51389846	5	+	27260156	MHHES1	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.06285025650344289	[886]	[1456,811,884,744]	-1	hSpCas9	negative selection	7432824
51384557	51384580	5	-	27260156	MHHES1	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.17792907811312908	[350]	[479,511,453,362]	3	hSpCas9	negative selection	7432825
51384647	51384670	5	+	27260156	MHHES1	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.0012620946994246207	[946]	[1394,1120,1145,706]	0	hSpCas9	negative selection	7432826
51387617	51387640	5	-	27260156	MEWO	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.2675495229889244	[174]	[257,198,145]	6	hSpCas9	negative selection	7489819
51387622	51387645	5	+	27260156	MEWO	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.54961926640792	[168]	[285,189,228]	9	hSpCas9	negative selection	7489820
51389788	51389811	5	+	27260156	MEWO	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	0.0030810746268555844	[327]	[397,311,229]	0	hSpCas9	negative selection	7489821
51389823	51389846	5	+	27260156	MEWO	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.13329256292077207	[886]	[1229,758,803]	3	hSpCas9	negative selection	7554075
51384557	51384580	5	-	27260156	MEWO	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.10689516030903101	[350]	[388,288,389]	2	hSpCas9	negative selection	7554076
51384647	51384670	5	+	27260156	MEWO	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.07213199636220013	[946]	[1055,725,787]	-1	hSpCas9	negative selection	7554077
51387617	51387640	5	-	27260156	LNCAPCLONEFGC	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	-0.2786254837462614	[174]	[110,136,166,112]	-4	hSpCas9	negative selection	7611070
51387622	51387645	5	+	27260156	LNCAPCLONEFGC	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.0824674673057475	[168]	[119,113,206,148]	-1	hSpCas9	negative selection	7611071
51389788	51389811	5	+	27260156	LNCAPCLONEFGC	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.462183343446966	[327]	[254,166,282,169]	-6	hSpCas9	negative selection	7611072
51389823	51389846	5	+	27260156	LNCAPCLONEFGC	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.10921814282247211	[886]	[780,823,783,589]	-2	hSpCas9	negative selection	7675326
51384557	51384580	5	-	27260156	LNCAPCLONEFGC	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.033114838178421147	[350]	[249,244,453,377]	0	hSpCas9	negative selection	7675327
51384647	51384670	5	+	27260156	LNCAPCLONEFGC	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.20949966283989885	[946]	[987,876,1128,1000]	3	hSpCas9	negative selection	7675328
51387617	51387640	5	-	27260156	PANC0327	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.3242600429907392	[174]	[229,195,103,250]	5	hSpCas9	negative selection	7732321
51387622	51387645	5	+	27260156	PANC0327	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	1.1630865446697856	[168]	[406,439,271,217]	9	hSpCas9	negative selection	7732322
51389788	51389811	5	+	27260156	PANC0327	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	0.3617567063629698	[327]	[655,287,440,146]	5	hSpCas9	negative selection	7732323
51389823	51389846	5	+	27260156	PANC0327	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.04934146546496332	[886]	[765,600,978,720]	0	hSpCas9	negative selection	7796577
51384557	51384580	5	-	27260156	PANC0327	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	-0.03675607182515661	[350]	[474,184,254,329]	0	hSpCas9	negative selection	7796578
51384647	51384670	5	+	27260156	PANC0327	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.4297686375921741	[946]	[1244,1187,941,1158]	6	hSpCas9	negative selection	7796579
51387617	51387640	5	-	27260156	NCIH2009	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.23578877773015972	[174]	[354,205,316]	3	hSpCas9	negative selection	7853572
51387622	51387645	5	+	27260156	NCIH2009	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.2721753223475005	[168]	[256,216,123]	-4	hSpCas9	negative selection	7853573
51389788	51389811	5	+	27260156	NCIH2009	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.017911922515706058	[327]	[565,368,445]	0	hSpCas9	negative selection	7853574
51389823	51389846	5	+	27260156	NCIH2009	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.21102885450437225	[886]	[1744,1675,936]	3	hSpCas9	negative selection	7917828
51384557	51384580	5	-	27260156	NCIH2009	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.06924630021375511	[350]	[690,544,340]	0	hSpCas9	negative selection	7917829
51384647	51384670	5	+	27260156	NCIH2009	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.1320919699111911	[946]	[1725,1284,1393]	1	hSpCas9	negative selection	7917830
51387617	51387640	5	-	27260156	NCIH1373	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.12958047258490257	[174]	[57,263,188,84]	1	hSpCas9	negative selection	7974823
51387622	51387645	5	+	27260156	NCIH1373	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.31877635741259125	[168]	[75,108,245,43]	-3	hSpCas9	negative selection	7974824
51389788	51389811	5	+	27260156	NCIH1373	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.5832130011564369	[327]	[208,311,115,88]	-5	hSpCas9	negative selection	7974825
51389823	51389846	5	+	27260156	NCIH1373	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.0050848770665826715	[886]	[1465,583,708,360]	0	hSpCas9	negative selection	8039079
51384557	51384580	5	-	27260156	NCIH1373	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.2185992453008294	[350]	[582,181,795,78]	2	hSpCas9	negative selection	8039080
51384647	51384670	5	+	27260156	NCIH1373	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.48237731055204525	[946]	[1778,1060,1928,320]	5	hSpCas9	negative selection	8039081
51387617	51387640	5	-	27260156	PATU8902	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.37375706805580844	[174]	[382,167,226,529]	4	hSpCas9	negative selection	8096074
51387622	51387645	5	+	27260156	PATU8902	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.04118989654212801	[168]	[146,197,291,264]	0	hSpCas9	negative selection	8096075
51389788	51389811	5	+	27260156	PATU8902	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	0.14937742034790358	[327]	[536,303,557,622]	1	hSpCas9	negative selection	8096076
51389823	51389846	5	+	27260156	PATU8902	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.2335513452145911	[886]	[1600,1498,1242,1514]	2	hSpCas9	negative selection	8160330
51384557	51384580	5	-	27260156	PATU8902	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.05345549628516311	[350]	[523,665,170,784]	0	hSpCas9	negative selection	8160331
51384647	51384670	5	+	27260156	PATU8902	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.3994989049259512	[946]	[1830,2144,1489,1516]	4	hSpCas9	negative selection	8160332
51387617	51387640	5	-	27260156	PANC1	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.5491860180867881	[174]	[226,222,216,210]	8	hSpCas9	negative selection	8217325
51387622	51387645	5	+	27260156	PANC1	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-0.1086444989580575	[168]	[173,171,91,108]	-2	hSpCas9	negative selection	8217326
51389788	51389811	5	+	27260156	PANC1	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.12648042517381775	[327]	[237,254,217,307]	-2	hSpCas9	negative selection	8217327
51389823	51389846	5	+	27260156	PANC1	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.02994079274291961	[886]	[469,799,1045,685]	0	hSpCas9	negative selection	8281581
51384557	51384580	5	-	27260156	PANC1	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.28561770683762155	[350]	[282,563,334,329]	4	hSpCas9	negative selection	8281582
51384647	51384670	5	+	27260156	PANC1	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.07092094818194239	[946]	[859,1260,728,666]	1	hSpCas9	negative selection	8281583
51387617	51387640	5	-	27260156	PANC0813	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.6700649526983304	[174]	[408,320,291,294]	9	hSpCas9	negative selection	8338576
51387622	51387645	5	+	27260156	PANC0813	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.6676048059892354	[168]	[245,228,324,446]	9	hSpCas9	negative selection	8338577
51389788	51389811	5	+	27260156	PANC0813	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.2352542324140683	[327]	[230,442,253,368]	-4	hSpCas9	negative selection	8338578
51389823	51389846	5	+	27260156	PANC0813	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.09699760550110692	[886]	[1053,1034,1234,1125]	1	hSpCas9	negative selection	8402832
51384557	51384580	5	-	27260156	PANC0813	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.5333573194260981	[350]	[565,783,535,501]	8	hSpCas9	negative selection	8402833
51384647	51384670	5	+	27260156	PANC0813	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.19376255451208535	[946]	[967,998,1065,861]	-3	hSpCas9	negative selection	8402834
51387617	51387640	5	-	27260156	RDES	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.23607201511669063	[174]	[145,242,219,371]	4	hSpCas9	negative selection	8459827
51387622	51387645	5	+	27260156	RDES	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.03437402619947072	[168]	[97,172,327,225]	0	hSpCas9	negative selection	8459828
51389788	51389811	5	+	27260156	RDES	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.3966736259178726	[327]	[245,222,339,355]	-6	hSpCas9	negative selection	8459829
51389823	51389846	5	+	27260156	RDES	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.19320037362491815	[886]	[806,857,831,1092]	-3	hSpCas9	negative selection	8524083
51384557	51384580	5	-	27260156	RDES	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.23636397504142195	[350]	[359,367,471,768]	4	hSpCas9	negative selection	8524084
51384647	51384670	5	+	27260156	RDES	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.061583472472790834	[946]	[953,1069,1245,1318]	1	hSpCas9	negative selection	8524085
51387617	51387640	5	-	27260156	PC3	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.4652065658443003	[174]	[194,111,579,205]	8	hSpCas9	negative selection	8581078
51387622	51387645	5	+	27260156	PC3	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.25626001305394674	[168]	[183,114,291,235]	5	hSpCas9	negative selection	8581079
51389788	51389811	5	+	27260156	PC3	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	0.18383455723592795	[327]	[127,566,415,467]	4	hSpCas9	negative selection	8581080
51389823	51389846	5	+	27260156	PC3	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.2356342398019512	[886]	[394,708,1533,767]	-5	hSpCas9	negative selection	8645334
51384557	51384580	5	-	27260156	PC3	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.00017587275139169245	[350]	[209,383,510,384]	0	hSpCas9	negative selection	8645335
51384647	51384670	5	+	27260156	PC3	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.2018556014982662	[946]	[510,788,1386,876]	-4	hSpCas9	negative selection	8645336
51387617	51387640	5	-	27260156	PATU8988T	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.334372067468897	[174]	[258,167,155,270]	6	hSpCas9	negative selection	8702329
51387622	51387645	5	+	27260156	PATU8988T	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.5390571126316702	[168]	[285,159,302,187]	8	hSpCas9	negative selection	8702330
51389788	51389811	5	+	27260156	PATU8988T	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.20821918831772912	[327]	[242,461,164,243]	-4	hSpCas9	negative selection	8702331
51389823	51389846	5	+	27260156	PATU8988T	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.02820827215002042	[886]	[1132,850,766,732]	0	hSpCas9	negative selection	8766585
51384557	51384580	5	-	27260156	PATU8988T	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.1713145650670477	[350]	[409,543,240,346]	3	hSpCas9	negative selection	8766586
51384647	51384670	5	+	27260156	PATU8988T	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.14362764079197132	[946]	[710,876,742,1001]	-2	hSpCas9	negative selection	8766587
51387617	51387640	5	-	27260156	T47D	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.3389439382555628	[174]	[235,205,305,287]	7	hSpCas9	negative selection	8823580
51387622	51387645	5	+	27260156	T47D	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.24320894962157902	[168]	[260,192,256,223]	5	hSpCas9	negative selection	8823581
51389788	51389811	5	+	27260156	T47D	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.36972567881303	[327]	[345,246,282,311]	-7	hSpCas9	negative selection	8823582
51389823	51389846	5	+	27260156	T47D	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.09396399556285118	[886]	[928,1018,871,1051]	-2	hSpCas9	negative selection	8887836
51384557	51384580	5	-	27260156	T47D	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.1716385504347986	[350]	[401,551,430,448]	3	hSpCas9	negative selection	8887837
51384647	51384670	5	+	27260156	T47D	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	0.05755996745673464	[946]	[1182,1031,1035,1359]	1	hSpCas9	negative selection	8887838
51387617	51387640	5	-	27260156	SU8686	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.34466884600712855	[174]	[160,188,256,296]	6	hSpCas9	negative selection	8944831
51387622	51387645	5	+	27260156	SU8686	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.7447402844692821	[168]	[178,295,310,357]	9	hSpCas9	negative selection	8944832
51389788	51389811	5	+	27260156	SU8686	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.4362005885807664	[327]	[241,244,227,243]	-6	hSpCas9	negative selection	8944833
51389823	51389846	5	+	27260156	SU8686	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.2823070703922018	[886]	[836,1013,1122,1381]	5	hSpCas9	negative selection	9009087
51384557	51384580	5	-	27260156	SU8686	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.5945584115740523	[350]	[526,552,481,531]	8	hSpCas9	negative selection	9009088
51384647	51384670	5	+	27260156	SU8686	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.2875650939672336	[946]	[636,713,1017,723]	-5	hSpCas9	negative selection	9009089
51387617	51387640	5	-	27260156	SKES1	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.17934644097648067	[174]	[235,211,178,171]	4	hSpCas9	negative selection	9066082
51387622	51387645	5	+	27260156	SKES1	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.11167395983467143	[168]	[147,163,160,239]	2	hSpCas9	negative selection	9066083
51389788	51389811	5	+	27260156	SKES1	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.521394645664838	[327]	[244,267,235,173]	-8	hSpCas9	negative selection	9066084
51389823	51389846	5	+	27260156	SKES1	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.17599009258458786	[886]	[1008,934,705,552]	-4	hSpCas9	negative selection	9130338
51384557	51384580	5	-	27260156	SKES1	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.053985585962032845	[350]	[309,315,385,417]	1	hSpCas9	negative selection	9130339
51384647	51384670	5	+	27260156	SKES1	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.19710833340194678	[946]	[937,966,693,733]	-4	hSpCas9	negative selection	9130340
51387617	51387640	5	-	27260156	TOV112D	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.6789266408073464	[174]	[264,313,274,274]	9	hSpCas9	negative selection	9187333
51387622	51387645	5	+	27260156	TOV112D	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	-1.0813337171489978	[168]	[68,107,75,72]	-9	hSpCas9	negative selection	9187334
51389788	51389811	5	+	27260156	TOV112D	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.3253234062809348	[327]	[143,398,192,333]	-6	hSpCas9	negative selection	9187335
51389823	51389846	5	+	27260156	TOV112D	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.1725584091250797	[886]	[876,835,711,746]	-3	hSpCas9	negative selection	9251589
51384557	51384580	5	-	27260156	TOV112D	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.03046709227115918	[350]	[407,439,301,310]	0	hSpCas9	negative selection	9251590
51384647	51384670	5	+	27260156	TOV112D	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.11948265633108213	[946]	[939,851,886,813]	-2	hSpCas9	negative selection	9251591
51387617	51387640	5	-	27260156	TC71	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.36577240593428106	[174]	[171,197,310,287]	8	hSpCas9	negative selection	9308584
51387622	51387645	5	+	27260156	TC71	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.15683983690128045	[168]	[146,177,224,261]	4	hSpCas9	negative selection	9308585
51389788	51389811	5	+	27260156	TC71	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.37921500874460734	[327]	[231,212,274,367]	-8	hSpCas9	negative selection	9308586
51389823	51389846	5	+	27260156	TC71	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	0.0044357302423174705	[886]	[1168,914,835,889]	0	hSpCas9	negative selection	9372840
51384557	51384580	5	-	27260156	TC71	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	-0.0853234813369595	[350]	[264,385,299,478]	-2	hSpCas9	negative selection	9372841
51384647	51384670	5	+	27260156	TC71	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.2103062838217149	[946]	[838,876,778,1027]	-5	hSpCas9	negative selection	9372842
51387617	51387640	5	-	27260156	TC32	viability	CGAAGCGCAAATTCGTCCCCAGG	ISL1	ENSG00000016082	0.3771581444794747	[174]	[171,207,224,246]	6	hSpCas9	negative selection	9429835
51387622	51387645	5	+	27260156	TC32	viability	GGACGAATTTGCGCTTCGGGAGG	ISL1	ENSG00000016082	0.5215961944804992	[168]	[161,289,225,200]	8	hSpCas9	negative selection	9429836
51389788	51389811	5	+	27260156	TC32	viability	TGCGCTCATGAAGGAGCAACTGG	ISL1	ENSG00000016082	-0.5256875329454844	[327]	[161,182,219,302]	-7	hSpCas9	negative selection	9429837
51389823	51389846	5	+	27260156	TC32	viability	GCCTCAGTCCCCGTGTGATCCGG	ISL1	ENSG00000016082	-0.13695987980510604	[886]	[714,684,878,758]	-2	hSpCas9	negative selection	9494091
51384557	51384580	5	-	27260156	TC32	viability	GATTGCCGCAACCAACACATAGG	ISL1	ENSG00000016082	0.010935317790407462	[350]	[336,234,449,344]	0	hSpCas9	negative selection	9494092
51384647	51384670	5	+	27260156	TC32	viability	TGCGGAGTGTAATCAGTATTTGG	ISL1	ENSG00000016082	-0.033165133905629585	[946]	[800,659,1264,856]	0	hSpCas9	negative selection	9494093
51387555	51387578	5	-	27869803	HPAFII	viability after 27 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.9259297733708105	[158]	[70,231,NaN]	7	hSpCas9	negative selection	9592046
51387725	51387748	5	-	27869803	HPAFII	viability after 27 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	0.2782130450539966	[75]	[42,52,NaN]	2	hSpCas9	negative selection	9592047
51389777	51389800	5	-	27869803	HPAFII	viability after 27 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.9591094513462142	[538]	[503,589,NaN]	7	hSpCas9	negative selection	9592048
51391333	51391356	5	+	27869803	HPAFII	viability after 27 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.13955625976681318	[555]	[387,266,NaN]	1	hSpCas9	negative selection	9592049
51393512	51393535	5	+	27869803	HPAFII	viability after 27 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	1.4060013611891402	[125]	[270,95,NaN]	9	hSpCas9	negative selection	9592050
51393528	51393551	5	-	27869803	HPAFII	viability after 27 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.5730287300661551	[246]	[232,159,NaN]	4	hSpCas9	negative selection	9592051
51387555	51387578	5	-	27869803	HPAFII	viability after 15 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.7057284155027347	[158]	[311,257,NaN]	7	hSpCas9	negative selection	9674495
51387725	51387748	5	-	27869803	HPAFII	viability after 15 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	0.3591844442910923	[75]	[142,80,NaN]	4	hSpCas9	negative selection	9674496
51389777	51389800	5	-	27869803	HPAFII	viability after 15 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.8779785729736236	[538]	[1576,745,NaN]	8	hSpCas9	negative selection	9674497
51391333	51391356	5	+	27869803	HPAFII	viability after 15 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	-0.07505424225025226	[555]	[824,406,NaN]	-1	hSpCas9	negative selection	9674498
51393512	51393535	5	+	27869803	HPAFII	viability after 15 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	1.0028310980863526	[125]	[591,71,NaN]	9	hSpCas9	negative selection	9674499
51393528	51393551	5	-	27869803	HPAFII	viability after 15 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.32922436457958565	[246]	[388,298,NaN]	4	hSpCas9	negative selection	9674500
51387555	51387578	5	-	27869803	ASPC1	viability after 36 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.8047713192815019	[374]	[78,97,434]	7	hSpCas9	negative selection	9756944
51387725	51387748	5	-	27869803	ASPC1	viability after 36 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	0.6897820285923493	[188]	[41,198,76]	6	hSpCas9	negative selection	9756945
51389777	51389800	5	-	27869803	ASPC1	viability after 36 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.9376574600489314	[1269]	[712,1067,761]	8	hSpCas9	negative selection	9756946
51391333	51391356	5	+	27869803	ASPC1	viability after 36 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.07922291757533961	[1315]	[387,626,435]	0	hSpCas9	negative selection	9756947
51393512	51393535	5	+	27869803	ASPC1	viability after 36 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	-0.2875141494327579	[389]	[46,163,113]	-3	hSpCas9	negative selection	9756948
51393528	51393551	5	-	27869803	ASPC1	viability after 36 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.6322636056176153	[658]	[96,591,347]	6	hSpCas9	negative selection	9756949
51387555	51387578	5	-	27869803	PATU8988S	viability after 35 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.25158742664856615	[438]	[206,213,NaN]	3	hSpCas9	negative selection	9839393
51387725	51387748	5	-	27869803	PATU8988S	viability after 35 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	0.5474610734002574	[201]	[75,161,NaN]	6	hSpCas9	negative selection	9839394
51389777	51389800	5	-	27869803	PATU8988S	viability after 35 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.12017455012585265	[1391]	[533,684,NaN]	1	hSpCas9	negative selection	9839395
51391333	51391356	5	+	27869803	PATU8988S	viability after 35 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	-0.1475735281904922	[1129]	[347,473,NaN]	-1	hSpCas9	negative selection	9839396
51393512	51393535	5	+	27869803	PATU8988S	viability after 35 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	0.7420293237035154	[392]	[145,383,NaN]	7	hSpCas9	negative selection	9839397
51393528	51393551	5	-	27869803	PATU8988S	viability after 35 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.6400737442726216	[445]	[249,309,NaN]	7	hSpCas9	negative selection	9839398
51387555	51387578	5	-	27869803	PATU8988S	viability after 31 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.039206837306888564	[438]	[134,236,NaN]	0	hSpCas9	negative selection	9921842
51387725	51387748	5	-	27869803	PATU8988S	viability after 31 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	0.3702359449150836	[201]	[60,158,NaN]	4	hSpCas9	negative selection	9921843
51389777	51389800	5	-	27869803	PATU8988S	viability after 31 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.04893777379244102	[1391]	[582,562,NaN]	0	hSpCas9	negative selection	9921844
51391333	51391356	5	+	27869803	PATU8988S	viability after 31 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.09575551909732494	[1129]	[389,597,NaN]	1	hSpCas9	negative selection	9921845
51393512	51393535	5	+	27869803	PATU8988S	viability after 31 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	0.25392611443106594	[392]	[108,285,NaN]	3	hSpCas9	negative selection	9921846
51393528	51393551	5	-	27869803	PATU8988S	viability after 31 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.7531750495562495	[445]	[242,371,NaN]	8	hSpCas9	negative selection	9921847
51387555	51387578	5	-	27869803	HPAFII	viability after 35 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.5596080705322695	[158]	[96,142,NaN]	3	hSpCas9	negative selection	10004291
51387725	51387748	5	-	27869803	HPAFII	viability after 35 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	-0.41081047683667515	[75]	[27,29,NaN]	-3	hSpCas9	negative selection	10004292
51389777	51389800	5	-	27869803	HPAFII	viability after 35 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	1.2827889868415714	[538]	[360,1004,NaN]	8	hSpCas9	negative selection	10004293
51391333	51391356	5	+	27869803	HPAFII	viability after 35 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.31795473434609356	[555]	[332,370,NaN]	2	hSpCas9	negative selection	10004294
51393512	51393535	5	+	27869803	HPAFII	viability after 35 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	1.7058513549782448	[125]	[383,9,NaN]	9	hSpCas9	negative selection	10004295
51393528	51393551	5	-	27869803	HPAFII	viability after 35 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.19598327163621873	[246]	[146,138,NaN]	1	hSpCas9	negative selection	10004296
51387555	51387578	5	-	27869803	HPAFII	viability after 31 days	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.7680767389066234	[158]	[72,237,NaN]	5	hSpCas9	negative selection	10086740
51387725	51387748	5	-	27869803	HPAFII	viability after 31 days	GCCATTTGCAGTGGCCGCGCTGG	ISL1	ENSG00000016082	-0.16040502889051922	[75]	[52,21,NaN]	-1	hSpCas9	negative selection	10086741
51389777	51389800	5	-	27869803	HPAFII	viability after 31 days	TTCATGAGCGCATCTGGCCGCGG	ISL1	ENSG00000016082	0.865044730987905	[538]	[404,709,NaN]	6	hSpCas9	negative selection	10086742
51391333	51391356	5	+	27869803	HPAFII	viability after 31 days	TGGCTTACAGGCTAACCCAGTGG	ISL1	ENSG00000016082	0.5677174011788766	[555]	[439,486,NaN]	4	hSpCas9	negative selection	10086743
51393512	51393535	5	+	27869803	HPAFII	viability after 31 days	GGACCGGGCTCTAATTCCACTGG	ISL1	ENSG00000016082	1.1850866955718928	[125]	[289,19,NaN]	8	hSpCas9	negative selection	10086744
51393528	51393551	5	-	27869803	HPAFII	viability after 31 days	TGATGCTACTTCACTGCCAGTGG	ISL1	ENSG00000016082	0.6755619237894258	[246]	[196,247,NaN]	5	hSpCas9	negative selection	10086745
51387616	51387639	5	-	28162770	P31FUJ	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.4858300640227229	[490]	[807]	5	hSpCas9	negative selection	10175943
51387667	51387690	5	-	28162770	P31FUJ	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.05127106527298109	[918]	[1118]	0	hSpCas9	negative selection	10175944
51387680	51387703	5	+	28162770	P31FUJ	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	-0.48914195767416424	[85]	[71]	-4	hSpCas9	negative selection	10175945
51387734	51387757	5	-	28162770	P31FUJ	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.6901868947587838	[201]	[382]	7	hSpCas9	negative selection	10175946
51389709	51389732	5	-	28162770	P31FUJ	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	0.21198263825851726	[71]	[97]	2	hSpCas9	negative selection	10175947
51389760	51389783	5	+	28162770	P31FUJ	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	-0.08931061082484604	[152]	[168]	-1	hSpCas9	negative selection	10175948
51391282	51391305	5	+	28162770	P31FUJ	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-1.564878254677824	[213]	[84]	-7	hSpCas9	negative selection	10175949
51391310	51391333	5	+	28162770	P31FUJ	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	0.7614614260364767	[125]	[250]	8	hSpCas9	negative selection	10175950
51387555	51387578	5	-	28162770	P31FUJ	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.06487834422630648	[239]	[294]	0	hSpCas9	negative selection	10175951
51387600	51387623	5	+	28162770	P31FUJ	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	-0.36983891209782693	[308]	[280]	-3	hSpCas9	negative selection	10175952
51387616	51387639	5	-	28162770	TF1	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	NaN	[NaN]	[361]	1	hSpCas9	negative selection	10345309
51387667	51387690	5	-	28162770	TF1	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	NaN	[NaN]	[560]	1	hSpCas9	negative selection	10345310
51387680	51387703	5	+	28162770	TF1	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	NaN	[NaN]	[105]	1	hSpCas9	negative selection	10345311
51387734	51387757	5	-	28162770	TF1	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	NaN	[NaN]	[227]	1	hSpCas9	negative selection	10345312
51389709	51389732	5	-	28162770	TF1	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	NaN	[NaN]	[7]	1	hSpCas9	negative selection	10345313
51389760	51389783	5	+	28162770	TF1	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	NaN	[NaN]	[79]	1	hSpCas9	negative selection	10345314
51391282	51391305	5	+	28162770	TF1	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	NaN	[NaN]	[4]	1	hSpCas9	negative selection	10345315
51391310	51391333	5	+	28162770	TF1	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	NaN	[NaN]	[33]	1	hSpCas9	negative selection	10345316
51387555	51387578	5	-	28162770	TF1	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	NaN	[NaN]	[263]	1	hSpCas9	negative selection	10345317
51387600	51387623	5	+	28162770	TF1	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	NaN	[NaN]	[235]	1	hSpCas9	negative selection	10345318
51387616	51387639	5	-	28162770	SKM1	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.3389901786502989	[143]	[321]	3	hSpCas9	negative selection	10514675
51387667	51387690	5	-	28162770	SKM1	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	-0.7659676631076777	[201]	[209]	-5	hSpCas9	negative selection	10514676
51387680	51387703	5	+	28162770	SKM1	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	-0.6799826931495776	[28]	[31]	-5	hSpCas9	negative selection	10514677
51387734	51387757	5	-	28162770	SKM1	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.17799830197799454	[74]	[149]	1	hSpCas9	negative selection	10514678
51389709	51389732	5	-	28162770	SKM1	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	-0.8220016980220053	[20]	[20]	-6	hSpCas9	negative selection	10514679
51389760	51389783	5	+	28162770	SKM1	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.6762491695058198	[39]	[112]	6	hSpCas9	negative selection	10514680
51391282	51391305	5	+	28162770	SKM1	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-1.5996092766855574	[47]	[27]	-8	hSpCas9	negative selection	10514681
51391310	51391333	5	+	28162770	SKM1	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	-0.022300348507836798	[26]	[46]	0	hSpCas9	negative selection	10514682
51387555	51387578	5	-	28162770	SKM1	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.9267410639205542	[60]	[204]	8	hSpCas9	negative selection	10514683
51387600	51387623	5	+	28162770	SKM1	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	0.8922438196441171	[63]	[209]	8	hSpCas9	negative selection	10514684
51387616	51387639	5	-	28162770	SKM1	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.3389901786502989	[143]	[321]	3	hSpCas9	negative selection	10684041
51387667	51387690	5	-	28162770	SKM1	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	-0.7659676631076777	[201]	[209]	-5	hSpCas9	negative selection	10684042
51387680	51387703	5	+	28162770	SKM1	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	-0.6799826931495776	[28]	[31]	-5	hSpCas9	negative selection	10684043
51387734	51387757	5	-	28162770	SKM1	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.17799830197799454	[74]	[149]	1	hSpCas9	negative selection	10684044
51389709	51389732	5	-	28162770	SKM1	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	-0.8220016980220053	[20]	[20]	-6	hSpCas9	negative selection	10684045
51389760	51389783	5	+	28162770	SKM1	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.6762491695058198	[39]	[112]	6	hSpCas9	negative selection	10684046
51391282	51391305	5	+	28162770	SKM1	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-1.5996092766855574	[47]	[27]	-8	hSpCas9	negative selection	10684047
51391310	51391333	5	+	28162770	SKM1	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	-0.022300348507836798	[26]	[46]	0	hSpCas9	negative selection	10684048
51387555	51387578	5	-	28162770	SKM1	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.9267410639205542	[60]	[204]	8	hSpCas9	negative selection	10684049
51387600	51387623	5	+	28162770	SKM1	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	0.8922438196441171	[63]	[209]	8	hSpCas9	negative selection	10684050
51387616	51387639	5	-	28162770	PL21	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.4824219049163925	[545]	[331]	4	hSpCas9	negative selection	10853407
51387667	51387690	5	-	28162770	PL21	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.2456391626359682	[592]	[305]	2	hSpCas9	negative selection	10853408
51387680	51387703	5	+	28162770	PL21	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	0.023261852405240924	[103]	[45]	0	hSpCas9	negative selection	10853409
51387734	51387757	5	-	28162770	PL21	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.7331743231666155	[263]	[190]	6	hSpCas9	negative selection	10853410
51389709	51389732	5	-	28162770	PL21	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	-2.5186786329666266	[78]	[5]	-9	hSpCas9	negative selection	10853411
51389760	51389783	5	+	28162770	PL21	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.6759803928303638	[150]	[104]	6	hSpCas9	negative selection	10853412
51391282	51391305	5	+	28162770	PL21	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-0.04006408296358843	[162]	[68]	0	hSpCas9	negative selection	10853413
51391310	51391333	5	+	28162770	PL21	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	1.132500897613957	[130]	[124]	8	hSpCas9	negative selection	10853414
51387555	51387578	5	-	28162770	PL21	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.6452791455575833	[165]	[112]	5	hSpCas9	negative selection	10853415
51387600	51387623	5	+	28162770	PL21	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	0.3346817378681478	[265]	[145]	3	hSpCas9	negative selection	10853416
51387616	51387639	5	-	28162770	P31FUJ	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.4858300640227229	[490]	[807]	5	hSpCas9	negative selection	11022773
51387667	51387690	5	-	28162770	P31FUJ	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.05127106527298109	[918]	[1118]	0	hSpCas9	negative selection	11022774
51387680	51387703	5	+	28162770	P31FUJ	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	-0.48914195767416424	[85]	[71]	-4	hSpCas9	negative selection	11022775
51387734	51387757	5	-	28162770	P31FUJ	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.6901868947587838	[201]	[382]	7	hSpCas9	negative selection	11022776
51389709	51389732	5	-	28162770	P31FUJ	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	0.21198263825851726	[71]	[97]	2	hSpCas9	negative selection	11022777
51389760	51389783	5	+	28162770	P31FUJ	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	-0.08931061082484604	[152]	[168]	-1	hSpCas9	negative selection	11022778
51391282	51391305	5	+	28162770	P31FUJ	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-1.564878254677824	[213]	[84]	-7	hSpCas9	negative selection	11022779
51391310	51391333	5	+	28162770	P31FUJ	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	0.7614614260364767	[125]	[250]	8	hSpCas9	negative selection	11022780
51387555	51387578	5	-	28162770	P31FUJ	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.06487834422630648	[239]	[294]	0	hSpCas9	negative selection	11022781
51387600	51387623	5	+	28162770	P31FUJ	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	-0.36983891209782693	[308]	[280]	-3	hSpCas9	negative selection	11022782
51387616	51387639	5	-	28162770	OCIAML5	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.7627974155710213	[190]	[584]	6	hSpCas9	negative selection	11192139
51387667	51387690	5	-	28162770	OCIAML5	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.079378698918251	[333]	[636]	0	hSpCas9	negative selection	11192140
51387680	51387703	5	+	28162770	OCIAML5	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	1.790039836960768	[32]	[205]	9	hSpCas9	negative selection	11192141
51387734	51387757	5	-	28162770	OCIAML5	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.5079768965949149	[126]	[325]	4	hSpCas9	negative selection	11192142
51389709	51389732	5	-	28162770	OCIAML5	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	0.754591000956478	[21]	[66]	6	hSpCas9	negative selection	11192143
51389760	51389783	5	+	28162770	OCIAML5	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.5023641637106949	[78]	[201]	4	hSpCas9	negative selection	11192144
51391282	51391305	5	+	28162770	OCIAML5	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-1.7609186828058017	[91]	[48]	-7	hSpCas9	negative selection	11192145
51391310	51391333	5	+	28162770	OCIAML5	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	0.36397035543262746	[64]	[150]	3	hSpCas9	negative selection	11192146
51387555	51387578	5	-	28162770	OCIAML5	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.029562454226122026	[202]	[358]	0	hSpCas9	negative selection	11192147
51387600	51387623	5	+	28162770	OCIAML5	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	0.2659306385344544	[175]	[381]	2	hSpCas9	negative selection	11192148
51387616	51387639	5	-	28162770	EOL1	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.9997221620273093	[859]	[905]	8	hSpCas9	negative selection	11361505
51387667	51387690	5	-	28162770	EOL1	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.5382692652731147	[744]	[569]	5	hSpCas9	negative selection	11361506
51387680	51387703	5	+	28162770	EOL1	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	-1.2638973178425759	[195]	[42]	-7	hSpCas9	negative selection	11361507
51387734	51387757	5	-	28162770	EOL1	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	-0.35481224970970815	[550]	[226]	-3	hSpCas9	negative selection	11361508
51389709	51389732	5	-	28162770	EOL1	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	1.556160365590512	[141]	[219]	9	hSpCas9	negative selection	11361509
51389760	51389783	5	+	28162770	EOL1	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.8314383671790531	[271]	[254]	7	hSpCas9	negative selection	11361510
51391282	51391305	5	+	28162770	EOL1	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-0.04873489005368603	[213]	[108]	0	hSpCas9	negative selection	11361511
51391310	51391333	5	+	28162770	EOL1	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	0.3738551729341246	[103]	[70]	3	hSpCas9	negative selection	11361512
51387555	51387578	5	-	28162770	EOL1	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.1716675436887687	[247]	[115]	-1	hSpCas9	negative selection	11361513
51387600	51387623	5	+	28162770	EOL1	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	1.005467766954102	[415]	[439]	8	hSpCas9	negative selection	11361514
51387616	51387639	5	-	28162770	MOLM13	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.8703567851045233	[633]	[837]	6	hSpCas9	negative selection	11530871
51387667	51387690	5	-	28162770	MOLM13	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.018933574031799072	[788]	[577]	0	hSpCas9	negative selection	11530872
51387680	51387703	5	+	28162770	MOLM13	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	0.4146473602675992	[137]	[132]	3	hSpCas9	negative selection	11530873
51387734	51387757	5	-	28162770	MOLM13	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	1.506989201233519	[272]	[560]	9	hSpCas9	negative selection	11530874
51389709	51389732	5	-	28162770	MOLM13	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	1.1081017428311974	[110]	[172]	8	hSpCas9	negative selection	11530875
51389760	51389783	5	+	28162770	MOLM13	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.4471308213777816	[209]	[206]	3	hSpCas9	negative selection	11530876
51391282	51391305	5	+	28162770	MOLM13	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-2.521139500634418	[261]	[32]	-8	hSpCas9	negative selection	11530877
51391310	51391333	5	+	28162770	MOLM13	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	-1.109768318553344	[196]	[65]	-5	hSpCas9	negative selection	11530878
51387555	51387578	5	-	28162770	MOLM13	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.2725071180219007	[420]	[251]	-2	hSpCas9	negative selection	11530879
51387600	51387623	5	+	28162770	MOLM13	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	-0.19217457441729618	[413]	[261]	-1	hSpCas9	negative selection	11530880
51387616	51387639	5	-	28162770	HEL	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	1.050530233470314	[498]	[661]	8	hSpCas9	negative selection	11700237
51387667	51387690	5	-	28162770	HEL	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.14283668231423552	[600]	[424]	1	hSpCas9	negative selection	11700238
51387680	51387703	5	+	28162770	HEL	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	0.002634777086739648	[119]	[76]	0	hSpCas9	negative selection	11700239
51387734	51387757	5	-	28162770	HEL	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.3545313549569957	[369]	[302]	3	hSpCas9	negative selection	11700240
51389709	51389732	5	-	28162770	HEL	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	0.3307948256856166	[71]	[57]	2	hSpCas9	negative selection	11700241
51389760	51389783	5	+	28162770	HEL	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.13318373393722344	[204]	[143]	1	hSpCas9	negative selection	11700242
51391282	51391305	5	+	28162770	HEL	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-1.4468983804843196	[165]	[38]	-7	hSpCas9	negative selection	11700243
51391310	51391333	5	+	28162770	HEL	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	0.6520766965796931	[153]	[154]	5	hSpCas9	negative selection	11700244
51387555	51387578	5	-	28162770	HEL	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.6617219353679297	[301]	[305]	5	hSpCas9	negative selection	11700245
51387600	51387623	5	+	28162770	HEL	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	0.04315076751904012	[346]	[228]	0	hSpCas9	negative selection	11700246
51387616	51387639	5	-	28162770	MV411	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.793687645169987	[490]	[716]	7	hSpCas9	negative selection	11869603
51387667	51387690	5	-	28162770	MV411	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.6100076301674835	[531]	[683]	5	hSpCas9	negative selection	11869604
51387680	51387703	5	+	28162770	MV411	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	0.8387978227020823	[74]	[112]	7	hSpCas9	negative selection	11869605
51387734	51387757	5	-	28162770	MV411	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	-0.31623017157515265	[268]	[181]	-2	hSpCas9	negative selection	11869606
51389709	51389732	5	-	28162770	MV411	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	-0.09586419489715414	[84]	[66]	0	hSpCas9	negative selection	11869607
51389760	51389783	5	+	28162770	MV411	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.7203734337698203	[115]	[160]	6	hSpCas9	negative selection	11869608
51391282	51391305	5	+	28162770	MV411	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-2.4107739319690196	[201]	[31]	-8	hSpCas9	negative selection	11869609
51391310	51391333	5	+	28162770	MV411	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	1.615413013189574	[73]	[190]	9	hSpCas9	negative selection	11869610
51387555	51387578	5	-	28162770	MV411	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	-0.49324633162954096	[258]	[154]	-4	hSpCas9	negative selection	11869611
51387600	51387623	5	+	28162770	MV411	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	-0.24456193031095275	[307]	[218]	-2	hSpCas9	negative selection	11869612
51387616	51387639	5	-	28162770	MONOMAC1	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.22386289125194958	[306]	[410]	2	hSpCas9	negative selection	12038969
51387667	51387690	5	-	28162770	MONOMAC1	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.46440438350896307	[348]	[551]	4	hSpCas9	negative selection	12038970
51387680	51387703	5	+	28162770	MONOMAC1	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	0.07257021269772634	[72]	[87]	0	hSpCas9	negative selection	12038971
51387734	51387757	5	-	28162770	MONOMAC1	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.010476397938123827	[180]	[208]	0	hSpCas9	negative selection	12038972
51389709	51389732	5	-	28162770	MONOMAC1	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	-0.8447351031286725	[46]	[29]	-6	hSpCas9	negative selection	12038973
51389760	51389783	5	+	28162770	MONOMAC1	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.7499447706409554	[96]	[186]	7	hSpCas9	negative selection	12038974
51391282	51391305	5	+	28162770	MONOMAC1	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-1.0219501405014624	[123]	[69]	-7	hSpCas9	negative selection	12038975
51391310	51391333	5	+	28162770	MONOMAC1	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	0.4352313684399593	[79]	[123]	4	hSpCas9	negative selection	12038976
51387555	51387578	5	-	28162770	MONOMAC1	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.2545265282444043	[116]	[159]	2	hSpCas9	negative selection	12038977
51387600	51387623	5	+	28162770	MONOMAC1	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	-0.5988506511822322	[180]	[136]	-5	hSpCas9	negative selection	12038978
51387616	51387639	5	-	28162770	OCIAML2	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.3120278596169139	[100]	[694]	3	hSpCas9	negative selection	12208335
51387667	51387690	5	-	28162770	OCIAML2	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.45828707669635627	[90]	[692]	4	hSpCas9	negative selection	12208336
51387680	51387703	5	+	28162770	OCIAML2	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	0.15872679483744845	[15]	[98]	1	hSpCas9	negative selection	12208337
51387734	51387757	5	-	28162770	OCIAML2	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	0.05293213081485171	[51]	[298]	0	hSpCas9	negative selection	12208338
51389709	51389732	5	-	28162770	OCIAML2	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	1.25426293662347	[8]	[118]	9	hSpCas9	negative selection	12208339
51389760	51389783	5	+	28162770	OCIAML2	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.7709561613275977	[23]	[226]	7	hSpCas9	negative selection	12208340
51391282	51391305	5	+	28162770	OCIAML2	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	-2.5307508176797318	[48]	[46]	-8	hSpCas9	negative selection	12208341
51391310	51391333	5	+	28162770	OCIAML2	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	0.5680506429218986	[22]	[188]	5	hSpCas9	negative selection	12208342
51387555	51387578	5	-	28162770	OCIAML2	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.4138929573379029	[38]	[287]	4	hSpCas9	negative selection	12208343
51387600	51387623	5	+	28162770	OCIAML2	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	0.37736708131278884	[49]	[359]	3	hSpCas9	negative selection	12208344
51387616	51387639	5	-	28162770	OCIAML3	viability	GAAGCGCAAATTCGTCCCCAGGG	ISL1	ENSG00000016082	0.12219939367524568	[132]	[436]	1	hSpCas9	negative selection	12377701
51387667	51387690	5	-	28162770	OCIAML3	viability	TGGCCCTCTCCACCACATCGTGG	ISL1	ENSG00000016082	0.3472397723917475	[212]	[817]	3	hSpCas9	negative selection	12377702
51387680	51387703	5	+	28162770	OCIAML3	viability	GAGAGGGCCAGTCTAGGCGCTGG	ISL1	ENSG00000016082	-1.0915072997949802	[23]	[33]	-7	hSpCas9	negative selection	12377703
51387734	51387757	5	-	28162770	OCIAML3	viability	GGAGTACCTGCCATTTGCAGTGG	ISL1	ENSG00000016082	-0.12337781508200196	[69]	[193]	-1	hSpCas9	negative selection	12377704
51389709	51389732	5	-	28162770	OCIAML3	viability	CAGCACAGTCCGCACGCGGGTGG	ISL1	ENSG00000016082	0.6913945785380853	[7]	[38]	6	hSpCas9	negative selection	12377705
51389760	51389783	5	+	28162770	OCIAML3	viability	CCTGCTACGCCGCAAACCCGCGG	ISL1	ENSG00000016082	0.8485105953767877	[38]	[211]	7	hSpCas9	negative selection	12377706
51391282	51391305	5	+	28162770	OCIAML3	viability	GGGGATGACAGGAACTCCCATGG	ISL1	ENSG00000016082	0.09283447441620646	[40]	[131]	0	hSpCas9	negative selection	12377707
51391310	51391333	5	+	28162770	OCIAML3	viability	GCCAGTCCAGAGAGACACGACGG	ISL1	ENSG00000016082	-0.6720101523254363	[18]	[35]	-5	hSpCas9	negative selection	12377708
51387555	51387578	5	-	28162770	OCIAML3	viability	GATGTGATACACCTTGGAGCGGG	ISL1	ENSG00000016082	0.4726633993211247	[36]	[154]	4	hSpCas9	negative selection	12377709
51387600	51387623	5	+	28162770	OCIAML3	viability	GCAGCCGCCAGCTCATCCCTGGG	ISL1	ENSG00000016082	-0.22758008526994117	[82]	[213]	-2	hSpCas9	negative selection	12377710