Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 4985
• Symbol: OPRD1
• Description: opioid receptor delta 1

DataSource: http://genomecrispr.dkfz.de/#!/results/OPRD1

Export (tab separated) Export to Excel

Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
28812448	28812471	1	-	26472758	Jiyoye	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	1.1480881601887423	[72]	[121]	7	hSpCas9	negative selection	113916
28859038	28859061	1	+	26472758	Jiyoye	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	2.6609319737516564	[12]	[61]	9	hSpCas9	negative selection	113917
28812541	28812564	1	-	26472758	Jiyoye	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.426804188254806	[145]	[147]	3	hSpCas9	negative selection	113918
28859070	28859093	1	-	26472758	Jiyoye	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	4.655102894949458	[0]	[18]	9	hSpCas9	negative selection	113919
28859197	28859220	1	+	26472758	Jiyoye	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.8550775146903438	[216]	[295]	6	hSpCas9	negative selection	113920
28859282	28859305	1	+	26472758	Jiyoye	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	-0.26161871001875353	[123]	[77]	-2	hSpCas9	negative selection	113921
28812469	28812492	1	+	26472758	Jiyoye	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	1.012896442393827	[68]	[104]	6	hSpCas9	negative selection	113922
28812517	28812540	1	-	26472758	Jiyoye	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	-2.177787119215283	[23]	[3]	-8	hSpCas9	negative selection	113923
28858996	28859019	1	-	26472758	Jiyoye	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.3171901758806993	[75]	[45]	-2	hSpCas9	negative selection	113924
28859019	28859042	1	-	26472758	Jiyoye	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.8546343584770946	[32]	[44]	6	hSpCas9	negative selection	113925
28812448	28812471	1	-	26472758	KBM7	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	0.8202724206891839	[563,454]	[383,452]	8	hSpCas9	negative selection	305034
28859038	28859061	1	+	26472758	KBM7	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	1.9839994463636534	[199,168]	[494,204]	9	hSpCas9	negative selection	305035
28812541	28812564	1	-	26472758	KBM7	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.6937875136620781	[455,378]	[342,291]	7	hSpCas9	negative selection	305036
28859070	28859093	1	-	26472758	KBM7	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	0.11066055940186104	[73,45]	[50,10]	1	hSpCas9	negative selection	305037
28859197	28859220	1	+	26472758	KBM7	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.3729890841319061	[781,607]	[507,340]	4	hSpCas9	negative selection	305038
28859282	28859305	1	+	26472758	KBM7	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	1.304310219352744	[457,165]	[285,400]	9	hSpCas9	negative selection	305039
28812469	28812492	1	+	26472758	KBM7	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.4067794242728111	[590,528]	[314,378]	4	hSpCas9	negative selection	305040
28812517	28812540	1	-	26472758	KBM7	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	0.23285135366544019	[22,34]	[26,6]	2	hSpCas9	negative selection	305041
28858996	28859019	1	-	26472758	KBM7	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.18161011654047243	[219,153]	[52,138]	1	hSpCas9	negative selection	305042
28859019	28859042	1	-	26472758	KBM7	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.8424266474483308	[243,234]	[173,227]	8	hSpCas9	negative selection	305043
28812448	28812471	1	-	26472758	Raji	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	-0.488983728619806	[253]	[41]	-4	hSpCas9	negative selection	496152
28859038	28859061	1	+	26472758	Raji	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.22155455529291052	[169]	[45]	2	hSpCas9	negative selection	496153
28812541	28812564	1	-	26472758	Raji	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.100259100940218	[202]	[100]	8	hSpCas9	negative selection	496154
28859070	28859093	1	-	26472758	Raji	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	-2.7995070602349195	[29]	[0]	-9	hSpCas9	negative selection	496155
28859197	28859220	1	+	26472758	Raji	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.4779023678737988	[361]	[116]	4	hSpCas9	negative selection	496156
28859282	28859305	1	+	26472758	Raji	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	0.7478411486864593	[135]	[52]	7	hSpCas9	negative selection	496157
28812469	28812492	1	+	26472758	Raji	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.39689015256858445	[251]	[76]	4	hSpCas9	negative selection	496158
28812517	28812540	1	-	26472758	Raji	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	-2.0625414660687134	[17]	[0]	-8	hSpCas9	negative selection	496159
28858996	28859019	1	-	26472758	Raji	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.3911765013741907	[91]	[27]	4	hSpCas9	negative selection	496160
28859019	28859042	1	-	26472758	Raji	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	1.1639670637399668	[74]	[38]	8	hSpCas9	negative selection	496161
28812448	28812471	1	-	26472758	K562	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	0.5074531335002406	[504]	[605]	4	hSpCas9	negative selection	687270
28859038	28859061	1	+	26472758	K562	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.65118861096169	[174]	[231]	5	hSpCas9	negative selection	687271
28812541	28812564	1	-	26472758	K562	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.4370638056088427	[342]	[783]	9	hSpCas9	negative selection	687272
28859070	28859093	1	-	26472758	K562	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	-3.2999017885573636	[34]	[2]	-8	hSpCas9	negative selection	687273
28859197	28859220	1	+	26472758	K562	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.6600800950808021	[577]	[770]	5	hSpCas9	negative selection	687274
28859282	28859305	1	+	26472758	K562	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	0.48030699148711786	[151]	[178]	4	hSpCas9	negative selection	687275
28812469	28812492	1	+	26472758	K562	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	1.2538790569155132	[379]	[764]	9	hSpCas9	negative selection	687276
28812517	28812540	1	-	26472758	K562	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	0.6488089827457819	[33]	[44]	5	hSpCas9	negative selection	687277
28858996	28859019	1	-	26472758	K562	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.029567855342617966	[158]	[136]	0	hSpCas9	negative selection	687278
28859019	28859042	1	-	26472758	K562	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.8392424769038788	[242]	[366]	7	hSpCas9	negative selection	687279
28812422	28812445	1	-	26627737	DLD1	viability	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	0.36944330285419075	[290]	[138,120,95]	4	hSpCas9	negative selection	770664
28812541	28812564	1	-	26627737	DLD1	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.8422292341014723	[1118]	[95,304,189]	-7	hSpCas9	negative selection	770665
28858996	28859019	1	-	26627737	DLD1	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.5309908553318712	[613]	[138,130,128]	-5	hSpCas9	negative selection	770666
28859046	28859069	1	+	26627737	DLD1	viability	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.6679232783942706	[1134]	[654,573,475]	6	hSpCas9	negative selection	770667
28862818	28862841	1	-	26627737	DLD1	viability	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.8148376374763971	[393]	[268,123,247]	7	hSpCas9	negative selection	770668
28863107	28863130	1	-	26627737	DLD1	viability	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-0.7189747885439831	[647]	[172,123,78]	-6	hSpCas9	negative selection	770669
28812422	28812445	1	-	26627737	GBM cells	viability after 5 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	0.27272871143801625	[141]	[93,89]	4	hSpCas9	negative selection	852979
28812541	28812564	1	-	26627737	GBM cells	viability after 5 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.4969720332185251	[328]	[258,238]	7	hSpCas9	negative selection	852980
28858996	28859019	1	-	26627737	GBM cells	viability after 5 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.6025208721054608	[174]	[129,154]	8	hSpCas9	negative selection	852981
28859046	28859069	1	+	26627737	GBM cells	viability after 5 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.2886719657161718	[805]	[498,556]	4	hSpCas9	negative selection	852982
28862818	28862841	1	-	26627737	GBM cells	viability after 5 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	-0.00675874256616138	[369]	[200,193]	0	hSpCas9	negative selection	852983
28863107	28863130	1	-	26627737	GBM cells	viability after 5 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	0.05000646338357545	[316]	[158,192]	0	hSpCas9	negative selection	852984
28812422	28812445	1	-	26627737	GBM cells	viability after 13 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	0.09352573055397828	[141]	[79,83]	1	hSpCas9	negative selection	935294
28812541	28812564	1	-	26627737	GBM cells	viability after 13 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.3211068187181578	[328]	[238,209]	4	hSpCas9	negative selection	935295
28858996	28859019	1	-	26627737	GBM cells	viability after 13 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.6032459791635547	[174]	[146,141]	7	hSpCas9	negative selection	935296
28859046	28859069	1	+	26627737	GBM cells	viability after 13 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.2593709690432071	[805]	[673,400]	3	hSpCas9	negative selection	935297
28862818	28862841	1	-	26627737	GBM cells	viability after 13 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.20256254615889924	[369]	[262,204]	2	hSpCas9	negative selection	935298
28863107	28863130	1	-	26627737	GBM cells	viability after 13 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	0.21592199574173926	[316]	[212,188]	2	hSpCas9	negative selection	935299
28812422	28812445	1	-	26627737	GBM cells	viability after 21 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	0.541414785048399	[141]	[93,128]	5	hSpCas9	negative selection	1017609
28812541	28812564	1	-	26627737	GBM cells	viability after 21 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.2703541852940664	[328]	[248,184]	3	hSpCas9	negative selection	1017610
28858996	28859019	1	-	26627737	GBM cells	viability after 21 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.47013372315248175	[174]	[126,135]	5	hSpCas9	negative selection	1017611
28859046	28859069	1	+	26627737	GBM cells	viability after 21 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.21355601002432123	[805]	[501,512]	2	hSpCas9	negative selection	1017612
28862818	28862841	1	-	26627737	GBM cells	viability after 21 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	-0.24666885332038668	[369]	[182,156]	-2	hSpCas9	negative selection	1017613
28863107	28863130	1	-	26627737	GBM cells	viability after 21 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	0.021272223449625483	[316]	[179,169]	0	hSpCas9	negative selection	1017614
28812422	28812445	1	-	26627737	RPE1	viability after 9 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	2.9045853736850473	[87]	[197,216]	9	hSpCas9	negative selection	1099924
28812541	28812564	1	-	26627737	RPE1	viability after 9 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.7748108090129324	[576]	[439,847]	8	hSpCas9	negative selection	1099925
28858996	28859019	1	-	26627737	RPE1	viability after 9 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.09487232893982664	[711]	[110,401]	0	hSpCas9	negative selection	1099926
28859046	28859069	1	+	26627737	RPE1	viability after 9 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	-0.26870357091124353	[3006]	[711,870]	-2	hSpCas9	negative selection	1099927
28862818	28862841	1	-	26627737	RPE1	viability after 9 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	1.4088294787233036	[501]	[408,427]	7	hSpCas9	negative selection	1099928
28863107	28863130	1	-	26627737	RPE1	viability after 9 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-2.8081320427142424	[1680]	[51,104]	-9	hSpCas9	negative selection	1099929
28812422	28812445	1	-	26627737	RPE1	viability after 12 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	2.702127405522444	[87]	[80,230]	9	hSpCas9	negative selection	1182239
28812541	28812564	1	-	26627737	RPE1	viability after 12 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.1807715811966533	[576]	[263,443]	7	hSpCas9	negative selection	1182240
28858996	28859019	1	-	26627737	RPE1	viability after 12 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.5081438773181115	[711]	[205,341]	3	hSpCas9	negative selection	1182241
28859046	28859069	1	+	26627737	RPE1	viability after 12 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	-0.25797222298684175	[3006]	[729,617]	-2	hSpCas9	negative selection	1182242
28862818	28862841	1	-	26627737	RPE1	viability after 12 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	1.4775113622828075	[501]	[394,354]	7	hSpCas9	negative selection	1182243
28863107	28863130	1	-	26627737	RPE1	viability after 12 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-1.6979771966016632	[1680]	[145,131]	-8	hSpCas9	negative selection	1182244
28812422	28812445	1	-	26627737	RPE1	viability after 15 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	2.347863018381821	[87]	[85,165]	9	hSpCas9	negative selection	1264554
28812541	28812564	1	-	26627737	RPE1	viability after 15 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.4790799681735176	[576]	[369,536]	7	hSpCas9	negative selection	1264555
28858996	28859019	1	-	26627737	RPE1	viability after 15 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.3480981967106616	[711]	[88,224]	-2	hSpCas9	negative selection	1264556
28859046	28859069	1	+	26627737	RPE1	viability after 15 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	-0.3132246791641311	[3006]	[565,798]	-2	hSpCas9	negative selection	1264557
28862818	28862841	1	-	26627737	RPE1	viability after 15 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	1.1715314863191066	[501]	[467,176]	6	hSpCas9	negative selection	1264558
28863107	28863130	1	-	26627737	RPE1	viability after 15 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-1.297485912512927	[1680]	[223,163]	-7	hSpCas9	negative selection	1264559
28812422	28812445	1	-	26627737	RPE1	viability after 18 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	2.4553893273238288	[87]	[20,246]	9	hSpCas9	negative selection	1346869
28812541	28812564	1	-	26627737	RPE1	viability after 18 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.911180618266688	[576]	[185,406]	5	hSpCas9	negative selection	1346870
28858996	28859019	1	-	26627737	RPE1	viability after 18 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.4084491374296862	[711]	[182,331]	2	hSpCas9	negative selection	1346871
28859046	28859069	1	+	26627737	RPE1	viability after 18 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	-0.25015142960139936	[3006]	[603,765]	-1	hSpCas9	negative selection	1346872
28862818	28862841	1	-	26627737	RPE1	viability after 18 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	1.227714204303159	[501]	[368,261]	7	hSpCas9	negative selection	1346873
28863107	28863130	1	-	26627737	RPE1	viability after 18 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-1.8251686872437516	[1680]	[84,173]	-8	hSpCas9	negative selection	1346874
28812422	28812445	1	-	26627737	HeLa	viability after 8 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	0.12105216968838106	[190]	[74,90,100]	1	hSpCas9	negative selection	1429184
28812541	28812564	1	-	26627737	HeLa	viability after 8 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.20077987340607467	[422]	[392,105,177]	2	hSpCas9	negative selection	1429185
28858996	28859019	1	-	26627737	HeLa	viability after 8 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-1.0620770995055306	[688]	[169,143,123]	-8	hSpCas9	negative selection	1429186
28859046	28859069	1	+	26627737	HeLa	viability after 8 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.7057224891479305	[748]	[684,523,426]	6	hSpCas9	negative selection	1429187
28862818	28862841	1	-	26627737	HeLa	viability after 8 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.47699224422360054	[605]	[548,193,395]	4	hSpCas9	negative selection	1429188
28863107	28863130	1	-	26627737	HeLa	viability after 8 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-1.0560441399497025	[624]	[160,76,158]	-8	hSpCas9	negative selection	1429189
28812422	28812445	1	-	26627737	HeLa	viability after 12 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	0.7358133854149174	[190]	[231,67,103]	6	hSpCas9	negative selection	1511499
28812541	28812564	1	-	26627737	HeLa	viability after 12 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.29684928480421796	[422]	[157,276,200]	2	hSpCas9	negative selection	1511500
28858996	28859019	1	-	26627737	HeLa	viability after 12 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.5084925291052835	[688]	[229,193,177]	-4	hSpCas9	negative selection	1511501
28859046	28859069	1	+	26627737	HeLa	viability after 12 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.907499578065993	[748]	[624,534,587]	7	hSpCas9	negative selection	1511502
28862818	28862841	1	-	26627737	HeLa	viability after 12 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	-0.2186117698658554	[605]	[261,224,158]	-2	hSpCas9	negative selection	1511503
28863107	28863130	1	-	26627737	HeLa	viability after 12 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-0.5162305388390551	[624]	[179,168,193]	-4	hSpCas9	negative selection	1511504
28812422	28812445	1	-	26627737	HeLa	viability after 15 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	1.118764076755356	[190]	[120,122,270]	7	hSpCas9	negative selection	1593814
28812541	28812564	1	-	26627737	HeLa	viability after 15 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.8760991303117993	[422]	[329,277,341]	6	hSpCas9	negative selection	1593815
28858996	28859019	1	-	26627737	HeLa	viability after 15 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.9734174621500384	[688]	[94,108,231]	-7	hSpCas9	negative selection	1593816
28859046	28859069	1	+	26627737	HeLa	viability after 15 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	1.0854244572209715	[748]	[607,669,664]	7	hSpCas9	negative selection	1593817
28862818	28862841	1	-	26627737	HeLa	viability after 15 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.3031545818579191	[605]	[394,248,264]	2	hSpCas9	negative selection	1593818
28863107	28863130	1	-	26627737	HeLa	viability after 15 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-0.01179844683466591	[624]	[325,82,354]	0	hSpCas9	negative selection	1593819
28812422	28812445	1	-	26627737	HeLa	viability after 18 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	1.1158410376752386	[190]	[85,94,270]	7	hSpCas9	negative selection	1676129
28812541	28812564	1	-	26627737	HeLa	viability after 18 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.8892453385196948	[422]	[223,233,341]	6	hSpCas9	negative selection	1676130
28858996	28859019	1	-	26627737	HeLa	viability after 18 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.9700247030047554	[688]	[62,91,231]	-7	hSpCas9	negative selection	1676131
28859046	28859069	1	+	26627737	HeLa	viability after 18 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	1.0815562780716776	[748]	[397,562,664]	7	hSpCas9	negative selection	1676132
28862818	28862841	1	-	26627737	HeLa	viability after 18 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.3220962770600181	[605]	[268,210,264]	2	hSpCas9	negative selection	1676133
28863107	28863130	1	-	26627737	HeLa	viability after 18 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	0.00364673296926743	[624]	[222,69,354]	0	hSpCas9	negative selection	1676134
28812422	28812445	1	-	26627737	HCT116	viability after 6 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	0.2436088265047079	[821]	[45,211]	1	hSpCas9	negative selection	1758444
28812541	28812564	1	-	26627737	HCT116	viability after 6 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.1368009971038554	[1082]	[237,108]	0	hSpCas9	negative selection	1758445
28858996	28859019	1	-	26627737	HCT116	viability after 6 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-1.4609550708082852	[850]	[65,38]	-7	hSpCas9	negative selection	1758446
28859046	28859069	1	+	26627737	HCT116	viability after 6 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.5318894366986813	[2606]	[598,588]	3	hSpCas9	negative selection	1758447
28862818	28862841	1	-	26627737	HCT116	viability after 6 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.01437963453841562	[1164]	[436,45]	0	hSpCas9	negative selection	1758448
28863107	28863130	1	-	26627737	HCT116	viability after 6 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	1.1484875484632457	[779]	[91,370]	6	hSpCas9	negative selection	1758449
28812422	28812445	1	-	26627737	HCT116	viability after 8 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	0.6802040424465428	[140]	[143,118,110]	6	hSpCas9	negative selection	1840759
28812541	28812564	1	-	26627737	HCT116	viability after 8 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.41169645647994635	[323]	[275,185,250]	4	hSpCas9	negative selection	1840760
28858996	28859019	1	-	26627737	HCT116	viability after 8 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.3627037187668509	[423]	[128,137,275]	-4	hSpCas9	negative selection	1840761
28859046	28859069	1	+	26627737	HCT116	viability after 8 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.363326898312722	[778]	[682,515,460]	4	hSpCas9	negative selection	1840762
28862818	28862841	1	-	26627737	HCT116	viability after 8 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.09809659908262458	[485]	[206,240,408]	1	hSpCas9	negative selection	1840763
28863107	28863130	1	-	26627737	HCT116	viability after 8 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-0.3198159394055681	[583]	[285,233,253]	-4	hSpCas9	negative selection	1840764
28812422	28812445	1	-	26627737	HCT116	viability after 9 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	-0.56224223465778	[821]	[89,194]	-4	hSpCas9	negative selection	1923074
28812541	28812564	1	-	26627737	HCT116	viability after 9 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.542249991340074	[1082]	[357,470]	4	hSpCas9	negative selection	1923075
28858996	28859019	1	-	26627737	HCT116	viability after 9 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.8776224425169517	[850]	[364,458]	6	hSpCas9	negative selection	1923076
28859046	28859069	1	+	26627737	HCT116	viability after 9 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.5464459704343674	[2606]	[1243,836]	4	hSpCas9	negative selection	1923077
28862818	28862841	1	-	26627737	HCT116	viability after 9 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	-0.9500461025531458	[1164]	[136,179]	-6	hSpCas9	negative selection	1923078
28863107	28863130	1	-	26627737	HCT116	viability after 9 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	0.5733645757305746	[779]	[181,410]	4	hSpCas9	negative selection	1923079
28812422	28812445	1	-	26627737	HCT116	viability after 12 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	1.2156903281315	[140]	[106,212,202]	8	hSpCas9	negative selection	2005389
28812541	28812564	1	-	26627737	HCT116	viability after 12 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.0419363449233598	[323]	[525,294,213]	8	hSpCas9	negative selection	2005390
28858996	28859019	1	-	26627737	HCT116	viability after 12 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.2783770207437357	[423]	[250,334,227]	3	hSpCas9	negative selection	2005391
28859046	28859069	1	+	26627737	HCT116	viability after 12 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.4407112013834551	[778]	[449,793,437]	4	hSpCas9	negative selection	2005392
28862818	28862841	1	-	26627737	HCT116	viability after 12 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	-0.463989597886992	[485]	[218,204,128]	-5	hSpCas9	negative selection	2005393
28863107	28863130	1	-	26627737	HCT116	viability after 12 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-0.1294265994530991	[583]	[250,349,244]	-1	hSpCas9	negative selection	2005394
28812422	28812445	1	-	26627737	HCT116	viability after 15 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	1.2468210294898976	[140]	[152,330,88]	8	hSpCas9	negative selection	2087704
28812541	28812564	1	-	26627737	HCT116	viability after 15 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.9081023727226033	[323]	[537,306,226]	7	hSpCas9	negative selection	2087705
28858996	28859019	1	-	26627737	HCT116	viability after 15 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.10534295475631361	[423]	[227,202,247]	-1	hSpCas9	negative selection	2087706
28859046	28859069	1	+	26627737	HCT116	viability after 15 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.48308884605599234	[778]	[523,912,428]	4	hSpCas9	negative selection	2087707
28862818	28862841	1	-	26627737	HCT116	viability after 15 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.04330250859291651	[485]	[379,282,211]	0	hSpCas9	negative selection	2087708
28863107	28863130	1	-	26627737	HCT116	viability after 15 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-0.5712925540881919	[583]	[405,224,69]	-5	hSpCas9	negative selection	2087709
28812422	28812445	1	-	26627737	HCT116	viability after 18 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	1.222285847409753	[140]	[88,265,112]	8	hSpCas9	negative selection	2170019
28812541	28812564	1	-	26627737	HCT116	viability after 18 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.7858603855238023	[323]	[390,281,129]	6	hSpCas9	negative selection	2170020
28858996	28859019	1	-	26627737	HCT116	viability after 18 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.48675338190738343	[423]	[58,137,246]	-4	hSpCas9	negative selection	2170021
28859046	28859069	1	+	26627737	HCT116	viability after 18 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.31763344428284657	[778]	[372,620,400]	2	hSpCas9	negative selection	2170022
28862818	28862841	1	-	26627737	HCT116	viability after 18 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	-0.40371070909305307	[485]	[175,210,141]	-4	hSpCas9	negative selection	2170023
28863107	28863130	1	-	26627737	HCT116	viability after 18 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-0.32246970926622986	[583]	[328,194,151]	-3	hSpCas9	negative selection	2170024
28822554	28822577	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACTGCAACCTCTGCTCCCCTGG	OPRD1	ENSG00000116329	-1.8290271006759882	[291,377]	[12,27]	-8	dCas9-VP64	positive selection	2406500
28823585	28823608	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGGGTTTCACCATGTTGGCCGGG	OPRD1	ENSG00000116329	2.4187836580270234	[16,66]	[4,98]	7	dCas9-VP64	positive selection	2461454
28842807	28842830	1	-	25494202	A375	resistance to PLX-4720 (puromycin)	TCCCAAAATGTTGGGATTACAAG	OPRD1	ENSG00000116329	-0.9779924112879362	[118,144]	[22,4]	-6	dCas9-VP64	positive selection	2469551
28858022	28858045	1	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGTGGGCGGATCACGAGGTCCAG	OPRD1	ENSG00000116329	2.37985785728498	[230,76]	[300,38]	7	dCas9-VP64	positive selection	2475702
28857855	28857878	1	-	25494202	A375	resistance to PLX-4720 (puromycin)	GAGGTTGCAGTGAGCCGAGATAG	OPRD1	ENSG00000116329	0.6330757747468561	[50,16]	[8,13]	2	dCas9-VP64	positive selection	2476884
28822554	28822577	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACTGCAACCTCTGCTCCCCTGG	OPRD1	ENSG00000116329	0.4396579999349357	[510,531]	[180,277]	3	dCas9-VP64	positive selection	2501755
28823585	28823608	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGGGTTTCACCATGTTGGCCGGG	OPRD1	ENSG00000116329	0.6489514996892785	[92,108]	[43,57]	5	dCas9-VP64	positive selection	2556709
28842807	28842830	1	-	25494202	A375	resistance to PLX-4720 (zeocin)	TCCCAAAATGTTGGGATTACAAG	OPRD1	ENSG00000116329	0.3469774473649052	[51,34]	[26,8]	3	dCas9-VP64	positive selection	2564806
28858022	28858045	1	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGTGGGCGGATCACGAGGTCCAG	OPRD1	ENSG00000116329	0.17249846111827716	[159,84]	[44,44]	1	dCas9-VP64	positive selection	2570957
28857855	28857878	1	-	25494202	A375	resistance to PLX-4720 (zeocin)	GAGGTTGCAGTGAGCCGAGATAG	OPRD1	ENSG00000116329	0.34517561365305327	[29,16]	[7,9]	2	dCas9-VP64	positive selection	2572139
28859039	28859062	1	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.277375958773251	[2,3]	[2,4]	6	hSpCas9	positive selection	3007448
28812541	28812564	1	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.9222694255956541	[1,2]	[2,5]	9	hSpCas9	positive selection	3007449
28812470	28812493	1	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	-0.33532482831819976	[3,3]	[2,2]	-5	hSpCas9	positive selection	3007450
28859069	28859092	1	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTGCAGAGCAGCTCGCCGAAGGG	OPRD1	ENSG00000116329	-0.7271500695948353	[2,2]	[2,0]	-8	hSpCas9	positive selection	3007451
28859039	28859062	1	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.04145505441952757	[2,2]	[3,1]	0	hSpCas9	positive selection	3075306
28812541	28812564	1	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.9853521546263322	[1,1]	[1,3]	9	hSpCas9	positive selection	3075307
28812470	28812493	1	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	-0.18018904827565718	[3,3]	[3,1]	-3	hSpCas9	positive selection	3075308
28859069	28859092	1	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTGCAGAGCAGCTCGCCGAAGGG	OPRD1	ENSG00000116329	-0.7601254248218389	[2,2]	[1,0]	-8	hSpCas9	positive selection	3075309
28859257	28859280		+	24336571	A375	resistance to PLX after 7 days	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.09172530424580116	[17,21]	[18,17]	-3	hSpCas9	positive selection	3132498
28858996	28859019		-	24336571	A375	resistance to PLX after 7 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.13616068385964636	[18,16]	[17,14]	-4	hSpCas9	positive selection	3132499
28812541	28812564		-	24336571	A375	resistance to PLX after 7 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.10692098316161447	[7,8]	[6,7]	-3	hSpCas9	positive selection	3132500
28859194	28859217		-	24336571	A375	resistance to PLX after 7 days	TGGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	-0.25276849838792076	[14,12]	[10,11]	-7	hSpCas9	positive selection	3132501
28859257	28859280		+	24336571	A375	resistance to PLX after 14 days	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.5760668119206453	[18,20]	[7,3]	-6	hSpCas9	positive selection	3190291
28858996	28859019		-	24336571	A375	resistance to PLX after 14 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-1.10521036443089	[25,18]	[3,4]	-9	hSpCas9	positive selection	3190292
28812541	28812564		-	24336571	A375	resistance to PLX after 14 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.49426512536636813	[5,10]	[3,5]	4	hSpCas9	positive selection	3190293
28859194	28859217		-	24336571	A375	resistance to PLX after 14 days	TGGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	-0.041199507209146356	[9,14]	[3,6]	0	hSpCas9	positive selection	3190294
28859257	28859280		+	24336571	A375	viability after 7 days	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	0.26697171715581386	[17]	[17,21]	4	hSpCas9	negative selection	3248084
28858996	28859019		-	24336571	A375	viability after 7 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.4668968536488454	[13]	[18,16]	7	hSpCas9	negative selection	3248085
28812541	28812564		-	24336571	A375	viability after 7 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.3352455939610417	[6]	[7,8]	5	hSpCas9	negative selection	3248086
28859194	28859217		-	24336571	A375	viability after 7 days	TGGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.16023486183580551	[12]	[14,12]	2	hSpCas9	negative selection	3248087
28859257	28859280		+	24336571	A375	viability after 14 days	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	0.25725208235904345	[17]	[18,20]	3	hSpCas9	negative selection	3305877
28858996	28859019		-	24336571	A375	viability after 14 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.7593963455261494	[13]	[25,18]	8	hSpCas9	negative selection	3305878
28812541	28812564		-	24336571	A375	viability after 14 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.36813640553723037	[6]	[5,10]	5	hSpCas9	negative selection	3305879
28859194	28859217		-	24336571	A375	viability after 14 days	TGGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	-0.03311973015759496	[12]	[9,14]	0	hSpCas9	negative selection	3305880
28863236	28863259	1	+	27383988	293T	resistance to West Nile virus (flavivirus)	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	0.6426163673306269	[97,97]	[0,0]	3	hSpCas9	positive selection	3383059
28863061	28863084	1	+	27383988	293T	resistance to West Nile virus (flavivirus)	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.41183616050145994	[114,114]	[0,0]	2	hSpCas9	positive selection	3383060
28859257	28859280	1	+	27383988	293T	resistance to West Nile virus (flavivirus)	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	0.23495839841738073	[129,129]	[0,0]	1	hSpCas9	positive selection	3383061
28859038	28859061	1	+	26780180	HT29	viability (Avana library 4 designs)	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.956659362876892	[]	[]	3	hSpCas9	negative selection	3445382
28812541	28812564	1	-	26780180	HT29	viability (Avana library 4 designs)	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.36263464231787	[]	[]	5	hSpCas9	negative selection	3445383
28812469	28812492	1	+	26780180	HT29	viability (Avana library 4 designs)	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.59171094761373	[]	[]	2	hSpCas9	negative selection	3445384
28859069	28859092	1	-	26780180	HT29	viability (Avana library 4 designs)	TTGCAGAGCAGCTCGCCGAAGGG	OPRD1	ENSG00000116329	0.605377160079961	[]	[]	2	hSpCas9	negative selection	3445385
28812541	28812564	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	5.01870291297361	[]	[]	8	hSpCas9	negative selection	3538085
28812469	28812492	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	7.83496355950972	[]	[]	9	hSpCas9	negative selection	3538086
28859069	28859092	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTGCAGAGCAGCTCGCCGAAGGG	OPRD1	ENSG00000116329	5.32261615082055	[]	[]	8	hSpCas9	negative selection	3538087
28859038	28859061	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	-5.45796220936995	[]	[]	-5	hSpCas9	negative selection	3538088
28812550	28812573	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	ACTCGGCCGTGTGCGCCGTGGGG	OPRD1	ENSG00000116329	7.64316749496502	[]	[]	9	hSpCas9	negative selection	3538089
28859203	28859226	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCTTGGCCTTGGCAGGCGTGCGG	OPRD1	ENSG00000116329	-11.6275653444017	[]	[]	-8	hSpCas9	negative selection	3538090
28812541	28812564	1	-	26780180	A375	viability (Avana lentiGuide)	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	5.06077082314929	[]	[]	4	hSpCas9	negative selection	3646744
28812469	28812492	1	+	26780180	A375	viability (Avana lentiGuide)	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	2.34274553232512	[]	[]	2	hSpCas9	negative selection	3646745
28859069	28859092	1	-	26780180	A375	viability (Avana lentiGuide)	TTGCAGAGCAGCTCGCCGAAGGG	OPRD1	ENSG00000116329	-10.555795675722	[]	[]	-9	hSpCas9	negative selection	3646746
28859038	28859061	1	+	26780180	A375	viability (Avana lentiGuide)	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	-3.25181092190242	[]	[]	-5	hSpCas9	negative selection	3646747
28812550	28812573	1	+	26780180	A375	viability (Avana lentiGuide)	ACTCGGCCGTGTGCGCCGTGGGG	OPRD1	ENSG00000116329	0.136316010356377	[]	[]	0	hSpCas9	negative selection	3646748
28859203	28859226	1	-	26780180	A375	viability (Avana lentiGuide)	GCTTGGCCTTGGCAGGCGTGCGG	OPRD1	ENSG00000116329	7.82468284560965	[]	[]	6	hSpCas9	negative selection	3646749
28812541	28812564	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.3526696411525082	[3]	[6,3]	9	hSpCas9	positive selection	3755403
28812469	28812492	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.32077243920405835	[4]	[6,5]	8	hSpCas9	positive selection	3755404
28859069	28859092	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTGCAGAGCAGCTCGCCGAAGGG	OPRD1	ENSG00000116329	0.09056749497833143	[4]	[5,3]	2	hSpCas9	positive selection	3755405
28859038	28859061	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	-0.2316909376806297	[4]	[4,3]	-4	hSpCas9	positive selection	3755406
28812550	28812573	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACTCGGCCGTGTGCGCCGTGGGG	OPRD1	ENSG00000116329	0.45039791974953847	[5]	[7,7]	9	hSpCas9	positive selection	3755407
28859203	28859226	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTTGGCCTTGGCAGGCGTGCGG	OPRD1	ENSG00000116329	-1.3571297338477555	[3]	[1,0]	-9	hSpCas9	positive selection	3755408
28812541	28812564	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.03268802269867804	[4]	[2,4]	0	hSpCas9	positive selection	3864010
28812469	28812492	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	-0.572781577968966	[5]	[4,0]	-6	hSpCas9	positive selection	3864011
28859069	28859092	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTGCAGAGCAGCTCGCCGAAGGG	OPRD1	ENSG00000116329	0.13934242593500593	[4]	[2,5]	3	hSpCas9	positive selection	3864012
28859038	28859061	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.2752071233633221	[4]	[5,4]	7	hSpCas9	positive selection	3864013
28812550	28812573	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACTCGGCCGTGTGCGCCGTGGGG	OPRD1	ENSG00000116329	0.25836820231783864	[6]	[7,5]	7	hSpCas9	positive selection	3864014
28859203	28859226	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTTGGCCTTGGCAGGCGTGCGG	OPRD1	ENSG00000116329	-0.1088095389069129	[5]	[4,2]	-1	hSpCas9	positive selection	3864015
28863236	28863259	1	+	26780180	A375	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	1.0790300918433	[]	[]	5	hSpCas9	negative selection	3975150
28859257	28859280	1	+	26780180	A375	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	1.3381587586762	[]	[]	7	hSpCas9	negative selection	3975151
28812533	28812556	1	+	26780180	A375	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	1.25886962094202	[]	[]	6	hSpCas9	negative selection	3975152
28812541	28812564	1	-	26780180	A375	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.658479660735053	[]	[]	2	hSpCas9	negative selection	3975153
28863061	28863084	1	+	26780180	A375	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.598744224045813	[]	[]	1	hSpCas9	negative selection	3975154
28859197	28859220	1	+	26780180	A375	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	1.53944400030167	[]	[]	8	hSpCas9	negative selection	3975155
28863236	28863259	1	+	26780180	HT29	viability (GeCKOv2 library)	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	1.50278828475603	[]	[]	7	hSpCas9	negative selection	4083116
28859257	28859280	1	+	26780180	HT29	viability (GeCKOv2 library)	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	1.53957967164609	[]	[]	7	hSpCas9	negative selection	4083117
28812533	28812556	1	+	26780180	HT29	viability (GeCKOv2 library)	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	1.13108613346699	[]	[]	5	hSpCas9	negative selection	4083118
28812541	28812564	1	-	26780180	HT29	viability (GeCKOv2 library)	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.60628763715597	[]	[]	8	hSpCas9	negative selection	4083119
28863061	28863084	1	+	26780180	HT29	viability (GeCKOv2 library)	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.962015463712355	[]	[]	4	hSpCas9	negative selection	4083120
28859197	28859220	1	+	26780180	HT29	viability (GeCKOv2 library)	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	1.53806551263044	[]	[]	7	hSpCas9	negative selection	4083121
28859257	28859280	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	0.007064716762857463	[3]	[2,2]	0	hSpCas9	positive selection	4157291
28858996	28859019	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.1834423322045744	[4]	[2,1]	-4	hSpCas9	positive selection	4157292
28812541	28812564	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.05012443861689511	[3]	[1,2]	-1	hSpCas9	positive selection	4157293
28859194	28859217	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	-0.12015804734089099	[3]	[2,2]	-3	hSpCas9	positive selection	4157294
28859257	28859280	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	0.7341640589257297	[4]	[2,3,0,3]	5	hSpCas9	positive selection	4221313
28858996	28859019	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	1.419551615677327	[3]	[1,3,1,5]	9	hSpCas9	positive selection	4221314
28812541	28812564	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.34192942455522335	[2]	[1,3,1,0]	2	hSpCas9	positive selection	4221315
28859194	28859217	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.5447642458848815	[3]	[4,0,5,0]	4	hSpCas9	positive selection	4221316
28812541	28812564	1	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.13593760401715838	[1]	[1,0]	-3	hSpCas9	positive selection	4287096
28812533	28812556	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	-0.31579045511649645	[2]	[1,0]	-6	hSpCas9	positive selection	4287097
28859197	28859220	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.08097756024488037	[2]	[2,1]	1	hSpCas9	positive selection	4287098
28863236	28863259	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.5765509829706239	[2]	[2,0]	-8	hSpCas9	positive selection	4351351
28863061	28863084	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.12831953364090587	[2]	[2,1]	2	hSpCas9	positive selection	4351352
28859257	28859280	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.15472708291338452	[3]	[1,1]	-3	hSpCas9	positive selection	4351353
28812550	28812572	1	+	27760321	OCIAML3	viability	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	-0.2258485286231	[1107,937]	[557,842]	-2	hSpCas9	negative selection	4424670
28812590	28812612	1	+	27760321	OCIAML3	viability	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	-0.3758799185356509	[820,756]	[468,483]	-4	hSpCas9	negative selection	4424671
28859001	28859023	1	-	27760321	OCIAML3	viability	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	-0.21569004561392585	[540,424]	[254,411]	-2	hSpCas9	negative selection	4424672
28859194	28859216	1	-	27760321	OCIAML3	viability	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.5789011395776479	[957,747]	[901,1103]	7	hSpCas9	negative selection	4424673
28859248	28859270	1	-	27760321	OCIAML3	viability	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	0.5556893135750403	[685,509]	[627,750]	6	hSpCas9	negative selection	4424674
28812550	28812572	1	+	27760321	OCIAML2	viability	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	0.0797150189343403	[1107,937]	[820,937]	1	hSpCas9	negative selection	4508133
28812590	28812612	1	+	27760321	OCIAML2	viability	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	-0.20545178382768547	[820,756]	[455,681]	-3	hSpCas9	negative selection	4508134
28859001	28859023	1	-	27760321	OCIAML2	viability	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	0.2170704977395006	[540,424]	[423,486]	3	hSpCas9	negative selection	4508135
28859194	28859216	1	-	27760321	OCIAML2	viability	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.19575309147948305	[957,747]	[648,963]	2	hSpCas9	negative selection	4508136
28859248	28859270	1	-	27760321	OCIAML2	viability	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	0.5402745711707144	[685,509]	[629,785]	7	hSpCas9	negative selection	4508137
28812550	28812572	1	+	27760321	MV411	viability	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	1.1928959361440539	[1107,937]	[1594,1451]	8	hSpCas9	negative selection	4591596
28812590	28812612	1	+	27760321	MV411	viability	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	0.318475140131498	[820,756]	[217,1296]	2	hSpCas9	negative selection	4591597
28859001	28859023	1	-	27760321	MV411	viability	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	1.3753590405744611	[540,424]	[892,713]	8	hSpCas9	negative selection	4591598
28859194	28859216	1	-	27760321	MV411	viability	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	1.5035984520277452	[957,747]	[1583,1586]	9	hSpCas9	negative selection	4591599
28859248	28859270	1	-	27760321	MV411	viability	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	1.6700680710651423	[685,509]	[1430,964]	9	hSpCas9	negative selection	4591600
28812550	28812572	1	+	27760321	HL60	viability	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	2.723088370797695	[1107,937]	[6003,4961]	9	hSpCas9	negative selection	4675059
28812590	28812612	1	+	27760321	HL60	viability	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	-0.7583923160650786	[820,756]	[330,433]	-7	hSpCas9	negative selection	4675060
28859001	28859023	1	-	27760321	HL60	viability	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	-0.0612686561367365	[540,424]	[380,369]	0	hSpCas9	negative selection	4675061
28859194	28859216	1	-	27760321	HL60	viability	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.24930968861911162	[957,747]	[692,959]	3	hSpCas9	negative selection	4675062
28859248	28859270	1	-	27760321	HL60	viability	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	0.45719087280164655	[685,509]	[655,673]	5	hSpCas9	negative selection	4675063
28812550	28812572	1	+	27760321	HT1080	viability	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	0.9296048618891917	[937,731]	[624,642]	5	hSpCas9	negative selection	4758522
28812590	28812612	1	+	27760321	HT1080	viability	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	0.04545203909609352	[756,590]	[352,193]	0	hSpCas9	negative selection	4758523
28859001	28859023	1	-	27760321	HT1080	viability	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	0.3716894919934301	[424,331]	[112,284]	2	hSpCas9	negative selection	4758524
28859194	28859216	1	-	27760321	HT1080	viability	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	1.148428881737846	[747,583]	[685,480]	6	hSpCas9	negative selection	4758525
28859248	28859270	1	-	27760321	HT1080	viability	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	0.7193821478915292	[509,397]	[250,348]	4	hSpCas9	negative selection	4758526
28812550	28812572	1	+	27760321	HT29	viability after 7 days	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	0.3567841514356427	[937,731]	[1236,1246,1610]	5	hSpCas9	negative selection	4841985
28812590	28812612	1	+	27760321	HT29	viability after 7 days	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	-0.7339115920387196	[756,590]	[808,512,288]	-7	hSpCas9	negative selection	4841986
28859001	28859023	1	-	27760321	HT29	viability after 7 days	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	0.7240234282364463	[424,331]	[1057,721,670]	9	hSpCas9	negative selection	4841987
28859194	28859216	1	-	27760321	HT29	viability after 7 days	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.29681144763593315	[747,583]	[1150,986,1030]	4	hSpCas9	negative selection	4841988
28859248	28859270	1	-	27760321	HT29	viability after 7 days	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	0.9458148220585179	[509,397]	[949,1123,1267]	9	hSpCas9	negative selection	4841989
28812550	28812572	1	+	27760321	HT29	viability after 25 days	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	0.40113658490248705	[937,731]	[1325,1173,1275]	4	hSpCas9	negative selection	4925448
28812590	28812612	1	+	27760321	HT29	viability after 25 days	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	-0.026198454959355355	[756,590]	[830,825,588]	0	hSpCas9	negative selection	4925449
28859001	28859023	1	-	27760321	HT29	viability after 25 days	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	0.6109063914207754	[424,331]	[535,574,902]	7	hSpCas9	negative selection	4925450
28859194	28859216	1	-	27760321	HT29	viability after 25 days	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.5720445825080416	[747,583]	[1038,1104,1268]	6	hSpCas9	negative selection	4925451
28859248	28859270	1	-	27760321	HT29	viability after 25 days	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	1.0848583492161947	[509,397]	[1041,778,1526]	9	hSpCas9	negative selection	4925452
28812550	28812572	1	+	27760321	HT29	viability after 22 days	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	0.4124013611510047	[937,731]	[891,1446,1527]	4	hSpCas9	negative selection	5008911
28812590	28812612	1	+	27760321	HT29	viability after 22 days	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	0.05009382203792667	[756,590]	[927,771,715]	0	hSpCas9	negative selection	5008912
28859001	28859023	1	-	27760321	HT29	viability after 22 days	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	0.7549342569123603	[424,331]	[676,487,1054]	8	hSpCas9	negative selection	5008913
28859194	28859216	1	-	27760321	HT29	viability after 22 days	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.5933449504849044	[747,583]	[1168,1122,1192]	6	hSpCas9	negative selection	5008914
28859248	28859270	1	-	27760321	HT29	viability after 22 days	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	0.9030890351282275	[509,397]	[984,908,1050]	9	hSpCas9	negative selection	5008915
28812550	28812572	1	+	27760321	HT29	viability after 19 days	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	0.4961769553587909	[937,731]	[1151,1184,1669]	5	hSpCas9	negative selection	5092374
28812590	28812612	1	+	27760321	HT29	viability after 19 days	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	0.18825056490229808	[756,590]	[671,882,1050]	1	hSpCas9	negative selection	5092375
28859001	28859023	1	-	27760321	HT29	viability after 19 days	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	0.6290118023249741	[424,331]	[775,461,776]	6	hSpCas9	negative selection	5092376
28859194	28859216	1	-	27760321	HT29	viability after 19 days	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.7872712659207348	[747,583]	[1666,738,1563]	7	hSpCas9	negative selection	5092377
28859248	28859270	1	-	27760321	HT29	viability after 19 days	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	0.7617669944443899	[509,397]	[795,962,872]	7	hSpCas9	negative selection	5092378
28812550	28812572	1	+	27760321	HT29	viability after 16 days	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	0.4088150308053149	[937,731]	[1077,1246,1379]	4	hSpCas9	negative selection	5175837
28812590	28812612	1	+	27760321	HT29	viability after 16 days	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	-0.04193949042722689	[756,590]	[826,933,439]	0	hSpCas9	negative selection	5175838
28859001	28859023	1	-	27760321	HT29	viability after 16 days	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	0.5241603797901825	[424,331]	[735,530,573]	6	hSpCas9	negative selection	5175839
28859194	28859216	1	-	27760321	HT29	viability after 16 days	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.7021483108872126	[747,583]	[1103,1458,1056]	8	hSpCas9	negative selection	5175840
28859248	28859270	1	-	27760321	HT29	viability after 16 days	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	1.0731314094020237	[509,397]	[1067,1253,878]	9	hSpCas9	negative selection	5175841
28812550	28812572	1	+	27760321	HT29	viability after 13 days	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	0.4706824973892312	[937,731]	[1606,1447,992]	6	hSpCas9	negative selection	5259300
28812590	28812612	1	+	27760321	HT29	viability after 13 days	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	-0.4359860561916559	[756,590]	[541,682,512]	-5	hSpCas9	negative selection	5259301
28859001	28859023	1	-	27760321	HT29	viability after 13 days	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	0.6204761648789914	[424,331]	[676,635,709]	7	hSpCas9	negative selection	5259302
28859194	28859216	1	-	27760321	HT29	viability after 13 days	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.5605714946623805	[747,583]	[1040,1158,1213]	7	hSpCas9	negative selection	5259303
28859248	28859270	1	-	27760321	HT29	viability after 13 days	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	1.0275938436754934	[509,397]	[1014,1045,1154]	9	hSpCas9	negative selection	5259304
28812550	28812572	1	+	27760321	HT29	viability after 10 days	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	0.3118681425471963	[937,731]	[1391,1407,1089]	4	hSpCas9	negative selection	5342763
28812590	28812612	1	+	27760321	HT29	viability after 10 days	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	-0.34895182557496573	[756,590]	[615,918,458]	-4	hSpCas9	negative selection	5342764
28859001	28859023	1	-	27760321	HT29	viability after 10 days	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	0.4714182300065986	[424,331]	[558,564,834]	6	hSpCas9	negative selection	5342765
28859194	28859216	1	-	27760321	HT29	viability after 10 days	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.5212246756423076	[747,583]	[968,1231,1375]	7	hSpCas9	negative selection	5342766
28859248	28859270	1	-	27760321	HT29	viability after 10 days	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	0.688648285963815	[509,397]	[863,1061,820]	8	hSpCas9	negative selection	5342767
28812550	28812572	1	+	27760321	MOLM13	viability	ACTCGGCCGTGTGCGCCGTGGG	OPRD1	ENSG00000116329	-0.24523414084750506	[1107,937]	[804,212]	-2	hSpCas9	negative selection	5426226
28812590	28812612	1	+	27760321	MOLM13	viability	TGTCATGTTCGGCATCGTCCGG	OPRD1	ENSG00000116329	0.6648730507559006	[820,756]	[500,879]	4	hSpCas9	negative selection	5426227
28859001	28859023	1	-	27760321	MOLM13	viability	GTGGCCAGCGCATCGGCTAAGG	OPRD1	ENSG00000116329	1.0078819932500427	[540,424]	[760,359]	7	hSpCas9	negative selection	5426228
28859194	28859216	1	-	27760321	MOLM13	viability	GGCAGGCGTGCGGAAGTCCAGG	OPRD1	ENSG00000116329	0.10836110378523067	[957,747]	[652,397]	0	hSpCas9	negative selection	5426229
28859248	28859270	1	-	27760321	MOLM13	viability	CACGCCAACGCCTGAGGCCAGG	OPRD1	ENSG00000116329	0.780082542680105	[685,509]	[583,565]	5	hSpCas9	negative selection	5426230
28812238	28812261	1	+	27661255	K562	viability	GACGAGGCGCAGAGACAGCGGGG	OPRD1	ENSG00000116329	0.1595851573836311	[1330,1340]	[1247,1143]	5	dCas9-KRAB	negative selection	5498476
28812336	28812359	1	+	27661255	K562	viability	GCCCAGGGCGCACGGTGGAGAGG	OPRD1	ENSG00000116329	-0.6950105441635923	[258,337]	[185,112]	-8	dCas9-KRAB	negative selection	5498477
28812343	28812366	1	+	27661255	K562	viability	GCGCACGGTGGAGAGGGACGCGG	OPRD1	ENSG00000116329	-0.5450856002963286	[449,477]	[263,244]	-8	dCas9-KRAB	negative selection	5498478
28812420	28812443	1	-	27661255	K562	viability	GAGGCGTTGGCGAAGAGCGGGGG	OPRD1	ENSG00000116329	-0.5056916382652218	[622,864]	[508,336]	-7	dCas9-KRAB	negative selection	5498479
28812541	28812564	1	-	27661255	K562	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.06223831182560735	[207,201]	[157,155]	-2	dCas9-KRAB	negative selection	5498480
28812541	28812564	1	-	27260156	BXPC3	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.05494398050210081	[132]	[93,129,145,222]	1	hSpCas9	negative selection	5559556
28812533	28812556	1	+	27260156	BXPC3	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.10677297318770584	[210]	[179,218,258,306]	2	hSpCas9	negative selection	5559557
28859197	28859220	1	+	27260156	BXPC3	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.06706448550702093	[306]	[280,278,361,443]	1	hSpCas9	negative selection	5559558
28863236	28863259	1	+	27260156	BXPC3	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.47933844052297403	[423]	[237,240,325,500]	-8	hSpCas9	negative selection	5623811
28863061	28863084	1	+	27260156	BXPC3	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.06987255525551472	[376]	[349,390,515,403]	1	hSpCas9	negative selection	5623812
28859257	28859280	1	+	27260156	BXPC3	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.03764248873458924	[487]	[432,557,419,586]	-1	hSpCas9	negative selection	5623813
28812541	28812564	1	-	27260156	A673	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.027089969345183373	[132]	[210,130,130,160]	0	hSpCas9	negative selection	5680807
28812533	28812556	1	+	27260156	A673	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.29770653985495177	[210]	[335,309,306,293]	7	hSpCas9	negative selection	5680808
28859197	28859220	1	+	27260156	A673	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.2545779324567273	[306]	[466,479,444,363]	6	hSpCas9	negative selection	5680809
28863236	28863259	1	+	27260156	A673	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.3930555338459518	[423]	[443,370,357,383]	-7	hSpCas9	negative selection	5745062
28863061	28863084	1	+	27260156	A673	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.20991025127998159	[376]	[688,503,440,476]	5	hSpCas9	negative selection	5745063
28859257	28859280	1	+	27260156	A673	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.2758934548618207	[487]	[553,451,498,435]	-6	hSpCas9	negative selection	5745064
28812541	28812564	1	-	27260156	A375	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.6999994566157977	[132]	[132,483,227,200]	9	hSpCas9	negative selection	5802058
28812533	28812556	1	+	27260156	A375	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.5625711800141568	[210]	[249,517,360,347]	8	hSpCas9	negative selection	5802059
28859197	28859220	1	+	27260156	A375	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.22380268504293194	[306]	[420,550,404,325]	3	hSpCas9	negative selection	5802060
28863236	28863259	1	+	27260156	A375	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.4724650508696159	[423]	[508,286,322,304]	-6	hSpCas9	negative selection	5866313
28863061	28863084	1	+	27260156	A375	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.06320101627809249	[376]	[602,424,331,472]	0	hSpCas9	negative selection	5866314
28859257	28859280	1	+	27260156	A375	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.03583991628768165	[487]	[524,647,501,558]	0	hSpCas9	negative selection	5866315
28812541	28812564	1	-	27260156	COLO741	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.06388065917389896	[132]	[160,176,191]	1	hSpCas9	negative selection	5923309
28812533	28812556	1	+	27260156	COLO741	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.3782659526331287	[210]	[426,337,295]	7	hSpCas9	negative selection	5923310
28859197	28859220	1	+	27260156	COLO741	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.28163538750147227	[306]	[564,496,381]	6	hSpCas9	negative selection	5923311
28863236	28863259	1	+	27260156	COLO741	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.42810984333297997	[423]	[315,496,387]	-7	hSpCas9	negative selection	5987564
28863061	28863084	1	+	27260156	COLO741	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.0833003474443082	[376]	[493,600,438]	1	hSpCas9	negative selection	5987565
28859257	28859280	1	+	27260156	COLO741	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.15044662150214352	[487]	[596,639,457]	-3	hSpCas9	negative selection	5987566
28812541	28812564	1	-	27260156	CAL120	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.12391404487408586	[132]	[126,181,142]	-2	hSpCas9	negative selection	6044560
28812533	28812556	1	+	27260156	CAL120	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.5151263961547724	[210]	[393,281,450]	7	hSpCas9	negative selection	6044561
28859197	28859220	1	+	27260156	CAL120	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.07446891150759527	[306]	[486,420,312]	1	hSpCas9	negative selection	6044562
28863236	28863259	1	+	27260156	CAL120	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.36691967888898513	[423]	[697,403,172]	-5	hSpCas9	negative selection	6108815
28863061	28863084	1	+	27260156	CAL120	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.3549400848810814	[376]	[835,553,447]	5	hSpCas9	negative selection	6108816
28859257	28859280	1	+	27260156	CAL120	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.4401999243736419	[487]	[258,542,510]	-6	hSpCas9	negative selection	6108817
28812541	28812564	1	-	27260156	CADOES1	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.21347466797331993	[132]	[180,97,163,129]	3	hSpCas9	negative selection	6165811
28812533	28812556	1	+	27260156	CADOES1	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.5492111956478646	[210]	[244,498,250,148]	8	hSpCas9	negative selection	6165812
28859197	28859220	1	+	27260156	CADOES1	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.24246439115918406	[306]	[471,200,428,244]	4	hSpCas9	negative selection	6165813
28863236	28863259	1	+	27260156	CADOES1	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.8407281361283333	[423]	[230,170,222,256]	-9	hSpCas9	negative selection	6230066
28863061	28863084	1	+	27260156	CADOES1	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	-0.146838747673052	[376]	[255,337,406,263]	-3	hSpCas9	negative selection	6230067
28859257	28859280	1	+	27260156	CADOES1	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.16993512965353588	[487]	[440,478,336,354]	-3	hSpCas9	negative selection	6230068
28812541	28812564	1	-	27260156	EWS502	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.4208204986528321	[132]	[183,177,200,191]	7	hSpCas9	negative selection	6287062
28812533	28812556	1	+	27260156	EWS502	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.40455862048179037	[210]	[343,312,230,285]	7	hSpCas9	negative selection	6287063
28859197	28859220	1	+	27260156	EWS502	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.4134628918406631	[306]	[386,485,379,483]	7	hSpCas9	negative selection	6287064
28863236	28863259	1	+	27260156	EWS502	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.3166892395726601	[423]	[298,381,376,391]	-5	hSpCas9	negative selection	6351317
28863061	28863084	1	+	27260156	EWS502	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.3704964699844031	[376]	[367,522,447,757]	6	hSpCas9	negative selection	6351318
28859257	28859280	1	+	27260156	EWS502	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.09568611592060458	[487]	[330,510,503,613]	-2	hSpCas9	negative selection	6351319
28812541	28812564	1	-	27260156	EW8	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.14130335573871444	[132]	[136,51,122,163]	2	hSpCas9	negative selection	6408313
28812533	28812556	1	+	27260156	EW8	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.5889542151476256	[210]	[254,231,272,264]	9	hSpCas9	negative selection	6408314
28859197	28859220	1	+	27260156	EW8	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.04042910569583169	[306]	[211,201,197,414]	0	hSpCas9	negative selection	6408315
28863236	28863259	1	+	27260156	EW8	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	0.04380286067337934	[423]	[434,402,307,286]	0	hSpCas9	negative selection	6472568
28863061	28863084	1	+	27260156	EW8	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.28922511749650753	[376]	[352,472,401,257]	5	hSpCas9	negative selection	6472569
28859257	28859280	1	+	27260156	EW8	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	0.00139019572400792	[487]	[372,456,390,359]	0	hSpCas9	negative selection	6472570
28812541	28812564	1	-	27260156	CORL105	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.19403789552462092	[132]	[167,192,216,139]	3	hSpCas9	negative selection	6529564
28812533	28812556	1	+	27260156	CORL105	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.2286893212772786	[210]	[290,225,359,292]	4	hSpCas9	negative selection	6529565
28859197	28859220	1	+	27260156	CORL105	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.10175800788947431	[306]	[402,382,352,398]	2	hSpCas9	negative selection	6529566
28863236	28863259	1	+	27260156	CORL105	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	0.17474352231694118	[423]	[732,472,641,413]	3	hSpCas9	negative selection	6593819
28863061	28863084	1	+	27260156	CORL105	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.4595566270719145	[376]	[525,685,618,593]	8	hSpCas9	negative selection	6593820
28859257	28859280	1	+	27260156	CORL105	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	0.09033533427994328	[487]	[697,475,619,645]	1	hSpCas9	negative selection	6593821
28812541	28812564	1	-	27260156	HS294T	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.2160232044235957	[132]	[83,186,50,163]	9	hSpCas9	negative selection	6650815
28812533	28812556	1	+	27260156	HS294T	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	-0.1132779936681394	[210]	[58,59,76,113]	-1	hSpCas9	negative selection	6650816
28859197	28859220	1	+	27260156	HS294T	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.30263463880520863	[306]	[83,203,150,150]	4	hSpCas9	negative selection	6650817
28863236	28863259	1	+	27260156	HS294T	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	0.05555149955718962	[423]	[112,149,239,186]	0	hSpCas9	negative selection	6715070
28863061	28863084	1	+	27260156	HS294T	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.36413420406209057	[376]	[110,188,170,305]	5	hSpCas9	negative selection	6715071
28859257	28859280	1	+	27260156	HS294T	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.23192493611500387	[487]	[158,155,123,211]	-3	hSpCas9	negative selection	6715072
28812541	28812564	1	-	27260156	HCC44	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.13806128154055997	[132]	[156,100,91,192]	-2	hSpCas9	negative selection	6772066
28812533	28812556	1	+	27260156	HCC44	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.36950945500210863	[210]	[407,238,387,230]	6	hSpCas9	negative selection	6772067
28859197	28859220	1	+	27260156	HCC44	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.16486945139864878	[306]	[436,280,463,403]	2	hSpCas9	negative selection	6772068
28863236	28863259	1	+	27260156	HCC44	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.7918307639845197	[423]	[256,155,451,285]	-8	hSpCas9	negative selection	6836321
28863061	28863084	1	+	27260156	HCC44	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.16361965815283477	[376]	[447,312,545,626]	2	hSpCas9	negative selection	6836322
28859257	28859280	1	+	27260156	HCC44	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.20958389298359023	[487]	[424,457,516,508]	-3	hSpCas9	negative selection	6836323
28812541	28812564	1	-	27260156	G402	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.21654233522953903	[132]	[247,201,83,226]	2	hSpCas9	negative selection	6893317
28812533	28812556	1	+	27260156	G402	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.24811978968160564	[210]	[488,357,216,192]	3	hSpCas9	negative selection	6893318
28859197	28859220	1	+	27260156	G402	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	-0.058786022665786475	[306]	[370,377,481,215]	0	hSpCas9	negative selection	6893319
28863236	28863259	1	+	27260156	G402	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.49922757802477213	[423]	[306,480,415,261]	-6	hSpCas9	negative selection	6957572
28863061	28863084	1	+	27260156	G402	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.13639445700179673	[376]	[844,396,479,348]	1	hSpCas9	negative selection	6957573
28859257	28859280	1	+	27260156	G402	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.6157875959081845	[487]	[239,822,282,218]	-6	hSpCas9	negative selection	6957574
28812541	28812564	1	-	27260156	L33	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.1425785947072038	[132]	[119,48,141,122]	3	hSpCas9	negative selection	7014568
28812533	28812556	1	+	27260156	L33	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.2770014367310223	[210]	[178,120,163,288]	6	hSpCas9	negative selection	7014569
28859197	28859220	1	+	27260156	L33	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.2543156266687872	[306]	[366,179,187,358]	5	hSpCas9	negative selection	7014570
28863236	28863259	1	+	27260156	L33	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	0.05506409614402527	[423]	[505,182,242,420]	1	hSpCas9	negative selection	7078823
28863061	28863084	1	+	27260156	L33	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.2670356046354264	[376]	[318,196,410,365]	6	hSpCas9	negative selection	7078824
28859257	28859280	1	+	27260156	L33	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.10012907094158727	[487]	[479,174,282,462]	-2	hSpCas9	negative selection	7078825
28812541	28812564	1	-	27260156	K562	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.09492487449275244	[132]	[187,90,130,99]	1	hSpCas9	negative selection	7135819
28812533	28812556	1	+	27260156	K562	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.6632084807476466	[210]	[298,177,557,159]	8	hSpCas9	negative selection	7135820
28859197	28859220	1	+	27260156	K562	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.37914072125695875	[306]	[395,424,304,302]	5	hSpCas9	negative selection	7135821
28863236	28863259	1	+	27260156	K562	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.7276729599620754	[423]	[460,192,135,144]	-7	hSpCas9	negative selection	7200074
28863061	28863084	1	+	27260156	K562	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.6781358472123713	[376]	[492,849,310,501]	8	hSpCas9	negative selection	7200075
28859257	28859280	1	+	27260156	K562	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.0693550152354657	[487]	[565,393,412,300]	-1	hSpCas9	negative selection	7200076
28812541	28812564	1	-	27260156	HT29	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.06953302791401428	[132]	[61,174,201,168]	-1	hSpCas9	negative selection	7257070
28812533	28812556	1	+	27260156	HT29	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.21277309278266743	[210]	[293,299,323,271]	4	hSpCas9	negative selection	7257071
28859197	28859220	1	+	27260156	HT29	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.39860035222498313	[306]	[480,609,403,479]	7	hSpCas9	negative selection	7257072
28863236	28863259	1	+	27260156	HT29	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.12061657703993645	[423]	[478,472,411,522]	-2	hSpCas9	negative selection	7321325
28863061	28863084	1	+	27260156	HT29	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.21016094131554677	[376]	[477,574,599,470]	4	hSpCas9	negative selection	7321326
28859257	28859280	1	+	27260156	HT29	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.16594823114376622	[487]	[665,612,518,352]	-3	hSpCas9	negative selection	7321327
28812541	28812564	1	-	27260156	MHHES1	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.1492586058495471	[132]	[140,167,319,55]	2	hSpCas9	negative selection	7378321
28812533	28812556	1	+	27260156	MHHES1	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.5421030358451266	[210]	[349,318,480,247]	8	hSpCas9	negative selection	7378322
28859197	28859220	1	+	27260156	MHHES1	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.41752037582358326	[306]	[717,470,358,346]	7	hSpCas9	negative selection	7378323
28863236	28863259	1	+	27260156	MHHES1	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.37712418757924326	[423]	[363,433,448,249]	-6	hSpCas9	negative selection	7442576
28863061	28863084	1	+	27260156	MHHES1	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.12906532828215045	[376]	[497,569,396,408]	2	hSpCas9	negative selection	7442577
28859257	28859280	1	+	27260156	MHHES1	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.4366555558734824	[487]	[512,408,423,305]	-7	hSpCas9	negative selection	7442578
28812541	28812564	1	-	27260156	MEWO	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.7669668200450863	[132]	[214,171,248]	9	hSpCas9	negative selection	7499572
28812533	28812556	1	+	27260156	MEWO	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.2972533231012602	[210]	[246,347,132]	6	hSpCas9	negative selection	7499573
28859197	28859220	1	+	27260156	MEWO	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.3497358779160255	[306]	[388,447,264]	7	hSpCas9	negative selection	7499574
28863236	28863259	1	+	27260156	MEWO	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.4099610907091855	[423]	[447,207,268]	-7	hSpCas9	negative selection	7563827
28863061	28863084	1	+	27260156	MEWO	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.22497085200619366	[376]	[595,246,429]	5	hSpCas9	negative selection	7563828
28859257	28859280	1	+	27260156	MEWO	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	0.3828077019331842	[487]	[778,457,584]	7	hSpCas9	negative selection	7563829
28812541	28812564	1	-	27260156	LNCAPCLONEFGC	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.4783515323044061	[132]	[131,160,191,190]	7	hSpCas9	negative selection	7620823
28812533	28812556	1	+	27260156	LNCAPCLONEFGC	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.5182999240076267	[210]	[269,268,251,300]	7	hSpCas9	negative selection	7620824
28859197	28859220	1	+	27260156	LNCAPCLONEFGC	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.3647936249445555	[306]	[341,308,433,361]	6	hSpCas9	negative selection	7620825
28863236	28863259	1	+	27260156	LNCAPCLONEFGC	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.4472207990084833	[423]	[398,247,297,183]	-6	hSpCas9	negative selection	7685078
28863061	28863084	1	+	27260156	LNCAPCLONEFGC	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.044254427613312164	[376]	[416,194,476,346]	0	hSpCas9	negative selection	7685079
28859257	28859280	1	+	27260156	LNCAPCLONEFGC	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.1401227143464816	[487]	[458,308,486,366]	-2	hSpCas9	negative selection	7685080
28812541	28812564	1	-	27260156	PANC0327	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.41944579969832585	[132]	[62,97,90,97]	-6	hSpCas9	negative selection	7742074
28812533	28812556	1	+	27260156	PANC0327	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.7199309744800848	[210]	[377,413,306,127]	9	hSpCas9	negative selection	7742075
28859197	28859220	1	+	27260156	PANC0327	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.5588205613309113	[306]	[483,261,617,267]	7	hSpCas9	negative selection	7742076
28863236	28863259	1	+	27260156	PANC0327	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	0.056064424681884203	[423]	[264,288,450,563]	0	hSpCas9	negative selection	7806329
28863061	28863084	1	+	27260156	PANC0327	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.09285318555329294	[376]	[426,343,369,294]	1	hSpCas9	negative selection	7806330
28859257	28859280	1	+	27260156	PANC0327	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	0.09854104213573034	[487]	[304,712,325,466]	1	hSpCas9	negative selection	7806331
28812541	28812564	1	-	27260156	NCIH2009	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.5190939805793784	[132]	[155,73,164]	-6	hSpCas9	negative selection	7863325
28812533	28812556	1	+	27260156	NCIH2009	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.6915645056732218	[210]	[538,583,314]	8	hSpCas9	negative selection	7863326
28859197	28859220	1	+	27260156	NCIH2009	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.8192804461511582	[306]	[792,834,646]	9	hSpCas9	negative selection	7863327
28863236	28863259	1	+	27260156	NCIH2009	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.17894024779959278	[423]	[571,391,616]	-2	hSpCas9	negative selection	7927580
28863061	28863084	1	+	27260156	NCIH2009	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.23715592083773068	[376]	[741,532,611]	3	hSpCas9	negative selection	7927581
28859257	28859280	1	+	27260156	NCIH2009	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.003354523099516525	[487]	[608,594,822]	0	hSpCas9	negative selection	7927582
28812541	28812564	1	-	27260156	NCIH1373	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.17292133044047797	[132]	[170,119,80,82]	1	hSpCas9	negative selection	7984576
28812533	28812556	1	+	27260156	NCIH1373	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.6875236414337873	[210]	[327,267,436,130]	6	hSpCas9	negative selection	7984577
28859197	28859220	1	+	27260156	NCIH1373	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.4186668901681726	[306]	[270,536,364,167]	4	hSpCas9	negative selection	7984578
28863236	28863259	1	+	27260156	NCIH1373	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.48043492612107275	[423]	[471,348,243,82]	-5	hSpCas9	negative selection	8048831
28863061	28863084	1	+	27260156	NCIH1373	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.26255546859621126	[376]	[443,701,316,140]	2	hSpCas9	negative selection	8048832
28859257	28859280	1	+	27260156	NCIH1373	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.22693508673448498	[487]	[530,339,640,96]	-2	hSpCas9	negative selection	8048833
28812541	28812564	1	-	27260156	PATU8902	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.9487007855607318	[132]	[469,313,439,155]	8	hSpCas9	negative selection	8105827
28812533	28812556	1	+	27260156	PATU8902	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	1.0957301104674604	[210]	[844,271,710,656]	9	hSpCas9	negative selection	8105828
28859197	28859220	1	+	27260156	PATU8902	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.8847896980429775	[306]	[904,953,676,623]	8	hSpCas9	negative selection	8105829
28863236	28863259	1	+	27260156	PATU8902	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.35182275446475564	[423]	[279,647,512,386]	-4	hSpCas9	negative selection	8170082
28863061	28863084	1	+	27260156	PATU8902	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	-0.2922454224125734	[376]	[415,579,145,672]	-3	hSpCas9	negative selection	8170083
28859257	28859280	1	+	27260156	PATU8902	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.9578564326968934	[487]	[223,726,234,228]	-7	hSpCas9	negative selection	8170084
28812541	28812564	1	-	27260156	PANC1	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.13964790772160418	[132]	[123,96,111,156]	2	hSpCas9	negative selection	8227078
28812533	28812556	1	+	27260156	PANC1	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	-0.0661667710908016	[210]	[170,206,182,140]	-1	hSpCas9	negative selection	8227079
28859197	28859220	1	+	27260156	PANC1	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	-0.16869299729116294	[306]	[185,296,195,263]	-3	hSpCas9	negative selection	8227080
28863236	28863259	1	+	27260156	PANC1	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.7225630079233303	[423]	[102,352,225,225]	-8	hSpCas9	negative selection	8291333
28863061	28863084	1	+	27260156	PANC1	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	-0.174045179006736	[376]	[270,326,341,222]	-3	hSpCas9	negative selection	8291334
28859257	28859280	1	+	27260156	PANC1	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.30554099183398853	[487]	[344,278,489,241]	-5	hSpCas9	negative selection	8291335
28812541	28812564	1	-	27260156	PANC0813	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.3975307281250924	[132]	[154,81,162,79]	-6	hSpCas9	negative selection	8348329
28812533	28812556	1	+	27260156	PANC0813	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.2992816291573861	[210]	[398,233,356,241]	5	hSpCas9	negative selection	8348330
28859197	28859220	1	+	27260156	PANC0813	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.34634264625613126	[306]	[526,548,447,322]	5	hSpCas9	negative selection	8348331
28863236	28863259	1	+	27260156	PANC0813	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.2711354266374132	[423]	[350,425,494,374]	-4	hSpCas9	negative selection	8412584
28863061	28863084	1	+	27260156	PANC0813	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.03499868737113493	[376]	[668,486,396,289]	0	hSpCas9	negative selection	8412585
28859257	28859280	1	+	27260156	PANC0813	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.3361210775543462	[487]	[622,319,481,408]	-5	hSpCas9	negative selection	8412586
28812541	28812564	1	-	27260156	RDES	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.30016611998162834	[132]	[149,88,227,320]	5	hSpCas9	negative selection	8469580
28812533	28812556	1	+	27260156	RDES	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.5742772326913549	[210]	[281,290,399,509]	8	hSpCas9	negative selection	8469581
28859197	28859220	1	+	27260156	RDES	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.1849084754319656	[306]	[333,271,365,691]	3	hSpCas9	negative selection	8469582
28863236	28863259	1	+	27260156	RDES	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.5761856929012374	[423]	[261,248,381,447]	-7	hSpCas9	negative selection	8533835
28863061	28863084	1	+	27260156	RDES	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.025560042922815607	[376]	[389,438,458,480]	0	hSpCas9	negative selection	8533836
28859257	28859280	1	+	27260156	RDES	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.25036903653282955	[487]	[362,405,471,696]	-4	hSpCas9	negative selection	8533837
28812541	28812564	1	-	27260156	PC3	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.20398593620679772	[132]	[91,35,229,149]	-4	hSpCas9	negative selection	8590831
28812533	28812556	1	+	27260156	PC3	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	-0.04535054303681485	[210]	[155,112,295,292]	-1	hSpCas9	negative selection	8590832
28859197	28859220	1	+	27260156	PC3	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.2660855353885134	[306]	[168,358,589,506]	6	hSpCas9	negative selection	8590833
28863236	28863259	1	+	27260156	PC3	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.301007200743501	[423]	[287,200,532,416]	-6	hSpCas9	negative selection	8655086
28863061	28863084	1	+	27260156	PC3	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.08543995455743553	[376]	[264,379,816,310]	2	hSpCas9	negative selection	8655087
28859257	28859280	1	+	27260156	PC3	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.002038924368001273	[487]	[347,417,1028,365]	0	hSpCas9	negative selection	8655088
28812541	28812564	1	-	27260156	PATU8988T	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.04797418620742544	[132]	[226,61,127,69]	-1	hSpCas9	negative selection	8712082
28812533	28812556	1	+	27260156	PATU8988T	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.6018704711553036	[210]	[422,339,174,303]	8	hSpCas9	negative selection	8712083
28859197	28859220	1	+	27260156	PATU8988T	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.14925519994526204	[306]	[367,205,413,313]	2	hSpCas9	negative selection	8712084
28863236	28863259	1	+	27260156	PATU8988T	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.6493628181560883	[423]	[162,358,268,262]	-7	hSpCas9	negative selection	8776337
28863061	28863084	1	+	27260156	PATU8988T	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.19470048964623496	[376]	[396,517,219,555]	3	hSpCas9	negative selection	8776338
28859257	28859280	1	+	27260156	PATU8988T	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	0.02809520815715661	[487]	[540,337,469,567]	0	hSpCas9	negative selection	8776339
28812541	28812564	1	-	27260156	T47D	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.43998376103059966	[132]	[218,210,196,213]	8	hSpCas9	negative selection	8833333
28812533	28812556	1	+	27260156	T47D	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.4452743196973894	[210]	[367,274,375,323]	8	hSpCas9	negative selection	8833334
28859197	28859220	1	+	27260156	T47D	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.5656510084671614	[306]	[626,560,518,403]	9	hSpCas9	negative selection	8833335
28863236	28863259	1	+	27260156	T47D	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.2785681772933679	[423]	[419,384,388,437]	-6	hSpCas9	negative selection	8897588
28863061	28863084	1	+	27260156	T47D	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.3295691325430694	[376]	[570,597,495,538]	7	hSpCas9	negative selection	8897589
28859257	28859280	1	+	27260156	T47D	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.04232708005998676	[487]	[509,532,605,559]	-1	hSpCas9	negative selection	8897590
28812541	28812564	1	-	27260156	SU8686	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.023200230985062964	[132]	[113,97,189,142]	0	hSpCas9	negative selection	8954584
28812533	28812556	1	+	27260156	SU8686	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.27939857764443254	[210]	[181,239,265,351]	5	hSpCas9	negative selection	8954585
28859197	28859220	1	+	27260156	SU8686	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.1659057226004973	[306]	[399,325,302,325]	3	hSpCas9	negative selection	8954586
28863236	28863259	1	+	27260156	SU8686	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	0.09901556523809958	[423]	[406,490,517,369]	1	hSpCas9	negative selection	9018839
28863061	28863084	1	+	27260156	SU8686	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.12510982236138027	[376]	[353,404,329,568]	2	hSpCas9	negative selection	9018840
28859257	28859280	1	+	27260156	SU8686	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	0.0653668029311609	[487]	[349,531,537,637]	1	hSpCas9	negative selection	9018841
28812541	28812564	1	-	27260156	SKES1	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.4054343608616642	[132]	[299,139,140,137]	8	hSpCas9	negative selection	9075835
28812533	28812556	1	+	27260156	SKES1	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.042151014496847994	[210]	[214,293,163,202]	0	hSpCas9	negative selection	9075836
28859197	28859220	1	+	27260156	SKES1	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.6288453547802136	[306]	[567,548,474,335]	9	hSpCas9	negative selection	9075837
28863236	28863259	1	+	27260156	SKES1	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.7377893827472994	[423]	[252,295,231,237]	-9	hSpCas9	negative selection	9140090
28863061	28863084	1	+	27260156	SKES1	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.250741385825653	[376]	[464,431,433,453]	5	hSpCas9	negative selection	9140091
28859257	28859280	1	+	27260156	SKES1	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.07329274492180485	[487]	[453,547,496,366]	-2	hSpCas9	negative selection	9140092
28812541	28812564	1	-	27260156	TOV112D	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.08773339803540336	[132]	[94,202,103,115]	-2	hSpCas9	negative selection	9197086
28812533	28812556	1	+	27260156	TOV112D	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.05195982022703416	[210]	[223,242,150,262]	1	hSpCas9	negative selection	9197087
28859197	28859220	1	+	27260156	TOV112D	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.15037600345691537	[306]	[352,545,217,299]	3	hSpCas9	negative selection	9197088
28863236	28863259	1	+	27260156	TOV112D	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.17945969974473336	[423]	[580,695,172,151]	-4	hSpCas9	negative selection	9261341
28863061	28863084	1	+	27260156	TOV112D	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.0015374885071651745	[376]	[452,488,298,305]	0	hSpCas9	negative selection	9261342
28859257	28859280	1	+	27260156	TOV112D	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.635731842920674	[487]	[283,322,289,358]	-8	hSpCas9	negative selection	9261343
28812541	28812564	1	-	27260156	TC71	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.33649415878107813	[132]	[190,145,192,189]	7	hSpCas9	negative selection	9318337
28812533	28812556	1	+	27260156	TC71	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.12266223759967287	[210]	[202,237,269,275]	3	hSpCas9	negative selection	9318338
28859197	28859220	1	+	27260156	TC71	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.20346925566142848	[306]	[409,429,294,382]	5	hSpCas9	negative selection	9318339
28863236	28863259	1	+	27260156	TC71	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.37689990584738	[423]	[412,375,286,322]	-8	hSpCas9	negative selection	9382592
28863061	28863084	1	+	27260156	TC71	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.09636969947387009	[376]	[367,450,427,485]	2	hSpCas9	negative selection	9382593
28859257	28859280	1	+	27260156	TC71	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.12438670695037485	[487]	[458,470,439,555]	-3	hSpCas9	negative selection	9382594
28812541	28812564	1	-	27260156	TC32	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.44493879146142445	[132]	[159,140,219,169]	7	hSpCas9	negative selection	9439588
28812533	28812556	1	+	27260156	TC32	viability	CGCCATCACCGCGCTCTACTCGG	OPRD1	ENSG00000116329	0.5270117260079694	[210]	[240,148,296,512]	8	hSpCas9	negative selection	9439589
28859197	28859220	1	+	27260156	TC32	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.38462607981213176	[306]	[385,207,631,365]	6	hSpCas9	negative selection	9439590
28863236	28863259	1	+	27260156	TC32	viability	ACCGCCTGCACCCCGTCCGATGG	OPRD1	ENSG00000116329	-0.39486655814441374	[423]	[247,271,364,339]	-6	hSpCas9	negative selection	9503843
28863061	28863084	1	+	27260156	TC32	viability	GCTGCACCTGTGCATCGCGCTGG	OPRD1	ENSG00000116329	0.055889413071032734	[376]	[375,244,628,287]	1	hSpCas9	negative selection	9503844
28859257	28859280	1	+	27260156	TC32	viability	AGGCGTTGGCGTGCCCATCATGG	OPRD1	ENSG00000116329	-0.49765207984802673	[487]	[324,213,491,319]	-7	hSpCas9	negative selection	9503845
28812422	28812445	1	-	27869803	HPAFII	viability after 27 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	0.38441776366278596	[183]	[158,98,NaN]	3	hSpCas9	negative selection	9533652
28812541	28812564	1	-	27869803	HPAFII	viability after 27 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.37892585481947705	[345]	[445,61,NaN]	3	hSpCas9	negative selection	9533653
28858996	28859019	1	-	27869803	HPAFII	viability after 27 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.008289208204580956	[235]	[250,16,NaN]	0	hSpCas9	negative selection	9533654
28859046	28859069	1	+	27869803	HPAFII	viability after 27 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	-0.07442189853544434	[720]	[431,299,NaN]	0	hSpCas9	negative selection	9533655
28862818	28862841	1	-	27869803	HPAFII	viability after 27 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.22291001286866152	[422]	[144,354,NaN]	1	hSpCas9	negative selection	9533656
28863107	28863130	1	-	27869803	HPAFII	viability after 27 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-0.30782765734621775	[441]	[184,189,NaN]	-2	hSpCas9	negative selection	9533657
28812422	28812445	1	-	27869803	HPAFII	viability after 15 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	0.4464633459560147	[183]	[340,224,NaN]	5	hSpCas9	negative selection	9616101
28812541	28812564	1	-	27869803	HPAFII	viability after 15 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.22362102031986575	[345]	[627,125,NaN]	-3	hSpCas9	negative selection	9616102
28858996	28859019	1	-	27869803	HPAFII	viability after 15 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.3189932900855344	[235]	[501,200,NaN]	3	hSpCas9	negative selection	9616103
28859046	28859069	1	+	27869803	HPAFII	viability after 15 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	-0.08330385556173359	[720]	[953,592,NaN]	-1	hSpCas9	negative selection	9616104
28862818	28862841	1	-	27869803	HPAFII	viability after 15 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.12828563475886434	[422]	[359,581,NaN]	1	hSpCas9	negative selection	9616105
28863107	28863130	1	-	27869803	HPAFII	viability after 15 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-0.4990891585293306	[441]	[435,273,NaN]	-5	hSpCas9	negative selection	9616106
28812422	28812445	1	-	27869803	ASPC1	viability after 36 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	1.3409321032365766	[480]	[111,696,424]	9	hSpCas9	negative selection	9698550
28812541	28812564	1	-	27869803	ASPC1	viability after 36 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-0.45709147482631934	[931]	[500,60,188]	-5	hSpCas9	negative selection	9698551
28858996	28859019	1	-	27869803	ASPC1	viability after 36 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.36332291592533544	[671]	[398,208,303]	3	hSpCas9	negative selection	9698552
28859046	28859069	1	+	27869803	ASPC1	viability after 36 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	-0.1749550447956454	[1831]	[569,466,636]	-2	hSpCas9	negative selection	9698553
28862818	28862841	1	-	27869803	ASPC1	viability after 36 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.8340315987049487	[794]	[762,353,412]	7	hSpCas9	negative selection	9698554
28863107	28863130	1	-	27869803	ASPC1	viability after 36 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	0.4914340702589348	[790]	[444,196,495]	5	hSpCas9	negative selection	9698555
28812422	28812445	1	-	27869803	PATU8988S	viability after 35 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	0.35438810472357907	[366]	[173,203,NaN]	4	hSpCas9	negative selection	9780999
28812541	28812564	1	-	27869803	PATU8988S	viability after 35 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.36814118735151924	[614]	[403,234,NaN]	4	hSpCas9	negative selection	9781000
28858996	28859019	1	-	27869803	PATU8988S	viability after 35 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.9692114662397866	[512]	[183,625,NaN]	8	hSpCas9	negative selection	9781001
28859046	28859069	1	+	27869803	PATU8988S	viability after 35 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	-0.24694323891862235	[1375]	[466,466,NaN]	-3	hSpCas9	negative selection	9781002
28862818	28862841	1	-	27869803	PATU8988S	viability after 35 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	-0.21661441457281339	[641]	[229,214,NaN]	-2	hSpCas9	negative selection	9781003
28863107	28863130	1	-	27869803	PATU8988S	viability after 35 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	-0.13966674269470147	[798]	[337,245,NaN]	-1	hSpCas9	negative selection	9781004
28812422	28812445	1	-	27869803	PATU8988S	viability after 31 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	-0.02290332755260749	[366]	[114,180,NaN]	0	hSpCas9	negative selection	9863448
28812541	28812564	1	-	27869803	PATU8988S	viability after 31 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.7320826289958554	[614]	[460,338,NaN]	8	hSpCas9	negative selection	9863449
28858996	28859019	1	-	27869803	PATU8988S	viability after 31 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.45215217690563253	[512]	[124,476,NaN]	5	hSpCas9	negative selection	9863450
28859046	28859069	1	+	27869803	PATU8988S	viability after 31 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	-0.022860807684216056	[1375]	[371,753,NaN]	0	hSpCas9	negative selection	9863451
28862818	28862841	1	-	27869803	PATU8988S	viability after 31 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.15868459978350716	[641]	[272,301,NaN]	2	hSpCas9	negative selection	9863452
28863107	28863130	1	-	27869803	PATU8988S	viability after 31 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	0.07044903939558844	[798]	[429,212,NaN]	0	hSpCas9	negative selection	9863453
28812422	28812445	1	-	27869803	HPAFII	viability after 35 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	-0.4489042640138988	[183]	[79,54,NaN]	-3	hSpCas9	negative selection	9945897
28812541	28812564	1	-	27869803	HPAFII	viability after 35 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.9438112703278215	[345]	[573,69,NaN]	6	hSpCas9	negative selection	9945898
28858996	28859019	1	-	27869803	HPAFII	viability after 35 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.5889206613333714	[235]	[293,50,NaN]	4	hSpCas9	negative selection	9945899
28859046	28859069	1	+	27869803	HPAFII	viability after 35 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	0.10100692287614832	[720]	[398,382,NaN]	0	hSpCas9	negative selection	9945900
28862818	28862841	1	-	27869803	HPAFII	viability after 35 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.514869363875098	[422]	[146,484,NaN]	3	hSpCas9	negative selection	9945901
28863107	28863130	1	-	27869803	HPAFII	viability after 35 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	0.08309765657012025	[441]	[173,307,NaN]	0	hSpCas9	negative selection	9945902
28812422	28812445	1	-	27869803	HPAFII	viability after 31 days	CCGAGGCGTTGGCGAAGAGCGGG	OPRD1	ENSG00000116329	-0.6121543468689173	[183]	[79,53,NaN]	-4	hSpCas9	negative selection	10028346
28812541	28812564	1	-	27869803	HPAFII	viability after 31 days	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.4561932442224328	[345]	[453,61,NaN]	3	hSpCas9	negative selection	10028347
28858996	28859019	1	-	27869803	HPAFII	viability after 31 days	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.12225585208121255	[235]	[203,31,NaN]	-1	hSpCas9	negative selection	10028348
28859046	28859069	1	+	27869803	HPAFII	viability after 31 days	CCAAGTACCTGATGGAGACGTGG	OPRD1	ENSG00000116329	-0.21591301412678	[720]	[345,350,NaN]	-1	hSpCas9	negative selection	10028349
28862818	28862841	1	-	27869803	HPAFII	viability after 31 days	TGGGCACCACGAAGGCGAAGAGG	OPRD1	ENSG00000116329	0.341415324107044	[422]	[172,439,NaN]	2	hSpCas9	negative selection	10028350
28863107	28863130	1	-	27869803	HPAFII	viability after 31 days	TCGAGGAAAGCGTAGAGCACGGG	OPRD1	ENSG00000116329	0.041639455137649106	[441]	[295,210,NaN]	0	hSpCas9	negative selection	10028351
28812448	28812471	1	-	28162770	P31FUJ	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	0.4570682720165262	[136]	[220]	5	hSpCas9	negative selection	10204907
28859038	28859061	1	+	28162770	P31FUJ	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.858051226036735	[199]	[425]	8	hSpCas9	negative selection	10204908
28812541	28812564	1	-	28162770	P31FUJ	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.24363583952860848	[183]	[255]	2	hSpCas9	negative selection	10204909
28859070	28859093	1	-	28162770	P31FUJ	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	0.473466592528911	[18]	[30]	5	hSpCas9	negative selection	10204910
28859197	28859220	1	+	28162770	P31FUJ	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.08332026879177787	[248]	[309]	0	hSpCas9	negative selection	10204911
28859282	28859305	1	+	28162770	P31FUJ	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	0.8546606368359606	[175]	[373]	8	hSpCas9	negative selection	10204912
28812469	28812492	1	+	28162770	P31FUJ	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.3594063941156642	[330]	[498]	4	hSpCas9	negative selection	10204913
28812517	28812540	1	-	28162770	P31FUJ	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	0.7147303756914858	[13]	[26]	7	hSpCas9	negative selection	10204914
28858996	28859019	1	-	28162770	P31FUJ	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.26146198601504034	[92]	[130]	3	hSpCas9	negative selection	10204915
28859019	28859042	1	-	28162770	P31FUJ	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.043210055417625126	[165]	[200]	0	hSpCas9	negative selection	10204916
28812448	28812471	1	-	28162770	TF1	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	NaN	[NaN]	[93]	1	hSpCas9	negative selection	10374273
28859038	28859061	1	+	28162770	TF1	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	NaN	[NaN]	[175]	1	hSpCas9	negative selection	10374274
28812541	28812564	1	-	28162770	TF1	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	NaN	[NaN]	[78]	1	hSpCas9	negative selection	10374275
28859070	28859093	1	-	28162770	TF1	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	NaN	[NaN]	[8]	1	hSpCas9	negative selection	10374276
28859197	28859220	1	+	28162770	TF1	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	NaN	[NaN]	[190]	1	hSpCas9	negative selection	10374277
28859282	28859305	1	+	28162770	TF1	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	NaN	[NaN]	[87]	1	hSpCas9	negative selection	10374278
28812469	28812492	1	+	28162770	TF1	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	NaN	[NaN]	[345]	1	hSpCas9	negative selection	10374279
28812517	28812540	1	-	28162770	TF1	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	NaN	[NaN]	[278]	1	hSpCas9	negative selection	10374280
28858996	28859019	1	-	28162770	TF1	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	NaN	[NaN]	[18]	1	hSpCas9	negative selection	10374281
28859019	28859042	1	-	28162770	TF1	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	NaN	[NaN]	[103]	1	hSpCas9	negative selection	10374282
28812448	28812471	1	-	28162770	SKM1	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	0.1915448338159424	[52]	[106]	1	hSpCas9	negative selection	10543639
28859038	28859061	1	+	28162770	SKM1	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.899282273911931	[36]	[121]	8	hSpCas9	negative selection	10543640
28812541	28812564	1	-	28162770	SKM1	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.0304411135641367	[53]	[194]	8	hSpCas9	negative selection	10543641
28859070	28859093	1	-	28162770	SKM1	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	-0.2370391973008492	[7]	[11]	-2	hSpCas9	negative selection	10543642
28859197	28859220	1	+	28162770	SKM1	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	-0.46111996879006706	[94]	[121]	-4	hSpCas9	negative selection	10543643
28859282	28859305	1	+	28162770	SKM1	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	0.14557682428561688	[44]	[87]	1	hSpCas9	negative selection	10543644
28812469	28812492	1	+	28162770	SKM1	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.8449541748964583	[56]	[180]	7	hSpCas9	negative selection	10543645
28812517	28812540	1	-	28162770	SKM1	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	2.6374299206152916	[2]	[32]	9	hSpCas9	negative selection	10543646
28858996	28859019	1	-	28162770	SKM1	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.11910461292442598	[24]	[47]	1	hSpCas9	negative selection	10543647
28859019	28859042	1	-	28162770	SKM1	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	1.5839906616538313	[19]	[105]	9	hSpCas9	negative selection	10543648
28812448	28812471	1	-	28162770	SKM1	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	0.1915448338159424	[52]	[106]	1	hSpCas9	negative selection	10713005
28859038	28859061	1	+	28162770	SKM1	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.899282273911931	[36]	[121]	8	hSpCas9	negative selection	10713006
28812541	28812564	1	-	28162770	SKM1	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.0304411135641367	[53]	[194]	8	hSpCas9	negative selection	10713007
28859070	28859093	1	-	28162770	SKM1	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	-0.2370391973008492	[7]	[11]	-2	hSpCas9	negative selection	10713008
28859197	28859220	1	+	28162770	SKM1	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	-0.46111996879006706	[94]	[121]	-4	hSpCas9	negative selection	10713009
28859282	28859305	1	+	28162770	SKM1	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	0.14557682428561688	[44]	[87]	1	hSpCas9	negative selection	10713010
28812469	28812492	1	+	28162770	SKM1	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.8449541748964583	[56]	[180]	7	hSpCas9	negative selection	10713011
28812517	28812540	1	-	28162770	SKM1	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	2.6374299206152916	[2]	[32]	9	hSpCas9	negative selection	10713012
28858996	28859019	1	-	28162770	SKM1	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.11910461292442598	[24]	[47]	1	hSpCas9	negative selection	10713013
28859019	28859042	1	-	28162770	SKM1	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	1.5839906616538313	[19]	[105]	9	hSpCas9	negative selection	10713014
28812448	28812471	1	-	28162770	PL21	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	0.5971431909379024	[160]	[105]	5	hSpCas9	negative selection	10882371
28859038	28859061	1	+	28162770	PL21	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	2.865863127174313	[109]	[348]	9	hSpCas9	negative selection	10882372
28812541	28812564	1	-	28162770	PL21	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.4158683055447574	[185]	[107]	3	hSpCas9	negative selection	10882373
28859070	28859093	1	-	28162770	PL21	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	-3.5547478876741487	[26]	[0]	-9	hSpCas9	negative selection	10882374
28859197	28859220	1	+	28162770	PL21	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	-0.11536221123860912	[335]	[134]	-1	hSpCas9	negative selection	10882375
28859282	28859305	1	+	28162770	PL21	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	-0.08431377497937924	[189]	[77]	0	hSpCas9	negative selection	10882376
28812469	28812492	1	+	28162770	PL21	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	1.0918867238372967	[165]	[153]	8	hSpCas9	negative selection	10882377
28812517	28812540	1	-	28162770	PL21	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	0.6151771137681639	[14]	[9]	5	hSpCas9	negative selection	10882378
28858996	28859019	1	-	28162770	PL21	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.7784867347181128	[66]	[16]	-5	hSpCas9	negative selection	10882379
28859019	28859042	1	-	28162770	PL21	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.8782115196019575	[69]	[55]	7	hSpCas9	negative selection	10882380
28812448	28812471	1	-	28162770	P31FUJ	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	0.4570682720165262	[136]	[220]	5	hSpCas9	negative selection	11051737
28859038	28859061	1	+	28162770	P31FUJ	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.858051226036735	[199]	[425]	8	hSpCas9	negative selection	11051738
28812541	28812564	1	-	28162770	P31FUJ	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.24363583952860848	[183]	[255]	2	hSpCas9	negative selection	11051739
28859070	28859093	1	-	28162770	P31FUJ	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	0.473466592528911	[18]	[30]	5	hSpCas9	negative selection	11051740
28859197	28859220	1	+	28162770	P31FUJ	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.08332026879177787	[248]	[309]	0	hSpCas9	negative selection	11051741
28859282	28859305	1	+	28162770	P31FUJ	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	0.8546606368359606	[175]	[373]	8	hSpCas9	negative selection	11051742
28812469	28812492	1	+	28162770	P31FUJ	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.3594063941156642	[330]	[498]	4	hSpCas9	negative selection	11051743
28812517	28812540	1	-	28162770	P31FUJ	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	0.7147303756914858	[13]	[26]	7	hSpCas9	negative selection	11051744
28858996	28859019	1	-	28162770	P31FUJ	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.26146198601504034	[92]	[130]	3	hSpCas9	negative selection	11051745
28859019	28859042	1	-	28162770	P31FUJ	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.043210055417625126	[165]	[200]	0	hSpCas9	negative selection	11051746
28812448	28812471	1	-	28162770	OCIAML5	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	1.1041517371080898	[91]	[356]	8	hSpCas9	negative selection	11221103
28859038	28859061	1	+	28162770	OCIAML5	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	-0.22982305406338127	[190]	[293]	-2	hSpCas9	negative selection	11221104
28812541	28812564	1	-	28162770	OCIAML5	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.8692174010699396	[73]	[243]	7	hSpCas9	negative selection	11221105
28859070	28859093	1	-	28162770	OCIAML5	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	0.4698615240233659	[3]	[9]	4	hSpCas9	negative selection	11221106
28859197	28859220	1	+	28162770	OCIAML5	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	-0.7875263186692866	[152]	[159]	-5	hSpCas9	negative selection	11221107
28859282	28859305	1	+	28162770	OCIAML5	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	-0.39889394269838196	[83]	[114]	-3	hSpCas9	negative selection	11221108
28812469	28812492	1	+	28162770	OCIAML5	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.547150410932448	[148]	[392]	5	hSpCas9	negative selection	11221109
28812517	28812540	1	-	28162770	OCIAML5	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	-1.640562465670285	[18]	[10]	-7	hSpCas9	negative selection	11221110
28858996	28859019	1	-	28162770	OCIAML5	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.981472282997262	[38]	[138]	8	hSpCas9	negative selection	11221111
28859019	28859042	1	-	28162770	OCIAML5	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.4853745233946899	[73]	[186]	4	hSpCas9	negative selection	11221112
28812448	28812471	1	-	28162770	EOL1	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	0.8949226024612563	[245]	[240]	7	hSpCas9	negative selection	11390469
28859038	28859061	1	+	28162770	EOL1	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	1.0850124437637807	[152]	[170]	8	hSpCas9	negative selection	11390470
28812541	28812564	1	-	28162770	EOL1	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.929583361467833	[285]	[286]	7	hSpCas9	negative selection	11390471
28859070	28859093	1	-	28162770	EOL1	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	-3.162915069679805	[16]	[0]	-9	hSpCas9	negative selection	11390472
28859197	28859220	1	+	28162770	EOL1	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.5737648140109871	[504]	[395]	5	hSpCas9	negative selection	11390473
28859282	28859305	1	+	28162770	EOL1	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	1.2842422370056032	[278]	[357]	9	hSpCas9	negative selection	11390474
28812469	28812492	1	+	28162770	EOL1	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.8505471901267578	[259]	[246]	7	hSpCas9	negative selection	11390475
28812517	28812540	1	-	28162770	EOL1	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	-1.3973803233168276	[24]	[4]	-7	hSpCas9	negative selection	11390476
28858996	28859019	1	-	28162770	EOL1	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.16084371966011002	[86]	[40]	-1	hSpCas9	negative selection	11390477
28859019	28859042	1	-	28162770	EOL1	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.9763867030901525	[81]	[84]	8	hSpCas9	negative selection	11390478
28812448	28812471	1	-	28162770	MOLM13	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	0.496744244216764	[197]	[201]	3	hSpCas9	negative selection	11559835
28859038	28859061	1	+	28162770	MOLM13	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	-0.9790632978110272	[258]	[94]	-5	hSpCas9	negative selection	11559836
28812541	28812564	1	-	28162770	MOLM13	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.1499632172147127	[224]	[360]	8	hSpCas9	negative selection	11559837
28859070	28859093	1	-	28162770	MOLM13	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	1.7898174764319414	[25]	[64]	9	hSpCas9	negative selection	11559838
28859197	28859220	1	+	28162770	MOLM13	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.37501980676729596	[400]	[375]	2	hSpCas9	negative selection	11559839
28859282	28859305	1	+	28162770	MOLM13	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	1.1192531079882446	[183]	[288]	8	hSpCas9	negative selection	11559840
28812469	28812492	1	+	28162770	MOLM13	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	-0.220166612140681	[260]	[161]	-1	hSpCas9	negative selection	11559841
28812517	28812540	1	-	28162770	MOLM13	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	-1.619573459705761	[33]	[7]	-7	hSpCas9	negative selection	11559842
28858996	28859019	1	-	28162770	MOLM13	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	1.6407259784067942	[54]	[123]	9	hSpCas9	negative selection	11559843
28859019	28859042	1	-	28162770	MOLM13	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.737496441301859	[145]	[175]	5	hSpCas9	negative selection	11559844
28812448	28812471	1	-	28162770	HEL	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	-0.9093590348151727	[216]	[73]	-5	hSpCas9	negative selection	11729201
28859038	28859061	1	+	28162770	HEL	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.4056996346995074	[230]	[195]	3	hSpCas9	negative selection	11729202
28812541	28812564	1	-	28162770	HEL	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.9170139512963033	[276]	[334]	7	hSpCas9	negative selection	11729203
28859070	28859093	1	-	28162770	HEL	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	0.8233110776421779	[14]	[16]	7	hSpCas9	negative selection	11729204
28859197	28859220	1	+	28162770	HEL	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.03562705401144506	[360]	[236]	0	hSpCas9	negative selection	11729205
28859282	28859305	1	+	28162770	HEL	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	1.9346543578212798	[135]	[332]	9	hSpCas9	negative selection	11729206
28812469	28812492	1	+	28162770	HEL	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.6549135459464591	[235]	[237]	5	hSpCas9	negative selection	11729207
28812517	28812540	1	-	28162770	HEL	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	0.16880764366794487	[24]	[17]	1	hSpCas9	negative selection	11729208
28858996	28859019	1	-	28162770	HEL	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.8466460087385681	[72]	[25]	-5	hSpCas9	negative selection	11729209
28859019	28859042	1	-	28162770	HEL	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.5756246361418199	[109]	[104]	5	hSpCas9	negative selection	11729210
28812448	28812471	1	-	28162770	MV411	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	-0.05512521923765601	[147]	[119]	0	hSpCas9	negative selection	11898567
28859038	28859061	1	+	28162770	MV411	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.0823783045122789	[110]	[98]	0	hSpCas9	negative selection	11898568
28812541	28812564	1	-	28162770	MV411	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.4243153128668544	[160]	[181]	4	hSpCas9	negative selection	11898569
28859070	28859093	1	-	28162770	MV411	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	-2.7525624492172245	[15]	[1]	-9	hSpCas9	negative selection	11898570
28859197	28859220	1	+	28162770	MV411	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.2699801194338637	[253]	[257]	2	hSpCas9	negative selection	11898571
28859282	28859305	1	+	28162770	MV411	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	1.7968638942771689	[136]	[400]	9	hSpCas9	negative selection	11898572
28812469	28812492	1	+	28162770	MV411	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.35227991664027336	[198]	[213]	3	hSpCas9	negative selection	11898573
28812517	28812540	1	-	28162770	MV411	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	-1.6270315671333657	[21]	[5]	-7	hSpCas9	negative selection	11898574
28858996	28859019	1	-	28162770	MV411	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	1.6495359943541212	[41]	[110]	9	hSpCas9	negative selection	11898575
28859019	28859042	1	-	28162770	MV411	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	-0.05634319739432758	[78]	[63]	0	hSpCas9	negative selection	11898576
28812448	28812471	1	-	28162770	MONOMAC1	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	-0.398670708229204	[91]	[79]	-3	hSpCas9	negative selection	12067933
28859038	28859061	1	+	28162770	MONOMAC1	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	1.1799326113857707	[71]	[186]	8	hSpCas9	negative selection	12067934
28812541	28812564	1	-	28162770	MONOMAC1	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	-1.2540677920959327	[128]	[61]	-7	hSpCas9	negative selection	12067935
28859070	28859093	1	-	28162770	MONOMAC1	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	0.6874859355205101	[12]	[23]	6	hSpCas9	negative selection	12067936
28859197	28859220	1	+	28162770	MONOMAC1	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.6715256298898653	[177]	[324]	6	hSpCas9	negative selection	12067937
28859282	28859305	1	+	28162770	MONOMAC1	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	0.4948408575781143	[103]	[167]	5	hSpCas9	negative selection	12067938
28812469	28812492	1	+	28162770	MONOMAC1	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	1.1113021830798533	[127]	[316]	8	hSpCas9	negative selection	12067939
28812517	28812540	1	-	28162770	MONOMAC1	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	-3.366961848501866	[17]	[1]	-9	hSpCas9	negative selection	12067940
28858996	28859019	1	-	28162770	MONOMAC1	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	-0.9519243492230225	[26]	[15]	-6	hSpCas9	negative selection	12067941
28859019	28859042	1	-	28162770	MONOMAC1	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.7774280608333087	[56]	[111]	7	hSpCas9	negative selection	12067942
28812448	28812471	1	-	28162770	OCIAML2	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	0.3818129863439808	[26]	[194]	3	hSpCas9	negative selection	12237299
28859038	28859061	1	+	28162770	OCIAML2	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.726907407408011	[22]	[210]	7	hSpCas9	negative selection	12237300
28812541	28812564	1	-	28162770	OCIAML2	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	0.5852234094913563	[37]	[315]	5	hSpCas9	negative selection	12237301
28859070	28859093	1	-	28162770	OCIAML2	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	-1.7925579201295236	[9]	[15]	-8	hSpCas9	negative selection	12237302
28859197	28859220	1	+	28162770	OCIAML2	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	0.8656535626222714	[39]	[403]	8	hSpCas9	negative selection	12237303
28859282	28859305	1	+	28162770	OCIAML2	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	0.5136028588995222	[22]	[181]	5	hSpCas9	negative selection	12237304
28812469	28812492	1	+	28162770	OCIAML2	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.38136901187028516	[49]	[360]	3	hSpCas9	negative selection	12237305
28812517	28812540	1	-	28162770	OCIAML2	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	-0.8267736354674367	[7]	[24]	-5	hSpCas9	negative selection	12237306
28858996	28859019	1	-	28162770	OCIAML2	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.1616383902573515	[9]	[61]	1	hSpCas9	negative selection	12237307
28859019	28859042	1	-	28162770	OCIAML2	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	-0.2142900719823757	[17]	[85]	-2	hSpCas9	negative selection	12237308
28812448	28812471	1	-	28162770	OCIAML3	viability	GCTGGGGCAGGCGCTAGGGTAGG	OPRD1	ENSG00000116329	-0.5940076403241632	[46]	[93]	-4	hSpCas9	negative selection	12406665
28859038	28859061	1	+	28162770	OCIAML3	viability	CCAGAGTGCCAAGTACCTGATGG	OPRD1	ENSG00000116329	0.1591551813698443	[61]	[208]	1	hSpCas9	negative selection	12406666
28812541	28812564	1	-	28162770	OCIAML3	viability	GCACACGGCCGAGTAGAGCGCGG	OPRD1	ENSG00000116329	1.0484403550577532	[40]	[255]	8	hSpCas9	negative selection	12406667
28859070	28859093	1	-	28162770	OCIAML3	viability	CTTGCAGAGCAGCTCGCCGAAGG	OPRD1	ENSG00000116329	-0.21549601707043342	[4]	[12]	-2	hSpCas9	negative selection	12406668
28859197	28859220	1	+	28162770	OCIAML3	viability	GGACTTCCGCACGCCTGCCAAGG	OPRD1	ENSG00000116329	-0.7639326417664754	[71]	[127]	-5	hSpCas9	negative selection	12406669
28859282	28859305	1	+	28162770	OCIAML3	viability	ATGGCTGTGACCCGTCCCCGGGG	OPRD1	ENSG00000116329	0.6283847810122849	[35]	[167]	6	hSpCas9	negative selection	12406670
28812469	28812492	1	+	28162770	OCIAML3	viability	GCGCTGGCGCCAATGCGTCGGGG	OPRD1	ENSG00000116329	0.7014482432020082	[54]	[269]	6	hSpCas9	negative selection	12406671
28812517	28812540	1	-	28162770	OCIAML3	viability	GATGGCGATTGCCAGGGCGAGGG	OPRD1	ENSG00000116329	-0.009045139603007346	[4]	[14]	0	hSpCas9	negative selection	12406672
28858996	28859019	1	-	28162770	OCIAML3	viability	CCAGCGCATCGGCTAAGGCCAGG	OPRD1	ENSG00000116329	0.32882449915337675	[23]	[90]	3	hSpCas9	negative selection	12406673
28859019	28859042	1	-	28162770	OCIAML3	viability	CTGGAAAGGCAGCGTGCTGGTGG	OPRD1	ENSG00000116329	0.27388882366849154	[19]	[72]	2	hSpCas9	negative selection	12406674