Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 5063
• Symbol: Pak3
• Description: p21 (RAC1) activated kinase 3

DataSource: http://genomecrispr.dkfz.de/#!/results/Pak3

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
111142166	111142189	X	+	26472758	Jiyoye	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	0.4478173660032194	[34]	[35]	3	hSpCas9	negative selection	115540
111162948	111162971	X	-	26472758	Jiyoye	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	-0.43235994630088037	[135]	[75]	-3	hSpCas9	negative selection	115541
111163629	111163652	X	-	26472758	Jiyoye	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.6349812990286854	[227]	[266]	4	hSpCas9	negative selection	115542
111216514	111216537	X	+	26472758	Jiyoye	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.5226525989258093	[131]	[142]	4	hSpCas9	negative selection	115543
111216525	111216548	X	+	26472758	Jiyoye	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	0.1661672820020783	[64]	[54]	1	hSpCas9	negative selection	115544
111196481	111196504	X	+	26472758	Jiyoye	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.11489274836703589	[288]	[235]	0	hSpCas9	negative selection	115545
111147806	111147829	X	-	26472758	Jiyoye	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.7769320014838508	[88]	[114]	5	hSpCas9	negative selection	115546
111162936	111162959	X	-	26472758	Jiyoye	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	-0.17778711921528279	[233]	[155]	-1	hSpCas9	negative selection	115547
111196511	111196534	X	+	26472758	Jiyoye	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	1.3283199607946339	[46]	[88]	7	hSpCas9	negative selection	115548
111123193	111123216	X	+	26472758	Jiyoye	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	0.6258156679812138	[109]	[127]	4	hSpCas9	negative selection	115549
111142166	111142189	X	+	26472758	KBM7	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	-0.5391773396453896	[213,73]	[34,52]	-5	hSpCas9	negative selection	306658
111162948	111162971	X	-	26472758	KBM7	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	-0.028028157765016826	[577,696]	[246,343]	0	hSpCas9	negative selection	306659
111163629	111163652	X	-	26472758	KBM7	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.8490085380978806	[987,544]	[705,567]	8	hSpCas9	negative selection	306660
111216514	111216537	X	+	26472758	KBM7	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.1700150157416459	[699,589]	[275,396]	1	hSpCas9	negative selection	306661
111216525	111216548	X	+	26472758	KBM7	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	0.04795555304977467	[415,247]	[195,123]	0	hSpCas9	negative selection	306662
111196481	111196504	X	+	26472758	KBM7	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.20037347572029196	[656,754]	[461,317]	2	hSpCas9	negative selection	306663
111147806	111147829	X	-	26472758	KBM7	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.010932934196571431	[528,601]	[211,315]	0	hSpCas9	negative selection	306664
111162936	111162959	X	-	26472758	KBM7	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	0.03204438592391223	[796,679]	[374,334]	0	hSpCas9	negative selection	306665
111196511	111196534	X	+	26472758	KBM7	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	0.13968026108384168	[582,501]	[341,224]	1	hSpCas9	negative selection	306666
111123193	111123216	X	+	26472758	KBM7	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	0.5046809048011727	[614,390]	[441,228]	5	hSpCas9	negative selection	306667
111142166	111142189	X	+	26472758	Raji	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	1.2733934868125285	[40]	[22]	9	hSpCas9	negative selection	497776
111162948	111162971	X	-	26472758	Raji	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	0.5066105198049815	[366]	[120]	5	hSpCas9	negative selection	497777
111163629	111163652	X	-	26472758	Raji	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.5709195523436337	[350]	[120]	5	hSpCas9	negative selection	497778
111216514	111216537	X	+	26472758	Raji	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.7910149658281378	[258]	[103]	7	hSpCas9	negative selection	497779
111216525	111216548	X	+	26472758	Raji	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	-1.8101543044344277	[135]	[8]	-8	hSpCas9	negative selection	497780
111196481	111196504	X	+	26472758	Raji	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.9971014803586891	[230]	[106]	8	hSpCas9	negative selection	497781
111147806	111147829	X	-	26472758	Raji	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.4395109245140372	[373]	[63]	-4	hSpCas9	negative selection	497782
111162936	111162959	X	-	26472758	Raji	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	0.2866080975536739	[377]	[106]	2	hSpCas9	negative selection	497783
111196511	111196534	X	+	26472758	Raji	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	-0.009480222317299059	[346]	[79]	0	hSpCas9	negative selection	497784
111123193	111123216	X	+	26472758	Raji	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	0.5672288300111186	[316]	[108]	5	hSpCas9	negative selection	497785
111142166	111142189	X	+	26472758	K562	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	-0.6840280113085191	[117]	[61]	-4	hSpCas9	negative selection	688894
111162948	111162971	X	-	26472758	K562	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	0.2699990971298388	[558]	[568]	2	hSpCas9	negative selection	688895
111163629	111163652	X	-	26472758	K562	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.8371844658557939	[798]	[1204]	7	hSpCas9	negative selection	688896
111216514	111216537	X	+	26472758	K562	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.31028437732772485	[577]	[604]	2	hSpCas9	negative selection	688897
111216525	111216548	X	+	26472758	K562	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	-0.801384961946678	[255]	[123]	-5	hSpCas9	negative selection	688898
111196481	111196504	X	+	26472758	K562	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	1.1325258475955495	[468]	[867]	8	hSpCas9	negative selection	688899
111147806	111147829	X	-	26472758	K562	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.1521602198144583	[451]	[423]	1	hSpCas9	negative selection	688900
111162936	111162959	X	-	26472758	K562	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	0.6019151424553786	[632]	[810]	5	hSpCas9	negative selection	688901
111196511	111196534	X	+	26472758	K562	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	0.8451732004311951	[423]	[642]	7	hSpCas9	negative selection	688902
111123193	111123216	X	+	26472758	K562	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	1.2554739161754425	[259]	[523]	9	hSpCas9	negative selection	688903
111123135	111123158	X	-	26627737	DLD1	viability	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	0.25664767618714673	[301]	[79,141,116]	2	hSpCas9	negative selection	844087
111146530	111146553	X	+	26627737	DLD1	viability	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	0.47799945995218884	[132]	[86,36,49]	5	hSpCas9	negative selection	844088
111147732	111147755	X	+	26627737	DLD1	viability	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	0.26129924326216836	[961]	[337,416,332]	2	hSpCas9	negative selection	844089
111162947	111162970	X	-	26627737	DLD1	viability	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	1.3504892712045762	[258]	[157,241,218]	9	hSpCas9	negative selection	844090
111192146	111192169	X	+	26627737	DLD1	viability	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	1.055281149672961	[623]	[406,490,332]	8	hSpCas9	negative selection	844091
111195856	111195879	X	+	26627737	DLD1	viability	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.25742810130273863	[465]	[168,268,99]	2	hSpCas9	negative selection	844092
111123135	111123158	X	-	26627737	GBM cells	viability after 5 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	-0.13103934721594213	[145]	[78,63]	-2	hSpCas9	negative selection	926402
111146530	111146553	X	+	26627737	GBM cells	viability after 5 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	-1.117027668983336	[90]	[16,27]	-9	hSpCas9	negative selection	926403
111147732	111147755	X	+	26627737	GBM cells	viability after 5 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.025057204448029835	[461]	[195,290]	0	hSpCas9	negative selection	926404
111162947	111162970	X	-	26627737	GBM cells	viability after 5 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.3860643522500718	[238]	[155,178]	6	hSpCas9	negative selection	926405
111192146	111192169	X	+	26627737	GBM cells	viability after 5 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.7929231791974717	[359]	[369,298]	9	hSpCas9	negative selection	926406
111195856	111195879	X	+	26627737	GBM cells	viability after 5 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.30460486735486536	[270]	[185,172]	5	hSpCas9	negative selection	926407
111123135	111123158	X	-	26627737	GBM cells	viability after 13 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	-0.12839773585700798	[145]	[45,93]	-1	hSpCas9	negative selection	1008717
111146530	111146553	X	+	26627737	GBM cells	viability after 13 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	-0.34655893179914976	[90]	[45,32]	-4	hSpCas9	negative selection	1008718
111147732	111147755	X	+	26627737	GBM cells	viability after 13 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	0.030229763699527123	[461]	[357,172]	0	hSpCas9	negative selection	1008719
111162947	111162970	X	-	26627737	GBM cells	viability after 13 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.2826652630429626	[238]	[197,124]	3	hSpCas9	negative selection	1008720
111192146	111192169	X	+	26627737	GBM cells	viability after 13 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.9345042416255213	[359]	[385,362]	9	hSpCas9	negative selection	1008721
111195856	111195879	X	+	26627737	GBM cells	viability after 13 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.3354581857647467	[270]	[211,163]	4	hSpCas9	negative selection	1008722
111123135	111123158	X	-	26627737	GBM cells	viability after 21 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	-0.4102007661665913	[145]	[66,52]	-4	hSpCas9	negative selection	1091032
111146530	111146553	X	+	26627737	GBM cells	viability after 21 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	-3.0425988398618817	[90]	[5,5]	-9	hSpCas9	negative selection	1091033
111147732	111147755	X	+	26627737	GBM cells	viability after 21 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	0.03054913988054464	[461]	[282,231]	0	hSpCas9	negative selection	1091034
111162947	111162970	X	-	26627737	GBM cells	viability after 21 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.6654778900117533	[238]	[218,193]	6	hSpCas9	negative selection	1091035
111192146	111192169	X	+	26627737	GBM cells	viability after 21 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	1.051226568445462	[359]	[409,400]	9	hSpCas9	negative selection	1091036
111195856	111195879	X	+	26627737	GBM cells	viability after 21 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.7670069959364689	[270]	[272,229]	7	hSpCas9	negative selection	1091037
111123135	111123158	X	-	26627737	RPE1	viability after 9 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	0.6585494102027876	[276]	[142,128]	4	hSpCas9	negative selection	1173347
111146530	111146553	X	+	26627737	RPE1	viability after 9 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	0.28403804329465987	[432]	[161,168]	2	hSpCas9	negative selection	1173348
111147732	111147755	X	+	26627737	RPE1	viability after 9 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	0.1344197381954491	[1063]	[369,359]	1	hSpCas9	negative selection	1173349
111162947	111162970	X	-	26627737	RPE1	viability after 9 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.5295114048103483	[625]	[257,314]	3	hSpCas9	negative selection	1173350
111192146	111192169	X	+	26627737	RPE1	viability after 9 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.3265318773725938	[1630]	[576,721]	2	hSpCas9	negative selection	1173351
111195856	111195879	X	+	26627737	RPE1	viability after 9 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	2.1320626715347966	[374]	[418,637]	9	hSpCas9	negative selection	1173352
111123135	111123158	X	-	26627737	RPE1	viability after 12 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	-0.07253561807465392	[276]	[113,24]	0	hSpCas9	negative selection	1255662
111146530	111146553	X	+	26627737	RPE1	viability after 12 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	0.16753038380840968	[432]	[152,106]	1	hSpCas9	negative selection	1255663
111147732	111147755	X	+	26627737	RPE1	viability after 12 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.3461228162624426	[1063]	[220,228]	-2	hSpCas9	negative selection	1255664
111162947	111162970	X	-	26627737	RPE1	viability after 12 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.935728754763145	[625]	[260,385]	6	hSpCas9	negative selection	1255665
111192146	111192169	X	+	26627737	RPE1	viability after 12 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.5516417431245755	[1630]	[634,649]	3	hSpCas9	negative selection	1255666
111195856	111195879	X	+	26627737	RPE1	viability after 12 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	1.890163507981252	[374]	[303,446]	8	hSpCas9	negative selection	1255667
111123135	111123158	X	-	26627737	RPE1	viability after 15 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	0.043659776719467525	[276]	[93,67]	0	hSpCas9	negative selection	1337977
111146530	111146553	X	+	26627737	RPE1	viability after 15 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	-0.6601814800774809	[432]	[76,77]	-4	hSpCas9	negative selection	1337978
111147732	111147755	X	+	26627737	RPE1	viability after 15 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.9043815475684747	[1063]	[199,122]	-5	hSpCas9	negative selection	1337979
111162947	111162970	X	-	26627737	RPE1	viability after 15 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	1.032071742831372	[625]	[326,395]	6	hSpCas9	negative selection	1337980
111192146	111192169	X	+	26627737	RPE1	viability after 15 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.2691958433770971	[1630]	[554,556]	1	hSpCas9	negative selection	1337981
111195856	111195879	X	+	26627737	RPE1	viability after 15 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	2.1159385696721045	[374]	[300,612]	9	hSpCas9	negative selection	1337982
111123135	111123158	X	-	26627737	RPE1	viability after 18 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	-1.3602105939344744	[276]	[17,40]	-7	hSpCas9	negative selection	1420292
111146530	111146553	X	+	26627737	RPE1	viability after 18 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	0.5772542647534066	[432]	[198,147]	3	hSpCas9	negative selection	1420293
111147732	111147755	X	+	26627737	RPE1	viability after 18 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.5890447551932677	[1063]	[172,209]	-4	hSpCas9	negative selection	1420294
111162947	111162970	X	-	26627737	RPE1	viability after 18 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.744380135634326	[625]	[195,375]	4	hSpCas9	negative selection	1420295
111192146	111192169	X	+	26627737	RPE1	viability after 18 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.2338659132776464	[1630]	[520,513]	1	hSpCas9	negative selection	1420296
111195856	111195879	X	+	26627737	RPE1	viability after 18 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	2.079717343540146	[374]	[421,433]	8	hSpCas9	negative selection	1420297
111123135	111123158	X	-	26627737	HeLa	viability after 8 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	1.0754392724798527	[77]	[124,83,20]	7	hSpCas9	negative selection	1502607
111146530	111146553	X	+	26627737	HeLa	viability after 8 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	1.8662920858666556	[60]	[102,51,133]	9	hSpCas9	negative selection	1502608
111147732	111147755	X	+	26627737	HeLa	viability after 8 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.25445039007852044	[1079]	[505,357,345]	-2	hSpCas9	negative selection	1502609
111162947	111162970	X	-	26627737	HeLa	viability after 8 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.7581132457180167	[173]	[170,129,94]	6	hSpCas9	negative selection	1502610
111192146	111192169	X	+	26627737	HeLa	viability after 8 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.024025827535397837	[587]	[413,164,236]	0	hSpCas9	negative selection	1502611
111195856	111195879	X	+	26627737	HeLa	viability after 8 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	-0.23988279770743698	[412]	[181,156,125]	-2	hSpCas9	negative selection	1502612
111123135	111123158	X	-	26627737	HeLa	viability after 12 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	1.4446539721814844	[77]	[125,5,140]	8	hSpCas9	negative selection	1584922
111146530	111146553	X	+	26627737	HeLa	viability after 12 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	2.0283067079636696	[60]	[91,47,173]	9	hSpCas9	negative selection	1584923
111147732	111147755	X	+	26627737	HeLa	viability after 12 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.5191231317362014	[1079]	[236,246,454]	-4	hSpCas9	negative selection	1584924
111162947	111162970	X	-	26627737	HeLa	viability after 12 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.6577348372604118	[173]	[159,100,81]	5	hSpCas9	negative selection	1584925
111192146	111192169	X	+	26627737	HeLa	viability after 12 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.08284386524657639	[587]	[201,242,326]	0	hSpCas9	negative selection	1584926
111195856	111195879	X	+	26627737	HeLa	viability after 12 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.017343871573012135	[412]	[173,212,126]	0	hSpCas9	negative selection	1584927
111123135	111123158	X	-	26627737	HeLa	viability after 15 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	1.6589847268576463	[77]	[174,22,101]	9	hSpCas9	negative selection	1667237
111146530	111146553	X	+	26627737	HeLa	viability after 15 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	2.0400260408558535	[60]	[141,35,129]	9	hSpCas9	negative selection	1667238
111147732	111147755	X	+	26627737	HeLa	viability after 15 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.7778089801365458	[1079]	[272,252,241]	-6	hSpCas9	negative selection	1667239
111162947	111162970	X	-	26627737	HeLa	viability after 15 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	1.1517492589172948	[173]	[143,186,139]	7	hSpCas9	negative selection	1667240
111192146	111192169	X	+	26627737	HeLa	viability after 15 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	-0.0726239743557685	[587]	[319,93,270]	0	hSpCas9	negative selection	1667241
111195856	111195879	X	+	26627737	HeLa	viability after 15 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.21916775221617216	[412]	[222,213,145]	1	hSpCas9	negative selection	1667242
111123135	111123158	X	-	26627737	HeLa	viability after 18 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	1.7405465422677713	[77]	[127,19,101]	9	hSpCas9	negative selection	1749552
111146530	111146553	X	+	26627737	HeLa	viability after 18 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	2.0318359367179326	[60]	[93,29,129]	9	hSpCas9	negative selection	1749553
111147732	111147755	X	+	26627737	HeLa	viability after 18 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.7456794450894565	[1079]	[181,224,241]	-6	hSpCas9	negative selection	1749554
111162947	111162970	X	-	26627737	HeLa	viability after 18 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	1.170049498338347	[173]	[101,152,139]	8	hSpCas9	negative selection	1749555
111192146	111192169	X	+	26627737	HeLa	viability after 18 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	-0.1055052722933641	[587]	[206,74,270]	-1	hSpCas9	negative selection	1749556
111195856	111195879	X	+	26627737	HeLa	viability after 18 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.2749792227906307	[412]	[159,182,145]	2	hSpCas9	negative selection	1749557
111123135	111123158	X	-	26627737	HCT116	viability after 6 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	3.12478673508782	[134]	[246,150]	9	hSpCas9	negative selection	1831867
111146530	111146553	X	+	26627737	HCT116	viability after 6 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	-0.887371307720398	[102]	[20,1]	-5	hSpCas9	negative selection	1831868
111147732	111147755	X	+	26627737	HCT116	viability after 6 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	0.6019988118902222	[1883]	[513,413]	3	hSpCas9	negative selection	1831869
111162947	111162970	X	-	26627737	HCT116	viability after 6 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	-0.7521757735163228	[492]	[94,18]	-4	hSpCas9	negative selection	1831870
111192146	111192169	X	+	26627737	HCT116	viability after 6 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.6475432340915913	[1075]	[516,125]	3	hSpCas9	negative selection	1831871
111195856	111195879	X	+	26627737	HCT116	viability after 6 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.4824996868111523	[489]	[86,118]	2	hSpCas9	negative selection	1831872
111123135	111123158	X	-	26627737	HCT116	viability after 8 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	-0.18007882586957313	[149]	[27,111,77]	-2	hSpCas9	negative selection	1914182
111146530	111146553	X	+	26627737	HCT116	viability after 8 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	-0.8606379719372841	[70]	[33,20,9]	-8	hSpCas9	negative selection	1914183
111147732	111147755	X	+	26627737	HCT116	viability after 8 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	0.46932368468322927	[471]	[318,441,318]	5	hSpCas9	negative selection	1914184
111162947	111162970	X	-	26627737	HCT116	viability after 8 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.17793575934292266	[225]	[159,123,138]	2	hSpCas9	negative selection	1914185
111192146	111192169	X	+	26627737	HCT116	viability after 8 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.18367955301605543	[432]	[204,352,253]	2	hSpCas9	negative selection	1914186
111195856	111195879	X	+	26627737	HCT116	viability after 8 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.0168075749016679	[329]	[173,215,161]	0	hSpCas9	negative selection	1914187
111123135	111123158	X	-	26627737	HCT116	viability after 9 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	1.2992268907515734	[134]	[162,29]	8	hSpCas9	negative selection	1996497
111146530	111146553	X	+	26627737	HCT116	viability after 9 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	1.3808125628792245	[102]	[17,113]	8	hSpCas9	negative selection	1996498
111147732	111147755	X	+	26627737	HCT116	viability after 9 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.9945825520292693	[1883]	[328,191]	-6	hSpCas9	negative selection	1996499
111162947	111162970	X	-	26627737	HCT116	viability after 9 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	-1.004948997502259	[492]	[78,54]	-6	hSpCas9	negative selection	1996500
111192146	111192169	X	+	26627737	HCT116	viability after 9 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.5697922396304654	[1075]	[588,297]	4	hSpCas9	negative selection	1996501
111195856	111195879	X	+	26627737	HCT116	viability after 9 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.6529583529959702	[489]	[317,116]	5	hSpCas9	negative selection	1996502
111123135	111123158	X	-	26627737	HCT116	viability after 12 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	1.0760744062721304	[149]	[125,243,133]	8	hSpCas9	negative selection	2078812
111146530	111146553	X	+	26627737	HCT116	viability after 12 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	0.44641102388134835	[70]	[62,72,15]	4	hSpCas9	negative selection	2078813
111147732	111147755	X	+	26627737	HCT116	viability after 12 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	0.5989120726176526	[471]	[430,325,363]	5	hSpCas9	negative selection	2078814
111162947	111162970	X	-	26627737	HCT116	viability after 12 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	-0.02226488388481962	[225]	[77,146,129]	0	hSpCas9	negative selection	2078815
111192146	111192169	X	+	26627737	HCT116	viability after 12 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.37546436103674397	[432]	[240,280,367]	4	hSpCas9	negative selection	2078816
111195856	111195879	X	+	26627737	HCT116	viability after 12 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.3490672866476649	[329]	[146,295,227]	3	hSpCas9	negative selection	2078817
111123135	111123158	X	-	26627737	HCT116	viability after 15 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	0.42419698570100883	[149]	[112,162,70]	4	hSpCas9	negative selection	2161127
111146530	111146553	X	+	26627737	HCT116	viability after 15 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	-0.09608402242998615	[70]	[38,74,0]	-1	hSpCas9	negative selection	2161128
111147732	111147755	X	+	26627737	HCT116	viability after 15 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	0.5851898480970815	[471]	[384,395,435]	5	hSpCas9	negative selection	2161129
111162947	111162970	X	-	26627737	HCT116	viability after 15 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.46480851605193485	[225]	[199,166,172]	4	hSpCas9	negative selection	2161130
111192146	111192169	X	+	26627737	HCT116	viability after 15 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.2264755038801739	[432]	[338,276,262]	2	hSpCas9	negative selection	2161131
111195856	111195879	X	+	26627737	HCT116	viability after 15 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.5067223730846757	[329]	[311,313,187]	5	hSpCas9	negative selection	2161132
111123135	111123158	X	-	26627737	HCT116	viability after 18 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	-0.5259953848726402	[149]	[28,76,42]	-5	hSpCas9	negative selection	2243442
111146530	111146553	X	+	26627737	HCT116	viability after 18 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	-0.478462015060352	[70]	[16,26,29]	-4	hSpCas9	negative selection	2243443
111147732	111147755	X	+	26627737	HCT116	viability after 18 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	0.6411888498584045	[471]	[544,360,151]	5	hSpCas9	negative selection	2243444
111162947	111162970	X	-	26627737	HCT116	viability after 18 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.4641340846183275	[225]	[108,194,144]	4	hSpCas9	negative selection	2243445
111192146	111192169	X	+	26627737	HCT116	viability after 18 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.8077412331018456	[432]	[408,342,347]	6	hSpCas9	negative selection	2243446
111195856	111195879	X	+	26627737	HCT116	viability after 18 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.5009199802195595	[329]	[158,289,223]	4	hSpCas9	negative selection	2243447
111123136	111123159	X	-	24336569	HL60	viability	TCATCCTCAGTGGAGGAGCCGGG	PAK3	ENSG00000077264	0.27207216689075053	[622]	[1591]	2	hSpCas9	negative selection	2282512
111123143	111123166	X	-	24336569	HL60	viability	TTACTATTCATCCTCAGTGGAGG	PAK3	ENSG00000077264	0.11318333022464733	[224]	[514]	1	hSpCas9	negative selection	2282513
111123150	111123173	X	+	24336569	HL60	viability	TGAGGATGAATAGTAACAACCGG	PAK3	ENSG00000077264	-0.29660678288595643	[1190]	[2051]	-3	hSpCas9	negative selection	2282514
111123169	111123192	X	-	24336569	HL60	viability	GGTTGAGTGCTGAAGAATCCCGG	PAK3	ENSG00000077264	2.0059987406214432	[59]	[509]	9	hSpCas9	negative selection	2282515
111123190	111123213	X	-	24336569	HL60	viability	TGGGAAGTGGTTTGGAGCTGTGG	PAK3	ENSG00000077264	0.5061455476989601	[725]	[2181]	4	hSpCas9	negative selection	2282516
111123217	111123240	X	-	24336569	HL60	viability	CTTTCTTATTCTTCTCTTCAGGG	PAK3	ENSG00000077264	1.4216213930378523	[144]	[821]	8	hSpCas9	negative selection	2282517
111123222	111123245	X	+	24336569	HL60	viability	AAGAGAAGAATAAGAAAGCCAGG	PAK3	ENSG00000077264	0.40262957224266993	[463]	[1297]	3	hSpCas9	negative selection	2282518
111123240	111123263	X	-	24336569	HL60	viability	TGGGAAGATAGAGCGAAGCCTGG	PAK3	ENSG00000077264	-0.3483594232386018	[1346]	[2238]	-3	hSpCas9	negative selection	2282519
111123245	111123268	X	+	24336569	HL60	viability	CTTCGCTCTATCTTCCCAGGAGG	PAK3	ENSG00000077264	3.5242569602590574	[45]	[1119]	9	hSpCas9	negative selection	2282520
111142088	111142111	X	+	24336569	HL60	viability	GCCTTTAGCCAATAAGAAGAAGG	PAK3	ENSG00000077264	0.30533209443570064	[560]	[1466]	3	hSpCas9	negative selection	2282521
111123136	111123159	X	-	24336569	KBM7	viability	TCATCCTCAGTGGAGGAGCCGGG	PAK3	ENSG00000077264	-0.05810340368406974	[241]	[633]	0	hSpCas9	negative selection	2349689
111123143	111123166	X	-	24336569	KBM7	viability	TTACTATTCATCCTCAGTGGAGG	PAK3	ENSG00000077264	0.3644310862468137	[220]	[775]	3	hSpCas9	negative selection	2349690
111123150	111123173	X	+	24336569	KBM7	viability	TGAGGATGAATAGTAACAACCGG	PAK3	ENSG00000077264	0.9552605796508882	[630]	[3336]	8	hSpCas9	negative selection	2349691
111123169	111123192	X	-	24336569	KBM7	viability	GGTTGAGTGCTGAAGAATCCCGG	PAK3	ENSG00000077264	0.07153075687764787	[253]	[727]	0	hSpCas9	negative selection	2349692
111123190	111123213	X	-	24336569	KBM7	viability	TGGGAAGTGGTTTGGAGCTGTGG	PAK3	ENSG00000077264	0.528002250857901	[714]	[2811]	5	hSpCas9	negative selection	2349693
111123217	111123240	X	-	24336569	KBM7	viability	CTTTCTTATTCTTCTCTTCAGGG	PAK3	ENSG00000077264	1.5416829917484631	[117]	[936]	9	hSpCas9	negative selection	2349694
111123222	111123245	X	+	24336569	KBM7	viability	AAGAGAAGAATAAGAAAGCCAGG	PAK3	ENSG00000077264	1.3016727709451534	[303]	[2043]	9	hSpCas9	negative selection	2349695
111123240	111123263	X	-	24336569	KBM7	viability	TGGGAAGATAGAGCGAAGCCTGG	PAK3	ENSG00000077264	0.6291656263823389	[905]	[3821]	6	hSpCas9	negative selection	2349696
111123245	111123268	X	+	24336569	KBM7	viability	CTTCGCTCTATCTTCCCAGGAGG	PAK3	ENSG00000077264	0.26104177192336203	[256]	[839]	2	hSpCas9	negative selection	2349697
111142088	111142111	X	+	24336569	KBM7	viability	GCCTTTAGCCAATAAGAAGAAGG	PAK3	ENSG00000077264	0.9829724447173536	[421]	[2274]	8	hSpCas9	negative selection	2349698
111122888	111122911	X	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATTGCATCAGGGTTTTTGGGAGG	PAK3	ENSG00000077264	-2.2750388637037533	[171,277]	[6,12]	-9	dCas9-VP64	positive selection	2397946
111122922	111122945	X	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTTAGGGGTTTCTCTTCTGGAGG	PAK3	ENSG00000077264	3.90263922843873	[695,170]	[2694,35]	9	dCas9-VP64	positive selection	2397947
111122939	111122962	X	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTTGTGTGAGGATCGTTTTTAGG	PAK3	ENSG00000077264	-1.732935913239892	[289,182]	[13,15]	-8	dCas9-VP64	positive selection	2397948
111148789	111148812	X	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATTCAAGTTGATATTTGGGTGGG	PAK3	ENSG00000077264	5.265840724048784	[105,51]	[41,1342]	9	dCas9-VP64	positive selection	2418169
111059232	111059255	X	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCACTGCAGCCTTTAACTCCTGG	PAK3	ENSG00000077264	-1.7142589782577375	[182,184]	[19,3]	-8	dCas9-VP64	positive selection	2429865
111095998	111096021	X	-	25494202	A375	resistance to PLX-4720 (puromycin)	AAACTGAAGGGGAGGGAACATGG	PAK3	ENSG00000077264	2.008368875378325	[63,44]	[82,10]	7	dCas9-VP64	positive selection	2430680
111096024	111096047	X	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGCAGGAAGCGCCTGGGAGGGGG	PAK3	ENSG00000077264	1.1496549621855887	[50,9]	[26,0]	4	dCas9-VP64	positive selection	2430681
111096045	111096068	X	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGGACCAATCTTTTGTTTCCAGG	PAK3	ENSG00000077264	-1.844392883964447	[232,69]	[4,12]	-8	dCas9-VP64	positive selection	2430682
111087153	111087176	X	+	25494202	A375	resistance to PLX-4720 (puromycin)	GTGTGTGTGTGTGTGTGTGGCAG	PAK3	ENSG00000077264	1.250295307438589	[24,5]	[12,2]	5	dCas9-VP64	positive selection	2434471
111226131	111226154	X	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATGCCATTGCACTCCAGCCTCGG	PAK3	ENSG00000077264	2.033062228314259	[28,209]	[4,221]	7	dCas9-VP64	positive selection	2456495
111122888	111122911	X	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATTGCATCAGGGTTTTTGGGAGG	PAK3	ENSG00000077264	-0.23489352121331353	[282,237]	[84,59]	-2	dCas9-VP64	positive selection	2493201
111122922	111122945	X	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTTAGGGGTTTCTCTTCTGGAGG	PAK3	ENSG00000077264	1.2750343030481028	[124,65]	[117,36]	7	dCas9-VP64	positive selection	2493202
111122939	111122962	X	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTTGTGTGAGGATCGTTTTTAGG	PAK3	ENSG00000077264	0.03883617331111844	[208,234]	[100,48]	0	dCas9-VP64	positive selection	2493203
111148789	111148812	X	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATTCAAGTTGATATTTGGGTGGG	PAK3	ENSG00000077264	-0.29595625450860175	[233,173]	[40,65]	-3	dCas9-VP64	positive selection	2513424
111059232	111059255	X	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCACTGCAGCCTTTAACTCCTGG	PAK3	ENSG00000077264	-1.495187672432472	[104,314]	[26,20]	-9	dCas9-VP64	positive selection	2525120
111095998	111096021	X	-	25494202	A375	resistance to PLX-4720 (zeocin)	AAACTGAAGGGGAGGGAACATGG	PAK3	ENSG00000077264	0.44259586962582725	[44,283]	[21,117]	3	dCas9-VP64	positive selection	2525935
111096024	111096047	X	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGCAGGAAGCGCCTGGGAGGGGG	PAK3	ENSG00000077264	-0.0705375423474982	[143,154]	[26,63]	0	dCas9-VP64	positive selection	2525936
111096045	111096068	X	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGGACCAATCTTTTGTTTCCAGG	PAK3	ENSG00000077264	-0.5366322484919546	[288,49]	[62,14]	-5	dCas9-VP64	positive selection	2525937
111087153	111087176	X	+	25494202	A375	resistance to PLX-4720 (zeocin)	GTGTGTGTGTGTGTGTGTGGCAG	PAK3	ENSG00000077264	0.8668431868856517	[26,20]	[22,6]	6	dCas9-VP64	positive selection	2529726
111226131	111226154	X	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATGCCATTGCACTCCAGCCTCGG	PAK3	ENSG00000077264	0.2042793589460996	[254,297]	[44,158]	1	dCas9-VP64	positive selection	2551750
111123092	111123115	X	+	27013184	SW480	treatment with recombinant TRAIL	TTGTAACTGAAAATGTCTGACGG	PAK3	ENSG00000077264	2.7910953813706962	[114,68]	[199,395]	9	hSpCas9	positive selection	2955301
111123097	111123120	X	+	27013184	SW480	treatment with recombinant TRAIL	ACTGAAAATGTCTGACGGTCTGG	PAK3	ENSG00000077264	0.842616024246139	[163,203]	[107,187]	4	hSpCas9	positive selection	2955302
111123250	111123273	X	+	27013184	SW480	treatment with recombinant TRAIL	CTCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	0.15135099961680254	[1,19]	[1,8]	0	hSpCas9	positive selection	2955303
111123275	111123298	X	+	27013184	SW480	treatment with recombinant TRAIL	AAAAGTAAAGTATCAGTGGCCGG	PAK3	ENSG00000077264	-3.17980225187621	[67,37]	[2,1]	-9	hSpCas9	positive selection	2955304
111123276	111123299	X	+	27013184	SW480	treatment with recombinant TRAIL	AAAGTAAAGTATCAGTGGCCGGG	PAK3	ENSG00000077264	1.4460157849775517	[282,159]	[206,351]	6	hSpCas9	positive selection	2955305
111142145	111142168	X	+	27013184	SW480	treatment with recombinant TRAIL	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	3.2171711953974444	[146,211]	[839,521]	9	hSpCas9	positive selection	2955306
111142146	111142169	X	+	27013184	SW480	treatment with recombinant TRAIL	TTTGAGCATACGATTCATGTGGG	PAK3	ENSG00000077264	1.2124738110114626	[1,1]	[1,1]	6	hSpCas9	positive selection	2955307
111142147	111142170	X	+	27013184	SW480	treatment with recombinant TRAIL	TTGAGCATACGATTCATGTGGGG	PAK3	ENSG00000077264	0.20181316897836266	[657,509]	[269,325]	1	hSpCas9	positive selection	2955308
111142164	111142187	X	+	27013184	SW480	treatment with recombinant TRAIL	GTGGGGTTTGATGCAGTCACCGG	PAK3	ENSG00000077264	-0.4913478210110369	[747,608]	[132,319]	-2	hSpCas9	positive selection	2955309
111142165	111142188	X	+	27013184	SW480	treatment with recombinant TRAIL	TGGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	1.461152812485575	[178,242]	[210,298]	6	hSpCas9	positive selection	2955310
111142166	111142189	X	+	27013184	SW480	treatment with recombinant TRAIL	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	0.9654009771169034	[335,490]	[302,398]	4	hSpCas9	positive selection	2955311
111123132	111123155	X	+	27013184	SW480	treatment with recombinant TRAIL	AACCCCCGGCTCCTCCACTGAGG	PAK3	ENSG00000077264	-2.1396908468577114	[285,134]	[31,5]	-7	hSpCas9	positive selection	2955312
111123150	111123173	X	+	27013184	SW480	treatment with recombinant TRAIL	TGAGGATGAATAGTAACAACCGG	PAK3	ENSG00000077264	1.553106585637876	[21,61]	[26,84]	7	hSpCas9	positive selection	2955313
111123134	111123157	X	-	27013184	SW480	treatment with recombinant TRAIL	ATCCTCAGTGGAGGAGCCGGGGG	PAK3	ENSG00000077264	-1.9479438738214632	[279,341]	[31,37]	-7	hSpCas9	positive selection	2955314
111123135	111123158	X	-	27013184	SW480	treatment with recombinant TRAIL	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	-1.7452457406349944	[222,436]	[32,52]	-7	hSpCas9	positive selection	2955315
111123136	111123159	X	-	27013184	SW480	treatment with recombinant TRAIL	TCATCCTCAGTGGAGGAGCCGGG	PAK3	ENSG00000077264	0.36330584514510383	[168,231]	[65,171]	1	hSpCas9	positive selection	2955316
111123137	111123160	X	-	27013184	SW480	treatment with recombinant TRAIL	TTCATCCTCAGTGGAGGAGCCGG	PAK3	ENSG00000077264	-0.3848185570762727	[165,409]	[58,137]	-2	hSpCas9	positive selection	2955317
111123143	111123166	X	-	27013184	SW480	treatment with recombinant TRAIL	TTACTATTCATCCTCAGTGGAGG	PAK3	ENSG00000077264	1.4141751430125833	[277,467]	[507,292]	6	hSpCas9	positive selection	2955318
111123146	111123169	X	-	27013184	SW480	treatment with recombinant TRAIL	TTGTTACTATTCATCCTCAGTGG	PAK3	ENSG00000077264	-1.0119863521803132	[353,366]	[17,160]	-4	hSpCas9	positive selection	2955319
111123151	111123174	X	+	27013184	SW480	treatment with recombinant TRAIL	GAGGATGAATAGTAACAACCGGG	PAK3	ENSG00000077264	-1.9106157034699698	[90,39]	[1,15]	-7	hSpCas9	positive selection	2955320
111123169	111123192	X	-	27013184	SW480	treatment with recombinant TRAIL	GGTTGAGTGCTGAAGAATCCCGG	PAK3	ENSG00000077264	-2.209177391855347	[272,353]	[11,52]	-7	hSpCas9	positive selection	2955321
111123210	111123233	X	-	27013184	SW480	treatment with recombinant TRAIL	ATTCTTCTCTTCAGGGGCCATGG	PAK3	ENSG00000077264	-0.3738411746805608	[567,553]	[172,206]	-2	hSpCas9	positive selection	2955322
111123240	111123263	X	-	27013184	SW480	treatment with recombinant TRAIL	TGGGAAGATAGAGCGAAGCCTGG	PAK3	ENSG00000077264	-1.1786808043851829	[389,646]	[113,71]	-5	hSpCas9	positive selection	2955323
111142121	111142144	X	-	27013184	SW480	treatment with recombinant TRAIL	CTGAAGGAAGAGAGATCTCTGGG	PAK3	ENSG00000077264	-1.720912327534558	[359,363]	[15,91]	-7	hSpCas9	positive selection	2955324
111142122	111142145	X	-	27013184	SW480	treatment with recombinant TRAIL	TCTGAAGGAAGAGAGATCTCTGG	PAK3	ENSG00000077264	0.46527076406211665	[140,69]	[53,79]	2	hSpCas9	positive selection	2955325
111142137	111142160	X	-	27013184	SW480	treatment with recombinant TRAIL	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.13390012969816756	[243,380]	[181,32]	0	hSpCas9	positive selection	2955326
111123242	111123265	X	+	27013184	SW480	treatment with recombinant TRAIL	AGGCTTCGCTCTATCTTCCCAGG	PAK3	ENSG00000077264	-0.5346002895078554	[527,733]	[124,270]	-2	hSpCas9	positive selection	2955327
111123245	111123268	X	+	27013184	SW480	treatment with recombinant TRAIL	CTTCGCTCTATCTTCCCAGGAGG	PAK3	ENSG00000077264	-0.5799650789977882	[682,1200]	[261,269]	-3	hSpCas9	positive selection	2955328
111123248	111123271	X	+	27013184	SW480	treatment with recombinant TRAIL	CGCTCTATCTTCCCAGGAGGAGG	PAK3	ENSG00000077264	-0.41230799939376683	[444,403]	[110,176]	-2	hSpCas9	positive selection	2955329
111123249	111123272	X	+	27013184	SW480	treatment with recombinant TRAIL	GCTCTATCTTCCCAGGAGGAGGG	PAK3	ENSG00000077264	0.6588148946766497	[379,658]	[309,395]	3	hSpCas9	positive selection	2955330
111147805	111147828	X	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GAACATCTAGAACAGCTTGTGGG	PAK3	ENSG00000077264	-0.070548927683389	[5,5]	[4,3]	-1	hSpCas9	positive selection	3009472
111123119	111123142	X	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGATAATGAAGAGAAACCCCCGG	PAK3	ENSG00000077264	-0.21982374587053893	[3,3]	[5,0]	-3	hSpCas9	positive selection	3009473
111142167	111142190	X	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	-0.261289058001471	[4,3]	[4,1]	-4	hSpCas9	positive selection	3009474
111123143	111123166	X	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTACTATTCATCCTCAGTGGAGG	PAK3	ENSG00000077264	0.0805437650338856	[4,4]	[4,3]	1	hSpCas9	positive selection	3009475
111147805	111147828	X	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GAACATCTAGAACAGCTTGTGGG	PAK3	ENSG00000077264	0.3639779889742123	[5,5]	[5,4]	6	hSpCas9	positive selection	3077330
111123119	111123142	X	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGATAATGAAGAGAAACCCCCGG	PAK3	ENSG00000077264	0.5254917100548793	[3,3]	[4,3]	8	hSpCas9	positive selection	3077331
111142167	111142190	X	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	-0.08781802439585396	[4,4]	[3,2]	-1	hSpCas9	positive selection	3077332
111123143	111123166	X	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTACTATTCATCCTCAGTGGAGG	PAK3	ENSG00000077264	0.2428538347105737	[4,4]	[3,3]	4	hSpCas9	positive selection	3077333
111147806	111147829		-	24336571	A375	resistance to PLX after 7 days	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.32182330123107206	[47,36]	[30,36]	-8	hSpCas9	positive selection	3133812
111147743	111147766		-	24336571	A375	resistance to PLX after 7 days	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.03539276510321798	[54,54]	[54,56]	1	hSpCas9	positive selection	3133813
111142137	111142160		-	24336571	A375	resistance to PLX after 7 days	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.14834985898143982	[42,42]	[36,39]	-5	hSpCas9	positive selection	3133814
111147806	111147829		-	24336571	A375	resistance to PLX after 14 days	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.2521780530495288	[30,31]	[18,15]	2	hSpCas9	positive selection	3191605
111147743	111147766		-	24336571	A375	resistance to PLX after 14 days	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.32504580713354114	[49,59]	[29,32]	3	hSpCas9	positive selection	3191606
111142137	111142160		-	24336571	A375	resistance to PLX after 14 days	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.282735467906001	[40,42]	[14,16]	-3	hSpCas9	positive selection	3191607
111147806	111147829		-	24336571	A375	viability after 7 days	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.19232928612548417	[38]	[47,36]	3	hSpCas9	negative selection	3249398
111147743	111147766		-	24336571	A375	viability after 7 days	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.26005173835014417	[47]	[54,54]	4	hSpCas9	negative selection	3249399
111142137	111142160		-	24336571	A375	viability after 7 days	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.2941110427319007	[54]	[42,42]	-4	hSpCas9	negative selection	3249400
111147806	111147829		-	24336571	A375	viability after 14 days	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.22614526520711165	[38]	[30,31]	-3	hSpCas9	negative selection	3307191
111147743	111147766		-	24336571	A375	viability after 14 days	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.2647171022510195	[47]	[49,59]	3	hSpCas9	negative selection	3307192
111142137	111142160		-	24336571	A375	viability after 14 days	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.30563931124158117	[54]	[40,42]	-4	hSpCas9	negative selection	3307193
111147806	111147829	X	-	27383988	293T	resistance to West Nile virus (flavivirus)	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.9075807152298527	[286,286]	[0,0]	-6	hSpCas9	positive selection	3384518
111152426	111152449	X	+	27383988	293T	resistance to West Nile virus (flavivirus)	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-1.1563017175783374	[340,340]	[0,0]	-7	hSpCas9	positive selection	3384519
111152403	111152426	X	+	27383988	293T	resistance to West Nile virus (flavivirus)	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	1.0285075209499543	[74,74]	[0,0]	5	hSpCas9	positive selection	3384520
111147805	111147828	X	-	26780180	HT29	viability (Avana library 4 designs)	GAACATCTAGAACAGCTTGTGGG	PAK3	ENSG00000077264	-0.402550237006269	[]	[]	-6	hSpCas9	negative selection	3447509
111123118	111123141	X	+	26780180	HT29	viability (Avana library 4 designs)	GGATAATGAAGAGAAACCCCCGG	PAK3	ENSG00000077264	1.62259733769134	[]	[]	6	hSpCas9	negative selection	3447510
111142166	111142189	X	+	26780180	HT29	viability (Avana library 4 designs)	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	1.41630711312373	[]	[]	5	hSpCas9	negative selection	3447511
111123143	111123166	X	-	26780180	HT29	viability (Avana library 4 designs)	TTACTATTCATCCTCAGTGGAGG	PAK3	ENSG00000077264	0.20173056271865	[]	[]	0	hSpCas9	negative selection	3447512
111142166	111142189	X	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	4.61492188234058	[]	[]	7	hSpCas9	negative selection	3541349
111123118	111123141	X	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGATAATGAAGAGAAACCCCCGG	PAK3	ENSG00000077264	-4.67604134740517	[]	[]	-5	hSpCas9	negative selection	3541350
111123143	111123166	X	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTACTATTCATCCTCAGTGGAGG	PAK3	ENSG00000077264	-3.98485863226116	[]	[]	-4	hSpCas9	negative selection	3541351
111147805	111147828	X	-	26780180	A375	viability (Avana lentiCRISPRv2)	GAACATCTAGAACAGCTTGTGGG	PAK3	ENSG00000077264	-0.677771324392888	[]	[]	-1	hSpCas9	negative selection	3541352
111163558	111163581	X	+	26780180	A375	viability (Avana lentiCRISPRv2)	TTAGATCTATACTCGTTCTGTGG	PAK3	ENSG00000077264	-1.19073475747596	[]	[]	-1	hSpCas9	negative selection	3541353
111152426	111152449	X	+	26780180	A375	viability (Avana lentiCRISPRv2)	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.0362492826419477	[]	[]	0	hSpCas9	negative selection	3541354
111142166	111142189	X	+	26780180	A375	viability (Avana lentiGuide)	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	-0.528761343925828	[]	[]	-1	hSpCas9	negative selection	3650008
111123118	111123141	X	+	26780180	A375	viability (Avana lentiGuide)	GGATAATGAAGAGAAACCCCCGG	PAK3	ENSG00000077264	8.23043111756172	[]	[]	6	hSpCas9	negative selection	3650009
111123143	111123166	X	-	26780180	A375	viability (Avana lentiGuide)	TTACTATTCATCCTCAGTGGAGG	PAK3	ENSG00000077264	1.63600707566567	[]	[]	1	hSpCas9	negative selection	3650010
111147805	111147828	X	-	26780180	A375	viability (Avana lentiGuide)	GAACATCTAGAACAGCTTGTGGG	PAK3	ENSG00000077264	-4.55558092436787	[]	[]	-7	hSpCas9	negative selection	3650011
111163558	111163581	X	+	26780180	A375	viability (Avana lentiGuide)	TTAGATCTATACTCGTTCTGTGG	PAK3	ENSG00000077264	-3.87466794059056	[]	[]	-6	hSpCas9	negative selection	3650012
111152426	111152449	X	+	26780180	A375	viability (Avana lentiGuide)	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-1.2281964895163	[]	[]	-2	hSpCas9	negative selection	3650013
111142166	111142189	X	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	0.16332398050563918	[5]	[6,5]	4	hSpCas9	positive selection	3758667
111123118	111123141	X	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGATAATGAAGAGAAACCCCCGG	PAK3	ENSG00000077264	-0.39017521453105786	[5]	[4,2]	-5	hSpCas9	positive selection	3758668
111123143	111123166	X	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTACTATTCATCCTCAGTGGAGG	PAK3	ENSG00000077264	-0.3496853870631178	[6]	[5,4]	-5	hSpCas9	positive selection	3758669
111147805	111147828	X	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GAACATCTAGAACAGCTTGTGGG	PAK3	ENSG00000077264	-0.01666266897900387	[6]	[6,6]	0	hSpCas9	positive selection	3758670
111163558	111163581	X	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTAGATCTATACTCGTTCTGTGG	PAK3	ENSG00000077264	-0.3740255081387376	[9]	[6,6]	-5	hSpCas9	positive selection	3758671
111152426	111152449	X	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.02175150275455906	[6]	[6,6]	0	hSpCas9	positive selection	3758672
111142166	111142189	X	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	0.1520413359275157	[6]	[6,5]	3	hSpCas9	positive selection	3867274
111123118	111123141	X	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGATAATGAAGAGAAACCCCCGG	PAK3	ENSG00000077264	-0.5993084960004093	[5]	[2,2]	-6	hSpCas9	positive selection	3867275
111123143	111123166	X	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTACTATTCATCCTCAGTGGAGG	PAK3	ENSG00000077264	0.05553705739489856	[6]	[5,4]	1	hSpCas9	positive selection	3867276
111147805	111147828	X	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GAACATCTAGAACAGCTTGTGGG	PAK3	ENSG00000077264	0.32100272886604003	[6]	[7,7]	8	hSpCas9	positive selection	3867277
111163558	111163581	X	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTAGATCTATACTCGTTCTGTGG	PAK3	ENSG00000077264	0.34621542868579847	[6]	[7,6]	8	hSpCas9	positive selection	3867278
111152426	111152449	X	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.18428873902445564	[7]	[7,7]	4	hSpCas9	positive selection	3867279
111147806	111147829	X	-	26780180	A375	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.428093033381199	[]	[]	1	hSpCas9	negative selection	3978171
111147743	111147766	X	-	26780180	A375	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.548239453674392	[]	[]	1	hSpCas9	negative selection	3978172
111152426	111152449	X	+	26780180	A375	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	1.01386055344223	[]	[]	5	hSpCas9	negative selection	3978173
111142137	111142160	X	-	26780180	A375	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	1.09150566400748	[]	[]	5	hSpCas9	negative selection	3978174
111142145	111142168	X	+	26780180	A375	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.852376360844405	[]	[]	3	hSpCas9	negative selection	3978175
111152403	111152426	X	+	26780180	A375	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	1.20951471677116	[]	[]	6	hSpCas9	negative selection	3978176
111147806	111147829	X	-	26780180	HT29	viability (GeCKOv2 library)	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.910487782122109	[]	[]	4	hSpCas9	negative selection	4086137
111147743	111147766	X	-	26780180	HT29	viability (GeCKOv2 library)	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.554952037888488	[]	[]	1	hSpCas9	negative selection	4086138
111152426	111152449	X	+	26780180	HT29	viability (GeCKOv2 library)	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.580949130109815	[]	[]	2	hSpCas9	negative selection	4086139
111142137	111142160	X	-	26780180	HT29	viability (GeCKOv2 library)	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	1.46849337032515	[]	[]	7	hSpCas9	negative selection	4086140
111142145	111142168	X	+	26780180	HT29	viability (GeCKOv2 library)	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	1.09401104332059	[]	[]	5	hSpCas9	negative selection	4086141
111152403	111152426	X	+	26780180	HT29	viability (GeCKOv2 library)	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	1.42017872441572	[]	[]	7	hSpCas9	negative selection	4086142
111147806	111147829	X	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.1535864364416124	[5]	[3,4]	4	hSpCas9	positive selection	4158659
111147743	111147766	X	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.3554901706338102	[5]	[4,4]	8	hSpCas9	positive selection	4158660
111142137	111142160	X	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.10540101277169034	[5]	[3,3]	2	hSpCas9	positive selection	4158661
111147806	111147829	X	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.7291074728526904	[5]	[5,6,2,3]	5	hSpCas9	positive selection	4222681
111147743	111147766	X	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.9893481416966831	[6]	[4,5,6,4]	7	hSpCas9	positive selection	4222682
111142137	111142160	X	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	1.0267196839876567	[5]	[6,4,4,5]	7	hSpCas9	positive selection	4222683
111142145	111142168	X	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.10590593051055121	[3]	[2,1]	2	hSpCas9	positive selection	4288695
111147743	111147766	X	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.32237798216668784	[3]	[4,3]	6	hSpCas9	positive selection	4288696
111142137	111142160	X	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.11089608272546705	[2]	[2,1]	2	hSpCas9	positive selection	4288697
111147806	111147829	X	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.17242775618938666	[4]	[4,2]	3	hSpCas9	positive selection	4352948
111152426	111152449	X	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.11261668885243742	[4]	[4,2]	2	hSpCas9	positive selection	4352949
111152403	111152426	X	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	-0.04279027758020154	[2]	[3,0]	-1	hSpCas9	positive selection	4352950
111123251	111123273	X	+	27760321	OCIAML3	viability	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	0.5104070278546348	[246,202]	[189,326]	6	hSpCas9	negative selection	4425404
111142166	111142188	X	+	27760321	OCIAML3	viability	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	0.32541252258575987	[651,579]	[498,737]	4	hSpCas9	negative selection	4425405
111147870	111147892	X	+	27760321	OCIAML3	viability	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	0.37788909762230105	[250,222]	[213,274]	4	hSpCas9	negative selection	4425406
111163011	111163033	X	-	27760321	OCIAML3	viability	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	-0.4510409614636143	[477,450]	[199,351]	-4	hSpCas9	negative selection	4425407
111163650	111163672	X	-	27760321	OCIAML3	viability	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	-0.6985330063955995	[73,75]	[34,37]	-6	hSpCas9	negative selection	4425408
111123251	111123273	X	+	27760321	OCIAML2	viability	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	0.725153648083553	[246,202]	[273,332]	8	hSpCas9	negative selection	4508867
111142166	111142188	X	+	27760321	OCIAML2	viability	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	0.31151433198044015	[651,579]	[525,737]	4	hSpCas9	negative selection	4508868
111147870	111147892	X	+	27760321	OCIAML2	viability	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	0.4957874280880686	[250,222]	[259,282]	6	hSpCas9	negative selection	4508869
111163011	111163033	X	-	27760321	OCIAML2	viability	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	0.14271306966372138	[477,450]	[384,454]	1	hSpCas9	negative selection	4508870
111163650	111163672	X	-	27760321	OCIAML2	viability	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	-1.0122355572074642	[73,75]	[40,15]	-7	hSpCas9	negative selection	4508871
111123251	111123273	X	+	27760321	MV411	viability	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	1.7469322998485919	[246,202]	[728,145]	9	hSpCas9	negative selection	4592330
111142166	111142188	X	+	27760321	MV411	viability	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	-0.11540183940492776	[651,579]	[231,588]	-1	hSpCas9	negative selection	4592331
111147870	111147892	X	+	27760321	MV411	viability	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	0.6817614102498797	[250,222]	[349,100]	5	hSpCas9	negative selection	4592332
111163011	111163033	X	-	27760321	MV411	viability	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	0.9422430943176111	[477,450]	[491,735]	7	hSpCas9	negative selection	4592333
111163650	111163672	X	-	27760321	MV411	viability	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	-0.2913755012726922	[73,75]	[62,6]	-2	hSpCas9	negative selection	4592334
111123251	111123273	X	+	27760321	HL60	viability	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	1.0036658305724016	[246,202]	[342,391]	9	hSpCas9	negative selection	4675793
111142166	111142188	X	+	27760321	HL60	viability	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	0.30426547673355725	[651,579]	[583,658]	4	hSpCas9	negative selection	4675794
111147870	111147892	X	+	27760321	HL60	viability	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	0.6908236968896475	[250,222]	[262,363]	7	hSpCas9	negative selection	4675795
111163011	111163033	X	-	27760321	HL60	viability	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	0.734959566887137	[477,450]	[634,628]	8	hSpCas9	negative selection	4675796
111163650	111163672	X	-	27760321	HL60	viability	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	0.7869969052590311	[73,75]	[111,99]	8	hSpCas9	negative selection	4675797
111123251	111123273	X	+	27760321	HT1080	viability	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	0.7815247132473825	[202,158]	[154,89]	4	hSpCas9	negative selection	4759256
111142166	111142188	X	+	27760321	HT1080	viability	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	0.47082695019594467	[579,452]	[330,234]	2	hSpCas9	negative selection	4759257
111147870	111147892	X	+	27760321	HT1080	viability	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	2.4183831700504084	[222,173]	[363,486]	9	hSpCas9	negative selection	4759258
111163011	111163033	X	-	27760321	HT1080	viability	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	1.4806747419164923	[450,351]	[506,379]	7	hSpCas9	negative selection	4759259
111163650	111163672	X	-	27760321	HT1080	viability	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	-4.76067111876748	[75,59]	[0,0]	-8	hSpCas9	negative selection	4759260
111123251	111123273	X	+	27760321	HT29	viability after 7 days	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	0.0942580149345198	[202,158]	[191,390,156]	1	hSpCas9	negative selection	4842719
111142166	111142188	X	+	27760321	HT29	viability after 7 days	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	0.06608663749342292	[579,452]	[457,647,936]	1	hSpCas9	negative selection	4842720
111147870	111147892	X	+	27760321	HT29	viability after 7 days	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	0.6704420402346225	[222,173]	[368,511,333]	8	hSpCas9	negative selection	4842721
111163011	111163033	X	-	27760321	HT29	viability after 7 days	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	-0.045377114028589266	[450,351]	[794,532,222]	0	hSpCas9	negative selection	4842722
111163650	111163672	X	-	27760321	HT29	viability after 7 days	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	-0.0934250071580367	[75,59]	[98,88,60]	-1	hSpCas9	negative selection	4842723
111123251	111123273	X	+	27760321	HT29	viability after 25 days	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	-0.5453390995121207	[202,158]	[158,131,131]	-5	hSpCas9	negative selection	4926182
111142166	111142188	X	+	27760321	HT29	viability after 25 days	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	-0.18362495405035506	[579,452]	[437,567,561]	-2	hSpCas9	negative selection	4926183
111147870	111147892	X	+	27760321	HT29	viability after 25 days	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	0.536599794388261	[222,173]	[319,253,422]	6	hSpCas9	negative selection	4926184
111163011	111163033	X	-	27760321	HT29	viability after 25 days	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	0.2922352998672614	[450,351]	[439,702,547]	3	hSpCas9	negative selection	4926185
111163650	111163672	X	-	27760321	HT29	viability after 25 days	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	-1.593628002727371	[75,59]	[25,18,32]	-7	hSpCas9	negative selection	4926186
111123251	111123273	X	+	27760321	HT29	viability after 22 days	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	0.05523453038496029	[202,158]	[187,264,199]	0	hSpCas9	negative selection	5009645
111142166	111142188	X	+	27760321	HT29	viability after 22 days	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	-0.28571112069160876	[579,452]	[273,747,452]	-3	hSpCas9	negative selection	5009646
111147870	111147892	X	+	27760321	HT29	viability after 22 days	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	0.491566419372433	[222,173]	[169,270,532]	5	hSpCas9	negative selection	5009647
111163011	111163033	X	-	27760321	HT29	viability after 22 days	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	0.8107483560408771	[450,351]	[776,906,758]	8	hSpCas9	negative selection	5009648
111163650	111163672	X	-	27760321	HT29	viability after 22 days	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	-0.7565246004786959	[75,59]	[41,31,65]	-6	hSpCas9	negative selection	5009649
111123251	111123273	X	+	27760321	HT29	viability after 19 days	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	0.38511839840917417	[202,158]	[312,245,256]	4	hSpCas9	negative selection	5093108
111142166	111142188	X	+	27760321	HT29	viability after 19 days	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	-0.01979013524370843	[579,452]	[730,363,664]	0	hSpCas9	negative selection	5093109
111147870	111147892	X	+	27760321	HT29	viability after 19 days	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	0.28942770546788366	[222,173]	[243,235,345]	2	hSpCas9	negative selection	5093110
111163011	111163033	X	-	27760321	HT29	viability after 19 days	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	-0.31326451700927604	[450,351]	[578,198,352]	-3	hSpCas9	negative selection	5093111
111163650	111163672	X	-	27760321	HT29	viability after 19 days	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	-0.6538496165159504	[75,59]	[75,21,52]	-5	hSpCas9	negative selection	5093112
111123251	111123273	X	+	27760321	HT29	viability after 16 days	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	0.10971559351547122	[202,158]	[144,320,179]	1	hSpCas9	negative selection	5176571
111142166	111142188	X	+	27760321	HT29	viability after 16 days	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	0.15714386002668768	[579,452]	[774,659,509]	1	hSpCas9	negative selection	5176572
111147870	111147892	X	+	27760321	HT29	viability after 16 days	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	0.938857633545126	[222,173]	[284,303,677]	9	hSpCas9	negative selection	5176573
111163011	111163033	X	-	27760321	HT29	viability after 16 days	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	0.49100488469147674	[450,351]	[719,754,423]	5	hSpCas9	negative selection	5176574
111163650	111163672	X	-	27760321	HT29	viability after 16 days	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	-0.38489203555300255	[75,59]	[56,49,67]	-4	hSpCas9	negative selection	5176575
111123251	111123273	X	+	27760321	HT29	viability after 13 days	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	0.31262439538366615	[202,158]	[371,315,103]	4	hSpCas9	negative selection	5260034
111142166	111142188	X	+	27760321	HT29	viability after 13 days	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	-0.18187046640944787	[579,452]	[486,641,459]	-2	hSpCas9	negative selection	5260035
111147870	111147892	X	+	27760321	HT29	viability after 13 days	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	0.298374548571832	[222,173]	[133,366,344]	4	hSpCas9	negative selection	5260036
111163011	111163033	X	-	27760321	HT29	viability after 13 days	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	0.4176685833355197	[450,351]	[702,451,705]	5	hSpCas9	negative selection	5260037
111163650	111163672	X	-	27760321	HT29	viability after 13 days	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	-2.0311362550418766	[75,59]	[1,36,18]	-8	hSpCas9	negative selection	5260038
111123251	111123273	X	+	27760321	HT29	viability after 10 days	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	0.5150604156885032	[202,158]	[378,397,196]	7	hSpCas9	negative selection	5343497
111142166	111142188	X	+	27760321	HT29	viability after 10 days	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	0.1319637189513032	[579,452]	[747,809,567]	1	hSpCas9	negative selection	5343498
111147870	111147892	X	+	27760321	HT29	viability after 10 days	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	-0.24405097819308652	[222,173]	[106,319,203]	-3	hSpCas9	negative selection	5343499
111163011	111163033	X	-	27760321	HT29	viability after 10 days	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	0.32252137330098307	[450,351]	[671,555,649]	4	hSpCas9	negative selection	5343500
111163650	111163672	X	-	27760321	HT29	viability after 10 days	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	0.4627892512633238	[75,59]	[18,315,23]	6	hSpCas9	negative selection	5343501
111123251	111123273	X	+	27760321	MOLM13	viability	TCTATCTTCCCAGGAGGAGGGG	PAK3	ENSG00000077264	1.3505834205234541	[246,202]	[285,352]	8	hSpCas9	negative selection	5426960
111142166	111142188	X	+	27760321	MOLM13	viability	GGGGTTTGATGCAGTCACCGGG	PAK3	ENSG00000077264	-0.6788778955239987	[651,579]	[266,173]	-4	hSpCas9	negative selection	5426961
111147870	111147892	X	+	27760321	MOLM13	viability	ACATGAGCTTTACATCAGGAGG	PAK3	ENSG00000077264	1.5653492181667048	[250,222]	[238,527]	9	hSpCas9	negative selection	5426962
111163011	111163033	X	-	27760321	MOLM13	viability	CTGGTCTTGGTGCGATAACTGG	PAK3	ENSG00000077264	1.5041419160837306	[477,450]	[608,858]	9	hSpCas9	negative selection	5426963
111163650	111163672	X	-	27760321	MOLM13	viability	GTGTTCCTGTACAAAGTACTGG	PAK3	ENSG00000077264	1.2829245251587258	[73,75]	[117,90]	8	hSpCas9	negative selection	5426964
111096139	111096162	X	+	27661255	K562	viability	GGTGACGTAATAGCAGAGAAGGG	PAK3	ENSG00000077264	0.07876605970310524	[1985,2082]	[1932,1528]	2	dCas9-KRAB	negative selection	5499997
111096145	111096168	X	+	27661255	K562	viability	GTAATAGCAGAGAAGGGCTAGGG	PAK3	ENSG00000077264	0.02747342001500991	[1005,811]	[777,712]	0	dCas9-KRAB	negative selection	5499998
111096180	111096203	X	+	27661255	K562	viability	GCAGGGGCTCTACCGCGGGCGGG	PAK3	ENSG00000077264	-0.04376267985834148	[286,446]	[333,237]	-2	dCas9-KRAB	negative selection	5499999
111096359	111096382	X	+	27661255	K562	viability	GCTGGAGCGCTCGGAGGTAGAGG	PAK3	ENSG00000077264	0.03051815161687907	[720,859]	[623,658]	1	dCas9-KRAB	negative selection	5500000
111096543	111096566	X	-	27661255	K562	viability	GGAGCCACGTAGGAGACTCGAGG	PAK3	ENSG00000077264	0.2407174123172988	[866,941]	[866,839]	7	dCas9-KRAB	negative selection	5500001
111142145	111142168	X	+	27260156	BXPC3	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.22387086552990146	[459]	[505,518,520,724]	5	hSpCas9	negative selection	5561155
111147743	111147766	X	-	27260156	BXPC3	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.18874306788886486	[818]	[845,863,1077,1153]	4	hSpCas9	negative selection	5561156
111142137	111142160	X	-	27260156	BXPC3	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.03005918767009874	[397]	[398,469,346,486]	0	hSpCas9	negative selection	5561157
111147806	111147829	X	-	27260156	BXPC3	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.3307098484544122	[1101]	[816,839,839,1211]	-6	hSpCas9	negative selection	5625408
111152426	111152449	X	+	27260156	BXPC3	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.005069103692998622	[1313]	[1361,1222,1398,1509]	0	hSpCas9	negative selection	5625409
111152403	111152426	X	+	27260156	BXPC3	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.2817670633860698	[244]	[318,338,255,327]	6	hSpCas9	negative selection	5625410
111142145	111142168	X	+	27260156	A673	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.0761769428101112	[459]	[643,442,594,660]	1	hSpCas9	negative selection	5682406
111147743	111147766	X	-	27260156	A673	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.24468898349937218	[818]	[1151,1267,908,1336]	6	hSpCas9	negative selection	5682407
111142137	111142160	X	-	27260156	A673	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.1733479832234382	[397]	[565,595,556,430]	4	hSpCas9	negative selection	5682408
111147806	111147829	X	-	27260156	A673	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.2285830383569023	[1101]	[1235,988,1096,1213]	-5	hSpCas9	negative selection	5746659
111152426	111152449	X	+	27260156	A673	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.1463466994057523	[1313]	[1525,1379,1403,1400]	-4	hSpCas9	negative selection	5746660
111152403	111152426	X	+	27260156	A673	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	-0.027161281735555987	[244]	[317,283,250,305]	0	hSpCas9	negative selection	5746661
111142145	111142168	X	+	27260156	A375	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.4089476695793518	[459]	[608,718,941,594]	6	hSpCas9	negative selection	5803657
111147743	111147766	X	-	27260156	A375	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.484947533297438	[818]	[1220,1447,1363,1331]	7	hSpCas9	negative selection	5803658
111142137	111142160	X	-	27260156	A375	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.3873225183256439	[397]	[617,634,502,669]	5	hSpCas9	negative selection	5803659
111147806	111147829	X	-	27260156	A375	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.2272428018290662	[1101]	[1274,1029,883,1185]	-3	hSpCas9	negative selection	5867910
111152426	111152449	X	+	27260156	A375	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.0744834031456354	[1313]	[1780,2190,1467,1154]	1	hSpCas9	negative selection	5867911
111152403	111152426	X	+	27260156	A375	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.46880783973781703	[244]	[405,437,500,259]	7	hSpCas9	negative selection	5867912
111142145	111142168	X	+	27260156	COLO741	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	-0.11665214724784528	[459]	[558,518,547]	-3	hSpCas9	negative selection	5924908
111147743	111147766	X	-	27260156	COLO741	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.15795549850129786	[818]	[1473,1046,1015]	3	hSpCas9	negative selection	5924909
111142137	111142160	X	-	27260156	COLO741	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.10255212658600185	[397]	[729,473,454]	2	hSpCas9	negative selection	5924910
111147806	111147829	X	-	27260156	COLO741	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.42806966060998564	[1101]	[1096,1033,1012]	-7	hSpCas9	negative selection	5989161
111152426	111152449	X	+	27260156	COLO741	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.022714047823255035	[1313]	[1952,1412,1615]	0	hSpCas9	negative selection	5989162
111152403	111152426	X	+	27260156	COLO741	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	-0.006769379041257961	[244]	[328,385,226]	0	hSpCas9	negative selection	5989163
111142145	111142168	X	+	27260156	CAL120	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.378696636863127	[459]	[954,725,585]	5	hSpCas9	negative selection	6046159
111147743	111147766	X	-	27260156	CAL120	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	-0.006836196715423348	[818]	[1334,750,1004]	0	hSpCas9	negative selection	6046160
111142137	111142160	X	-	27260156	CAL120	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.6971020043724796	[397]	[710,842,839]	8	hSpCas9	negative selection	6046161
111147806	111147829	X	-	27260156	CAL120	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.14093899982390012	[1101]	[1512,1122,1136]	-2	hSpCas9	negative selection	6110412
111152426	111152449	X	+	27260156	CAL120	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.01459608940329371	[1313]	[1791,1773,1413]	0	hSpCas9	negative selection	6110413
111152403	111152426	X	+	27260156	CAL120	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.11498568136529674	[244]	[159,319,481]	1	hSpCas9	negative selection	6110414
111142145	111142168	X	+	27260156	CADOES1	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.5971566760795246	[459]	[638,669,678,598]	8	hSpCas9	negative selection	6167410
111147743	111147766	X	-	27260156	CADOES1	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.28046669314921924	[818]	[874,1004,971,845]	5	hSpCas9	negative selection	6167411
111142137	111142160	X	-	27260156	CADOES1	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.04136784583504066	[397]	[280,414,396,432]	0	hSpCas9	negative selection	6167412
111147806	111147829	X	-	27260156	CADOES1	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.21031573730023845	[1101]	[912,953,832,841]	-4	hSpCas9	negative selection	6231663
111152426	111152449	X	+	27260156	CADOES1	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.20654647176300944	[1313]	[988,1212,1047,983]	-4	hSpCas9	negative selection	6231664
111152403	111152426	X	+	27260156	CADOES1	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.1334350856931431	[244]	[235,381,236,140]	2	hSpCas9	negative selection	6231665
111142145	111142168	X	+	27260156	EWS502	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.18534912032724085	[459]	[598,471,494,651]	3	hSpCas9	negative selection	6288661
111147743	111147766	X	-	27260156	EWS502	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.3406298809780717	[818]	[891,1090,1036,1416]	6	hSpCas9	negative selection	6288662
111142137	111142160	X	-	27260156	EWS502	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.1750188095024461	[397]	[263,345,470,430]	-3	hSpCas9	negative selection	6288663
111147806	111147829	X	-	27260156	EWS502	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.2215317311592655	[1101]	[955,1034,893,1126]	-4	hSpCas9	negative selection	6352914
111152426	111152449	X	+	27260156	EWS502	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.2017432294664796	[1313]	[1181,1214,1253,1186]	-4	hSpCas9	negative selection	6352915
111152403	111152426	X	+	27260156	EWS502	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.08841355138729912	[244]	[183,321,178,436]	1	hSpCas9	negative selection	6352916
111142145	111142168	X	+	27260156	EW8	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.3141083016307938	[459]	[531,397,347,600]	6	hSpCas9	negative selection	6409912
111147743	111147766	X	-	27260156	EW8	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.37301634596544453	[818]	[1369,688,661,803]	6	hSpCas9	negative selection	6409913
111142137	111142160	X	-	27260156	EW8	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.31945190801678447	[397]	[261,261,225,288]	-5	hSpCas9	negative selection	6409914
111147806	111147829	X	-	27260156	EW8	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.17987283934326315	[1101]	[700,771,735,940]	-3	hSpCas9	negative selection	6474165
111152426	111152449	X	+	27260156	EW8	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.20568611905303436	[1313]	[1068,832,854,960]	-4	hSpCas9	negative selection	6474166
111152403	111152426	X	+	27260156	EW8	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.3785105945525994	[244]	[248,317,270,190]	7	hSpCas9	negative selection	6474167
111142145	111142168	X	+	27260156	CORL105	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.11937648583337049	[459]	[619,554,706,478]	2	hSpCas9	negative selection	6531163
111147743	111147766	X	-	27260156	CORL105	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.2596204504174029	[818]	[1271,1029,1375,955]	5	hSpCas9	negative selection	6531164
111142137	111142160	X	-	27260156	CORL105	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.20186835995431812	[397]	[487,546,576,535]	4	hSpCas9	negative selection	6531165
111147806	111147829	X	-	27260156	CORL105	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.09256680821102292	[1101]	[1159,1196,1512,1015]	-2	hSpCas9	negative selection	6595416
111152426	111152449	X	+	27260156	CORL105	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.09096351433563887	[1313]	[1420,1274,1710,1413]	-2	hSpCas9	negative selection	6595417
111152403	111152426	X	+	27260156	CORL105	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.09282858258708127	[244]	[375,292,253,294]	1	hSpCas9	negative selection	6595418
111142145	111142168	X	+	27260156	HS294T	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.06767692591131	[459]	[230,134,211,159]	0	hSpCas9	negative selection	6652414
111147743	111147766	X	-	27260156	HS294T	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.3946247348854035	[818]	[424,479,327,429]	5	hSpCas9	negative selection	6652415
111142137	111142160	X	-	27260156	HS294T	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.2198468831480707	[397]	[190,229,139,146]	3	hSpCas9	negative selection	6652416
111147806	111147829	X	-	27260156	HS294T	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.0390213410052056	[1101]	[326,450,368,647]	0	hSpCas9	negative selection	6716667
111152426	111152449	X	+	27260156	HS294T	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.0409055932328759	[1313]	[471,534,390,592]	0	hSpCas9	negative selection	6716668
111152403	111152426	X	+	27260156	HS294T	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.08836004805599418	[244]	[69,169,77,81]	1	hSpCas9	negative selection	6716669
111142145	111142168	X	+	27260156	HCC44	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.4878518467773911	[459]	[772,439,1419,452]	7	hSpCas9	negative selection	6773665
111147743	111147766	X	-	27260156	HCC44	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.2781660955632521	[818]	[1138,1102,1172,1082]	4	hSpCas9	negative selection	6773666
111142137	111142160	X	-	27260156	HCC44	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.013569448046746563	[397]	[559,337,639,305]	0	hSpCas9	negative selection	6773667
111147806	111147829	X	-	27260156	HCC44	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.18577641320238691	[1101]	[1101,959,1148,1188]	-3	hSpCas9	negative selection	6837918
111152426	111152449	X	+	27260156	HCC44	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.03215127626402703	[1313]	[1395,1258,1746,1471]	0	hSpCas9	negative selection	6837919
111152403	111152426	X	+	27260156	HCC44	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.19221819903356874	[244]	[213,265,372,414]	3	hSpCas9	negative selection	6837920
111142145	111142168	X	+	27260156	G402	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.4558427022253603	[459]	[1187,756,694,508]	5	hSpCas9	negative selection	6894916
111147743	111147766	X	-	27260156	G402	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.25043575851064626	[818]	[1290,742,1550,1155]	3	hSpCas9	negative selection	6894917
111142137	111142160	X	-	27260156	G402	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.1962645017648833	[397]	[582,602,486,556]	2	hSpCas9	negative selection	6894918
111147806	111147829	X	-	27260156	G402	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.4339406221577137	[1101]	[830,1083,687,1338]	-5	hSpCas9	negative selection	6959169
111152426	111152449	X	+	27260156	G402	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.012343417070852514	[1313]	[1150,1411,1937,1768]	0	hSpCas9	negative selection	6959170
111152403	111152426	X	+	27260156	G402	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.6223549132271113	[244]	[370,505,368,576]	7	hSpCas9	negative selection	6959171
111142145	111142168	X	+	27260156	L33	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	-0.061569701813630355	[459]	[450,174,232,512]	-1	hSpCas9	negative selection	7016167
111147743	111147766	X	-	27260156	L33	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.14017738141216285	[818]	[1019,371,507,870]	3	hSpCas9	negative selection	7016168
111142137	111142160	X	-	27260156	L33	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.010410667269234702	[397]	[392,196,254,301]	0	hSpCas9	negative selection	7016169
111147806	111147829	X	-	27260156	L33	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.005409170654647966	[1101]	[1300,431,620,1042]	0	hSpCas9	negative selection	7080420
111152426	111152449	X	+	27260156	L33	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.06191093599544084	[1313]	[1281,486,885,1155]	-1	hSpCas9	negative selection	7080421
111152403	111152426	X	+	27260156	L33	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	-0.19553176693119623	[244]	[231,102,93,221]	-4	hSpCas9	negative selection	7080422
111142145	111142168	X	+	27260156	K562	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.7097297081369396	[459]	[368,538,810,890]	8	hSpCas9	negative selection	7137418
111147743	111147766	X	-	27260156	K562	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.35302552320615654	[818]	[933,1001,909,873]	4	hSpCas9	negative selection	7137419
111142137	111142160	X	-	27260156	K562	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.8098476966590198	[397]	[579,612,568,698]	8	hSpCas9	negative selection	7137420
111147806	111147829	X	-	27260156	K562	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.08971384327747778	[1101]	[1146,1140,774,1101]	1	hSpCas9	negative selection	7201671
111152426	111152449	X	+	27260156	K562	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.3284897716934678	[1313]	[1501,1132,1987,1239]	4	hSpCas9	negative selection	7201672
111152403	111152426	X	+	27260156	K562	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.5430050686133084	[244]	[136,226,750,150]	7	hSpCas9	negative selection	7201673
111142145	111142168	X	+	27260156	HT29	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.30504760998760333	[459]	[833,644,591,693]	6	hSpCas9	negative selection	7258669
111147743	111147766	X	-	27260156	HT29	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.1406656238304057	[818]	[1353,964,1112,973]	2	hSpCas9	negative selection	7258670
111142137	111142160	X	-	27260156	HT29	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.26156792717686383	[397]	[607,676,629,429]	5	hSpCas9	negative selection	7258671
111147806	111147829	X	-	27260156	HT29	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.09916545166022517	[1101]	[1263,1400,1187,1164]	-2	hSpCas9	negative selection	7322922
111152426	111152449	X	+	27260156	HT29	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.08402188390808707	[1313]	[1612,1572,1475,1383]	-2	hSpCas9	negative selection	7322923
111152403	111152426	X	+	27260156	HT29	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	-0.2765567035485681	[244]	[327,217,268,178]	-5	hSpCas9	negative selection	7322924
111142145	111142168	X	+	27260156	MHHES1	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.17438973373631828	[459]	[555,651,661,482]	3	hSpCas9	negative selection	7379920
111147743	111147766	X	-	27260156	MHHES1	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.27664480421919824	[818]	[961,1268,1142,1075]	5	hSpCas9	negative selection	7379921
111142137	111142160	X	-	27260156	MHHES1	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.017204722511349496	[397]	[390,393,579,396]	0	hSpCas9	negative selection	7379922
111147806	111147829	X	-	27260156	MHHES1	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.04132142437366637	[1101]	[1640,1287,1230,1023]	0	hSpCas9	negative selection	7444173
111152426	111152449	X	+	27260156	MHHES1	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.05266689996891816	[1313]	[1196,1598,1446,1421]	-1	hSpCas9	negative selection	7444174
111152403	111152426	X	+	27260156	MHHES1	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.08411054773759619	[244]	[372,332,302,191]	1	hSpCas9	negative selection	7444175
111142145	111142168	X	+	27260156	MEWO	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.21711491900721977	[459]	[510,443,547]	5	hSpCas9	negative selection	7501171
111147743	111147766	X	-	27260156	MEWO	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.09472327962197913	[818]	[924,852,696]	2	hSpCas9	negative selection	7501172
111142137	111142160	X	-	27260156	MEWO	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.22113026067663774	[397]	[377,235,355]	-5	hSpCas9	negative selection	7501173
111147806	111147829	X	-	27260156	MEWO	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.18755191769005752	[1101]	[932,921,865]	-4	hSpCas9	negative selection	7565424
111152426	111152449	X	+	27260156	MEWO	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.18037529712776124	[1313]	[1217,900,1161]	-4	hSpCas9	negative selection	7565425
111152403	111152426	X	+	27260156	MEWO	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	-0.07140263264958446	[244]	[278,253,132]	-1	hSpCas9	negative selection	7565426
111142145	111142168	X	+	27260156	LNCAPCLONEFGC	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.4570896672549983	[459]	[467,624,738,478]	7	hSpCas9	negative selection	7622422
111147743	111147766	X	-	27260156	LNCAPCLONEFGC	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.40295882816316353	[818]	[1025,961,1226,744]	6	hSpCas9	negative selection	7622423
111142137	111142160	X	-	27260156	LNCAPCLONEFGC	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.08334663107893356	[397]	[431,344,414,341]	1	hSpCas9	negative selection	7622424
111147806	111147829	X	-	27260156	LNCAPCLONEFGC	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.15078043271608377	[1101]	[1042,908,1339,1188]	2	hSpCas9	negative selection	7686675
111152426	111152449	X	+	27260156	LNCAPCLONEFGC	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.08342638042578843	[1313]	[1352,1313,1257,1112]	1	hSpCas9	negative selection	7686676
111152403	111152426	X	+	27260156	LNCAPCLONEFGC	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.028645623650928265	[244]	[174,133,404,224]	0	hSpCas9	negative selection	7686677
111142145	111142168	X	+	27260156	PANC0327	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	-0.06367986568139913	[459]	[307,298,499,461]	-1	hSpCas9	negative selection	7743673
111147743	111147766	X	-	27260156	PANC0327	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.3523307357557568	[818]	[1212,752,991,802]	5	hSpCas9	negative selection	7743674
111142137	111142160	X	-	27260156	PANC0327	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.09299170415976019	[397]	[176,289,597,253]	-1	hSpCas9	negative selection	7743675
111147806	111147829	X	-	27260156	PANC0327	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.13568722786453336	[1101]	[1041,891,782,858]	-2	hSpCas9	negative selection	7807926
111152426	111152449	X	+	27260156	PANC0327	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.23064423654676514	[1313]	[1715,1234,1442,1129]	3	hSpCas9	negative selection	7807927
111152403	111152426	X	+	27260156	PANC0327	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.35410782024121734	[244]	[202,206,462,242]	5	hSpCas9	negative selection	7807928
111142145	111142168	X	+	27260156	NCIH2009	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.3638091626377745	[459]	[989,710,812]	5	hSpCas9	negative selection	7864924
111147743	111147766	X	-	27260156	NCIH2009	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.11302208586834628	[818]	[1523,1186,1056]	1	hSpCas9	negative selection	7864925
111142137	111142160	X	-	27260156	NCIH2009	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.051971164027701466	[397]	[529,423,767]	0	hSpCas9	negative selection	7864926
111147806	111147829	X	-	27260156	NCIH2009	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.3056519577216261	[1101]	[1595,1038,1172]	-4	hSpCas9	negative selection	7929177
111152426	111152449	X	+	27260156	NCIH2009	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.2979405551886458	[1313]	[1991,1381,1203]	-4	hSpCas9	negative selection	7929178
111152403	111152426	X	+	27260156	NCIH2009	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	-0.14296428711434928	[244]	[258,277,382]	-2	hSpCas9	negative selection	7929179
111142145	111142168	X	+	27260156	NCIH1373	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	1.2669675753863956	[459]	[835,1474,1240,346]	9	hSpCas9	negative selection	7986175
111147743	111147766	X	-	27260156	NCIH1373	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.8120614322406616	[818]	[2117,1024,1823,422]	7	hSpCas9	negative selection	7986176
111142137	111142160	X	-	27260156	NCIH1373	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.32920448671704916	[397]	[452,480,505,211]	3	hSpCas9	negative selection	7986177
111147806	111147829	X	-	27260156	NCIH1373	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.31384413643638254	[1101]	[1505,648,666,338]	-3	hSpCas9	negative selection	8050428
111152426	111152449	X	+	27260156	NCIH1373	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.30232239226113644	[1313]	[2839,1544,1255,476]	3	hSpCas9	negative selection	8050429
111152403	111152426	X	+	27260156	NCIH1373	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.5642306357134947	[244]	[351,527,328,102]	5	hSpCas9	negative selection	8050430
111142145	111142168	X	+	27260156	PATU8902	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	1.0402376426747961	[459]	[940,1211,1228,1984]	9	hSpCas9	negative selection	8107426
111147743	111147766	X	-	27260156	PATU8902	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.19035355077124572	[818]	[1332,1807,1053,1033]	2	hSpCas9	negative selection	8107427
111142137	111142160	X	-	27260156	PATU8902	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.22139176669626276	[397]	[842,420,664,641]	2	hSpCas9	negative selection	8107428
111147806	111147829	X	-	27260156	PATU8902	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.10020136159399318	[1101]	[1439,1612,1574,998]	-1	hSpCas9	negative selection	8171679
111152426	111152449	X	+	27260156	PATU8902	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.21505823023001347	[1313]	[1920,2324,1804,2567]	2	hSpCas9	negative selection	8171680
111152403	111152426	X	+	27260156	PATU8902	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.8766098398195186	[244]	[516,786,237,1120]	8	hSpCas9	negative selection	8171681
111142145	111142168	X	+	27260156	PANC1	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.595829533430703	[459]	[463,812,733,441]	8	hSpCas9	negative selection	8228677
111147743	111147766	X	-	27260156	PANC1	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.26127313146847886	[818]	[844,1266,643,709]	4	hSpCas9	negative selection	8228678
111142137	111142160	X	-	27260156	PANC1	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.1240233967049797	[397]	[251,730,303,286]	2	hSpCas9	negative selection	8228679
111147806	111147829	X	-	27260156	PANC1	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.13927454206751633	[1101]	[1121,1129,1202,761]	2	hSpCas9	negative selection	8292930
111152426	111152449	X	+	27260156	PANC1	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.3403415636760767	[1313]	[1461,1609,1481,1210]	5	hSpCas9	negative selection	8292931
111152403	111152426	X	+	27260156	PANC1	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.2380907096923246	[244]	[329,286,235,156]	4	hSpCas9	negative selection	8292932
111142145	111142168	X	+	27260156	PANC0813	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.06133060221682762	[459]	[662,518,581,502]	1	hSpCas9	negative selection	8349928
111147743	111147766	X	-	27260156	PANC0813	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.27655358338863034	[818]	[1243,1062,1249,1112]	4	hSpCas9	negative selection	8349929
111142137	111142160	X	-	27260156	PANC0813	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.2853698354923617	[397]	[784,506,428,575]	4	hSpCas9	negative selection	8349930
111147806	111147829	X	-	27260156	PANC0813	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.0020450828620994788	[1101]	[1322,1274,1471,1125]	0	hSpCas9	negative selection	8414181
111152426	111152449	X	+	27260156	PANC0813	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.10778898002730442	[1313]	[1552,1982,1548,1559]	1	hSpCas9	negative selection	8414182
111152403	111152426	X	+	27260156	PANC0813	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.0370497479985501	[244]	[238,251,322,357]	0	hSpCas9	negative selection	8414183
111142145	111142168	X	+	27260156	RDES	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.35698763784096327	[459]	[554,579,782,835]	6	hSpCas9	negative selection	8471179
111147743	111147766	X	-	27260156	RDES	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.314005514655044	[818]	[885,965,1508,1421]	5	hSpCas9	negative selection	8471180
111142137	111142160	X	-	27260156	RDES	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.048876857820779884	[397]	[310,406,639,588]	0	hSpCas9	negative selection	8471181
111147806	111147829	X	-	27260156	RDES	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.12657003149986412	[1101]	[1113,935,1214,1412]	-2	hSpCas9	negative selection	8535432
111152426	111152449	X	+	27260156	RDES	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.06426729923587837	[1313]	[1189,1536,1609,2106]	1	hSpCas9	negative selection	8535433
111152403	111152426	X	+	27260156	RDES	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.13142868024232435	[244]	[247,371,246,371]	2	hSpCas9	negative selection	8535434
111142145	111142168	X	+	27260156	PC3	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.029032705508355714	[459]	[275,332,974,537]	0	hSpCas9	negative selection	8592430
111147743	111147766	X	-	27260156	PC3	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.013876103443617671	[818]	[618,944,1213,649]	0	hSpCas9	negative selection	8592431
111142137	111142160	X	-	27260156	PC3	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.19583855594417762	[397]	[290,325,593,247]	-4	hSpCas9	negative selection	8592432
111147806	111147829	X	-	27260156	PC3	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.11923768669307933	[1101]	[670,1073,1658,930]	-3	hSpCas9	negative selection	8656683
111152426	111152449	X	+	27260156	PC3	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.12461858278539739	[1313]	[727,1242,2051,1204]	-3	hSpCas9	negative selection	8656684
111152403	111152426	X	+	27260156	PC3	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	-0.3749340061924622	[244]	[108,184,351,188]	-7	hSpCas9	negative selection	8656685
111142145	111142168	X	+	27260156	PATU8988T	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.21217293501027354	[459]	[811,456,444,325]	3	hSpCas9	negative selection	8713681
111147743	111147766	X	-	27260156	PATU8988T	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.4129840602464512	[818]	[1070,1136,1036,970]	7	hSpCas9	negative selection	8713682
111142137	111142160	X	-	27260156	PATU8988T	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.10046927466941555	[397]	[351,187,601,265]	-2	hSpCas9	negative selection	8713683
111147806	111147829	X	-	27260156	PATU8988T	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.1344436378984708	[1101]	[1002,913,1092,853]	-2	hSpCas9	negative selection	8777934
111152426	111152449	X	+	27260156	PATU8988T	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.16229499585219131	[1313]	[834,1466,1126,1140]	-3	hSpCas9	negative selection	8777935
111152403	111152426	X	+	27260156	PATU8988T	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	-0.34750990747027055	[244]	[175,210,131,231]	-5	hSpCas9	negative selection	8777936
111142145	111142168	X	+	27260156	T47D	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.17438348982620036	[459]	[767,574,477,602]	3	hSpCas9	negative selection	8834932
111147743	111147766	X	-	27260156	T47D	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.3007907500243452	[818]	[1089,1145,1212,1255]	6	hSpCas9	negative selection	8834933
111142137	111142160	X	-	27260156	T47D	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.02137822895266156	[397]	[520,411,509,442]	0	hSpCas9	negative selection	8834934
111147806	111147829	X	-	27260156	T47D	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.03816156354868361	[1101]	[1325,1117,1206,1365]	-1	hSpCas9	negative selection	8899185
111152426	111152449	X	+	27260156	T47D	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.023321015625421326	[1313]	[1540,1495,1416,1782]	0	hSpCas9	negative selection	8899186
111152403	111152426	X	+	27260156	T47D	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.09651094769515578	[244]	[323,305,262,328]	2	hSpCas9	negative selection	8899187
111142145	111142168	X	+	27260156	SU8686	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	-0.07164406445253191	[459]	[333,470,452,490]	-1	hSpCas9	negative selection	8956183
111147743	111147766	X	-	27260156	SU8686	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.36527364044890165	[818]	[1214,934,984,1031]	6	hSpCas9	negative selection	8956184
111142137	111142160	X	-	27260156	SU8686	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.3645022196141388	[397]	[553,514,400,556]	6	hSpCas9	negative selection	8956185
111147806	111147829	X	-	27260156	SU8686	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.10550987634441822	[1101]	[963,872,1032,1246]	-2	hSpCas9	negative selection	9020436
111152426	111152449	X	+	27260156	SU8686	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.0014931552897401446	[1313]	[1015,1140,1639,1492]	0	hSpCas9	negative selection	9020437
111152403	111152426	X	+	27260156	SU8686	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.13787782406049198	[244]	[223,220,348,289]	2	hSpCas9	negative selection	9020438
111142145	111142168	X	+	27260156	SKES1	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.1488548360129907	[459]	[422,571,582,452]	3	hSpCas9	negative selection	9077434
111147743	111147766	X	-	27260156	SKES1	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	-0.038828885137532354	[818]	[1058,751,707,697]	-1	hSpCas9	negative selection	9077435
111142137	111142160	X	-	27260156	SKES1	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.05709377082457581	[397]	[585,461,361,283]	1	hSpCas9	negative selection	9077436
111147806	111147829	X	-	27260156	SKES1	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.010392800007171576	[1101]	[1141,1248,1044,1014]	0	hSpCas9	negative selection	9141687
111152426	111152449	X	+	27260156	SKES1	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.02226730591907833	[1313]	[1447,1760,1261,953]	0	hSpCas9	negative selection	9141688
111152403	111152426	X	+	27260156	SKES1	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.022973074032096363	[244]	[266,299,181,250]	0	hSpCas9	negative selection	9141689
111142145	111142168	X	+	27260156	TOV112D	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.32797072829851515	[459]	[511,453,836,475]	6	hSpCas9	negative selection	9198685
111147743	111147766	X	-	27260156	TOV112D	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.4412220960214859	[818]	[894,1644,1042,985]	7	hSpCas9	negative selection	9198686
111142137	111142160	X	-	27260156	TOV112D	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.2586207103744619	[397]	[380,297,220,424]	-5	hSpCas9	negative selection	9198687
111147806	111147829	X	-	27260156	TOV112D	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.023192619159734917	[1101]	[1402,1300,640,1204]	0	hSpCas9	negative selection	9262938
111152426	111152449	X	+	27260156	TOV112D	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	0.08203720562154881	[1313]	[1570,1754,1247,1107]	1	hSpCas9	negative selection	9262939
111152403	111152426	X	+	27260156	TOV112D	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	-0.6451469979478903	[244]	[198,210,105,128]	-8	hSpCas9	negative selection	9262940
111142145	111142168	X	+	27260156	TC71	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.10547146369966928	[459]	[504,538,506,574]	2	hSpCas9	negative selection	9319936
111147743	111147766	X	-	27260156	TC71	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.117548607579125	[818]	[1012,878,1012,897]	3	hSpCas9	negative selection	9319937
111142137	111142160	X	-	27260156	TC71	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	-0.10908344876422862	[397]	[441,368,333,440]	-3	hSpCas9	negative selection	9319938
111147806	111147829	X	-	27260156	TC71	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.11905484348679729	[1101]	[993,1098,1160,1096]	-3	hSpCas9	negative selection	9384189
111152426	111152449	X	+	27260156	TC71	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.06699678125867203	[1313]	[1238,1346,1310,1493]	-2	hSpCas9	negative selection	9384190
111152403	111152426	X	+	27260156	TC71	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	0.2831576494536703	[244]	[367,322,286,298]	7	hSpCas9	negative selection	9384191
111142145	111142168	X	+	27260156	TC32	viability	CTTTGAGCATACGATTCATGTGG	PAK3	ENSG00000077264	0.13703053991486833	[459]	[411,355,634,555]	2	hSpCas9	negative selection	9441187
111147743	111147766	X	-	27260156	TC32	viability	AGTAATCGTGCCCATTGCTCTGG	PAK3	ENSG00000077264	0.32456141524938964	[818]	[843,767,1057,1248]	6	hSpCas9	negative selection	9441188
111142137	111142160	X	-	27260156	TC32	viability	ATCGTATGCTCAAAGTCTGAAGG	PAK3	ENSG00000077264	0.3540131246934807	[397]	[500,401,474,531]	6	hSpCas9	negative selection	9441189
111147806	111147829	X	-	27260156	TC32	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.26931323177002753	[1101]	[847,611,1268,820]	-5	hSpCas9	negative selection	9505440
111152426	111152449	X	+	27260156	TC32	viability	ATACATAGCAGCCCATCCTTCGG	PAK3	ENSG00000077264	-0.1292089902550515	[1313]	[968,924,1282,1410]	-2	hSpCas9	negative selection	9505441
111152403	111152426	X	+	27260156	TC32	viability	TTTGCAGATAAAAGTGCACATGG	PAK3	ENSG00000077264	-0.1311381354622263	[244]	[284,156,207,185]	-2	hSpCas9	negative selection	9505442
111123135	111123158	X	-	27869803	HPAFII	viability after 27 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	0.30804069265630085	[118]	[83,71,NaN]	2	hSpCas9	negative selection	9607192
111146530	111146553	X	+	27869803	HPAFII	viability after 27 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	0.996787729729947	[110]	[134,100,NaN]	7	hSpCas9	negative selection	9607193
111147732	111147755	X	+	27869803	HPAFII	viability after 27 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.1634507662374728	[390]	[194,173,NaN]	-1	hSpCas9	negative selection	9607194
111162947	111162970	X	-	27869803	HPAFII	viability after 27 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	1.169645086362374	[209]	[63,401,NaN]	8	hSpCas9	negative selection	9607195
111192146	111192169	X	+	27869803	HPAFII	viability after 27 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.5826931756341537	[356]	[219,331,NaN]	5	hSpCas9	negative selection	9607196
111195856	111195879	X	+	27869803	HPAFII	viability after 27 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	-1.039753356703974	[261]	[66,66,NaN]	-6	hSpCas9	negative selection	9607197
111123135	111123158	X	-	27869803	HPAFII	viability after 15 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	-0.4831200662182529	[118]	[72,102,NaN]	-5	hSpCas9	negative selection	9689641
111146530	111146553	X	+	27869803	HPAFII	viability after 15 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	0.38663621584916075	[110]	[253,94,NaN]	4	hSpCas9	negative selection	9689642
111147732	111147755	X	+	27869803	HPAFII	viability after 15 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	0.2210613314234222	[390]	[704,355,NaN]	2	hSpCas9	negative selection	9689643
111162947	111162970	X	-	27869803	HPAFII	viability after 15 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.12380763079285867	[209]	[248,243,NaN]	1	hSpCas9	negative selection	9689644
111192146	111192169	X	+	27869803	HPAFII	viability after 15 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.5172095456838809	[356]	[529,560,NaN]	6	hSpCas9	negative selection	9689645
111195856	111195879	X	+	27869803	HPAFII	viability after 15 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	-0.5144788308118982	[261]	[214,185,NaN]	-5	hSpCas9	negative selection	9689646
111123135	111123158	X	-	27869803	ASPC1	viability after 36 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	-1.3320087429190335	[212]	[92,8,0]	-8	hSpCas9	negative selection	9772090
111146530	111146553	X	+	27869803	ASPC1	viability after 36 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	1.6068575878112434	[136]	[290,63,106]	9	hSpCas9	negative selection	9772091
111147732	111147755	X	+	27869803	ASPC1	viability after 36 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	0.5969432141176678	[978]	[772,338,472]	6	hSpCas9	negative selection	9772092
111162947	111162970	X	-	27869803	ASPC1	viability after 36 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.10631951493225739	[507]	[220,80,254]	1	hSpCas9	negative selection	9772093
111192146	111192169	X	+	27869803	ASPC1	viability after 36 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	-0.3005073168624691	[776]	[220,226,211]	-3	hSpCas9	negative selection	9772094
111195856	111195879	X	+	27869803	ASPC1	viability after 36 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.6034539892305177	[694]	[390,612,154]	6	hSpCas9	negative selection	9772095
111123135	111123158	X	-	27869803	PATU8988S	viability after 35 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	0.9923559839750896	[251]	[163,239,NaN]	8	hSpCas9	negative selection	9854539
111146530	111146553	X	+	27869803	PATU8988S	viability after 35 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	-0.847558435815827	[202]	[16,73,NaN]	-7	hSpCas9	negative selection	9854540
111147732	111147755	X	+	27869803	PATU8988S	viability after 35 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.2718961123956962	[1026]	[375,308,NaN]	-3	hSpCas9	negative selection	9854541
111162947	111162970	X	-	27869803	PATU8988S	viability after 35 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.4722748513386421	[411]	[316,142,NaN]	5	hSpCas9	negative selection	9854542
111192146	111192169	X	+	27869803	PATU8988S	viability after 35 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	-0.15261707527868917	[780]	[270,294,NaN]	-2	hSpCas9	negative selection	9854543
111195856	111195879	X	+	27869803	PATU8988S	viability after 35 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.46425020170765585	[430]	[229,248,NaN]	5	hSpCas9	negative selection	9854544
111123135	111123158	X	-	27869803	PATU8988S	viability after 31 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	0.9687626424437644	[251]	[109,306,NaN]	9	hSpCas9	negative selection	9936988
111146530	111146553	X	+	27869803	PATU8988S	viability after 31 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	-0.35180778144267055	[202]	[7,133,NaN]	-4	hSpCas9	negative selection	9936989
111147732	111147755	X	+	27869803	PATU8988S	viability after 31 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.5377959526209553	[1026]	[278,285,NaN]	-5	hSpCas9	negative selection	9936990
111162947	111162970	X	-	27869803	PATU8988S	viability after 31 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	0.2925312028153813	[411]	[253,133,NaN]	3	hSpCas9	negative selection	9936991
111192146	111192169	X	+	27869803	PATU8988S	viability after 31 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	-0.10169736658785694	[780]	[203,399,NaN]	-1	hSpCas9	negative selection	9936992
111195856	111195879	X	+	27869803	PATU8988S	viability after 31 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	0.7552269945881513	[430]	[286,293,NaN]	8	hSpCas9	negative selection	9936993
111123135	111123158	X	-	27869803	HPAFII	viability after 35 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	-0.3932638827737338	[118]	[19,74,NaN]	-2	hSpCas9	negative selection	10019437
111146530	111146553	X	+	27869803	HPAFII	viability after 35 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	1.3825657683010528	[110]	[114,181,NaN]	8	hSpCas9	negative selection	10019438
111147732	111147755	X	+	27869803	HPAFII	viability after 35 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.43981488647185074	[390]	[120,173,NaN]	-3	hSpCas9	negative selection	10019439
111162947	111162970	X	-	27869803	HPAFII	viability after 35 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	1.2204289123928864	[209]	[44,475,NaN]	7	hSpCas9	negative selection	10019440
111192146	111192169	X	+	27869803	HPAFII	viability after 35 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.8016068180384618	[356]	[235,403,NaN]	5	hSpCas9	negative selection	10019441
111195856	111195879	X	+	27869803	HPAFII	viability after 35 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	-1.3575995839971264	[261]	[39,64,NaN]	-6	hSpCas9	negative selection	10019442
111123135	111123158	X	-	27869803	HPAFII	viability after 31 days	CATCCTCAGTGGAGGAGCCGGGG	PAK3	ENSG00000077264	0.1060432671281808	[118]	[57,86,NaN]	0	hSpCas9	negative selection	10101886
111146530	111146553	X	+	27869803	HPAFII	viability after 31 days	TATGGCTCACAGATGTGCCCAGG	PAK3	ENSG00000077264	1.3673738157267006	[110]	[120,203,NaN]	8	hSpCas9	negative selection	10101887
111147732	111147755	X	+	27869803	HPAFII	viability after 31 days	CACAGGGAATTCCAGAGCAATGG	PAK3	ENSG00000077264	-0.5044574423620972	[390]	[102,210,NaN]	-3	hSpCas9	negative selection	10101888
111162947	111162970	X	-	27869803	HPAFII	viability after 31 days	CTTCTTCTTCAGACACAGGAGGG	PAK3	ENSG00000077264	1.1383589684753854	[209]	[56,479,NaN]	8	hSpCas9	negative selection	10101889
111192146	111192169	X	+	27869803	HPAFII	viability after 31 days	ACAGCACTAGACATTGCAACAGG	PAK3	ENSG00000077264	0.4974842964025702	[356]	[178,395,NaN]	3	hSpCas9	negative selection	10101890
111195856	111195879	X	+	27869803	HPAFII	viability after 31 days	GGATTTCCTGCACTCAAACCAGG	PAK3	ENSG00000077264	-1.063133906308198	[261]	[33,109,NaN]	-6	hSpCas9	negative selection	10101891
111142166	111142189	X	+	28162770	P31FUJ	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	-0.06062122903169853	[70]	[79]	0	hSpCas9	negative selection	10206452
111162948	111162971	X	-	28162770	P31FUJ	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	0.11682540521817719	[422]	[538]	1	hSpCas9	negative selection	10206453
111163629	111163652	X	-	28162770	P31FUJ	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.935669199886435	[330]	[743]	9	hSpCas9	negative selection	10206454
111216514	111216537	X	+	28162770	P31FUJ	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.8931066928795268	[158]	[346]	8	hSpCas9	negative selection	10206455
111216525	111216548	X	+	28162770	P31FUJ	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	-0.5301881150389494	[101]	[82]	-4	hSpCas9	negative selection	10206456
111196481	111196504	X	+	28162770	P31FUJ	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.5604775324315026	[205]	[356]	6	hSpCas9	negative selection	10206457
111147806	111147829	X	-	28162770	P31FUJ	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.905992899583763	[202]	[446]	9	hSpCas9	negative selection	10206458
111162936	111162959	X	-	28162770	P31FUJ	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	0.0153710205244596	[308]	[366]	0	hSpCas9	negative selection	10206459
111196511	111196534	X	+	28162770	P31FUJ	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	0.4439763836767385	[278]	[445]	5	hSpCas9	negative selection	10206460
111123193	111123216	X	+	28162770	P31FUJ	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	0.5322118074037322	[325]	[553]	6	hSpCas9	negative selection	10206461
111142166	111142189	X	+	28162770	TF1	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	NaN	[NaN]	[57]	1	hSpCas9	negative selection	10375818
111162948	111162971	X	-	28162770	TF1	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	NaN	[NaN]	[642]	1	hSpCas9	negative selection	10375819
111163629	111163652	X	-	28162770	TF1	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	NaN	[NaN]	[480]	1	hSpCas9	negative selection	10375820
111216514	111216537	X	+	28162770	TF1	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	NaN	[NaN]	[281]	1	hSpCas9	negative selection	10375821
111216525	111216548	X	+	28162770	TF1	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	NaN	[NaN]	[118]	1	hSpCas9	negative selection	10375822
111196481	111196504	X	+	28162770	TF1	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	NaN	[NaN]	[317]	1	hSpCas9	negative selection	10375823
111147806	111147829	X	-	28162770	TF1	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	NaN	[NaN]	[271]	1	hSpCas9	negative selection	10375824
111162936	111162959	X	-	28162770	TF1	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	NaN	[NaN]	[444]	1	hSpCas9	negative selection	10375825
111196511	111196534	X	+	28162770	TF1	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	NaN	[NaN]	[228]	1	hSpCas9	negative selection	10375826
111123193	111123216	X	+	28162770	TF1	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	NaN	[NaN]	[378]	1	hSpCas9	negative selection	10375827
111142166	111142189	X	+	28162770	SKM1	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	0.4219238848640836	[18]	[44]	4	hSpCas9	negative selection	10545184
111162948	111162971	X	-	28162770	SKM1	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	0.8300749985576875	[83]	[263]	7	hSpCas9	negative selection	10545185
111163629	111163652	X	-	28162770	SKM1	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.612718167118538	[90]	[245]	6	hSpCas9	negative selection	10545186
111216514	111216537	X	+	28162770	SKM1	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.8379228603803728	[49]	[157]	7	hSpCas9	negative selection	10545187
111216525	111216548	X	+	28162770	SKM1	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	-0.5100576917072654	[28]	[35]	-4	hSpCas9	negative selection	10545188
111196481	111196504	X	+	28162770	SKM1	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.32029218444311625	[81]	[180]	3	hSpCas9	negative selection	10545189
111147806	111147829	X	-	28162770	SKM1	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.8723720194197327	[54]	[177]	8	hSpCas9	negative selection	10545190
111162936	111162959	X	-	28162770	SKM1	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	-0.026821489910503704	[67]	[117]	0	hSpCas9	negative selection	10545191
111196511	111196534	X	+	28162770	SKM1	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	0.31126483284145856	[61]	[135]	3	hSpCas9	negative selection	10545192
111123193	111123216	X	+	28162770	SKM1	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	-0.545670469574754	[89]	[108]	-4	hSpCas9	negative selection	10545193
111142166	111142189	X	+	28162770	SKM1	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	0.4219238848640836	[18]	[44]	4	hSpCas9	negative selection	10714550
111162948	111162971	X	-	28162770	SKM1	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	0.8300749985576875	[83]	[263]	7	hSpCas9	negative selection	10714551
111163629	111163652	X	-	28162770	SKM1	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.612718167118538	[90]	[245]	6	hSpCas9	negative selection	10714552
111216514	111216537	X	+	28162770	SKM1	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.8379228603803728	[49]	[157]	7	hSpCas9	negative selection	10714553
111216525	111216548	X	+	28162770	SKM1	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	-0.5100576917072654	[28]	[35]	-4	hSpCas9	negative selection	10714554
111196481	111196504	X	+	28162770	SKM1	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.32029218444311625	[81]	[180]	3	hSpCas9	negative selection	10714555
111147806	111147829	X	-	28162770	SKM1	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.8723720194197327	[54]	[177]	8	hSpCas9	negative selection	10714556
111162936	111162959	X	-	28162770	SKM1	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	-0.026821489910503704	[67]	[117]	0	hSpCas9	negative selection	10714557
111196511	111196534	X	+	28162770	SKM1	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	0.31126483284145856	[61]	[135]	3	hSpCas9	negative selection	10714558
111123193	111123216	X	+	28162770	SKM1	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	-0.545670469574754	[89]	[108]	-4	hSpCas9	negative selection	10714559
111142166	111142189	X	+	28162770	PL21	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	-0.45882346767561266	[59]	[18]	-3	hSpCas9	negative selection	10883916
111162948	111162971	X	-	28162770	PL21	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	0.250325371657537	[225]	[116]	2	hSpCas9	negative selection	10883917
111163629	111163652	X	-	28162770	PL21	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	-0.022252806847127937	[342]	[146]	0	hSpCas9	negative selection	10883918
111216514	111216537	X	+	28162770	PL21	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	1.1360092770696046	[183]	[175]	8	hSpCas9	negative selection	10883919
111216525	111216548	X	+	28162770	PL21	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	-0.11473372286409178	[101]	[40]	-1	hSpCas9	negative selection	10883920
111196481	111196504	X	+	28162770	PL21	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.4689563729171202	[248]	[149]	4	hSpCas9	negative selection	10883921
111147806	111147829	X	-	28162770	PL21	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	1.6037179983931	[157]	[208]	9	hSpCas9	negative selection	10883922
111162936	111162959	X	-	28162770	PL21	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	1.2068342670633285	[214]	[215]	8	hSpCas9	negative selection	10883923
111196511	111196534	X	+	28162770	PL21	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	-1.273791573843092	[149]	[26]	-7	hSpCas9	negative selection	10883924
111123193	111123216	X	+	28162770	PL21	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	0.5232950127606846	[234]	[146]	4	hSpCas9	negative selection	10883925
111142166	111142189	X	+	28162770	P31FUJ	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	-0.06062122903169853	[70]	[79]	0	hSpCas9	negative selection	11053282
111162948	111162971	X	-	28162770	P31FUJ	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	0.11682540521817719	[422]	[538]	1	hSpCas9	negative selection	11053283
111163629	111163652	X	-	28162770	P31FUJ	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.935669199886435	[330]	[743]	9	hSpCas9	negative selection	11053284
111216514	111216537	X	+	28162770	P31FUJ	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.8931066928795268	[158]	[346]	8	hSpCas9	negative selection	11053285
111216525	111216548	X	+	28162770	P31FUJ	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	-0.5301881150389494	[101]	[82]	-4	hSpCas9	negative selection	11053286
111196481	111196504	X	+	28162770	P31FUJ	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.5604775324315026	[205]	[356]	6	hSpCas9	negative selection	11053287
111147806	111147829	X	-	28162770	P31FUJ	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.905992899583763	[202]	[446]	9	hSpCas9	negative selection	11053288
111162936	111162959	X	-	28162770	P31FUJ	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	0.0153710205244596	[308]	[366]	0	hSpCas9	negative selection	11053289
111196511	111196534	X	+	28162770	P31FUJ	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	0.4439763836767385	[278]	[445]	5	hSpCas9	negative selection	11053290
111123193	111123216	X	+	28162770	P31FUJ	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	0.5322118074037322	[325]	[553]	6	hSpCas9	negative selection	11053291
111142166	111142189	X	+	28162770	OCIAML5	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	0.4877834320206278	[31]	[80]	4	hSpCas9	negative selection	11222648
111162948	111162971	X	-	28162770	OCIAML5	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	0.7551487367042868	[192]	[587]	6	hSpCas9	negative selection	11222649
111163629	111163652	X	-	28162770	OCIAML5	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.9615966036618303	[162]	[572]	8	hSpCas9	negative selection	11222650
111216514	111216537	X	+	28162770	OCIAML5	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.814579727450867	[102]	[326]	7	hSpCas9	negative selection	11222651
111216525	111216548	X	+	28162770	OCIAML5	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	-0.15162685272290477	[31]	[51]	-1	hSpCas9	negative selection	11222652
111196481	111196504	X	+	28162770	OCIAML5	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	1.0824234756766047	[106]	[408]	8	hSpCas9	negative selection	11222653
111147806	111147829	X	-	28162770	OCIAML5	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.6662981811281353	[132]	[380]	6	hSpCas9	negative selection	11222654
111162936	111162959	X	-	28162770	OCIAML5	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	0.3569674676174318	[185]	[429]	3	hSpCas9	negative selection	11222655
111196511	111196534	X	+	28162770	OCIAML5	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	1.6857833340190398	[82]	[481]	9	hSpCas9	negative selection	11222656
111123193	111123216	X	+	28162770	OCIAML5	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	0.21832275702740112	[199]	[419]	1	hSpCas9	negative selection	11222657
111142166	111142189	X	+	28162770	EOL1	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	0.18758217740432848	[129]	[77]	1	hSpCas9	negative selection	11392014
111162948	111162971	X	-	28162770	EOL1	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	0.936389384215051	[363]	[366]	7	hSpCas9	negative selection	11392015
111163629	111163652	X	-	28162770	EOL1	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.7377422587711591	[633]	[556]	6	hSpCas9	negative selection	11392016
111216514	111216537	X	+	28162770	EOL1	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.6531011259205406	[343]	[284]	6	hSpCas9	negative selection	11392017
111216525	111216548	X	+	28162770	EOL1	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	-0.6295537654458612	[184]	[62]	-4	hSpCas9	negative selection	11392018
111196481	111196504	X	+	28162770	EOL1	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.5347064251183105	[472]	[360]	5	hSpCas9	negative selection	11392019
111147806	111147829	X	-	28162770	EOL1	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.8715988916215753	[221]	[213]	7	hSpCas9	negative selection	11392020
111162936	111162959	X	-	28162770	EOL1	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	-0.9664283346746103	[292]	[78]	-6	hSpCas9	negative selection	11392021
111196511	111196534	X	+	28162770	EOL1	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	-0.2391986549426537	[232]	[103]	-2	hSpCas9	negative selection	11392022
111123193	111123216	X	+	28162770	EOL1	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	-0.6419420690791426	[387]	[130]	-4	hSpCas9	negative selection	11392023
111142166	111142189	X	+	28162770	MOLM13	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	1.65551638472035	[71]	[163]	9	hSpCas9	negative selection	11561380
111162948	111162971	X	-	28162770	MOLM13	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	-0.20730958194645877	[601]	[376]	-1	hSpCas9	negative selection	11561381
111163629	111163652	X	-	28162770	MOLM13	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	1.3449078817125417	[513]	[943]	8	hSpCas9	negative selection	11561382
111216514	111216537	X	+	28162770	MOLM13	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	1.0235079206835906	[297]	[437]	7	hSpCas9	negative selection	11561383
111216525	111216548	X	+	28162770	MOLM13	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	1.7158168949881643	[143]	[341]	9	hSpCas9	negative selection	11561384
111196481	111196504	X	+	28162770	MOLM13	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.40899569249101037	[349]	[335]	3	hSpCas9	negative selection	11561385
111147806	111147829	X	-	28162770	MOLM13	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.3370701710998575	[322]	[294]	2	hSpCas9	negative selection	11561386
111162936	111162959	X	-	28162770	MOLM13	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	0.3427100761752388	[372]	[341]	2	hSpCas9	negative selection	11561387
111196511	111196534	X	+	28162770	MOLM13	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	1.3599414681774644	[214]	[398]	9	hSpCas9	negative selection	11561388
111123193	111123216	X	+	28162770	MOLM13	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	-0.5639360643108189	[549]	[268]	-3	hSpCas9	negative selection	11561389
111142166	111142189	X	+	28162770	HEL	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	1.3232789927037443	[72]	[116]	9	hSpCas9	negative selection	11730746
111162948	111162971	X	-	28162770	HEL	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	-0.3666803203320369	[460]	[228]	-3	hSpCas9	negative selection	11730747
111163629	111163652	X	-	28162770	HEL	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.7288539897889497	[503]	[534]	6	hSpCas9	negative selection	11730748
111216514	111216537	X	+	28162770	HEL	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.832484019436958	[248]	[283]	7	hSpCas9	negative selection	11730749
111216525	111216548	X	+	28162770	HEL	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	0.25466838032178263	[105]	[80]	2	hSpCas9	negative selection	11730750
111196481	111196504	X	+	28162770	HEL	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.6474923619709916	[302]	[303]	5	hSpCas9	negative selection	11730751
111147806	111147829	X	-	28162770	HEL	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	1.5207483076217465	[184]	[339]	9	hSpCas9	negative selection	11730752
111162936	111162959	X	-	28162770	HEL	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	-0.22024168889135293	[270]	[148]	-1	hSpCas9	negative selection	11730753
111196511	111196534	X	+	28162770	HEL	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	-0.3694358819457455	[237]	[117]	-3	hSpCas9	negative selection	11730754
111123193	111123216	X	+	28162770	HEL	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	0.12164253558926419	[474]	[330]	1	hSpCas9	negative selection	11730755
111142166	111142189	X	+	28162770	MV411	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	-0.03984440129769595	[71]	[58]	0	hSpCas9	negative selection	11900112
111162948	111162971	X	-	28162770	MV411	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	1.0179557046600083	[220]	[376]	8	hSpCas9	negative selection	11900113
111163629	111163652	X	-	28162770	MV411	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.6769455328699523	[371]	[500]	6	hSpCas9	negative selection	11900114
111216514	111216537	X	+	28162770	MV411	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	1.134055751365033	[171]	[317]	8	hSpCas9	negative selection	11900115
111216525	111216548	X	+	28162770	MV411	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	-0.0645064555319651	[107]	[86]	0	hSpCas9	negative selection	11900116
111196481	111196504	X	+	28162770	MV411	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.595360854203082	[208]	[265]	5	hSpCas9	negative selection	11900117
111147806	111147829	X	-	28162770	MV411	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.3055405053463435	[145]	[151]	2	hSpCas9	negative selection	11900118
111162936	111162959	X	-	28162770	MV411	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	-0.9334585684805401	[296]	[130]	-6	hSpCas9	negative selection	11900119
111196511	111196534	X	+	28162770	MV411	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	0.1944191684832844	[193]	[186]	1	hSpCas9	negative selection	11900120
111123193	111123216	X	+	28162770	MV411	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	0.9786894937545876	[252]	[419]	8	hSpCas9	negative selection	11900121
111142166	111142189	X	+	28162770	MONOMAC1	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	0.5316611311230519	[34]	[57]	5	hSpCas9	negative selection	12069478
111162948	111162971	X	-	28162770	MONOMAC1	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	0.5709556427272768	[137]	[234]	5	hSpCas9	negative selection	12069479
111163629	111163652	X	-	28162770	MONOMAC1	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.33769135114146587	[262]	[380]	3	hSpCas9	negative selection	12069480
111216514	111216537	X	+	28162770	MONOMAC1	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.6654596291905115	[109]	[199]	6	hSpCas9	negative selection	12069481
111216525	111216548	X	+	28162770	MONOMAC1	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	0.2546591227981382	[67]	[92]	2	hSpCas9	negative selection	12069482
111196481	111196504	X	+	28162770	MONOMAC1	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.6132179655038451	[141]	[248]	6	hSpCas9	negative selection	12069483
111147806	111147829	X	-	28162770	MONOMAC1	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.274034687133618	[100]	[139]	2	hSpCas9	negative selection	12069484
111162936	111162959	X	-	28162770	MONOMAC1	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	0.70771483779263	[179]	[336]	6	hSpCas9	negative selection	12069485
111196511	111196534	X	+	28162770	MONOMAC1	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	0.251236981693222	[117]	[160]	2	hSpCas9	negative selection	12069486
111123193	111123216	X	+	28162770	MONOMAC1	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	0.4906393401101813	[130]	[210]	5	hSpCas9	negative selection	12069487
111142166	111142189	X	+	28162770	OCIAML2	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	-0.47062982524216146	[13]	[55]	-4	hSpCas9	negative selection	12238844
111162948	111162971	X	-	28162770	OCIAML2	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	0.33672509681544294	[39]	[279]	3	hSpCas9	negative selection	12238845
111163629	111163652	X	-	28162770	OCIAML2	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.3262517655859345	[78]	[548]	3	hSpCas9	negative selection	12238846
111216514	111216537	X	+	28162770	OCIAML2	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.10909602711284788	[45]	[274]	1	hSpCas9	negative selection	12238847
111216525	111216548	X	+	28162770	OCIAML2	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	0.30042896759245297	[22]	[156]	3	hSpCas9	negative selection	12238848
111196481	111196504	X	+	28162770	OCIAML2	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.5821116368298123	[46]	[389]	5	hSpCas9	negative selection	12238849
111147806	111147829	X	-	28162770	OCIAML2	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	0.3083432954456205	[43]	[301]	3	hSpCas9	negative selection	12238850
111162936	111162959	X	-	28162770	OCIAML2	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	0.204679177575249	[48]	[312]	2	hSpCas9	negative selection	12238851
111196511	111196534	X	+	28162770	OCIAML2	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	-0.02317084827093986	[32]	[179]	0	hSpCas9	negative selection	12238852
111123193	111123216	X	+	28162770	OCIAML2	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	-0.008151331046000021	[42]	[236]	0	hSpCas9	negative selection	12238853
111142166	111142189	X	+	28162770	OCIAML3	viability	GGGGTTTGATGCAGTCACCGGGG	PAK3	ENSG00000077264	-1.049687124100353	[23]	[34]	-6	hSpCas9	negative selection	12408210
111162948	111162971	X	-	28162770	OCIAML3	viability	TCTTCTTCTTCAGACACAGGAGG	PAK3	ENSG00000077264	-0.03727882033195096	[85]	[252]	0	hSpCas9	negative selection	12408211
111163629	111163652	X	-	28162770	OCIAML3	viability	GGAATTGGCATTTTCAGCAGAGG	PAK3	ENSG00000077264	0.3803057160121871	[84]	[333]	3	hSpCas9	negative selection	12408212
111216514	111216537	X	+	28162770	OCIAML3	viability	GAGATGGATGTGGATAGGCGAGG	PAK3	ENSG00000077264	0.5480113645482648	[57]	[255]	5	hSpCas9	negative selection	12408213
111216525	111216548	X	+	28162770	OCIAML3	viability	GGATAGGCGAGGATCTGCCAAGG	PAK3	ENSG00000077264	1.1544535926798725	[24]	[167]	8	hSpCas9	negative selection	12408214
111196481	111196504	X	+	28162770	OCIAML3	viability	AAGTAAACGAAGCACTATGGTGG	PAK3	ENSG00000077264	0.986495212206293	[53]	[322]	8	hSpCas9	negative selection	12408215
111147806	111147829	X	-	28162770	OCIAML3	viability	AGAACATCTAGAACAGCTTGTGG	PAK3	ENSG00000077264	-0.4674752343952314	[59]	[130]	-4	hSpCas9	negative selection	12408216
111162936	111162959	X	-	28162770	OCIAML3	viability	GACACAGGAGGGGCCAATGGAGG	PAK3	ENSG00000077264	0.3310303019946148	[78]	[299]	3	hSpCas9	negative selection	12408217
111196511	111196534	X	+	28162770	OCIAML3	viability	ATATTGGATGGCACCTGAGGTGG	PAK3	ENSG00000077264	0.06782362378126361	[66]	[211]	0	hSpCas9	negative selection	12408218
111123193	111123216	X	+	28162770	OCIAML3	viability	CAGCTCCAAACCACTTCCCATGG	PAK3	ENSG00000077264	-0.5854456268207393	[83]	[168]	-4	hSpCas9	negative selection	12408219